Protein
Protein (NP_001763)
SIGLEC-3
Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)
CD33
CD33 molecule
CD33
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)Gal(b1-4)GlcNAc
NP_001763
945
P20138
ENSP00000262262.3
P20138
0.398
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (364 amino acids) Download
MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTHPTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSEVRTQ
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P20138-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
aNeuAc26Gal
NeuAc(a2-6)Gal
5J0B
5J0B
GlyConnect Structures
aNeuAc23Gal
NeuAc(a2-3)Gal
5J06
5J06
GlyConnect Structures
P22 ligand analog of 6-sialyllactose
NeuAc(a2-6)Gal(b1-4)Glc
6D49, 6D4A, 7AW6
6D49, 6D4A, 7AW6
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CD33 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Quantitative analyses of CD7, CD33, CD34, CD56, and CD123 within the FLT3-ITD/NPM1-MUT myeloblastic/monocytic bulk AML blastic populations. [34034609]
  • CD33M inhibits microglial phagocytosis, migration and proliferation, but the Alzheimer's disease-protective variant CD33m stimulates phagocytosis and proliferation, and inhibits adhesion. [33720433]
  • Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia. [34188106]
  • SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection. [34060491]
  • CD33 rs3865444 as a risk factor for Parkinson's disease. [33582190]
  • Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. [7718872]
  • Expression of an early myelopoietic antigen (CD33) on a subset of human umbilical cord blood-derived natural killer cells. [7505004]
  • Identification of potent mixed leukocyte reaction-stimulatory cells in human bone marrow. Putative differentiation stage of human blood dendritic cells. [8454872]
  • Expression of the myeloid differentiation antigen CD33 depends on the presence of human chromosome 19 in human-mouse hybrids. [1696442]
  • Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. [3139766]
UniProt Main References (14 PubMed Identifiers)
  • Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. [11943481]
  • A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. [16380601]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • A single N-linked glycosylation site is implicated in the regulation of ligand recognition by the I-type lectins CD22 and CD33. [8702538]
  • The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. [10556798]
  • The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. [10206955]
  • Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. [10611343]
  • Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2. [10887109]
    • Show more
All isoforms of this gene containing a lectin domain
NP_001171079.1, NP_001763.3, XP_011525834.1, XP_011525833.1, XP_016882997.1, XP_016882998.1, NP_001076087.1, XP_016882999.1
RNA
RNA (Transcript ID: NM_001772.4)
NM_001772.4
CD33 molecule, transcript variant 1
All isoforms of CD33 containing a lectin domain
ENST00000262262.5
40..1134 (or 51225119.. 51239688)
51225080.. 51240016
NCBI Matured mRNA sequence 1462 NTPDownload 
m7G-5')ppp(5'-CUGCUCACACAGGAAGCCCUGGAAGCUGCUUCCUCAGACAUGCCGCUGCUGCUACUGCUGCCCCUGCUGUGGGCAGGGGCCCUGGCUAUGGAUCCAAAUUUCUGGCUGCAAGUGCAGGAGUCAGUGACGGUACAGGAGGGUUUGUGCGUCCUCGUGCCCUGCACUUUCUUCCAUCCCAUACCCUACUACGACAAGAACUCCCCAGUUCAUGGUUACUGGUUCCGGGAAGGAGCCAUUAUAUCCAGGGACUCUCCAGUGGCCACAAACAAGCUAGAUCAAGAAGUACAGGAGGAGACUCAGGGCAGAUUCCGCCUCCUUGGGGAUCCCAGUAGGAACAACUGCUCCCUGAGCAUCGUAGACGCCAGGAGGAGGGAUAAUGGUUCAUACUUCUUUCGGAUGGAGAGAGGAAGUACCAAAUACAGUUACAAAUCUCCCCAGCUCUCUGUGCAUGUGACAGACUUGACCCACAGGCCCAAAAUCCUCAUCCCUGGCACUCUAGAACCCGGCCACUCCAAAAACCUGACCUGCUCUGUGUCCUGGGCCUGUGAGCAGGGAACACCCCCGAUCUUCUCCUGGUUGUCAGCUGCCCCCACCUCCCUGGGCCCCAGGACUACUCACUCCUCGGUGCUCAUAAUCACCCCACGGCCCCAGGACCACGGCACCAACCUGACCUGUCAGGUGAAGUUCGCUGGAGCUGGUGUGACUACGGAGAGAACCAUCCAGCUCAACGUCACCUAUGUUCCACAGAACCCAACAACUGGUAUCUUUCCAGGAGAUGGCUCAGGGAAACAAGAGACCAGAGCAGGAGUGGUUCAUGGGGCCAUUGGAGGAGCUGGUGUUACAGCCCUGCUCGCUCUUUGUCUCUGCCUCAUCUUCUUCAUAGUGAAGACCCACAGGAGGAAAGCAGCCAGGACAGCAGUGGGCAGGAAUGACACCCACCCUACCACAGGGUCAGCCUCCCCGAAACACCAGAAGAAGUCCAAGUUACAUGGCCCCACUGAAACCUCAAGCUGUUCAGGUGCCGCCCCUACUGUGGAGAUGGAUGAGGAGCUGCAUUAUGCUUCCCUCAACUUUCAUGGGAUGAAUCCUUCCAAGGACACCUCCACCGAAUACUCAGAGGUCAGGACCCAGUGAGGAACCCACAAGAGCAUCAGGCUCAGCUAGAAGAUCCACAUCCUCUACAGGUCGGGGACCAAAGGCUGAUUCUUGGAGAUUUAACACCCCACAGGCAAUGGGUUUAUAGACAUUAUGUGAGUUUCCUGCUAUAUUAACAUCAUCUUAGACUUUGCAAGCAGAGAGUCGUGGAAUCAAAUCUGUGCUCUUUCAUUUGCUAAGUGUAUGAUGUCACACAAGCUCCUUAACCUUCCAUGUCUCCAUUUUCUUCUCUGUGAAGUAGGUAUAAGAAGUCCUAUCUCAUAGGGAUGCUGUGAGCAUUAAAUAAAGGUACACAUGGAAAACACCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 945)
CD33
CD33 molecule
NC_000019.10
19  51225119.. 51239688
51225119.. 51239688
strand +
CCDS33084.1
MGI:99440
ClinVar, dbVar
ENSG00000105383
SIGLEC3, SIGLEC-3, p67, FLJ00391
uc002pwa.3
INSDC: M23197
1659
159590
OTTHUMG00000182891
ENA, DDBJ, Monarch
CD33
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1095 bp)
5'-ATGCCGCTGCTGCTACTGCTGCCCCTGCTGTGGGCAGGGGCCCTGGCTATGGATCCAAATTTCTGGCTGCAAGTGCAGGAGTCAGTGACGGTACAGGAGGGTTTGTGCGTCCTCGTGCCCTGCACTTTCTTCCATCCCATACCCTACTACGACAAGAACTCCCCAGTTCATGGTTACTGGTTCCGGGAAGGAGCCATTATATCCAGGGACTCTCCAGTGGCCACAAACAAGCTAGATCAAGAAGTACAGGAGGAGACTCAGGGCAGATTCCGCCTCCTTGGGGATCCCAGTAGGAACAACTGCTCCCTGAGCATCGTAGACGCCAGGAGGAGGGATAATGGTTCATACTTCTTTCGGATGGAGAGAGGAAGTACCAAATACAGTTACAAATCTCCCCAGCTCTCTGTGCATGTGACAGACTTGACCCACAGGCCCAAAATCCTCATCCCTGGCACTCTAGAACCCGGCCACTCCAAAAACCTGACCTGCTCTGTGTCCTGGGCCTGTGAGCAGGGAACACCCCCGATCTTCTCCTGGTTGTCAGCTGCCCCCACCTCCCTGGGCCCCAGGACTACTCACTCCTCGGTGCTCATAATCACCCCACGGCCCCAGGACCACGGCACCAACCTGACCTGTCAGGTGAAGTTCGCTGGAGCTGGTGTGACTACGGAGAGAACCATCCAGCTCAACGTCACCTATGTTCCACAGAACCCAACAACTGGTATCTTTCCAGGAGATGGCTCAGGGAAACAAGAGACCAGAGCAGGAGTGGTTCATGGGGCCATTGGAGGAGCTGGTGTTACAGCCCTGCTCGCTCTTTGTCTCTGCCTCATCTTCTTCATAGTGAAGACCCACAGGAGGAAAGCAGCCAGGACAGCAGTGGGCAGGAATGACACCCACCCTACCACAGGGTCAGCCTCCCCGAAACACCAGAAGAAGTCCAAGTTACATGGCCCCACTGAAACCTCAAGCTGTTCAGGTGCCGCCCCTACTGTGGAGATGGATGAGGAGCTGCATTATGCTTCCCTCAACTTTCATGGGATGAATCCTTCCAAGGACACCTCCACCGAATACTCAGAGGTCAGGACCCAGTGA-3'
NCBI CDS gene sequence with introns (location: 51225119.. 51239688) (14570 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51225080.. 51240016) (14937 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51225080 - 1000].. 51240016) (15937 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905