Protein
Protein (NP_001762)
SIGLEC-2
B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22)
CD22
CD22 molecule
CD22
Curated
I-type lectin
I-Type Lectins - Siglecs common to mammals
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)Gal(b1-4)(6S)GlcNAc
NP_001762
933
P20273
ENSP00000085219.4
P20273
0.43
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (847 amino acids) Download
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P20273-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
6-sialyllactose
NeuAc(a2-6)Gal(b1-4)Glc
5VKM
5VKM
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CD22 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial. [34642489]
  • Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments. [34638774]
  • The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells. [33990399]
  • Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy. [33314603]
  • Inotuzumab ozogamicin resistance associated with a novel CD22 truncating mutation in a case of B-acute lymphoblastic leukaemia. [32648276]
  • A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. [7618087]
  • Regulation of CD45 engagement by the B-cell receptor CD22. [7537381]
  • Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule. [1401903]
  • cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions. [1985119]
  • The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. [1691828]
UniProt Main References (8 PubMed Identifiers)
  • Genomic structure and chromosomal mapping of the human CD22 gene. [8496602]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Identification of the gene variations in human CD22. [10079291]
  • Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition. [8463235]
  • Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. [8647200]
  • CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation. [8627166]
  • CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. [9143697]
All isoforms of this gene containing a lectin domain
NP_001172029.1, NP_001762.2, NP_001172028.1, NP_001172030.1, NP_001265346.1
RNA
RNA (Transcript ID: NM_001771.4)
NM_001771.4
CD22 molecule, transcript variant 1
All isoforms of CD22 containing a lectin domain
ENST00000085219.10
