HumanLectome - Human Lectin Entry

Paired immunoglobulin-like type 2 receptor alpha
NP_038467 Q9UKJ1-1

NCBI Summary

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008].

Protein

Protein (NP_038467)

Protein name

Paired immunoglobulin-like type 2 receptor alpha

Synonym(s)

Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha)

HGNC gene name

PILRA

HGNC name

paired immunoglobin like type 2 receptor alpha

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

I-type lectin

Known lectin group

Undefined

Lectin fold

b-sandwich / Ig-like

Glycan specificity

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.199

Reference

10.1371/journal.pgen.1007427

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (303 amino acids) Download

MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q9UKJ1-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand

Glycan ligands from structural data

Name

Sialylated T-antigen

IUPAC

NeuAc(a2-6)GalNAc

PDB

3WV0

UniLectin3D

3WV0

Parent structures

GlyConnect Structures

Name

analog of sialyl Tn glycopeptide

IUPAC

NeuAc(a2-6)GlcNAc

PDB

5XOF

UniLectin3D

5XOF

Parent structures

GlyConnect Structures

Name

Sialyl Tn analog

IUPAC

NeuAc

PDB

5XO2

UniLectin3D

5XO2

Parent structures

GlyConnect Structures

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for PILRA Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

The PILRA G78R Variant Correlates with Higher HSV-1-Specific IgG Titers in Alzheimer's Disease. [31297637]

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. [30388101]

Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease. [29181857]

Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRalpha immune cell receptor. [29046357]

Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population. [29202958]

PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. [18358807]

Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRalpha). [18097101]

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. [15085135]

FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. [10903717]

PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. [10660620]

UniProt Main References (4 PubMed Identifiers)

The DNA sequence of human chromosome 7. [12853948]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]

PANP is a novel O-glycosylated PILRalpha ligand expressed in neural tissues. [21241660]

All isoforms of this gene containing a lectin domain

NP_038467.2, XP_024302507.1, NP_840057.1, NP_840056.1

RNA

RNA (Transcript ID: NM_013439.3)

RNA RefSeq ID

NM_013439.3

RNA name

paired immunoglobin like type 2 receptor alpha, transcript variant 1

Isoforms

All isoforms of PILRA containing a lectin domain

RNA Ensembl ID

ENST00000198536.7

Coding region

171..1082 (or 100373657.. 100399907)

mRNA location

100373487.. 100400096

NCBI Matured mRNA sequence 1271 NTP Download

m⁷G-5')ppp(5'-ACCCUGGAGGUGCACUGGUUUGGGGAAGGCUCCUGGCCCCCACAGCCCUCUUCGGAGCCUGAGCCCGGCUCUCCUCACUCACCUCAACCCCCAGGCGGCCCCUCCACAGGGCCCCUCUCCUGCCUGGACGGCUCUGCUGGUCUCCCCGUCCCCUGGAGAAGAACAAGGCCAUGGGUCGGCCCCUGCUGCUGCCCCUACUGCCCUUGCUGCUGCCGCCAGCAUUUCUGCAGCCUAGUGGCUCCACAGGAUCUGGUCCAAGCUACCUUUAUGGGGUCACUCAACCAAAACACCUCUCAGCCUCCAUGGGUGGCUCUGUGGAAAUCCCCUUCUCCUUCUAUUACCCCUGGGAGUUAGCCACAGCUCCCGACGUGAGAAUAUCCUGGAGACGGGGCCACUUCCACAGGCAGUCCUUCUACAGCACAAGGCCGCCUUCCAUUCACAAGGAUUAUGUGAACCGGCUCUUUCUGAACUGGACAGAGGGUCAGAAGAGCGGCUUCCUCAGGAUCUCCAACCUGCAGAAGCAGGACCAGUCUGUGUAUUUCUGCCGAGUUGAGCUGGACACACGGAGCUCAGGGAGGCAGCAGUGGCAGUCCAUCGAGGGGACCAAACUCUCCAUCACCCAGGCUGUCACGACCACCACCCAGAGGCCCAGCAGCAUGACUACCACCUGGAGGCUCAGUAGCACAACCACCACAACCGGCCUCAGGGUCACACAGGGCAAACGACGCUCAGACUCUUGGCACAUAAGUCUGGAGACUGCUGUGGGGGUGGCAGUGGCUGUCACUGUGCUCGGAAUCAUGAUUUUGGGACUGAUCUGCCUCCUCAGGUGGAGGAGAAGGAAAGGUCAGCAGCGGACUAAAGCCACAACCCCAGCCAGGGAACCCUUCCAAAACACAGAGGAGCCAUAUGAGAAUAUCAGGAAUGAAGGACAAAAUACAGAUCCCAAGCUAAAUCCCAAGGAUGACGGCAUCGUCUAUGCUUCCCUUGCCCUCUCCAGCUCCACCUCACCCAGAGCACCUCCCAGCCACCGUCCCCUCAAGAGCCCCCAGAACGAGACCCUGUACUCUGUCUUAAAGGCCUAACCAAUGGACAGCCCUCUCAAGACUGAAUGGUGAGGCCAGGUACAGUGGCGCACACCUGUAAUCCCAGCUACUCUGAAGCCUGAGGCAGAAUCAAGUGAGCCCAGGAGUUCAGGGCCAGCUUUGAUAAUGGAGCGAGAUGCCAUCUCUAGUUAAAAAUAUAUAUUAACAAUAAAGUAACAAAUUUAAAAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 29992)

HGNC Gene symbol

PILRA

HGNC Gene name

paired immunoglobin like type 2 receptor alpha

Chr. RefSeq ID

NC_000007.14

Chromosome N°

7 100373657.. 100399907

CDS location

100373657.. 100399907

DNA strand

strand +

CCDS ID

CCDS5691.1

Mouse ortholog gene

MGI:2450529

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000085514

HGNC other symbol

FDF03

UCSC ID

uc003uuo.1

GeneBank

INSDC: AF161080

GeneCards

20396

MIM

605341

VEGA ID