HumanLectome - Human Lectin Entry

Protein name

SIGLEC-2

Synonym(s)

B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)

HGNC gene name

CD22

HGNC name

CD22 molecule

Protein_CD_name

CD22

Lectin confidence

Curated

UniLectin class

I-type lectin

Known lectin group

I-Type Lectins - Siglecs common to mammals

Lectin fold

b-sandwich / Ig-like

Glycan specificity

NeuAc / Neu5Ac(a2-6)Gal(b1-4)(6S)GlcNAc

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.43

Reference

10.1146/annurev-immunol-102419-035900

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (847 amino acids) Download

MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P20273-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for CD22 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial. [34642489]

Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments. [34638774]

The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells. [33990399]

Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy. [33314603]

Inotuzumab ozogamicin resistance associated with a novel CD22 truncating mutation in a case of B-acute lymphoblastic leukaemia. [32648276]

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. [7618087]

Regulation of CD45 engagement by the B-cell receptor CD22. [7537381]

Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule. [1401903]

cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions. [1985119]

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. [1691828]

UniProt Main References (8 PubMed Identifiers)

Genomic structure and chromosomal mapping of the human CD22 gene. [8496602]

The DNA sequence and biology of human chromosome 19. [15057824]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Identification of the gene variations in human CD22. [10079291]

Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition. [8463235]

Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. [8647200]

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. [8627166]

CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. [9143697]

All isoforms of this gene containing a lectin domain

NP_001172029.1, NP_001762.2, NP_001172028.1, NP_001172030.1, NP_001265346.1

RNA

RNA (Transcript ID: NM_001771.4)

RNA RefSeq ID

NM_001771.4

RNA name

CD22 molecule, transcript variant 1

Isoforms

All isoforms of CD22 containing a lectin domain

RNA Ensembl ID

ENST00000085219.10

Coding region

67..2610 (or 35332041.. 35346697)

