NCBI Summary
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015].
Protein (NP_002429)
CysR - macrophage mannose receptor
Macrophage mannose receptor 1 (MMR) (CD antigen 206)
mannose receptor C-type 1
Cys-rich man-receptor
Cys-rich man-receptor
Sulfated GalNAc
The macrophage mannose receptor contains an N-terminal Cys-rich man-receptor domain adopting a beta trefoil fold followed by eight repeats of a C-type lectin domain classified as mixed alpha/beta. Exceptionally, this lectin therefore belongs to two distinct classes
Protein sequence and protein families
No protein sequence available.
Mol* PDB structure viewerUniLectin3D
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
NCBI References (10 PubMed Identifiers)
  • CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma. [34267749]
  • Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. [33545173]
  • The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer. [34486997]
  • Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis. [33192174]
  • Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors. [32690608]
  • Organization of the gene encoding the human macrophage mannose receptor (MRC1). [1294118]
  • Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. [1730714]
  • Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. [2258707]
  • Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. [2373685]
  • Isolation and characterization of a mannose-specific endocytosis receptor from human placenta. [3611070]
UniProt Main References (8 PubMed Identifiers)
  • The DNA sequence and comparative analysis of human chromosome 10. [15164054]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. [18780401]
  • The mannose receptor mediates dengue virus infection of macrophages. [18266465]
  • The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells. [19683778]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. [10779515]
  • Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. [20035344]
RNA (Transcript ID: NM_002438.4)
mannose receptor C-type 1
DNA (Gene ID: 4360)
mannose receptor C-type 1
strand +
CLEC13D, CD206, bA541I19.1, CLEC13DL
NCBI CDS gene sequence with introns (location: 17809466.. 17910465) (101000 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 17809348.. 17911164) (101817 bp)Download
NCBI gene sequence (location: [17809348 - 1000].. 17911164) (102817 bp)Download
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