NCBI Summary
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2018].
Protein
Protein (NP_001737)
Calnexin
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
CANX
calnexin
Undefined
Curated
calnexin-calreticulin like
L-Type Lectins
b-sandwich / ConA-like
Glc(a1-3)Man(a1-2)Man(a1-2)Man / glucosylated N-glycan
NP_001737
821
P27824
ENSP00000247461.4
P27824
0.608
10.1074/jbc.270.9.4697
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (592 amino acids) Download
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKKDDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFHDKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPVNPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRCESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDWANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDEEEEGEEKLEEKQKSDAEEDGGTVSQEEEDRKPKAEEDEILNRSPRNRKPRRE
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-P27824-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [0.3, 0.78] ÅDownload
The location of the lectin domain structural model is: 68-466
We infer [0.3, 0.78] Å as the interval of error of this structural model.
Template 1: 1JHN chain: A, P24643, NP_001003232.1, sequence identity: 94.0%, coverage: 97.7%, location in sequence: 61-458, (61-458 in PDB).
Template 2: 6ENY chain: G, P27797, NP_004334.1, sequence identity: 38.6%, coverage: 84.2%, location in sequence: 18-386, (18-386 in PDB).
Template 3: 3O0W chain: A, P14211, NP_031617.1, sequence identity: 38.1%, coverage: 84.2%, location in sequence: 18-362, (18-362 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CANX Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Circulating small extracellular vesicles increase after an acute bout of moderate-intensity exercise in pregnant compared to non-pregnant women. [34135428]
  • Ca2+ Regulates ERp57-Calnexin Complex Formation. [34064874]
  • The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence. [33562550]
  • Calnexin mediates the maturation of GPI-anchors through ER retention. [32967966]
  • ER-resident oxidoreductases are glycosylated and trafficked to the cell surface to promote matrix degradation by tumour cells. [33077910]
  • The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly. [8163531]
  • Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. [8136357]
  • The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin. [8055875]
  • Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. [1286667]
  • The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. [1326756]
UniProt Main References (30 PubMed Identifiers)
  • Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin). [8486646]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and comparative analysis of human chromosome 5. [15372022]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Formation of intracellular particles by hepatitis B virus large surface protein. [9188622]
  • Role for calnexin and N-linked glycosylation in the assembly and secretion of hepatitis B virus middle envelope protein particles. [9420286]
  • Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. [12643545]
  • Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. [17081983]
  • Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. [16361248]
  • Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. [17081065]
    • Show more
All isoforms of this gene containing a lectin domain
NP_001350927.1, NP_001350928.1, NP_001019820.1, NP_001350925.1, NP_001350926.1, NP_001737.1, XP_011532967.1, NP_001350923.1, NP_001350922.1, XP_011532966.1, NP_001350924.1, NP_001350929.1, NP_001350930.1
RNA
RNA (Transcript ID: NM_001746.4)
NM_001746.4
calnexin, transcript variant 1
All isoforms of CANX containing a lectin domain
ENST00000247461.9
140..1918 (or 179705682.. 179728644)
179698967.. 179731641
NCBI Matured mRNA sequence 4915 NTPDownload 
m7G-5')ppp(5'-AGCGGUGGCCGAGGCCUCUUGGUUCUGCGGCACGUGACGGUCGGGCCGCCUCCGCCUCUCUCUUUACUGCGGCGCGGGGCAAGGUGUGCGGGCGGGAAGGGGCACGGGCACCCCCGCGGUCCCCGGGAGGCUAGAGAUCAUGGAAGGGAAGUGGUUGCUGUGUAUGUUACUGGUGCUUGGAACUGCUAUUGUUGAGGCUCAUGAUGGACAUGAUGAUGAUGUGAUUGAUAUUGAGGAUGACCUUGACGAUGUCAUUGAAGAGGUAGAAGACUCAAAACCAGAUACCACUGCUCCUCCUUCAUCUCCCAAGGUUACUUACAAAGCUCCAGUUCCAACAGGGGAAGUAUAUUUUGCUGAUUCUUUUGACAGAGGAACUCUGUCAGGGUGGAUUUUAUCCAAAGCCAAGAAAGACGAUACCGAUGAUGAAAUUGCCAAAUAUGAUGGAAAGUGGGAGGUAGAGGAAAUGAAGGAGUCAAAGCUUCCAGGUGAUAAAGGACUUGUGUUGAUGUCUCGGGCCAAGCAUCAUGCCAUCUCUGCUAAACUGAACAAGCCCUUCCUGUUUGACACCAAGCCUCUCAUUGUUCAGUAUGAGGUUAAUUUCCAAAAUGGAAUAGAAUGUGGUGGUGCCUAUGUGAAACUGCUUUCUAAAACACCAGAACUCAACCUGGAUCAGUUCCAUGACAAGACCCCUUAUACGAUUAUGUUUGGUCCAGAUAAAUGUGGAGAGGACUAUAAACUGCACUUCAUCUUCCGACACAAAAACCCCAAAACGGGUAUCUAUGAAGAAAAACAUGCUAAGAGGCCAGAUGCAGAUCUGAAGACCUAUUUUACUGAUAAGAAAACACAUCUUUACACACUAAUCUUGAAUCCAGAUAAUAGUUUUGAAAUACUGGUUGACCAAUCUGUGGUGAAUAGUGGAAAUCUGCUCAAUGACAUGACUCCUCCUGUAAAUCCUUCACGUGAAAUUGAGGACCCAGAAGACCGGAAGCCCGAGGAUUGGGAUGAAAGACCAAAAAUCCCAGAUCCAGAAGCUGUCAAGCCAGAUGACUGGGAUGAAGAUGCCCCUGCUAAGAUUCCAGAUGAAGAGGCCACAAAACCCGAAGGCUGGUUAGAUGAUGAGCCUGAGUACGUACCUGAUCCAGACGCAGAGAAACCUGAGGAUUGGGAUGAAGACAUGGAUGGAGAAUGGGAGGCUCCUCAGAUUGCCAACCCUAGAUGUGAGUCAGCUCCUGGAUGUGGUGUCUGGCAGCGACCUGUGAUUGACAACCCCAAUUAUAAAGGCAAAUGGAAGCCUCCUAUGAUUGACAAUCCCAGUUACCAGGGAAUCUGGAAACCCAGGAAAAUACCAAAUCCAGAUUUCUUUGAAGAUCUGGAACCUUUCAGAAUGACUCCUUUUAGUGCUAUUGGUUUGGAGCUGUGGUCCAUGACCUCUGACAUUUUUUUUGACAACUUUAUCAUUUGUGCUGAUCGAAGAAUAGUUGAUGAUUGGGCCAAUGAUGGAUGGGGCCUGAAGAAAGCUGCUGAUGGGGCUGCUGAGCCAGGCGUUGUGGGGCAGAUGAUCGAGGCAGCUGAAGAGCGCCCGUGGCUGUGGGUAGUCUAUAUUCUAACUGUAGCCCUUCCUGUGUUCCUGGUUAUCCUCUUCUGCUGUUCUGGAAAGAAACAGACCAGUGGUAUGGAGUAUAAGAAAACUGAUGCACCUCAACCGGAUGUGAAGGAAGAGGAAGAAGAGAAGGAAGAGGAAAAGGACAAGGGAGAUGAGGAGGAGGAAGGAGAAGAGAAACUUGAAGAGAAACAGAAAAGUGAUGCUGAAGAAGAUGGUGGCACUGUCAGUCAAGAGGAGGAAGACAGAAAACCUAAAGCAGAGGAGGAUGAAAUUUUGAACAGAUCACCAAGAAACAGAAAGCCACGAAGAGAGUGAAACAAUCUUAAGAGCUUGAUCUGUGAUUUCUUCUCCCUCCUCCCCUGCAAGAGUGGUCCUAGGAGAGGACCUGGCACACCUUAGGUUGACAUUCAGAAAACUUCAAGACAUCACCAUCAGCAGGCUCCAGUUGAACACUAGUCUGUGUAACUUUAAACAUCUAGCAGUAAAUACUUGCAGUUGUGAUAUAAAGGACCCUGUUUCUGUAGAAAAGAAAACAUUUAACAUAAUGGUUGUGAAAUGUAACAUGAAGCAAACUAACUUUUUUUUUUUUAACAUCUUUGUUUUUAAAAUAGAAUGAUAGAACUUUGCCAGUCUUUAAGAUCUUGGCUUAAUUUAAUGUAUUAAUCUGUUUGUGCAAACAUAAUACCACCAUUUAAAAAUGUUAGGGAGAUGAGUUGCAGUUUUUAUAAUAGAUUUUUUUUAAAGUUUGGUAUUGUAAAACAUUCACACCUCUGUCCCUCAAAAUUGAUAAUUACGUUUAAAGUGCAGUCAUUUGUGGUUAGAAUCUUGUUUUGUUUGCUUCCAUUAUUGAGUUCCUCCUAAGGAAAUUGAGGAGAGGGACUGAAUAGAAGCCCAAAUUCAUAUAAAAGUUGCGUUUAAGUUGUAUUAAAAAUAGAUAUAUAAGAAAAAAUUCUUUCACUUGAUGUUUGUUAGACCAGAAAGUGUGUGUGUUCUGUAGCUCAGUUCCCAGACAGCUUUUUAGGUAGUGGAGGAGGUGGCUUCAUGUGGCACUUGGGCAUUUAUAUUCCACUUGGGAGGGUCAGGCUGUGGCCUUCUGGAGCAGGUGGCUUGUUAAGGAAUGCUAGCAGGGCAUGGCACGUGAGCUCCGGAAUAGAUGUCUUCAUCACUUCUUCCACUGUGUGUUGACACUGUUUUCCUUACCUAUUUCCUCAGAUCCCCAGCUUUCUCCUCUGCUAUGCAUUUUCUUCACAGUGCAGCUUGCAGUCCGUUGCUGAAAAUGAUUAUAAGCCCUGCAUAAUGUUAAGCUUUAUUGUGAUUACGUGUAUGUUUCUUCUUUCUUUUAAGCAGACCCAUACCUUUCCAGGGUCAAAGUACAGAAUAGAAUACAUUGAUACAAAGUACAGAAAAAUACUUUGAUUUUUAUCCAUUUCUUUUACUCUGUGUAAAGACUUGAGAAGUCUAAUUCACAGGCAAACCAAUACAGAAUUGACUGCAGUUGAACAGACUAGAAGUAUUUGUGGGAGGAGUGACAUGAAGCAUGAGUUAUCUGAUUUUUUUUGUAGCUGCUAUAUAUUUUAAGCCUUCAUUUGCAAUUCAUGUAACAGUUGUGUCAUAAAUUACACAAUAAAGCAGUCCUGUUCAAAUUUUUUUUUAACGUGGCUUGUAGAAUUUUUAAAAAAGUGAUCUUAGGUUUGUUUUUUCAUGCGGGAUGCAGAUGGGUGCUAUCAGAGCCUCUCCCACACCACUAUAGUGUAAUAAUGUUAUUAUUACUCUACACUGAAACGUAUUCAGAGUUAGAUAUUAUUUUAGCUUCAGUUGUUCUUUAGAGGCUUUCAAAUGUACCGAUGAUACUGUUUCUUGCACUGAAUAUAUAAACACUCCACAGUGUUUAUAUUGGGAAGAUAUUGGGAAGGAAAUAUAUUUGUAAAAGAUGAAGGCUGUAUCUAUUUUUUUUUCUUUUUAAAGUUUGUUCACUUAAAUUCUUUUGAGGAUGGGAUGUAUUUUUCUUGCUGUUCAGUGCUUUUUCCUUUUCAUCUGUUGUUCUGUGGUCACAGUGACCUUAGCUACAUAGCAGACUUUCCCAAAUGUAUUGAUUACAAAUAAACAGUUGUUACUUAGCAAGACCUGAAAAUAUGUCUGCAGGUUUCUCCUUGAAGCAAAUGUGUGGGAUCAUUGCAUUUCCAGAAAUCUGCCUCCUUCACCCUCCGUUGACAGUAUAUGUCAUGCCUCACUUUCUUCUAGCUGAGCUUUAAAUCAUUAGAGCUUAAAUUGUCAGAUCGUUCAUUGCCUUUCCAGGGUUAUUUAGUAAAGUUUGUUGAAAACAAAAACGCCUUUUCUUGGUUCUUUUUUCAGUUAUUUUGAAGGUCCAGCAUCCUGAUUAAAUGUCUGACACAUUAAUGAAUGACCAGCAGCAGCUUUCAGCUCUUAAAAAGACACUUAUAUUUUGAUUUUACAUGCUGGUUACCUGUUCCAUUGUUGUCAAAUGCCCACUCUCCAUCAGAUGUGUUCCUCCAUUUUCUUAUCCACAAAGUACUCCUCACUUUUCAAUUUGUCAUGUUACUAAAUGGUGUUACAUUAAAGCCCUGUGUUAAGUGUCUGCUUUUGACUGAAUUUCUUCAUAGUAACCUUCAGUGUGUGUGUGUGACUAUGUUCAAUUAGUGGGUUGAUCUUCGUAUAAUUGGCCACUAUGUGAGAGUUCACUACUAGGCAGAAACUAUUAUGGACAGUGAAAUAAUGACUUUUAUCUCACCACGUGAGUUUGAUGCAGUCUUUUCUGUCUAGCCCUUGCCUCUUCCUGCCCAUGUGAUUGCGGUGCAGUAGUUUCUGUUGUAUAAUAGUGUGGACAGCAGCUCAGAAAAGGAGGGAAUGCUACUGAUAAUUUGUAGAUAAUAUUCUUUAAGACUUAGGGGAACCAUUGAACUUUGAAAUUUUUAUUAGAAAAUUAUUUGUUCAGAAUCAGACUCCAUUAUUUUACAUAUACUUAAAUACUUUAGGGGUAUUUUUGAAAGUUAGCCCAGUUUUUUAUGUGCUAUUAAAUUUUUAGAUUACAUACUAAAGAAAAGUAUGUACACAGAAUGUAGUGCUCCUAGUUACUAUUUUUUCUAUUAAGAAAUAGUUUAGUUCUGGUGUAAAAUUUGUUUGAAUGCUAAAAAAAAAAAAGCAGGACUGCAUUAUGGCACUUUUGCCUUGGUGGCCCACUUUCUCCAUUUAAAACAUUAGGAUUUGUAUUUUUCUGCUGCGUUUGUAUGAAGACAUAUUUGAUUGUUGUUUUCUCUUGAUUUUAAAAUAAAACCUCAUGAGCCCUAGUAAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 821)
CANX
calnexin
NC_000005.10
5  179705682.. 179728644
179705682.. 179728644
strand +
CCDS4447.1
MGI:88261
ClinVar, dbVar
ENSG00000127022
CNX, IP90, P90
uc003mkl.4
INSDC: L18887
1473
114217
OTTHUMG00000130910
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1779 bp)
5'-ATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGATCAGTTCCATGACAAGACCCCTTATACGATTATGTTTGGTCCAGATAAATGTGGAGAGGACTATAAACTGCACTTCATCTTCCGACACAAAAACCCCAAAACGGGTATCTATGAAGAAAAACATGCTAAGAGGCCAGATGCAGATCTGAAGACCTATTTTACTGATAAGAAAACACATCTTTACACACTAATCTTGAATCCAGATAATAGTTTTGAAATACTGGTTGACCAATCTGTGGTGAATAGTGGAAATCTGCTCAATGACATGACTCCTCCTGTAAATCCTTCACGTGAAATTGAGGACCCAGAAGACCGGAAGCCCGAGGATTGGGATGAAAGACCAAAAATCCCAGATCCAGAAGCTGTCAAGCCAGATGACTGGGATGAAGATGCCCCTGCTAAGATTCCAGATGAAGAGGCCACAAAACCCGAAGGCTGGTTAGATGATGAGCCTGAGTACGTACCTGATCCAGACGCAGAGAAACCTGAGGATTGGGATGAAGACATGGATGGAGAATGGGAGGCTCCTCAGATTGCCAACCCTAGATGTGAGTCAGCTCCTGGATGTGGTGTCTGGCAGCGACCTGTGATTGACAACCCCAATTATAAAGGCAAATGGAAGCCTCCTATGATTGACAATCCCAGTTACCAGGGAATCTGGAAACCCAGGAAAATACCAAATCCAGATTTCTTTGAAGATCTGGAACCTTTCAGAATGACTCCTTTTAGTGCTATTGGTTTGGAGCTGTGGTCCATGACCTCTGACATTTTTTTTGACAACTTTATCATTTGTGCTGATCGAAGAATAGTTGATGATTGGGCCAATGATGGATGGGGCCTGAAGAAAGCTGCTGATGGGGCTGCTGAGCCAGGCGTTGTGGGGCAGATGATCGAGGCAGCTGAAGAGCGCCCGTGGCTGTGGGTAGTCTATATTCTAACTGTAGCCCTTCCTGTGTTCCTGGTTATCCTCTTCTGCTGTTCTGGAAAGAAACAGACCAGTGGTATGGAGTATAAGAAAACTGATGCACCTCAACCGGATGTGAAGGAAGAGGAAGAAGAGAAGGAAGAGGAAAAGGACAAGGGAGATGAGGAGGAGGAAGGAGAAGAGAAACTTGAAGAGAAACAGAAAAGTGATGCTGAAGAAGATGGTGGCACTGTCAGTCAAGAGGAGGAAGACAGAAAACCTAAAGCAGAGGAGGATGAAATTTTGAACAGATCACCAAGAAACAGAAAGCCACGAAGAGAGTGA-3'
NCBI CDS gene sequence with introns (location: 179705682.. 179728644) (22963 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 179698967.. 179731641) (32675 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [179698967 - 1000].. 179731641) (33675 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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