NCBI Summary
FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010].
Protein
Protein (NP_116232)
Fibrinogen C domain containing 1
Fibrinogen C domain-containing protein 1
FIBCD1
fibrinogen C domain containing 1
Undefined
Curated
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
ManNAc, GlcNAc
NP_116232
84929
Q8N539
ENSP00000361413.4
Q8N539
0.662
10.1074/jbc.M113.520577
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (461 amino acids) Download
MVNDRWKTMGGAAQLEDRPRDKPQRPSCGYVLCTVLLALAVLLAVAVTGAVLFLNHAHAPGTAPPPVVSTGAASANSALVTVERADSSHLSILIDPRCPDLTDSFARLESAQASVLQALTEHQAQPRLVGDQEQELLDTLADQLPRLLARASELQTECMGLRKGHGTLGQGLSALQSEQGRLIQLLSESQGHMAHLVNSVSDILDALQRDRGLGRPRNKADLQRAPARGTRPRGCATGSRPRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWDAYRDGFGRLTGEHWLGLKRIHALTTQAAYELHVDLEDFENGTAYARYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8N539-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
ManNAc
ManNAc
4M7F
4M7F
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for FIBCD1 Gene
ProteomicsDB
References
NCBI References (9 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • FIBCD1 Binds Aspergillus fumigatus and Regulates Lung Epithelial Response to Cell Wall Components. [30279687]
  • Overexpression of FIBCD1 Is Predictive of Poor Prognosis in Gastric Cancer. [29659669]
  • Immunohistochemical Localization of Fibrinogen C Domain Containing 1 on Epithelial and Mucosal Surfaces in Human Tissues. [29220632]
  • Crystal structure of the tetrameric fibrinogen-like recognition domain of fibrinogen C domain containing 1 (FIBCD1) protein. [24293368]
  • New genetic associations detected in a host response study to hepatitis B vaccine. [20237496]
  • The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. [19892701]
  • Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. [19710473]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • DNA sequence and analysis of human chromosome 9. [15164053]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_001138578.1, NP_116232.3
RNA
RNA (Transcript ID: NM_032843.5)
NM_032843.5
fibrinogen C domain containing 1, transcript variant 1
All isoforms of FIBCD1 containing a lectin domain
ENST00000372338.9
641..2026 (or 130904064.. 130938607)
130902440.. 130939247
NCBI Matured mRNA sequence 3650 NTPDownload 
