Protein
Protein (NP_835228)
Angiopoietin-related protein 5
Angiopoietin-related protein 5 (Angiopoietin-like protein 5)
ANGPTL5
angiopoietin like 5
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_835228
253935
Q86XS5
ENSP00000335255.3
Q86XS5
0.494
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (388 amino acids) Download
MMSPSQASLLFLNVCIFICGEAVQGNCVHHSTDSSVVNIVEDGSNAKDESKSNDTVCKEDCEESCDVKTKITREEKHFMCRNLQNSIVSYTRSTKKLLRNMMDEQQASLDYLSNQVNELMNRVLLLTTEVFRKQLDPFPHRPVQSHGLDCTDIKDTIGSVTKTPSGLYIIHPEGSSYPFEVMCDMDYRGGGRTVIQKRIDGIIDFQRLWCDYLDGFGDLLGEFWLGLKKIFYIVNQKNTSFMLYVALESEDDTLAYASYDNFWLEDETRFFKMHLGRYSGNAGDAFRGLKKEDNQNAMPFSTSDVDNDGCRPACLVNGQSVKSCSHLHNKTGWWFNECGLANLNGIHHFSGKLLATGIQWGTWTKNNSPVKIKSVSMKIRRMYNPYFK
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q86XS5-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.5, 1.9] ÅDownload
The location of the lectin domain structural model is: 141-383
We infer [1.5, 1.9] Å as the interval of error of this structural model.
Template 1: 6ZQX chain: A, Q8N539, NP_116232.3, sequence identity: 32.5%, coverage: 87.7%, location in sequence: 239-457, (239-457 in PDB).
Template 2: 2J3U chain: B, Q15485, NP_004099.2, sequence identity: 31.3%, coverage: 88.9%, location in sequence: 96-313, (71-288 in PDB).
Template 3: 2JHK chain: F, O00602, NP_001994.2, sequence identity: 30.5%, coverage: 88.5%, location in sequence: 110-326, (81-297 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for ANGPTL5 Gene
References
NCBI References (8 PubMed Identifiers)
  • Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is More Positively Associated with Glucose Metabolism Disorders in Patients with Metabolic Syndrome. [33486501]
  • Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents. [32286392]
  • A motif in LILRB2 critical for Angptl2 binding and activation. [24899623]
  • Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. [24709693]
  • Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. [22660330]
  • Human CD34+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID Il2rgamma-/- (NSG) mice. [21559522]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Identification of a novel human angiopoietin-like gene expressed mainly in heart. [12624729]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • Human chromosome 11 DNA sequence and analysis including novel gene identification. [16554811]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_835228.2, XP_011541037.1, XP_016872955.1
