NCBI Summary
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015].
Protein
Protein (NP_002429)
CysR - macrophage mannose receptor
Macrophage mannose receptor 1 (MMR) (CD antigen 206)
MRC1
mannose receptor C-type 1
Curated
Cys-rich man-receptor
Cys-rich man-receptor
b-trefoil
Sulfated GalNAc
0.899
Undefined
The macrophage mannose receptor contains an N-terminal Cys-rich man-receptor domain adopting a beta trefoil fold followed by eight repeats of a C-type lectin domain classified as mixed alpha/beta. Exceptionally, this lectin therefore belongs to two distinct classes
Protein sequence and protein families
No protein sequence available.
Mol* PDB structure viewerUniLectin3D
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.


Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
  • CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma. [34267749]
  • Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. [33545173]
  • The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer. [34486997]
  • Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis. [33192174]
  • Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors. [32690608]
  • Organization of the gene encoding the human macrophage mannose receptor (MRC1). [1294118]
  • Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. [1730714]
  • Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. [2258707]
  • Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. [2373685]
  • Isolation and characterization of a mannose-specific endocytosis receptor from human placenta. [3611070]
UniProt Main References (8 PubMed Identifiers)
  • The DNA sequence and comparative analysis of human chromosome 10. [15164054]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. [18780401]
  • The mannose receptor mediates dengue virus infection of macrophages. [18266465]
  • The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells. [19683778]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. [10779515]
  • Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. [20035344]
RNA
RNA (Transcript ID: NM_002438.4)
mannose receptor C-type 1
;
DNA
DNA (Gene ID: 4360)
mannose receptor C-type 1
strand +
CLEC13D, CD206, bA541I19.1, CLEC13DL
NCBI CDS gene sequence with introns (location: 17809466.. 17910465) (101000 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 17809348.. 17911164) (101817 bp)Download
NCBI gene sequence (location: [17809348 - 1000].. 17911164) (102817 bp)Download
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