NCBI Summary
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011].
Protein
Protein (NP_001772)
CD69
Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)
CD69
CD69 molecule
CD69
Very low evidence
C-type lectin
Undefined
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Uncharacterised
NP_001772
969
Q07108
ENSP00000228434.3
Q07108
0.344
Undefined
PFAM, InterPro
Protein sequence and protein families (fasta) (199 amino acids) Download
MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPGHPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q07108-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Homodimer; disulfide-linked (PubMed:37039481). Interacts with S100A8 and S100A9 (PubMed:26296369). Interacts with galactin-1/LGALS1 (PubMed:24752896). Interacts with S1PR1; this interaction mediates S1PR1 degradation (PubMed:37039481)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Prognostic Relevance of Concordant Expression CD69 and CD56 in Response to Bortezomib Combination Therapy in Multiple Myeloma Patients. [34344244]
  • T cells selectively filter oscillatory signals on the minutes timescale. [33627405]
  • A reference map of the human binary protein interactome. [32296183]
  • Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings. [31928947]
  • Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. [7665567]
  • CD 69 antigen of human lymphocytes is a calcium-dependent carbohydrate-binding protein. [7887967]
  • Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors. [8026529]
  • Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. [8340758]
  • Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. [8100776]
  • Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. [1612643]
UniProt Main References (6 PubMed Identifiers)
  • Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. [8496594]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Toward a comprehensive characterization of a human cancer cell phosphoproteome. [23186163]
  • Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. [11101293]
  • Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69. [11036086]
  • Soluble recombinant CD69 receptors optimized to have an exceptional physical and chemical stability display prolonged circulation and remain intact in the blood of mice. [18959746]
RNA
RNA (Transcript ID: NM_001781.2)
NM_001781.2
CD69 molecule
All isoforms of CD69 containing a lectin domain
ENST00000228434.7
82..681 (or 9753481.. 9760820)
9752486.. 9760901
NCBI Matured mRNA sequence 1676 NTPDownload 
