HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

Protein name

Hepatic asialoglycoprotein receptor 1

Synonym(s)

Asialoglycoprotein receptor 1 (ASGP-R 1) (ASGPR 1) (C-type lectin domain family 4 member H1) (Hepatic lectin H1) (HL-1)

HGNC gene name

ASGR1

HGNC name

asialoglycoprotein receptor 1

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

C-type lectin

C-type classification

CLEC4H1

Known lectin group

C-type - Type II transmembrane receptors

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.422

Reference

10.1016/j.bmc.2008.03.017

Other links

neXtProt, PFAM, InterPro, CFG data

Protein sequence and protein families (fasta) (291 amino acids) Download

MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P07306-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for ASGR1 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Common gene variants in ASGR1 gene locus associate with reduced cardiovascular risk in absence of pleiotropic effects. [32679274]

A reference map of the human binary protein interactome. [32296183]

Clec10a regulates mite-induced dermatitis. [31811054]

Establishment of a functional cell line expressing both subunits of H1a and H2c of human hepatocyte surface molecule ASGPR. [21063834]

A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes. [20886072]

In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesicles. [1935897]

Assignment of human asialoglycoprotein receptor gene (ASGR1) to chromosome 17p11-13. [1774077]

Endocytosis by the asialoglycoprotein receptor is independent of cytoplasmic serine residues. [1924301]

The H1 and H2 polypeptides associate to form the asialoglycoprotein receptor in human hepatoma cells. [2834401]

Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion. [2982798]

UniProt Main References (10 PubMed Identifiers)

An internal signal sequence: the asialoglycoprotein receptor membrane anchor. [3753585]

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. [16625196]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits. [8943311]

Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. [11543633]

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]

Initial characterization of the human central proteome. [21269460]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]

Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2. [27155063]

Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor. [10891274]

All isoforms of this gene containing a lectin domain

NP_001184145.1, NP_001662.1, XP_011522163.1

RNA

RNA (Transcript ID: NM_001671.5)

RNA RefSeq ID

NM_001671.5

RNA name

asialoglycoprotein receptor 1, transcript variant 1

Isoforms

All isoforms of ASGR1 containing a lectin domain

RNA Ensembl ID

ENST00000269299.8

Coding region

207..1082 (or 7173659.. 7178563)

mRNA location

7173431.. 7179370

NCBI Matured mRNA sequence 1310 NTP Download

m⁷G-5')ppp(5'-ACACAGACACGCAGACACAGAGACACCGGGGCCCAGGGCCCUCCUAUGGACCCUGCCCGCUCCCCUCCCAUUGUCCACGGCUGUCCGCCCACCCCCAUUCUCCAAGCUUCAGCCCCCUCCUUAGUUCGGCAUCUGCACAGCACUGAAGAACCUGGGAAUCAGACCCUGAGACCCUGAGCAAUCCCAGGUCCAGCGCCAGCCCUAUCAUGACCAAGGAGUAUCAAGACCUUCAGCAUCUGGACAAUGAGGAGAGUGACCACCAUCAGCUCAGAAAAGGGCCACCUCCUCCCCAGCCCCUCCUGCAGCGUCUCUGCUCCGGACCUCGCCUCCUCCUGCUCUCCCUGGGCCUCAGCCUCCUGCUGCUUGUGGUUGUCUGUGUGAUCGGAUCCCAAAACUCCCAGCUGCAGGAGGAGCUGCGGGGCCUGAGAGAGACGUUCAGCAACUUCACAGCGAGCACGGAGGCCCAGGUCAAGGGCUUGAGCACCCAGGGAGGCAAUGUGGGAAGAAAGAUGAAGUCGCUAGAGUCCCAGCUGGAGAAACAGCAGAAGGACCUGAGUGAAGAUCACUCCAGCCUGCUGCUCCACGUGAAGCAGUUCGUGUCUGACCUGCGGAGCCUGAGCUGUCAGAUGGCGGCGCUCCAGGGCAAUGGCUCAGAAAGGACCUGCUGCCCGGUCAACUGGGUGGAGCACGAGCGCAGCUGCUACUGGUUCUCUCGCUCCGGGAAGGCCUGGGCUGACGCCGACAACUACUGCCGGCUGGAGGACGCGCACCUGGUGGUGGUCACGUCCUGGGAGGAGCAGAAAUUUGUCCAGCACCACAUAGGCCCUGUGAACACCUGGAUGGGCCUCCACGACCAAAACGGGCCCUGGAAGUGGGUGGACGGGACGGACUACGAGACGGGCUUCAAGAACUGGAGGCCGGAGCAGCCGGACGACUGGUACGGCCACGGGCUCGGAGGAGGCGAGGACUGUGCCCACUUCACCGACGACGGCCGCUGGAACGACGACGUCUGCCAGAGGCCCUACCGCUGGGUCUGCGAGACAGAGCUGGACAAGGCCAGCCAGGAGCCACCUCUCCUUUAAUUUAUUUCUUCAAUGCCUCGACCUGCCGCAGGGGUCCGGGAUUGGGAAUCCGCCCAUCUGGGGGCCUCUUCUGCUUUCUCGGGAAUUUUCAUCUAGGAUUUUAAGGGAAGGGGAAGGAUAGGGUGAUGUUCCGAAGGUGAGGAGCUUGAAACCCGUGGCGCUUUCUGCAGUUUGCAGGUUAUCAUUGUGAACUUUUUUUUUUUAAGAGUAAAAAGAAAUAUACCUAAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 432)

HGNC Gene symbol

ASGR1

HGNC Gene name

asialoglycoprotein receptor 1

Chr. RefSeq ID

NC_000017.11

Chromosome N°

17 7173659.. 7178563

CDS location

7173659.. 7178563

DNA strand

strand -

CCDS ID

CCDS11089.1

Mouse ortholog gene

MGI:88081

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000141505

HGNC other symbol

CLEC4H1

UCSC ID

uc002ges.5

GeneBank

INSDC:

GeneCards

742

MIM

108360

VEGA ID

OTTHUMG00000102159

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