NCBI Summary
FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010].
Protein
Protein (NP_116232)
Fibrinogen C domain containing 1
Fibrinogen C domain-containing protein 1
FIBCD1
fibrinogen C domain containing 1
Undefined
Curated
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
0.662
Protein sequence and protein families (fasta) (461 amino acids) Download
MVNDRWKTMGGAAQLEDRPRDKPQRPSCGYVLCTVLLALAVLLAVAVTGAVLFLNHAHAPGTAPPPVVSTGAASANSALVTVERADSSHLSILIDPRCPDLTDSFARLESAQASVLQALTEHQAQPRLVGDQEQELLDTLADQLPRLLARASELQTECMGLRKGHGTLGQGLSALQSEQGRLIQLLSESQGHMAHLVNSVSDILDALQRDRGLGRPRNKADLQRAPARGTRPRGCATGSRPRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWDAYRDGFGRLTGEHWLGLKRIHALTTQAAYELHVDLEDFENGTAYARYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVREDR
Mol* PDB structure viewerUniLectin3D
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.


Ligand
Glycan ligands from structural data
ManNAc
ManNAc
References
NCBI References (9 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • FIBCD1 Binds Aspergillus fumigatus and Regulates Lung Epithelial Response to Cell Wall Components. [30279687]
  • Overexpression of FIBCD1 Is Predictive of Poor Prognosis in Gastric Cancer. [29659669]
  • Immunohistochemical Localization of Fibrinogen C Domain Containing 1 on Epithelial and Mucosal Surfaces in Human Tissues. [29220632]
  • Crystal structure of the tetrameric fibrinogen-like recognition domain of fibrinogen C domain containing 1 (FIBCD1) protein. [24293368]
  • New genetic associations detected in a host response study to hepatitis B vaccine. [20237496]
  • The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. [19892701]
  • Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. [19710473]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • DNA sequence and analysis of human chromosome 9. [15164053]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_001138578.1, NP_116232.3
RNA
RNA (Transcript ID: NM_032843.5)
fibrinogen C domain containing 1, transcript variant 1
m7G-5')ppp(5'-GCCCUCGGGGCCCGCCCCGCGCAUGGUGACUUGUGUGAGUCCGGUCCGGGAGGAAGUUUGUGCAGAGGCGCCGCCGGGGGGCUCUCAGGCCCCUCCGGGAGCCAGCAGGAGCCGGGCCGCCCGCGGCUGUUUGCUGCCCUCCGGCCGGCCGCGUUAUCUGGGGGCCAGUUCGGCCUCCUUUCCCUAGGUCUUUUCGGAGGCGGAGUUUAGUAUCCAAGUCCGCGGGUGUGAGCGCGCGCGUGUGUGUGAGUGUGUCGGGGGAGGCCGAGGGGAGCAAUAAAAAGCAAAGAGAGUCCGAGACCAGAAAAGAUGCGGAGAUUGAGAAGGAGGGAGGAGGGACGAGGGAGGAGAGAGAGGAGCGCGCCGGGGAGGCGCCGGAGCCGGGAGCGGGGACGGCGCGCAGCGCGAGCGGCGGGCGUUGGGCUGGCGGCUUUCGCGCUCCCGCUCCUGCUCCCGCCCGCACACAGCGGCGCGCUCAUCCUCACACGCCCGCCCGCUCCCGGGCCGCCCCGGCGCGGGGCACAGAGGCGGGGACCCGGCGGACAGAGCGCGCCCCGCGCCCGCGCCCGCGCCCACCCCGUCUCCUUUGCGCUCCGCAGCGGCGCGCCUCGCCCGGCGCCCCCGCCAGUCCUGCCGGAAGAUGGUCAACGACCGGUGGAAGACCAUGGGCGGCGCUGCCCAACUUGAGGACCGGCCGCGCGACAAGCCGCAGCGGCCGAGCUGCGGCUACGUGCUGUGCACCGUGCUGCUGGCCCUGGCUGUGCUGCUGGCUGUAGCUGUCACCGGUGCCGUGCUCUUCCUGAACCACGCCCACGCGCCGGGCACGGCGCCCCCACCUGUCGUCAGCACUGGGGCUGCCAGCGCCAACAGCGCCCUGGUCACUGUGGAAAGGGCGGACAGCUCGCACCUCAGCAUCCUCAUUGACCCGCGCUGCCCCGACCUCACCGACAGCUUCGCACGCCUGGAGAGCGCCCAGGCCUCGGUGCUGCAGGCGCUGACAGAGCACCAGGCCCAGCCACGGCUGGUGGGCGACCAGGAGCAGGAGCUGCUGGACACGCUGGCCGACCAGCUGCCCCGGCUGCUGGCCCGAGCCUCAGAGCUGCAGACGGAGUGCAUGGGGCUGCGGAAGGGGCAUGGCACGCUGGGCCAGGGCCUCAGCGCCCUGCAGAGUGAGCAGGGCCGCCUCAUCCAGCUUCUCUCUGAGAGCCAGGGCCACAUGGCUCACCUGGUGAACUCCGUCAGCGACAUCCUGGAUGCCCUGCAGAGGGACCGGGGGCUGGGCCGGCCCCGCAACAAGGCCGACCUUCAGAGAGCGCCUGCCCGGGGAACCCGGCCCCGGGGCUGUGCCACUGGCUCCCGGCCCCGAGACUGUCUGGACGUCCUCCUAAGCGGACAGCAGGACGAUGGCGUCUACUCUGUCUUUCCCACCCACUACCCGGCCGGCUUCCAGGUGUACUGUGACAUGCGCACGGACGGCGGCGGCUGGACGGUGUUUCAGCGCCGGGAGGACGGCUCCGUGAACUUCUUCCGGGGCUGGGAUGCGUACCGAGACGGCUUUGGCAGGCUCACCGGGGAGCACUGGCUAGGGCUCAAGAGGAUCCACGCCCUGACCACACAGGCUGCCUACGAGCUGCACGUGGACCUGGAGGACUUUGAGAAUGGCACGGCCUAUGCCCGCUACGGGAGCUUCGGCGUGGGCUUGUUCUCCGUGGACCCUGAGGAAGACGGGUACCCGCUCACCGUGGCUGACUAUUCCGGCACUGCAGGCGACUCCCUCCUGAAGCACAGCGGCAUGAGGUUCACCACCAAGGACCGUGACAGCGACCAUUCAGAGAACAACUGUGCCGCCUUCUACCGCGGUGCCUGGUGGUACCGCAACUGCCACACGUCCAACCUCAAUGGGCAGUACCUGCGCGGUGCGCACGCCUCCUAUGCCGACGGCGUGGAGUGGUCCUCCUGGACCGGCUGGCAGUACUCACUCAAGUUCUCUGAGAUGAAGAUCCGGCCGGUCCGGGAGGACCGCUAGACUGGUGCACCUUGUCCUUGGCCCUGCUGGUCCCUGUCGCCCCAUCCCCGACCCCACCUCACUCUUUCGUGAAUGUUCUCCACCCACCUGUGCCUGGCGGACCCACUCUCCAGUAGGGAGGGGCCGGGCCAUCCCUGACACGAAGCUCCCUGGGCCGGUGAAGUCACACAUCGCCUUCUCGCCGUCCCCACCCCCUCCAUUUGGCAGCUCACUGAUCUCUUGCCUCUGCUGAUGGGGGCUGGCAAACUUGACGACCCCAACUCCUGCCUGCCCCCACUGUGACUCCGGUGCUGUUUGCCGUCCCCUGGCCAGGAUGGUGGAGUCUGCCCCAGGCACCCUCUGCCCUGCCCGGCCAAAUACCCGGCAUUAUGGGGACAGAGAGCAGGGGGCAGACAGCACCCCUGGAGUCCUCCUAGCAGAUCGUGGGGAACGUCAGGUCUCUCUGAGGUCAGGUCUGAGGCCAGUAUCCUCCAGCCCUCCCAAUGCCAACCCCCACCCCGUUUCCCUGGUGCCCAGAGAACCCACCUCUCCCCCAAGGGCCUCAGCCUGGCUGUGGGCUGGGUGGCCCCAUCCUACCAGGCCCUGAGGUCAGGAUGGGGAGCUGCUGCCUUUGGGGACCCACGCUCCAAGGCUGAGACCAGUUCCCUGGAGGCCACCCACCCUGUGCCCCGGCAGGCCUGGGGUCUGCAGUCCUCUUACCUGCUGUGCCCACCUGCUCUCUGUCUCAAAUGAGGCCCAACCCAUCCCCCACCCAGCUCCCGGCCGUCCUCCUACCUGGGGCAGCUGGGGCUGCCAUCCCAUUUCUCCUGCCUCUGGAAGGUGGGUGGGGCCCUGCACCGUGGGGCUGGACUGCGCUAAUGGGAAGCUCUUGGUUUUCUGGGCUGGGGCCUAGGCAGGGCUGGGAUGAGGCUUGUACAACCCCCACCACCAAUUUCCCAGGGACUCCAGGGUCCUGAGGCCUCCCAGGAGGGCCUUGGGGGUGAUGACCCCUUCCCUGAGGUGGCUGUCUCCAUGAGGAGGCCAACCCUUGCCAUUGACCGUGGCCACCUGGACCCAGGCCAGGCCCGGCCCGGCGAGUGGUCAAGGGACAGGGACCACCUCACCGGGCAAAUGGGGUCGGGGGGACUGGGGCACCAGACCAGGCACCACCUGGACACUUUCUUGUUGAAUCCUCCCAACACCCAGCACGCUGUCAUCCCCACUCCUUGUGUGCACACAUGCAGAGGUGAGACCCGCAGGCUCCCAGGACCAGCAGCCACAAGGGCAGGGCUGGAGCCGGGUCCUCAGCUGUCUGCUCAGCAGCCCUGGACCCGCGUGCGUUACGUCAGGCCCAGAUGCAGGGCGGCUUUUCCAAGGCCUCCUGAUGGGGGGCCUCCGAAAGGGCUGGAGUCAGCCUUGGGGAGCUGCCUAGCAGCCUCUCCUCGGGCAGGAGGGGAGGUGGCUUCCUCCAAAGGACACCCGAUGGCAGGUGCCUAGGGGGUGUGGGGUUCCGUUCUCCCUUCCCCUCCCACUGAAGUUUGUGCUUAAAAAACAAUAAAUUUGACUUGGCACCACUGGGGGUUGGUGGGAGAGGCCGUGUGACCUGGCUCUCUGUCCCAGUGCCACCAGGUCAUCCACAUGCGCA-3'- Poly-A tail
  • Coding region
;
DNA
DNA (Gene ID: 84929)
fibrinogen C domain containing 1
strand -
FLJ14810
NCBI CDS gene sequence (1386 bp)
5'-ATGGTCAACGACCGGTGGAAGACCATGGGCGGCGCTGCCCAACTTGAGGACCGGCCGCGCGACAAGCCGCAGCGGCCGAGCTGCGGCTACGTGCTGTGCACCGTGCTGCTGGCCCTGGCTGTGCTGCTGGCTGTAGCTGTCACCGGTGCCGTGCTCTTCCTGAACCACGCCCACGCGCCGGGCACGGCGCCCCCACCTGTCGTCAGCACTGGGGCTGCCAGCGCCAACAGCGCCCTGGTCACTGTGGAAAGGGCGGACAGCTCGCACCTCAGCATCCTCATTGACCCGCGCTGCCCCGACCTCACCGACAGCTTCGCACGCCTGGAGAGCGCCCAGGCCTCGGTGCTGCAGGCGCTGACAGAGCACCAGGCCCAGCCACGGCTGGTGGGCGACCAGGAGCAGGAGCTGCTGGACACGCTGGCCGACCAGCTGCCCCGGCTGCTGGCCCGAGCCTCAGAGCTGCAGACGGAGTGCATGGGGCTGCGGAAGGGGCATGGCACGCTGGGCCAGGGCCTCAGCGCCCTGCAGAGTGAGCAGGGCCGCCTCATCCAGCTTCTCTCTGAGAGCCAGGGCCACATGGCTCACCTGGTGAACTCCGTCAGCGACATCCTGGATGCCCTGCAGAGGGACCGGGGGCTGGGCCGGCCCCGCAACAAGGCCGACCTTCAGAGAGCGCCTGCCCGGGGAACCCGGCCCCGGGGCTGTGCCACTGGCTCCCGGCCCCGAGACTGTCTGGACGTCCTCCTAAGCGGACAGCAGGACGATGGCGTCTACTCTGTCTTTCCCACCCACTACCCGGCCGGCTTCCAGGTGTACTGTGACATGCGCACGGACGGCGGCGGCTGGACGGTGTTTCAGCGCCGGGAGGACGGCTCCGTGAACTTCTTCCGGGGCTGGGATGCGTACCGAGACGGCTTTGGCAGGCTCACCGGGGAGCACTGGCTAGGGCTCAAGAGGATCCACGCCCTGACCACACAGGCTGCCTACGAGCTGCACGTGGACCTGGAGGACTTTGAGAATGGCACGGCCTATGCCCGCTACGGGAGCTTCGGCGTGGGCTTGTTCTCCGTGGACCCTGAGGAAGACGGGTACCCGCTCACCGTGGCTGACTATTCCGGCACTGCAGGCGACTCCCTCCTGAAGCACAGCGGCATGAGGTTCACCACCAAGGACCGTGACAGCGACCATTCAGAGAACAACTGTGCCGCCTTCTACCGCGGTGCCTGGTGGTACCGCAACTGCCACACGTCCAACCTCAATGGGCAGTACCTGCGCGGTGCGCACGCCTCCTATGCCGACGGCGTGGAGTGGTCCTCCTGGACCGGCTGGCAGTACTCACTCAAGTTCTCTGAGATGAAGATCCGGCCGGTCCGGGAGGACCGCTAG-3'
NCBI CDS gene sequence with introns (location: 130904064.. 130938607) (34544 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 130902440.. 130939247) (36808 bp)Download
NCBI gene sequence (location: [130902440.. 130939247 + 1000]) (37808 bp)Download
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