m7G-5')ppp(5'-AGACUCAACAAGAGCUCCAGCAAAGACUUUCACUGUAGCUUGACUUGACCUGAGAUUAACUAGGGAAUCUUGAGAAUAAAGAUGAGCUCUGAAAAUUGUUUCGUAGCAGAGAACAGCUCUUUGCAUCCGGAGAGUGGACAAGAAAAUGAUGCCACCAGUCCCCAUUUCUCAACACGUCAUGAAGGGUCCUUCCAAGUUCCUGUCCUGUGUGCUGUAAUGAAUGUGGUCUUCAUCACCAUUUUAAUCAUAGCUCUCAUUGCCUUAUCAGUGGGCCAAUACAAUUGUCCAGGCCAAUACACAUUCUCAAUGCCAUCAGACAGCCAUGUUUCUUCAUGCUCUGAGGACUGGGUUGGCUACCAGAGGAAAUGCUACUUUAUUUCUACUGUGAAGAGGAGCUGGACUUCAGCCCAAAAUGCUUGUUCUGAACAUGGUGCUACUCUUGCUGUCAUUGAUUCUGAAAAGGACAUGAACUUUCUAAAACGAUACGCAGGUAGAGAGGAACACUGGGUUGGACUGAAAAAGGAACCUGGUCACCCAUGGAAGUGGUCAAAUGGCAAAGAAUUUAACAACUGGUUCAACGUUACAGGGUCUGACAAGUGUGUUUUUCUGAAAAACACAGAGGUCAGCAGCAUGGAAUGUGAGAAGAAUUUAUACUGGAUAUGUAACAAACCUUACAAAUAAUAAGGAAACAUGUUCACUUAUUGACUAUUAUAGAAUGGAACUCAAGGAAAUCUGUGUCAGUGGAUGCUGCUCUGUGGUCCGAAGUCUUCCAUAGAGACUUUGUGAAAAAAAAUUUUAUAGUGUCUUGGGAAUUUUCUUCCAAACAGAACUAUGGAAAAAAAGGAAGAAAUUCCAGGAAAAUCUGCACUGUGGGCUUUUAUUGCCAUGAGCUAGAAGCAUCACAGGUUGACCAAUAACCAUGCCCAAGAAUGAGAAGAAUGACUAUGCAACCUUUGGAUGCACUUUAUAUUAUUUUGAAUCCAGAAAUAAUGAAAUAACUAGGCGUGGACUUACUAUUUAUUGCUGAAUGACUACCAACAGUGAGAGCCCUUCAUGCAUUUGCACUAUUGGAAGGAGUUAGAUGUUGGUACUAGAUACUGAAUGUAAACAAAGGAAUUAUGGCUGGUAACAUAGGUUUUUAGUCUAAUUGAAUCCCUUAAACUCAGGGAGCAUUUAUAAAUGGACAAAUGCUUAUGAAACUAAGAUUUGUAAUAUUUCUCUCUUUUUAGAGAAAUUUGCCAAUUUACUUUGUUAUUUUUCCCCAAAAAGAAUGGGAUGAUCAUGUAUUUAUUUUUUUACUUCCUCAGCUGUAGACAGGUCCUUUUCGAUGGUACAUAUUUCUUUGCCUUUAUAAUCUUUUAUACAGUGUCUUACAGAGAAAAGACAUAAGCAAAGACUAUGAGGAAUAUUUGCAAGACAUAGAAUAGUGUUGGAAAAUGUGCAAUAUGUGAUGUGGCAAAUCUCUAUUAGGAAAUAUUCUGUAAUCUUCAGACCUAGAAUAAUACUAGUCUUAUAAUAGGUUUGUGACUUUCCUAAAUCAAUUCUAUUACGUGCAAUACUUCAAUACUUCAUUUAAAAUAUUUUUAUGUGCAAUAAAAUGUAUUUGUUUGUAUUUUGUGUUCAGUACAAUUAUAAGCUGUUUUUAUAUAUGUGAAAUAAAAGUAGAAUAAACACAA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 969)
CD69
CD69 molecule
NC_000012.12
12  9753481.. 9760820
9753481.. 9760820
strand -
CCDS8604.1
MGI:88343
ClinVar, dbVar
ENSG00000110848
CLEC2C
uc001qwk.3
INSDC: Z22576
1694
107273
OTTHUMG00000168481
ENA, DDBJ, Monarch
CD69
Gene-related data
NCBI CDS gene sequence (600 bp)
5'-ATGAGCTCTGAAAATTGTTTCGTAGCAGAGAACAGCTCTTTGCATCCGGAGAGTGGACAAGAAAATGATGCCACCAGTCCCCATTTCTCAACACGTCATGAAGGGTCCTTCCAAGTTCCTGTCCTGTGTGCTGTAATGAATGTGGTCTTCATCACCATTTTAATCATAGCTCTCATTGCCTTATCAGTGGGCCAATACAATTGTCCAGGCCAATACACATTCTCAATGCCATCAGACAGCCATGTTTCTTCATGCTCTGAGGACTGGGTTGGCTACCAGAGGAAATGCTACTTTATTTCTACTGTGAAGAGGAGCTGGACTTCAGCCCAAAATGCTTGTTCTGAACATGGTGCTACTCTTGCTGTCATTGATTCTGAAAAGGACATGAACTTTCTAAAACGATACGCAGGTAGAGAGGAACACTGGGTTGGACTGAAAAAGGAACCTGGTCACCCATGGAAGTGGTCAAATGGCAAAGAATTTAACAACTGGTTCAACGTTACAGGGTCTGACAAGTGTGTTTTTCTGAAAAACACAGAGGTCAGCAGCATGGAATGTGAGAAGAATTTATACTGGATATGTAACAAACCTTACAAATAA-3'
NCBI CDS gene sequence with introns (location: 9753481.. 9760820) (7340 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 9752486.. 9760901) (8416 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [9752486.. 9760901 + 1000]) (9416 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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