mRNA location

35329187.. 35347361

NCBI Matured mRNA sequence 3274 NTP Download

m⁷G-5')ppp(5'-AGAUGCUGCCAGGGUCCCUGAAGAGGGAAGACACGCGGAAACAGGCUUGCACCCAGACACGACACCAUGCAUCUCCUCGGCCCCUGGCUCCUGCUCCUGGUUCUAGAAUACUUGGCUUUCUCUGACUCAAGUAAAUGGGUUUUUGAGCACCCUGAAACCCUCUACGCCUGGGAGGGGGCCUGCGUCUGGAUCCCCUGCACCUACAGAGCCCUAGAUGGUGACCUGGAAAGCUUCAUCCUGUUCCACAAUCCUGAGUAUAACAAGAACACCUCGAAGUUUGAUGGGACAAGACUCUAUGAAAGCACAAAGGAUGGGAAGGUUCCUUCUGAGCAGAAAAGGGUGCAAUUCCUGGGAGACAAGAAUAAGAACUGCACACUGAGUAUCCACCCGGUGCACCUCAAUGACAGUGGUCAGCUGGGGCUGAGGAUGGAGUCCAAGACUGAGAAAUGGAUGGAACGAAUACACCUCAAUGUCUCUGAAAGGCCUUUUCCACCUCAUAUCCAGCUCCCUCCAGAAAUUCAAGAGUCCCAGGAAGUCACUCUGACCUGCUUGCUGAAUUUCUCCUGCUAUGGGUAUCCGAUCCAAUUGCAGUGGCUCCUAGAGGGGGUUCCAAUGAGGCAGGCUGCUGUCACCUCGACCUCCUUGACCAUCAAGUCUGUCUUCACCCGGAGCGAGCUCAAGUUCUCCCCACAGUGGAGUCACCAUGGGAAGAUUGUGACCUGCCAGCUUCAGGAUGCAGAUGGGAAGUUCCUCUCCAAUGACACGGUGCAGCUGAACGUGAAGCACACCCCGAAGUUGGAGAUCAAGGUCACUCCCAGUGAUGCCAUAGUGAGGGAGGGGGACUCUGUGACCAUGACCUGCGAGGUCAGCAGCAGCAACCCGGAGUACACGACGGUAUCCUGGCUCAAGGAUGGGACCUCGCUGAAGAAGCAGAAUACAUUCACGCUAAACCUGCGCGAAGUGACCAAGGACCAGAGUGGGAAGUACUGCUGUCAGGUCUCCAAUGACGUGGGCCCGGGAAGGUCGGAAGAAGUGUUCCUGCAAGUGCAGUAUGCCCCGGAACCUUCCACGGUUCAGAUCCUCCACUCACCGGCUGUGGAGGGAAGUCAAGUCGAGUUUCUUUGCAUGUCACUGGCCAAUCCUCUUCCAACAAAUUACACGUGGUACCACAAUGGGAAAGAAAUGCAGGGAAGGACAGAGGAGAAAGUCCACAUCCCAAAGAUCCUCCCCUGGCACGCUGGGACUUAUUCCUGUGUGGCAGAAAACAUUCUUGGUACUGGACAGAGGGGCCCGGGAGCUGAGCUGGAUGUCCAGUAUCCUCCCAAGAAGGUGACCACAGUGAUUCAAAACCCCAUGCCGAUUCGAGAAGGAGACACAGUGACCCUUUCCUGUAACUACAAUUCCAGUAACCCCAGUGUUACCCGGUAUGAAUGGAAACCCCAUGGCGCCUGGGAGGAGCCAUCGCUUGGGGUGCUGAAGAUCCAAAACGUUGGCUGGGACAACACAACCAUCGCCUGCGCAGCUUGUAAUAGUUGGUGCUCGUGGGCCUCCCCUGUCGCCCUGAAUGUCCAGUAUGCCCCCCGAGACGUGAGGGUCCGGAAAAUCAAGCCCCUUUCCGAGAUUCACUCUGGAAACUCGGUCAGCCUCCAAUGUGACUUCUCAAGCAGCCACCCCAAAGAAGUCCAGUUCUUCUGGGAGAAAAAUGGCAGGCUUCUGGGGAAAGAAAGCCAGCUGAAUUUUGACUCCAUCUCCCCAGAAGAUGCUGGGAGUUACAGCUGCUGGGUGAACAACUCCAUAGGACAGACAGCGUCCAAGGCCUGGACACUUGAAGUGCUGUAUGCACCCAGGAGGCUGCGUGUGUCCAUGAGCCCGGGGGACCAAGUGAUGGAGGGGAAGAGUGCAACCCUGACCUGUGAGAGCGACGCCAACCCUCCCGUCUCCCACUACACCUGGUUUGACUGGAAUAACCAAAGCCUCCCCUACCACAGCCAGAAGCUGAGAUUGGAGCCGGUGAAGGUCCAGCACUCGGGUGCCUACUGGUGCCAGGGGACCAACAGUGUGGGCAAGGGCCGUUCGCCUCUCAGCACCCUCACCGUCUACUAUAGCCCGGAGACCAUCGGCAGGCGAGUGGCUGUGGGACUCGGGUCCUGCCUCGCCAUCCUCAUCCUGGCAAUCUGUGGGCUCAAGCUCCAGCGACGUUGGAAGAGGACACAGAGCCAGCAGGGGCUUCAGGAGAAUUCCAGCGGCCAGAGCUUCUUUGUGAGGAAUAAAAAGGUUAGAAGGGCCCCCCUCUCUGAAGGCCCCCACUCCCUGGGAUGCUACAAUCCAAUGAUGGAAGAUGGCAUUAGCUACACCACCCUGCGCUUUCCCGAGAUGAACAUACCACGAACUGGAGAUGCAGAGUCCUCAGAGAUGCAGAGACCUCCCCCGGACUGCGAUGACACGGUCACUUAUUCAGCAUUGCACAAGCGCCAAGUGGGCGACUAUGAGAACGUCAUUCCAGAUUUUCCAGAAGAUGAGGGGAUUCAUUACUCAGAGCUGAUCCAGUUUGGGGUCGGGGAGCGGCCUCAGGCACAAGAAAAUGUGGACUAUGUGAUCCUCAAACAUUGACACUGGAUGGGCUGCAGCAGAGGCACUGGGGGCAGCGGGGGCCAGGGAAGUCCCCGAGUUUCCCCAGACACCGCCACAUGGCUUCCUCCUGCGCGCAUGUGCGCACACACACACACACACGCACACACACACACACACACUCACUGCGGAGAACCUUGUGCCUGGCUCAGAGCCAGUCUUUUUGGUGAGGGUAACCCCAAACCUCCAAAACUCCUGCCCCUGUUCUCUUCCACUCUCCUUGCUACCCAGAAAUCCAUCUAAAUACCUGCCCUGACAUGCACACCUCCCCCUGCCCCCACCACGGCCACUGGCCAUCUCCACCCCCAGCUGCUUGUGUCCCUCCUGGGAUCUGCUCGUCAUCAUUUUUCCUUCCCUUCUCCAUCUCUCUGGCCCUCUACCCCUGAUCUGACAUCCCCACUCACGAAUAUUAUGCCCAGUUUCUGCCUCUGAGGGAAAGCCCAGAAAAGGACAGAAACGAAGUAGAAAGGGGCCCAGUCCUGGCCUGGCUUCUCCUUUGGAAGUGAGGCAUUGCACGGGGAGACGUACGUAUCAGCGGCCCCUUGACUCUGGGGACUCCGGGUUUGAGAUGGACACACUGGUGUGGAUUAACCUGCCAGGGAGACAGAGCUCACAAUAAAAAUGGCUCAGAUGCCACUUCAAAGAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 933)

