NCBI Summary
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_000352)
Thrombomodulin
Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)
THBD
thrombomodulin
CD141
Low evidence
C-type lectin
Undefined
C-type - Endosialin
a/b mixed / C-type lectin-like
Lipopolysaccharide
NP_000352
7056
P07204
ENSP00000366307.2
P07204
0.27
10.1186/1423-0127-19-34
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (575 amino acids) Download
MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P07204-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for THBD Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Recombinant human thrombomodulin for pneumonia-induced severe ARDS complicated by DIC in children: a preliminary study. [34259911]
  • The associations between THBD c.1418C>T polymorphism and lower extremity deep vein thrombosis or endothelial progenitor cell. [34236150]
  • Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Kruppel-like Factor 2 Pathway in Endothelial Cells. [34638626]
  • Thrombomodulin gene polymorphism and the occurrence and prognostic value of sepsis acute kidney injury. [34190147]
  • Elevated B-type natriuretic peptide (BNP) and soluble thrombomodulin (sTM) indicates severity and poor prognosis of sepsis. [34044565]
  • Genetic Atypical Hemolytic-Uremic Syndrome [20301541]
  • Thrombomodulin in the central nervous system. [1667949]
  • Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin. [2544585]
  • The roles of protein C and thrombomodulin in the regulation of blood coagulation. [2538457]
  • Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control. [2819876]
UniProt Main References (21 PubMed Identifiers)
  • Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation. [2820710]
  • Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. [2822087]
  • Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C. [2836377]
  • The DNA sequence and comparative analysis of human chromosome 20. [11780052]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474. [8216207]
  • Urinary thrombomodulin, its isolation and characterization. [8390446]
  • LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin. [27055590]
  • The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin. [7559494]
  • Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin. [8528067]
    • Show more
RNA
RNA (Transcript ID: NM_000361.3)
NM_000361.3
thrombomodulin
All isoforms of THBD containing a lectin domain
ENST00000377103.3
169..1896 (or 23047777.. 23049504)
23045633.. 23049672
NCBI Matured mRNA sequence 4040 NTPDownload 
m7G-5')ppp(5'-AUGUCAGAGGCUGCCUCGCAGGGGCUGCGCGCAGCGGCAAGAAGUGUCUGGGCUGGGACGGACAGGAGAGGCUGUCGCCAUCGGCGUCCUGUGCCCCUCUGCUCCGGCACGGCCCUGUCGCAGUGCCCGCGCUUUCCCCGGCGCCUGCACGCGGCGCGCCUGGGUAACAUGCUUGGGGUCCUGGUCCUUGGCGCGCUGGCCCUGGCCGGCCUGGGGUUCCCCGCACCCGCAGAGCCGCAGCCGGGUGGCAGCCAGUGCGUCGAGCACGACUGCUUCGCGCUCUACCCGGGCCCCGCGACCUUCCUCAAUGCCAGUCAGAUCUGCGACGGACUGCGGGGCCACCUAAUGACAGUGCGCUCCUCGGUGGCUGCCGAUGUCAUUUCCUUGCUACUGAACGGCGACGGCGGCGUUGGCCGCCGGCGCCUCUGGAUCGGCCUGCAGCUGCCACCCGGCUGCGGCGACCCCAAGCGCCUCGGGCCCCUGCGCGGCUUCCAGUGGGUUACGGGAGACAACAACACCAGCUAUAGCAGGUGGGCACGGCUCGACCUCAAUGGGGCUCCCCUCUGCGGCCCGUUGUGCGUCGCUGUCUCCGCUGCUGAGGCCACUGUGCCCAGCGAGCCGAUCUGGGAGGAGCAGCAGUGCGAAGUGAAGGCCGAUGGCUUCCUCUGCGAGUUCCACUUCCCAGCCACCUGCAGGCCACUGGCUGUGGAGCCCGGCGCCGCGGCUGCCGCCGUCUCGAUCACCUACGGCACCCCGUUCGCGGCCCGCGGAGCGGACUUCCAGGCGCUGCCGGUGGGCAGCUCCGCCGCGGUGGCUCCCCUCGGCUUACAGCUAAUGUGCACCGCGCCGCCCGGAGCGGUCCAGGGGCACUGGGCCAGGGAGGCGCCGGGCGCUUGGGACUGCAGCGUGGAGAACGGCGGCUGCGAGCACGCGUGCAAUGCGAUCCCUGGGGCUCCCCGCUGCCAGUGCCCAGCCGGCGCCGCCCUGCAGGCAGACGGGCGCUCCUGCACCGCAUCCGCGACGCAGUCCUGCAACGACCUCUGCGAGCACUUCUGCGUUCCCAACCCCGACCAGCCGGGCUCCUACUCGUGCAUGUGCGAGACCGGCUACCGGCUGGCGGCCGACCAACACCGGUGCGAGGACGUGGAUGACUGCAUACUGGAGCCCAGUCCGUGUCCGCAGCGCUGUGUCAACACACAGGGUGGCUUCGAGUGCCACUGCUACCCUAACUACGACCUGGUGGACGGCGAGUGUGUGGAGCCCGUGGACCCGUGCUUCAGAGCCAACUGCGAGUACCAGUGCCAGCCCCUGAACCAAACUAGCUACCUCUGCGUCUGCGCCGAGGGCUUCGCGCCCAUUCCCCACGAGCCGCACAGGUGCCAGAUGUUUUGCAACCAGACUGCCUGUCCAGCCGACUGCGACCCCAACACCCAGGCUAGCUGUGAGUGCCCUGAAGGCUACAUCCUGGACGACGGUUUCAUCUGCACGGACAUCGACGAGUGCGAAAACGGCGGCUUCUGCUCCGGGGUGUGCCACAACCUCCCCGGUACCUUCGAGUGCAUCUGCGGGCCCGACUCGGCCCUUGCCCGCCACAUUGGCACCGACUGUGACUCCGGCAAGGUGGACGGUGGCGACAGCGGCUCUGGCGAGCCCCCGCCCAGCCCGACGCCCGGCUCCACCUUGACUCCUCCGGCCGUGGGGCUCGUGCAUUCGGGCUUGCUCAUAGGCAUCUCCAUCGCGAGCCUGUGCCUGGUGGUGGCGCUUUUGGCGCUCCUCUGCCACCUGCGCAAGAAGCAGGGCGCCGCCAGGGCCAAGAUGGAGUACAAGUGCGCGGCCCCUUCCAAGGAGGUAGUGCUGCAGCACGUGCGGACCGAGCGGACGCCGCAGAGACUCUGAGCGGCCUCCGUCCAGGAGCCUGGCUCCGUCCAGGAGCCUGUGCCUCCUCACCCCCAGCUUUGCUACCAAAGCACCUUAGCUGGCAUUACAGCUGGAGAAGACCCUCCCCGCACCCCCCAAGCUGUUUUCUUCUAUUCCAUGGCUAACUGGCGAGGGGGUGAUUAGAGGGAGGAGAAUGAGCCUCGGCCUCUUCCGUGACGUCACUGGACCACUGGGCAAUGAUGGCAAUUUUGUAACGAAGACACAGACUGCGAUUUGUCCCAGGUCCUCACUACCGGGCGCAGGAGGGUGAGCGUUAUUGGUCGGCAGCCUUCUGGGCAGACCUUGACCUCGUGGGCUAGGGAUGACUAAAAUAUUUAUUUUUUUUAAGUAUUUAGGUUUUUGUUUGUUUCCUUUGUUCUUACCUGUAUGUCUCCAGUAUCCACUUUGCACAGCUCUCCGGUCUCUCUCUCUCUACAAACUCCCACUUGUCAUGUGACAGGUAAACUAUCUUGGUGAAUUUUUUUUUCCUAGCCCUCUCACAUUUAUGAAGCAAGCCCCACUUAUUCCCCAUUCUUCCUAGUUUUCUCCUCCCAGGAACUGGGCCAACUCACCUGAGUCACCCUACCUGUGCCUGACCCUACUUCUUUUGCUCUUAGCUGUCUGCUCAGACAGAACCCCUACAUGAAACAGAAACAAAAACACUAAAAAUAAAAAUGGCCAUUUGCUUUUUCACCAGAUUUGCUAAUUUAUCCUGAAAUUUCAGAUUCCCAGAGCAAAAUAAUUUUAAACAAAGGUUGAGAUGUAAAAGGUAUUAAAUUGAUGUUGCUGGACUGUCAUAGAAAUUACACCCAAAGAGGUAUUUAUCUUUACUUUUAAACAGUGAGCCUGAAUUUUGUUGCUGUUUUGAUUUGUACUGAAAAAUGGUAAUUGUUGCUAAUCUUCUUAUGCAAUUUCCUUUUUUGUUAUUAUUACUUAUUUUUGACAGUGUUGAAAAUGUUCAGAAGGUUGCUCUAGAUUGAGAGAAGAGACAAACACCUCCCAGGAGACAGUUCAAGAAAGCUUCAAACUGCAUGAUUCAUGCCAAUUAGCAAUUGACUGUCACUGUUCCUUGUCACUGGUAGACCAAAAUAAAACCAGCUCUACUGGUCUUGUGGAAUUGGGAGCUUGGGAAUGGAUCCUGGAGGAUGCCCAAUUAGGGCCUAGCCUUAAUCAGGUCCUCAGAGAAUUUCUACCAUUUCAGAGAGGCCUUUUGGAAUGUGGCCCCUGAACAAGAAUUGGAAGCUGCCCUGCCCAUGGGAGCUGGUUAGAAAUGCAGAAUCCUAGGCUCCACCCCAUCCAGUUCAUGAGAAUCUAUAUUUAACAAGAUCUGCAGGGGGUGUGUCUGCUCAGUAAUUUGAGGACAACCAUUCCAGACUGCUUCCAAUUUUCUGGAAUACAUGAAAUAUAGAUCAGUUAUAAGUAGCAGGCCAAGUCAGGCCCUUAUUUUCAAGAAACUGAGGAAUUUUCUUUGUGUAGCUUUGCUCUUUGGUAGAAAAGGCUAGGUACACAGCUCUAGACACUGCCACACAGGGUCUGCAAGGUCUUUGGUUCAGCUAAGCUAGGAAUGAAAUCCUGCUUCAGUGUAUGGAAAUAAAUGUAUCAUAGAAAUGUAACUUUUGUAAGACAAAGGUUUUCCUCUUCUAUUUUGUAAACUCAAAAUAUUUGUACAUAGUUAUUUAUUUAUUGGAGAUAAUCUAGAACACAGGCAAAAUCCUUGCUUAUGACAUCACUUGUACAAAAUAAACAAAUAACAAUGUGCUCUCGGGUUGUGUGUCUGUUCACUUUUCCUCCCUCAGUGCCCUCAUUUUAUGUCAUUAAAUGGGGCUCACAAACCAUGCAAAUGCUAUGAGAUGCAUGGAGGGCUGCCCUGUACCCCAGCACUUGUGUUGUCUGGUGGUGGCACCAUCUCUGAUUUUCAAAGCUUUUUCCAGAGGCUAUUAUUUUCACUGUAGAAUGAUUUCAUGCUAUCUCUGUGUGCACAAAUAUUUAUUUUCUUUCUGUAACCAUAACAACUUCAUAUAUGAGGACUUGUGUCUCUGUGCUUUUAAAUGCAUAAAUGCAUUAUAGGAUCAUUUGUUGGAAUGAAUUAAAUAAACCCUUCCUGGGGCAUCUGGCGAAUCCCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 7056)
THBD
thrombomodulin
NC_000020.11
20  23047777.. 23049504
23047777.. 23049504
strand -
CCDS13148.1
MGI:98736
ClinVar, dbVar
