NCBI Summary
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_038467)
Paired immunoglobulin-like type 2 receptor alpha
Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha)
PILRA
paired immunoglobin like type 2 receptor alpha
Undefined
Curated
I-type lectin
Undefined
b-sandwich / Ig-like
Sialylated O-glycans
NP_038467
29992
Q9UKJ1
ENSP00000198536.2
Q9UKJ1
0.199
10.1371/journal.pgen.1007427
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (303 amino acids) Download
MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETAVGVAVAVTVLGIMILGLICLLRWRRRKGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKDDGIVYASLALSSSTSPRAPPSHRPLKSPQNETLYSVLKA
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9UKJ1-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
Sialylated T-antigen
NeuAc(a2-6)GalNAc
3WV0
3WV0
GlyConnect Structures
analog of sialyl Tn glycopeptide
NeuAc(a2-6)GlcNAc
5XOF
5XOF
GlyConnect Structures
Sialyl Tn analog
NeuAc
5XO2
5XO2
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for PILRA Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • The PILRA G78R Variant Correlates with Higher HSV-1-Specific IgG Titers in Alzheimer's Disease. [31297637]
  • Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. [30388101]
  • Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease. [29181857]
  • Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRalpha immune cell receptor. [29046357]
  • Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population. [29202958]
  • PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. [18358807]
  • Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRalpha). [18097101]
  • Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. [15085135]
  • FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. [10903717]
  • PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. [10660620]
UniProt Main References (4 PubMed Identifiers)
  • The DNA sequence of human chromosome 7. [12853948]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]
  • PANP is a novel O-glycosylated PILRalpha ligand expressed in neural tissues. [21241660]
All isoforms of this gene containing a lectin domain
NP_038467.2, XP_024302507.1, NP_840057.1, NP_840056.1
RNA
RNA (Transcript ID: NM_013439.3)
NM_013439.3
paired immunoglobin like type 2 receptor alpha, transcript variant 1
All isoforms of PILRA containing a lectin domain
ENST00000198536.7
171..1082 (or 100373657.. 100399907)
100373487.. 100400096
NCBI Matured mRNA sequence 1271 NTPDownload 