HGNC Gene symbol

CD22

HGNC Gene name

CD22 molecule

Chr. RefSeq ID

NC_000019.10

Chromosome N°

19 35332041.. 35346697

CDS location

35332041.. 35346697

DNA strand

strand +

CCDS ID

CCDS12457.1

Mouse ortholog gene

MGI:88322

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000012124

HGNC other symbol

SIGLEC-2, SIGLEC2

UCSC ID

uc010edt.5

GeneBank

INSDC: X52785

GeneCards

1643

MIM

107266

VEGA ID

OTTHUMG00000183298

Other links

ENA, DDBJ, Monarch

CD gene name

CD22

NCBI CDS Gene viewer

More about the NCBI sViewer.

NCBI CDS gene sequence (2544 bp)

5'-ATGCATCTCCTCGGCCCCTGGCTCCTGCTCCTGGTTCTAGAATACTTGGCTTTCTCTGACTCAAGTAAATGGGTTTTTGAGCACCCTGAAACCCTCTACGCCTGGGAGGGGGCCTGCGTCTGGATCCCCTGCACCTACAGAGCCCTAGATGGTGACCTGGAAAGCTTCATCCTGTTCCACAATCCTGAGTATAACAAGAACACCTCGAAGTTTGATGGGACAAGACTCTATGAAAGCACAAAGGATGGGAAGGTTCCTTCTGAGCAGAAAAGGGTGCAATTCCTGGGAGACAAGAATAAGAACTGCACACTGAGTATCCACCCGGTGCACCTCAATGACAGTGGTCAGCTGGGGCTGAGGATGGAGTCCAAGACTGAGAAATGGATGGAACGAATACACCTCAATGTCTCTGAAAGGCCTTTTCCACCTCATATCCAGCTCCCTCCAGAAATTCAAGAGTCCCAGGAAGTCACTCTGACCTGCTTGCTGAATTTCTCCTGCTATGGGTATCCGATCCAATTGCAGTGGCTCCTAGAGGGGGTTCCAATGAGGCAGGCTGCTGTCACCTCGACCTCCTTGACCATCAAGTCTGTCTTCACCCGGAGCGAGCTCAAGTTCTCCCCACAGTGGAGTCACCATGGGAAGATTGTGACCTGCCAGCTTCAGGATGCAGATGGGAAGTTCCTCTCCAATGACACGGTGCAGCTGAACGTGAAGCACACCCCGAAGTTGGAGATCAAGGTCACTCCCAGTGATGCCATAGTGAGGGAGGGGGACTCTGTGACCATGACCTGCGAGGTCAGCAGCAGCAACCCGGAGTACACGACGGTATCCTGGCTCAAGGATGGGACCTCGCTGAAGAAGCAGAATACATTCACGCTAAACCTGCGCGAAGTGACCAAGGACCAGAGTGGGAAGTACTGCTGTCAGGTCTCCAATGACGTGGGCCCGGGAAGGTCGGAAGAAGTGTTCCTGCAAGTGCAGTATGCCCCGGAACCTTCCACGGTTCAGATCCTCCACTCACCGGCTGTGGAGGGAAGTCAAGTCGAGTTTCTTTGCATGTCACTGGCCAATCCTCTTCCAACAAATTACACGTGGTACCACAATGGGAAAGAAATGCAGGGAAGGACAGAGGAGAAAGTCCACATCCCAAAGATCCTCCCCTGGCACGCTGGGACTTATTCCTGTGTGGCAGAAAACATTCTTGGTACTGGACAGAGGGGCCCGGGAGCTGAGCTGGATGTCCAGTATCCTCCCAAGAAGGTGACCACAGTGATTCAAAACCCCATGCCGATTCGAGAAGGAGACACAGTGACCCTTTCCTGTAACTACAATTCCAGTAACCCCAGTGTTACCCGGTATGAATGGAAACCCCATGGCGCCTGGGAGGAGCCATCGCTTGGGGTGCTGAAGATCCAAAACGTTGGCTGGGACAACACAACCATCGCCTGCGCAGCTTGTAATAGTTGGTGCTCGTGGGCCTCCCCTGTCGCCCTGAATGTCCAGTATGCCCCCCGAGACGTGAGGGTCCGGAAAATCAAGCCCCTTTCCGAGATTCACTCTGGAAACTCGGTCAGCCTCCAATGTGACTTCTCAAGCAGCCACCCCAAAGAAGTCCAGTTCTTCTGGGAGAAAAATGGCAGGCTTCTGGGGAAAGAAAGCCAGCTGAATTTTGACTCCATCTCCCCAGAAGATGCTGGGAGTTACAGCTGCTGGGTGAACAACTCCATAGGACAGACAGCGTCCAAGGCCTGGACACTTGAAGTGCTGTATGCACCCAGGAGGCTGCGTGTGTCCATGAGCCCGGGGGACCAAGTGATGGAGGGGAAGAGTGCAACCCTGACCTGTGAGAGCGACGCCAACCCTCCCGTCTCCCACTACACCTGGTTTGACTGGAATAACCAAAGCCTCCCCTACCACAGCCAGAAGCTGAGATTGGAGCCGGTGAAGGTCCAGCACTCGGGTGCCTACTGGTGCCAGGGGACCAACAGTGTGGGCAAGGGCCGTTCGCCTCTCAGCACCCTCACCGTCTACTATAGCCCGGAGACCATCGGCAGGCGAGTGGCTGTGGGACTCGGGTCCTGCCTCGCCATCCTCATCCTGGCAATCTGTGGGCTCAAGCTCCAGCGACGTTGGAAGAGGACACAGAGCCAGCAGGGGCTTCAGGAGAATTCCAGCGGCCAGAGCTTCTTTGTGAGGAATAAAAAGGTTAGAAGGGCCCCCCTCTCTGAAGGCCCCCACTCCCTGGGATGCTACAATCCAATGATGGAAGATGGCATTAGCTACACCACCCTGCGCTTTCCCGAGATGAACATACCACGAACTGGAGATGCAGAGTCCTCAGAGATGCAGAGACCTCCCCCGGACTGCGATGACACGGTCACTTATTCAGCATTGCACAAGCGCCAAGTGGGCGACTATGAGAACGTCATTCCAGATTTTCCAGAAGATGAGGGGATTCATTACTCAGAGCTGATCCAGTTTGGGGTCGGGGAGCGGCCTCAGGCACAAGAAAATGTGGACTATGTGATCCTCAAACATTGA-3'

NCBI CDS gene sequence with introns (location: 35332041.. 35346697) (14657 bp)Download

NCBI Gene Viewer (CDS + introns)

NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 35329187.. 35347361) (18175 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions)

NCBI gene sequence (location: [35329187 - 1000].. 35347361) (19175 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)