RNA
RNA (Transcript ID: NM_178127.5)
NM_178127.5
angiopoietin like 5
All isoforms of ANGPTL5 containing a lectin domain
ENST00000334289.7
597..1763 (or 101891279.. 101907909)
101890674.. 101916522
NCBI Matured mRNA sequence 2368 NTPDownload 
m7G-5')ppp(5'-GAUGAGAGGAACUAGAAGCAGCUAUUGCAAGCUACCAUUUUGAGAACCUGCCCAAAGAAAGAAAAGACUGAAGGGAUGGAAGAUUGCAGAAAGCAUGAUCGGAGAAGAGAUAUUUUACUUUUAGUGAAGCUCUAUACACAUUUGUCUUCCUCACUAGAUUUGUAUCCCUAGAACCUAGAACAGAGUCAGCCAAAGAGCAGGCACUCAAUACAAAUUGUUGACUUGCUGCUAAAAUUGUAACAGAGUACAAAGAACAUCCUAGAAAUUGGAGACAAAGGGGAUAAGAAAACAGAGUUAACUUGGAAAGAGAAGACACUCAUCUCUGACAAGACUGAAGAUGAUUACACAACACCAUCAUUGCCAACCAAGUCCUUUGGGAAUACAAAGGUUAAAUCCUAAUCAUCACAACAGUCUCUAAAGGAAUAAACCUGAUUUACAGAUUUUGAUAACAAAAUACUUCUCCUCUUUCCAUUUUCUACAAUGCAACCAACAGCAACAUCAAAGAGGUUUUUAACUGAAGACUCUAUGCUCUGUAGUUCUUUCCACAAAGAGCUGACUGAUAUUUGAAGAAGUGUUUUCAUCUAUCCAAGAAAAAUAUGAUGUCUCCAUCCCAAGCCUCACUCUUAUUCUUAAAUGUAUGUAUUUUUAUUUGUGGAGAAGCUGUACAAGGUAACUGUGUACAUCAUUCUACGGACUCUUCAGUAGUUAACAUUGUAGAAGAUGGAUCUAAUGCAAAAGAUGAAAGUAAAAGUAAUGAUACUGUUUGUAAGGAAGACUGUGAGGAAUCAUGUGAUGUUAAAACUAAAAUUACACGAGAAGAAAAACAUUUCAUGUGUAGAAAUUUGCAAAAUUCUAUUGUUUCCUACACAAGAAGUACCAAAAAACUACUAAGGAAUAUGAUGGAUGAGCAACAAGCUUCCUUGGAUUAUUUAUCUAAUCAGGUUAACGAGCUCAUGAAUAGAGUUCUCCUUUUGACUACAGAAGUUUUUAGAAAACAGCUGGAUCCUUUUCCUCACAGACCUGUUCAGUCACAUGGUUUAGAUUGCACUGAUAUUAAGGAUACCAUUGGCUCUGUCACCAAAACACCGAGUGGUUUAUACAUAAUUCACCCAGAAGGAUCUAGCUACCCAUUUGAGGUAAUGUGUGACAUGGAUUACAGAGGAGGUGGACGGACUGUGAUACAGAAAAGAAUUGAUGGGAUAAUUGAUUUCCAGAGGUUGUGGUGUGAUUAUCUGGAUGGAUUUGGAGAUCUUCUAGGAGAAUUUUGGCUAGGACUGAAAAAGAUUUUUUAUAUAGUAAAUCAGAAAAAUACCAGUUUUAUGCUGUAUGUGGCUUUGGAAUCUGAAGAUGACACUCUUGCUUAUGCAUCAUAUGAUAAUUUUUGGCUAGAGGAUGAAACGAGAUUUUUUAAAAUGCACUUAGGACGGUAUUCAGGAAAUGCUGGUGAUGCAUUCCGGGGUCUCAAAAAAGAAGAUAAUCAAAAUGCAAUGCCUUUUAGCACAUCAGAUGUUGAUAAUGAUGGGUGUCGCCCUGCAUGCCUGGUCAAUGGUCAGUCUGUGAAGAGCUGCAGUCACCUCCAUAACAAGACCGGCUGGUGGUUUAACGAGUGUGGUCUAGCAAAUCUAAAUGGCAUUCAUCACUUCUCUGGAAAAUUGCUUGCAACUGGAAUUCAAUGGGGCACGUGGACCAAAAACAACUCACCUGUCAAGAUUAAAUCUGUUUCAAUGAAAAUUAGAAGAAUGUACAAUCCAUAUUUUAAAUAAUCUCAUUUAACAUUGUAAUGCAAGUUCUACAAUGAUAAUAUAUUAAAGAUUUUUAAAAGUUUAUCUUUUCACUUAGUGUUUCAAACAUAUUAGGCAAAAUUUAACUGUAGAUGGCAUUUAGAUGUUAUGAGUUUAAUUAGAAAACUUCAAUUUUGUAGUAUUCUAUAAAAGAAAACAUGGCUUAUUGUAUGUUUUUACUUCUGACUAUAUUAACAAUAUACAAUGAAAUUUGUUUCAAGUGAACUACAACUUGUCUUCCUAAAAUUUAUAGUGAUUUUAAAGGAUUUUGCCUUUUCUUUGAAGCAUUUUUAAACCAUAAUAUGUUGUAAGGAAAAUUGAAGGGAAUAUUUUACUUAUUUUUAUACUUUAUAUGAUUAUAUAAUCUACAGAUAAUUUCUACUGAAGACAGUUACAAUAAAUAACUUUAUGCAGAUUAAUAUAUAAGCUACACAUGAUGUAAAAACCUUACUAUUUCUAGGUGAUGCCAUACCAUUUUAAAAGUAGUAAGAGUUUGCUGCCCAAAUAGUUUUUCUUGUUUUCAUAUCUAAUCAUGGUUAACUAUUUUGUUAUUGUUUGUAAUAAAUAUAUGUACUUUUAUAUCCUGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 253935)
ANGPTL5
angiopoietin like 5
NC_000011.10
11  101891279.. 101907909
101891279.. 101907909
strand -
CCDS8312.1
ClinVar, dbVar
ENSG00000187151
uc001pgl.3
INSDC: BC049170
19705
607666
OTTHUMG00000167318
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1167 bp)
5'-ATGATGTCTCCATCCCAAGCCTCACTCTTATTCTTAAATGTATGTATTTTTATTTGTGGAGAAGCTGTACAAGGTAACTGTGTACATCATTCTACGGACTCTTCAGTAGTTAACATTGTAGAAGATGGATCTAATGCAAAAGATGAAAGTAAAAGTAATGATACTGTTTGTAAGGAAGACTGTGAGGAATCATGTGATGTTAAAACTAAAATTACACGAGAAGAAAAACATTTCATGTGTAGAAATTTGCAAAATTCTATTGTTTCCTACACAAGAAGTACCAAAAAACTACTAAGGAATATGATGGATGAGCAACAAGCTTCCTTGGATTATTTATCTAATCAGGTTAACGAGCTCATGAATAGAGTTCTCCTTTTGACTACAGAAGTTTTTAGAAAACAGCTGGATCCTTTTCCTCACAGACCTGTTCAGTCACATGGTTTAGATTGCACTGATATTAAGGATACCATTGGCTCTGTCACCAAAACACCGAGTGGTTTATACATAATTCACCCAGAAGGATCTAGCTACCCATTTGAGGTAATGTGTGACATGGATTACAGAGGAGGTGGACGGACTGTGATACAGAAAAGAATTGATGGGATAATTGATTTCCAGAGGTTGTGGTGTGATTATCTGGATGGATTTGGAGATCTTCTAGGAGAATTTTGGCTAGGACTGAAAAAGATTTTTTATATAGTAAATCAGAAAAATACCAGTTTTATGCTGTATGTGGCTTTGGAATCTGAAGATGACACTCTTGCTTATGCATCATATGATAATTTTTGGCTAGAGGATGAAACGAGATTTTTTAAAATGCACTTAGGACGGTATTCAGGAAATGCTGGTGATGCATTCCGGGGTCTCAAAAAAGAAGATAATCAAAATGCAATGCCTTTTAGCACATCAGATGTTGATAATGATGGGTGTCGCCCTGCATGCCTGGTCAATGGTCAGTCTGTGAAGAGCTGCAGTCACCTCCATAACAAGACCGGCTGGTGGTTTAACGAGTGTGGTCTAGCAAATCTAAATGGCATTCATCACTTCTCTGGAAAATTGCTTGCAACTGGAATTCAATGGGGCACGTGGACCAAAAACAACTCACCTGTCAAGATTAAATCTGTTTCAATGAAAATTAGAAGAATGTACAATCCATATTTTAAATAA-3'
NCBI CDS gene sequence with introns (location: 101891279.. 101907909) (16631 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 101890674.. 101916522) (25849 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [101890674.. 101916522 + 1000]) (26849 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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