m7G-5')ppp(5'-GCCCUCGGGGCCCGCCCCGCGCAUGGUGACUUGUGUGAGUCCGGUCCGGGAGGAAGUUUGUGCAGAGGCGCCGCCGGGGGGCUCUCAGGCCCCUCCGGGAGCCAGCAGGAGCCGGGCCGCCCGCGGCUGUUUGCUGCCCUCCGGCCGGCCGCGUUAUCUGGGGGCCAGUUCGGCCUCCUUUCCCUAGGUCUUUUCGGAGGCGGAGUUUAGUAUCCAAGUCCGCGGGUGUGAGCGCGCGCGUGUGUGUGAGUGUGUCGGGGGAGGCCGAGGGGAGCAAUAAAAAGCAAAGAGAGUCCGAGACCAGAAAAGAUGCGGAGAUUGAGAAGGAGGGAGGAGGGACGAGGGAGGAGAGAGAGGAGCGCGCCGGGGAGGCGCCGGAGCCGGGAGCGGGGACGGCGCGCAGCGCGAGCGGCGGGCGUUGGGCUGGCGGCUUUCGCGCUCCCGCUCCUGCUCCCGCCCGCACACAGCGGCGCGCUCAUCCUCACACGCCCGCCCGCUCCCGGGCCGCCCCGGCGCGGGGCACAGAGGCGGGGACCCGGCGGACAGAGCGCGCCCCGCGCCCGCGCCCGCGCCCACCCCGUCUCCUUUGCGCUCCGCAGCGGCGCGCCUCGCCCGGCGCCCCCGCCAGUCCUGCCGGAAGAUGGUCAACGACCGGUGGAAGACCAUGGGCGGCGCUGCCCAACUUGAGGACCGGCCGCGCGACAAGCCGCAGCGGCCGAGCUGCGGCUACGUGCUGUGCACCGUGCUGCUGGCCCUGGCUGUGCUGCUGGCUGUAGCUGUCACCGGUGCCGUGCUCUUCCUGAACCACGCCCACGCGCCGGGCACGGCGCCCCCACCUGUCGUCAGCACUGGGGCUGCCAGCGCCAACAGCGCCCUGGUCACUGUGGAAAGGGCGGACAGCUCGCACCUCAGCAUCCUCAUUGACCCGCGCUGCCCCGACCUCACCGACAGCUUCGCACGCCUGGAGAGCGCCCAGGCCUCGGUGCUGCAGGCGCUGACAGAGCACCAGGCCCAGCCACGGCUGGUGGGCGACCAGGAGCAGGAGCUGCUGGACACGCUGGCCGACCAGCUGCCCCGGCUGCUGGCCCGAGCCUCAGAGCUGCAGACGGAGUGCAUGGGGCUGCGGAAGGGGCAUGGCACGCUGGGCCAGGGCCUCAGCGCCCUGCAGAGUGAGCAGGGCCGCCUCAUCCAGCUUCUCUCUGAGAGCCAGGGCCACAUGGCUCACCUGGUGAACUCCGUCAGCGACAUCCUGGAUGCCCUGCAGAGGGACCGGGGGCUGGGCCGGCCCCGCAACAAGGCCGACCUUCAGAGAGCGCCUGCCCGGGGAACCCGGCCCCGGGGCUGUGCCACUGGCUCCCGGCCCCGAGACUGUCUGGACGUCCUCCUAAGCGGACAGCAGGACGAUGGCGUCUACUCUGUCUUUCCCACCCACUACCCGGCCGGCUUCCAGGUGUACUGUGACAUGCGCACGGACGGCGGCGGCUGGACGGUGUUUCAGCGCCGGGAGGACGGCUCCGUGAACUUCUUCCGGGGCUGGGAUGCGUACCGAGACGGCUUUGGCAGGCUCACCGGGGAGCACUGGCUAGGGCUCAAGAGGAUCCACGCCCUGACCACACAGGCUGCCUACGAGCUGCACGUGGACCUGGAGGACUUUGAGAAUGGCACGGCCUAUGCCCGCUACGGGAGCUUCGGCGUGGGCUUGUUCUCCGUGGACCCUGAGGAAGACGGGUACCCGCUCACCGUGGCUGACUAUUCCGGCACUGCAGGCGACUCCCUCCUGAAGCACAGCGGCAUGAGGUUCACCACCAAGGACCGUGACAGCGACCAUUCAGAGAACAACUGUGCCGCCUUCUACCGCGGUGCCUGGUGGUACCGCAACUGCCACACGUCCAACCUCAAUGGGCAGUACCUGCGCGGUGCGCACGCCUCCUAUGCCGACGGCGUGGAGUGGUCCUCCUGGACCGGCUGGCAGUACUCACUCAAGUUCUCUGAGAUGAAGAUCCGGCCGGUCCGGGAGGACCGCUAGACUGGUGCACCUUGUCCUUGGCCCUGCUGGUCCCUGUCGCCCCAUCCCCGACCCCACCUCACUCUUUCGUGAAUGUUCUCCACCCACCUGUGCCUGGCGGACCCACUCUCCAGUAGGGAGGGGCCGGGCCAUCCCUGACACGAAGCUCCCUGGGCCGGUGAAGUCACACAUCGCCUUCUCGCCGUCCCCACCCCCUCCAUUUGGCAGCUCACUGAUCUCUUGCCUCUGCUGAUGGGGGCUGGCAAACUUGACGACCCCAACUCCUGCCUGCCCCCACUGUGACUCCGGUGCUGUUUGCCGUCCCCUGGCCAGGAUGGUGGAGUCUGCCCCAGGCACCCUCUGCCCUGCCCGGCCAAAUACCCGGCAUUAUGGGGACAGAGAGCAGGGGGCAGACAGCACCCCUGGAGUCCUCCUAGCAGAUCGUGGGGAACGUCAGGUCUCUCUGAGGUCAGGUCUGAGGCCAGUAUCCUCCAGCCCUCCCAAUGCCAACCCCCACCCCGUUUCCCUGGUGCCCAGAGAACCCACCUCUCCCCCAAGGGCCUCAGCCUGGCUGUGGGCUGGGUGGCCCCAUCCUACCAGGCCCUGAGGUCAGGAUGGGGAGCUGCUGCCUUUGGGGACCCACGCUCCAAGGCUGAGACCAGUUCCCUGGAGGCCACCCACCCUGUGCCCCGGCAGGCCUGGGGUCUGCAGUCCUCUUACCUGCUGUGCCCACCUGCUCUCUGUCUCAAAUGAGGCCCAACCCAUCCCCCACCCAGCUCCCGGCCGUCCUCCUACCUGGGGCAGCUGGGGCUGCCAUCCCAUUUCUCCUGCCUCUGGAAGGUGGGUGGGGCCCUGCACCGUGGGGCUGGACUGCGCUAAUGGGAAGCUCUUGGUUUUCUGGGCUGGGGCCUAGGCAGGGCUGGGAUGAGGCUUGUACAACCCCCACCACCAAUUUCCCAGGGACUCCAGGGUCCUGAGGCCUCCCAGGAGGGCCUUGGGGGUGAUGACCCCUUCCCUGAGGUGGCUGUCUCCAUGAGGAGGCCAACCCUUGCCAUUGACCGUGGCCACCUGGACCCAGGCCAGGCCCGGCCCGGCGAGUGGUCAAGGGACAGGGACCACCUCACCGGGCAAAUGGGGUCGGGGGGACUGGGGCACCAGACCAGGCACCACCUGGACACUUUCUUGUUGAAUCCUCCCAACACCCAGCACGCUGUCAUCCCCACUCCUUGUGUGCACACAUGCAGAGGUGAGACCCGCAGGCUCCCAGGACCAGCAGCCACAAGGGCAGGGCUGGAGCCGGGUCCUCAGCUGUCUGCUCAGCAGCCCUGGACCCGCGUGCGUUACGUCAGGCCCAGAUGCAGGGCGGCUUUUCCAAGGCCUCCUGAUGGGGGGCCUCCGAAAGGGCUGGAGUCAGCCUUGGGGAGCUGCCUAGCAGCCUCUCCUCGGGCAGGAGGGGAGGUGGCUUCCUCCAAAGGACACCCGAUGGCAGGUGCCUAGGGGGUGUGGGGUUCCGUUCUCCCUUCCCCUCCCACUGAAGUUUGUGCUUAAAAAACAAUAAAUUUGACUUGGCACCACUGGGGGUUGGUGGGAGAGGCCGUGUGACCUGGCUCUCUGUCCCAGUGCCACCAGGUCAUCCACAUGCGCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 84929)
FIBCD1
fibrinogen C domain containing 1
NC_000009.12
9  130904064.. 130938607
130904064.. 130938607
strand -
CCDS6937.1
MGI:2138953
ClinVar, dbVar
ENSG00000130720
FLJ14810
uc011mcc.2
INSDC: AK027716
25922
613357
OTTHUMG00000020814
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1386 bp)
5'-ATGGTCAACGACCGGTGGAAGACCATGGGCGGCGCTGCCCAACTTGAGGACCGGCCGCGCGACAAGCCGCAGCGGCCGAGCTGCGGCTACGTGCTGTGCACCGTGCTGCTGGCCCTGGCTGTGCTGCTGGCTGTAGCTGTCACCGGTGCCGTGCTCTTCCTGAACCACGCCCACGCGCCGGGCACGGCGCCCCCACCTGTCGTCAGCACTGGGGCTGCCAGCGCCAACAGCGCCCTGGTCACTGTGGAAAGGGCGGACAGCTCGCACCTCAGCATCCTCATTGACCCGCGCTGCCCCGACCTCACCGACAGCTTCGCACGCCTGGAGAGCGCCCAGGCCTCGGTGCTGCAGGCGCTGACAGAGCACCAGGCCCAGCCACGGCTGGTGGGCGACCAGGAGCAGGAGCTGCTGGACACGCTGGCCGACCAGCTGCCCCGGCTGCTGGCCCGAGCCTCAGAGCTGCAGACGGAGTGCATGGGGCTGCGGAAGGGGCATGGCACGCTGGGCCAGGGCCTCAGCGCCCTGCAGAGTGAGCAGGGCCGCCTCATCCAGCTTCTCTCTGAGAGCCAGGGCCACATGGCTCACCTGGTGAACTCCGTCAGCGACATCCTGGATGCCCTGCAGAGGGACCGGGGGCTGGGCCGGCCCCGCAACAAGGCCGACCTTCAGAGAGCGCCTGCCCGGGGAACCCGGCCCCGGGGCTGTGCCACTGGCTCCCGGCCCCGAGACTGTCTGGACGTCCTCCTAAGCGGACAGCAGGACGATGGCGTCTACTCTGTCTTTCCCACCCACTACCCGGCCGGCTTCCAGGTGTACTGTGACATGCGCACGGACGGCGGCGGCTGGACGGTGTTTCAGCGCCGGGAGGACGGCTCCGTGAACTTCTTCCGGGGCTGGGATGCGTACCGAGACGGCTTTGGCAGGCTCACCGGGGAGCACTGGCTAGGGCTCAAGAGGATCCACGCCCTGACCACACAGGCTGCCTACGAGCTGCACGTGGACCTGGAGGACTTTGAGAATGGCACGGCCTATGCCCGCTACGGGAGCTTCGGCGTGGGCTTGTTCTCCGTGGACCCTGAGGAAGACGGGTACCCGCTCACCGTGGCTGACTATTCCGGCACTGCAGGCGACTCCCTCCTGAAGCACAGCGGCATGAGGTTCACCACCAAGGACCGTGACAGCGACCATTCAGAGAACAACTGTGCCGCCTTCTACCGCGGTGCCTGGTGGTACCGCAACTGCCACACGTCCAACCTCAATGGGCAGTACCTGCGCGGTGCGCACGCCTCCTATGCCGACGGCGTGGAGTGGTCCTCCTGGACCGGCTGGCAGTACTCACTCAAGTTCTCTGAGATGAAGATCCGGCCGGTCCGGGAGGACCGCTAG-3'
NCBI CDS gene sequence with introns (location: 130904064.. 130938607) (34544 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 130902440.. 130939247) (36808 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [130902440.. 130939247 + 1000]) (37808 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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