ENSG00000178726
CD141, THRM, BDCA-3
uc002wss.4
INSDC:
11784
188040
OTTHUMG00000032053
ENA, DDBJ, Monarch
CD141
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1728 bp)
5'-ATGCTTGGGGTCCTGGTCCTTGGCGCGCTGGCCCTGGCCGGCCTGGGGTTCCCCGCACCCGCAGAGCCGCAGCCGGGTGGCAGCCAGTGCGTCGAGCACGACTGCTTCGCGCTCTACCCGGGCCCCGCGACCTTCCTCAATGCCAGTCAGATCTGCGACGGACTGCGGGGCCACCTAATGACAGTGCGCTCCTCGGTGGCTGCCGATGTCATTTCCTTGCTACTGAACGGCGACGGCGGCGTTGGCCGCCGGCGCCTCTGGATCGGCCTGCAGCTGCCACCCGGCTGCGGCGACCCCAAGCGCCTCGGGCCCCTGCGCGGCTTCCAGTGGGTTACGGGAGACAACAACACCAGCTATAGCAGGTGGGCACGGCTCGACCTCAATGGGGCTCCCCTCTGCGGCCCGTTGTGCGTCGCTGTCTCCGCTGCTGAGGCCACTGTGCCCAGCGAGCCGATCTGGGAGGAGCAGCAGTGCGAAGTGAAGGCCGATGGCTTCCTCTGCGAGTTCCACTTCCCAGCCACCTGCAGGCCACTGGCTGTGGAGCCCGGCGCCGCGGCTGCCGCCGTCTCGATCACCTACGGCACCCCGTTCGCGGCCCGCGGAGCGGACTTCCAGGCGCTGCCGGTGGGCAGCTCCGCCGCGGTGGCTCCCCTCGGCTTACAGCTAATGTGCACCGCGCCGCCCGGAGCGGTCCAGGGGCACTGGGCCAGGGAGGCGCCGGGCGCTTGGGACTGCAGCGTGGAGAACGGCGGCTGCGAGCACGCGTGCAATGCGATCCCTGGGGCTCCCCGCTGCCAGTGCCCAGCCGGCGCCGCCCTGCAGGCAGACGGGCGCTCCTGCACCGCATCCGCGACGCAGTCCTGCAACGACCTCTGCGAGCACTTCTGCGTTCCCAACCCCGACCAGCCGGGCTCCTACTCGTGCATGTGCGAGACCGGCTACCGGCTGGCGGCCGACCAACACCGGTGCGAGGACGTGGATGACTGCATACTGGAGCCCAGTCCGTGTCCGCAGCGCTGTGTCAACACACAGGGTGGCTTCGAGTGCCACTGCTACCCTAACTACGACCTGGTGGACGGCGAGTGTGTGGAGCCCGTGGACCCGTGCTTCAGAGCCAACTGCGAGTACCAGTGCCAGCCCCTGAACCAAACTAGCTACCTCTGCGTCTGCGCCGAGGGCTTCGCGCCCATTCCCCACGAGCCGCACAGGTGCCAGATGTTTTGCAACCAGACTGCCTGTCCAGCCGACTGCGACCCCAACACCCAGGCTAGCTGTGAGTGCCCTGAAGGCTACATCCTGGACGACGGTTTCATCTGCACGGACATCGACGAGTGCGAAAACGGCGGCTTCTGCTCCGGGGTGTGCCACAACCTCCCCGGTACCTTCGAGTGCATCTGCGGGCCCGACTCGGCCCTTGCCCGCCACATTGGCACCGACTGTGACTCCGGCAAGGTGGACGGTGGCGACAGCGGCTCTGGCGAGCCCCCGCCCAGCCCGACGCCCGGCTCCACCTTGACTCCTCCGGCCGTGGGGCTCGTGCATTCGGGCTTGCTCATAGGCATCTCCATCGCGAGCCTGTGCCTGGTGGTGGCGCTTTTGGCGCTCCTCTGCCACCTGCGCAAGAAGCAGGGCGCCGCCAGGGCCAAGATGGAGTACAAGTGCGCGGCCCCTTCCAAGGAGGTAGTGCTGCAGCACGTGCGGACCGAGCGGACGCCGCAGAGACTCTGA-3'
NCBI CDS gene sequence with introns (location: 23047777.. 23049504) (1728 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 23045633.. 23049672) (4040 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [23045633.. 23049672 + 1000]) (5040 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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