m7G-5')ppp(5'-ACCCUGGAGGUGCACUGGUUUGGGGAAGGCUCCUGGCCCCCACAGCCCUCUUCGGAGCCUGAGCCCGGCUCUCCUCACUCACCUCAACCCCCAGGCGGCCCCUCCACAGGGCCCCUCUCCUGCCUGGACGGCUCUGCUGGUCUCCCCGUCCCCUGGAGAAGAACAAGGCCAUGGGUCGGCCCCUGCUGCUGCCCCUACUGCCCUUGCUGCUGCCGCCAGCAUUUCUGCAGCCUAGUGGCUCCACAGGAUCUGGUCCAAGCUACCUUUAUGGGGUCACUCAACCAAAACACCUCUCAGCCUCCAUGGGUGGCUCUGUGGAAAUCCCCUUCUCCUUCUAUUACCCCUGGGAGUUAGCCACAGCUCCCGACGUGAGAAUAUCCUGGAGACGGGGCCACUUCCACAGGCAGUCCUUCUACAGCACAAGGCCGCCUUCCAUUCACAAGGAUUAUGUGAACCGGCUCUUUCUGAACUGGACAGAGGGUCAGAAGAGCGGCUUCCUCAGGAUCUCCAACCUGCAGAAGCAGGACCAGUCUGUGUAUUUCUGCCGAGUUGAGCUGGACACACGGAGCUCAGGGAGGCAGCAGUGGCAGUCCAUCGAGGGGACCAAACUCUCCAUCACCCAGGCUGUCACGACCACCACCCAGAGGCCCAGCAGCAUGACUACCACCUGGAGGCUCAGUAGCACAACCACCACAACCGGCCUCAGGGUCACACAGGGCAAACGACGCUCAGACUCUUGGCACAUAAGUCUGGAGACUGCUGUGGGGGUGGCAGUGGCUGUCACUGUGCUCGGAAUCAUGAUUUUGGGACUGAUCUGCCUCCUCAGGUGGAGGAGAAGGAAAGGUCAGCAGCGGACUAAAGCCACAACCCCAGCCAGGGAACCCUUCCAAAACACAGAGGAGCCAUAUGAGAAUAUCAGGAAUGAAGGACAAAAUACAGAUCCCAAGCUAAAUCCCAAGGAUGACGGCAUCGUCUAUGCUUCCCUUGCCCUCUCCAGCUCCACCUCACCCAGAGCACCUCCCAGCCACCGUCCCCUCAAGAGCCCCCAGAACGAGACCCUGUACUCUGUCUUAAAGGCCUAACCAAUGGACAGCCCUCUCAAGACUGAAUGGUGAGGCCAGGUACAGUGGCGCACACCUGUAAUCCCAGCUACUCUGAAGCCUGAGGCAGAAUCAAGUGAGCCCAGGAGUUCAGGGCCAGCUUUGAUAAUGGAGCGAGAUGCCAUCUCUAGUUAAAAAUAUAUAUUAACAAUAAAGUAACAAAUUUAAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 29992)
PILRA
paired immunoglobin like type 2 receptor alpha
NC_000007.14
7  100373657.. 100399907
100373657.. 100399907
strand +
CCDS5691.1
MGI:2450529
ClinVar, dbVar
ENSG00000085514
FDF03
uc003uuo.1
INSDC: AF161080
20396
605341
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (912 bp)
5'-ATGGGTCGGCCCCTGCTGCTGCCCCTACTGCCCTTGCTGCTGCCGCCAGCATTTCTGCAGCCTAGTGGCTCCACAGGATCTGGTCCAAGCTACCTTTATGGGGTCACTCAACCAAAACACCTCTCAGCCTCCATGGGTGGCTCTGTGGAAATCCCCTTCTCCTTCTATTACCCCTGGGAGTTAGCCACAGCTCCCGACGTGAGAATATCCTGGAGACGGGGCCACTTCCACAGGCAGTCCTTCTACAGCACAAGGCCGCCTTCCATTCACAAGGATTATGTGAACCGGCTCTTTCTGAACTGGACAGAGGGTCAGAAGAGCGGCTTCCTCAGGATCTCCAACCTGCAGAAGCAGGACCAGTCTGTGTATTTCTGCCGAGTTGAGCTGGACACACGGAGCTCAGGGAGGCAGCAGTGGCAGTCCATCGAGGGGACCAAACTCTCCATCACCCAGGCTGTCACGACCACCACCCAGAGGCCCAGCAGCATGACTACCACCTGGAGGCTCAGTAGCACAACCACCACAACCGGCCTCAGGGTCACACAGGGCAAACGACGCTCAGACTCTTGGCACATAAGTCTGGAGACTGCTGTGGGGGTGGCAGTGGCTGTCACTGTGCTCGGAATCATGATTTTGGGACTGATCTGCCTCCTCAGGTGGAGGAGAAGGAAAGGTCAGCAGCGGACTAAAGCCACAACCCCAGCCAGGGAACCCTTCCAAAACACAGAGGAGCCATATGAGAATATCAGGAATGAAGGACAAAATACAGATCCCAAGCTAAATCCCAAGGATGACGGCATCGTCTATGCTTCCCTTGCCCTCTCCAGCTCCACCTCACCCAGAGCACCTCCCAGCCACCGTCCCCTCAAGAGCCCCCAGAACGAGACCCTGTACTCTGTCTTAAAGGCCTAA-3'
NCBI CDS gene sequence with introns (location: 100373657.. 100399907) (26251 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 100373487.. 100400096) (26610 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [100373487 - 1000].. 100400096) (27610 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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