67..2610 (or 35332041.. 35346697)
35329187.. 35347361
NCBI Matured mRNA sequence 3274 NTPDownload 
m7G-5')ppp(5'-AGAUGCUGCCAGGGUCCCUGAAGAGGGAAGACACGCGGAAACAGGCUUGCACCCAGACACGACACCAUGCAUCUCCUCGGCCCCUGGCUCCUGCUCCUGGUUCUAGAAUACUUGGCUUUCUCUGACUCAAGUAAAUGGGUUUUUGAGCACCCUGAAACCCUCUACGCCUGGGAGGGGGCCUGCGUCUGGAUCCCCUGCACCUACAGAGCCCUAGAUGGUGACCUGGAAAGCUUCAUCCUGUUCCACAAUCCUGAGUAUAACAAGAACACCUCGAAGUUUGAUGGGACAAGACUCUAUGAAAGCACAAAGGAUGGGAAGGUUCCUUCUGAGCAGAAAAGGGUGCAAUUCCUGGGAGACAAGAAUAAGAACUGCACACUGAGUAUCCACCCGGUGCACCUCAAUGACAGUGGUCAGCUGGGGCUGAGGAUGGAGUCCAAGACUGAGAAAUGGAUGGAACGAAUACACCUCAAUGUCUCUGAAAGGCCUUUUCCACCUCAUAUCCAGCUCCCUCCAGAAAUUCAAGAGUCCCAGGAAGUCACUCUGACCUGCUUGCUGAAUUUCUCCUGCUAUGGGUAUCCGAUCCAAUUGCAGUGGCUCCUAGAGGGGGUUCCAAUGAGGCAGGCUGCUGUCACCUCGACCUCCUUGACCAUCAAGUCUGUCUUCACCCGGAGCGAGCUCAAGUUCUCCCCACAGUGGAGUCACCAUGGGAAGAUUGUGACCUGCCAGCUUCAGGAUGCAGAUGGGAAGUUCCUCUCCAAUGACACGGUGCAGCUGAACGUGAAGCACACCCCGAAGUUGGAGAUCAAGGUCACUCCCAGUGAUGCCAUAGUGAGGGAGGGGGACUCUGUGACCAUGACCUGCGAGGUCAGCAGCAGCAACCCGGAGUACACGACGGUAUCCUGGCUCAAGGAUGGGACCUCGCUGAAGAAGCAGAAUACAUUCACGCUAAACCUGCGCGAAGUGACCAAGGACCAGAGUGGGAAGUACUGCUGUCAGGUCUCCAAUGACGUGGGCCCGGGAAGGUCGGAAGAAGUGUUCCUGCAAGUGCAGUAUGCCCCGGAACCUUCCACGGUUCAGAUCCUCCACUCACCGGCUGUGGAGGGAAGUCAAGUCGAGUUUCUUUGCAUGUCACUGGCCAAUCCUCUUCCAACAAAUUACACGUGGUACCACAAUGGGAAAGAAAUGCAGGGAAGGACAGAGGAGAAAGUCCACAUCCCAAAGAUCCUCCCCUGGCACGCUGGGACUUAUUCCUGUGUGGCAGAAAACAUUCUUGGUACUGGACAGAGGGGCCCGGGAGCUGAGCUGGAUGUCCAGUAUCCUCCCAAGAAGGUGACCACAGUGAUUCAAAACCCCAUGCCGAUUCGAGAAGGAGACACAGUGACCCUUUCCUGUAACUACAAUUCCAGUAACCCCAGUGUUACCCGGUAUGAAUGGAAACCCCAUGGCGCCUGGGAGGAGCCAUCGCUUGGGGUGCUGAAGAUCCAAAACGUUGGCUGGGACAACACAACCAUCGCCUGCGCAGCUUGUAAUAGUUGGUGCUCGUGGGCCUCCCCUGUCGCCCUGAAUGUCCAGUAUGCCCCCCGAGACGUGAGGGUCCGGAAAAUCAAGCCCCUUUCCGAGAUUCACUCUGGAAACUCGGUCAGCCUCCAAUGUGACUUCUCAAGCAGCCACCCCAAAGAAGUCCAGUUCUUCUGGGAGAAAAAUGGCAGGCUUCUGGGGAAAGAAAGCCAGCUGAAUUUUGACUCCAUCUCCCCAGAAGAUGCUGGGAGUUACAGCUGCUGGGUGAACAACUCCAUAGGACAGACAGCGUCCAAGGCCUGGACACUUGAAGUGCUGUAUGCACCCAGGAGGCUGCGUGUGUCCAUGAGCCCGGGGGACCAAGUGAUGGAGGGGAAGAGUGCAACCCUGACCUGUGAGAGCGACGCCAACCCUCCCGUCUCCCACUACACCUGGUUUGACUGGAAUAACCAAAGCCUCCCCUACCACAGCCAGAAGCUGAGAUUGGAGCCGGUGAAGGUCCAGCACUCGGGUGCCUACUGGUGCCAGGGGACCAACAGUGUGGGCAAGGGCCGUUCGCCUCUCAGCACCCUCACCGUCUACUAUAGCCCGGAGACCAUCGGCAGGCGAGUGGCUGUGGGACUCGGGUCCUGCCUCGCCAUCCUCAUCCUGGCAAUCUGUGGGCUCAAGCUCCAGCGACGUUGGAAGAGGACACAGAGCCAGCAGGGGCUUCAGGAGAAUUCCAGCGGCCAGAGCUUCUUUGUGAGGAAUAAAAAGGUUAGAAGGGCCCCCCUCUCUGAAGGCCCCCACUCCCUGGGAUGCUACAAUCCAAUGAUGGAAGAUGGCAUUAGCUACACCACCCUGCGCUUUCCCGAGAUGAACAUACCACGAACUGGAGAUGCAGAGUCCUCAGAGAUGCAGAGACCUCCCCCGGACUGCGAUGACACGGUCACUUAUUCAGCAUUGCACAAGCGCCAAGUGGGCGACUAUGAGAACGUCAUUCCAGAUUUUCCAGAAGAUGAGGGGAUUCAUUACUCAGAGCUGAUCCAGUUUGGGGUCGGGGAGCGGCCUCAGGCACAAGAAAAUGUGGACUAUGUGAUCCUCAAACAUUGACACUGGAUGGGCUGCAGCAGAGGCACUGGGGGCAGCGGGGGCCAGGGAAGUCCCCGAGUUUCCCCAGACACCGCCACAUGGCUUCCUCCUGCGCGCAUGUGCGCACACACACACACACACGCACACACACACACACACACUCACUGCGGAGAACCUUGUGCCUGGCUCAGAGCCAGUCUUUUUGGUGAGGGUAACCCCAAACCUCCAAAACUCCUGCCCCUGUUCUCUUCCACUCUCCUUGCUACCCAGAAAUCCAUCUAAAUACCUGCCCUGACAUGCACACCUCCCCCUGCCCCCACCACGGCCACUGGCCAUCUCCACCCCCAGCUGCUUGUGUCCCUCCUGGGAUCUGCUCGUCAUCAUUUUUCCUUCCCUUCUCCAUCUCUCUGGCCCUCUACCCCUGAUCUGACAUCCCCACUCACGAAUAUUAUGCCCAGUUUCUGCCUCUGAGGGAAAGCCCAGAAAAGGACAGAAACGAAGUAGAAAGGGGCCCAGUCCUGGCCUGGCUUCUCCUUUGGAAGUGAGGCAUUGCACGGGGAGACGUACGUAUCAGCGGCCCCUUGACUCUGGGGACUCCGGGUUUGAGAUGGACACACUGGUGUGGAUUAACCUGCCAGGGAGACAGAGCUCACAAUAAAAAUGGCUCAGAUGCCACUUCAAAGAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 933)
CD22
CD22 molecule
NC_000019.10
19  35332041.. 35346697
35332041.. 35346697
strand +
CCDS12457.1
MGI:88322
ClinVar, dbVar
ENSG00000012124
SIGLEC-2, SIGLEC2
uc010edt.5
INSDC: X52785
1643
107266
OTTHUMG00000183298
ENA, DDBJ, Monarch
CD22
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (2544 bp)
5'-ATGCATCTCCTCGGCCCCTGGCTCCTGCTCCTGGTTCTAGAATACTTGGCTTTCTCTGACTCAAGTAAATGGGTTTTTGAGCACCCTGAAACCCTCTACGCCTGGGAGGGGGCCTGCGTCTGGATCCCCTGCACCTACAGAGCCCTAGATGGTGACCTGGAAAGCTTCATCCTGTTCCACAATCCTGAGTATAACAAGAACACCTCGAAGTTTGATGGGACAAGACTCTATGAAAGCACAAAGGATGGGAAGGTTCCTTCTGAGCAGAAAAGGGTGCAATTCCTGGGAGACAAGAATAAGAACTGCACACTGAGTATCCACCCGGTGCACCTCAATGACAGTGGTCAGCTGGGGCTGAGGATGGAGTCCAAGACTGAGAAATGGATGGAACGAATACACCTCAATGTCTCTGAAAGGCCTTTTCCACCTCATATCCAGCTCCCTCCAGAAATTCAAGAGTCCCAGGAAGTCACTCTGACCTGCTTGCTGAATTTCTCCTGCTATGGGTATCCGATCCAATTGCAGTGGCTCCTAGAGGGGGTTCCAATGAGGCAGGCTGCTGTCACCTCGACCTCCTTGACCATCAAGTCTGTCTTCACCCGGAGCGAGCTCAAGTTCTCCCCACAGTGGAGTCACCATGGGAAGATTGTGACCTGCCAGCTTCAGGATGCAGATGGGAAGTTCCTCTCCAATGACACGGTGCAGCTGAACGTGAAGCACACCCCGAAGTTGGAGATCAAGGTCACTCCCAGTGATGCCATAGTGAGGGAGGGGGACTCTGTGACCATGACCTGCGAGGTCAGCAGCAGCAACCCGGAGTACACGACGGTATCCTGGCTCAAGGATGGGACCTCGCTGAAGAAGCAGAATACATTCACGCTAAACCTGCGCGAAGTGACCAAGGACCAGAGTGGGAAGTACTGCTGTCAGGTCTCCAATGACGTGGGCCCGGGAAGGTCGGAAGAAGTGTTCCTGCAAGTGCAGTATGCCCCGGAACCTTCCACGGTTCAGATCCTCCACTCACCGGCTGTGGAGGGAAGTCAAGTCGAGTTTCTTTGCATGTCACTGGCCAATCCTCTTCCAACAAATTACACGTGGTACCACAATGGGAAAGAAATGCAGGGAAGGACAGAGGAGAAAGTCCACATCCCAAAGATCCTCCCCTGGCACGCTGGGACTTATTCCTGTGTGGCAGAAAACATTCTTGGTACTGGACAGAGGGGCCCGGGAGCTGAGCTGGATGTCCAGTATCCTCCCAAGAAGGTGACCACAGTGATTCAAAACCCCATGCCGATTCGAGAAGGAGACACAGTGACCCTTTCCTGTAACTACAATTCCAGTAACCCCAGTGTTACCCGGTATGAATGGAAACCCCATGGCGCCTGGGAGGAGCCATCGCTTGGGGTGCTGAAGATCCAAAACGTTGGCTGGGACAACACAACCATCGCCTGCGCAGCTTGTAATAGTTGGTGCTCGTGGGCCTCCCCTGTCGCCCTGAATGTCCAGTATGCCCCCCGAGACGTGAGGGTCCGGAAAATCAAGCCCCTTTCCGAGATTCACTCTGGAAACTCGGTCAGCCTCCAATGTGACTTCTCAAGCAGCCACCCCAAAGAAGTCCAGTTCTTCTGGGAGAAAAATGGCAGGCTTCTGGGGAAAGAAAGCCAGCTGAATTTTGACTCCATCTCCCCAGAAGATGCTGGGAGTTACAGCTGCTGGGTGAACAACTCCATAGGACAGACAGCGTCCAAGGCCTGGACACTTGAAGTGCTGTATGCACCCAGGAGGCTGCGTGTGTCCATGAGCCCGGGGGACCAAGTGATGGAGGGGAAGAGTGCAACCCTGACCTGTGAGAGCGACGCCAACCCTCCCGTCTCCCACTACACCTGGTTTGACTGGAATAACCAAAGCCTCCCCTACCACAGCCAGAAGCTGAGATTGGAGCCGGTGAAGGTCCAGCACTCGGGTGCCTACTGGTGCCAGGGGACCAACAGTGTGGGCAAGGGCCGTTCGCCTCTCAGCACCCTCACCGTCTACTATAGCCCGGAGACCATCGGCAGGCGAGTGGCTGTGGGACTCGGGTCCTGCCTCGCCATCCTCATCCTGGCAATCTGTGGGCTCAAGCTCCAGCGACGTTGGAAGAGGACACAGAGCCAGCAGGGGCTTCAGGAGAATTCCAGCGGCCAGAGCTTCTTTGTGAGGAATAAAAAGGTTAGAAGGGCCCCCCTCTCTGAAGGCCCCCACTCCCTGGGATGCTACAATCCAATGATGGAAGATGGCATTAGCTACACCACCCTGCGCTTTCCCGAGATGAACATACCACGAACTGGAGATGCAGAGTCCTCAGAGATGCAGAGACCTCCCCCGGACTGCGATGACACGGTCACTTATTCAGCATTGCACAAGCGCCAAGTGGGCGACTATGAGAACGTCATTCCAGATTTTCCAGAAGATGAGGGGATTCATTACTCAGAGCTGATCCAGTTTGGGGTCGGGGAGCGGCCTCAGGCACAAGAAAATGTGGACTATGTGATCCTCAAACATTGA-3'
NCBI CDS gene sequence with introns (location: 35332041.. 35346697) (14657 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 35329187.. 35347361) (18175 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [35329187 - 1000].. 35347361) (19175 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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