NCBI Summary
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_115859)
Isoform XB-short of Tenascin-X
Tenascin-X (TN-X) (Hexabrachion-like protein)
TNXB
tenascin XB
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_115859
7148
P22105
Undefined
P22105
0.572
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (673 amino acids) Download
MRLSWSVAQGPFDSFVVQYEDTNGQPQALLVDGDQSKILISGLEPSTPYRFLLYGLHEGKRLGPLSAEGTTGLAPAGQTSEESRPRLSQLSVTDVTTSSLRLNWEAPPGAFDSFLLRFGVPSPSTLEPHPRPLLQRELMVPGTRHSAVLRDLRSGTLYSLTLYGLRGPHKADSIQGTARTLSPVLESPRDLQFSEIRETSAKVNWMPPPSRADSFKVSYQLADGGEPQSVQVDGQARTQKLQGLIPGARYEVTVVSVRGFEESEPLTGFLTTVPDGPTQLRALNLTEGFAVLHWKPPQNPVDTYDVQVTAPGAPPLQAETPGSAVDYPLHDLVLHTNYTATVRGLRGPNLTSPASITFTTGLEAPRDLEAKEVTPRTALLTWTEPPVRPAGYLLSFHTPGGQNQEILLPGGITSHQLLGLFPSTSYNARLQAMWGQSLLPPVSTSFTTGGLRIPFPRDCGEEMQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSMRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG
Mol* PDB structure viewer
Structural models
No AlphaFold model available for P22105.
SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.27, 1.55] ÅDownload
The location of the lectin domain structural model is: 455-663
We infer [1.27, 1.55] Å as the interval of error of this structural model.
Template 1: 2J3U chain: B, Q15485, NP_004099.2, sequence identity: 47.8%, coverage: 99.0%, location in sequence: 96-313, (71-288 in PDB).
Template 2: 2JHK chain: F, O00602, NP_001994.2, sequence identity: 46.9%, coverage: 99.0%, location in sequence: 110-326, (81-297 in PDB).
Template 3: 6ZQX chain: A, Q8N539, NP_116232.3, sequence identity: 45.0%, coverage: 99.5%, location in sequence: 239-457, (239-457 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for TNXB Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • A TNXB splice donor site variant as a cause of hypermobility type Ehlers-Danlos syndrome in patients with congenital adrenal hyperplasia. [33332743]
  • Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma. [32606567]
  • A functional variant in TNXB promoter associates with the risk of esophageal squamous-cell carcinoma. [32056283]
  • Tenascin XB Is a Novel Diagnostic Marker for Malignant Mesothelioma. [30711938]
  • Whole-genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration reveals differential methylation of the SKI, GTF2H4, and TNXB genes. [30642396]
  • Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X. [8530023]
  • Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. [7686164]
  • Ehlers-Danlos Syndrome, Hypermobility Type [20301456]
  • Mechanism and consequences of the duplication of the human C4/P450c21/gene X locus. [1373808]
  • Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus. [2475872]
UniProt Main References (13 PubMed Identifiers)
  • Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. [14656967]
  • The DNA sequence and analysis of human chromosome 6. [14574404]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes. [8923003]
  • Cluster of fibronectin type III repeats found in the human major histocompatibility complex class III region shows the highest homology with the repeats in an extracellular matrix protein, tenascin. [1373119]
  • Identification and characterization of multiple species of tenascin-X in human serum. [17263730]
  • Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]
  • Interactions of human tenascin-X domains with dermal extracellular matrix molecules. [17033827]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency. [11642233]
    • Show more
All isoforms of this gene containing a lectin domain
NP_115859.2, NP_061978.6, NP_001352205.1
RNA
RNA (Transcript ID: NM_032470.4)
NM_032470.4
tenascin XB, transcript variant XB-S
All isoforms of TNXB containing a lectin domain
910..2931 (or 32041349.. 32045219)
32041153.. 32046128
NCBI Matured mRNA sequence 3127 NTPDownload 
m7G-5')ppp(5'-CCUUGUGCAUUUGGGCUGAAGACAAAGAUGACUGCAGGAGUGGGCAGGCCGGAGUGGGGCGCCCUGGCCUGUCCCCAGGAAGGAGGAGGAGUCUGCAGCCCUGUGGGCUUCAACAUCCAUCAAGGAGUCCAGAGCAGGAGCCAGGCCAGGCGGGAGGGAAAGGCCCUGGGAGGGGCUCUCUAAUCUCCCAGCCCCGACUCUGCCCCGUCACUGCCACUGCUCCUCAUUACUCGCUGGGGCUGCUGUCGCCUCCCCGAAGGGUGGCCUUGUCCAGAUAGCGGCAAACCUCCCUGCCGUGGAUGAGUCAGGAGCAUUUUCUUAAGAGGAACAUCACUGGAAAACAAAAUGAGCGGGGACACAGAAACCAACAGCAGUGGCUGCAUUUGUGGUACAGGCUCCUCUUCCAGAGCUCGCUGAUGCCCACCUCAGACAGGCCUGACCACGGCACGGCUGGUGGGAUUUGCCAGUCACCUCAACCAGCCAGUUCCACCCUCAGCUUCUCUCAGAAGGGAGCACCACACUCCUCAAGCUCAGUGAAUGUAUCCCGGCAUGGGUGGGGCCAGAGCCUGUGAUAUCUCGAGGUGGGCUCGGCAGGACACCGGGGUGUGGAAGGGGGAAGCGAGCACCUGACUCAGACAGCGCGGGAGCUCGCAGGAGUCACGAGGCCACAGCGACUUCAUUGUCUGACUGGGCCUGGACCUAUAAACUUCCCACCUCAGCCUUGGGCCAAGCCUGGAAGAUAAAAAUGGAGCACCCCAUGGCGCCCCUCACUCAGAUUCUCCCCUGGGCUUCUCCCACGCAGCCCCAGAAGAGGACACACCAGCCCCAGAGUUAGCCCCAGAGGCCCCUGAGCCUCCUGAAGAGCCCCGCCUAGGAGUGCUGACCGUGACCGACACAACCCCAGACUCCAUGCGCCUCUCGUGGAGCGUGGCCCAGGGCCCCUUUGAUUCCUUCGUGGUCCAGUAUGAGGACACGAACGGGCAGCCCCAGGCCUUGCUCGUGGACGGCGACCAGAGCAAGAUCCUCAUCUCAGGCCUGGAGCCCAGCACCCCCUACAGGUUCCUCCUCUAUGGCCUCCAUGAAGGGAAGCGCCUGGGGCCCCUCUCAGCUGAGGGCACCACAGGGCUGGCUCCUGCUGGUCAGACCUCAGAGGAGUCAAGGCCCCGCCUGUCCCAGCUGUCUGUGACUGACGUGACCACCAGUUCACUGAGGCUCAACUGGGAGGCCCCACCGGGGGCCUUCGACUCCUUCCUGCUCCGCUUUGGGGUUCCAUCACCAAGCACUCUGGAGCCGCAUCCGCGUCCACUGCUGCAGCGCGAGCUGAUGGUGCCGGGGACGCGGCACUCGGCCGUGCUCCGGGACCUGCGUUCCGGGACUCUGUACAGCCUGACACUGUAUGGGCUGCGAGGACCCCACAAGGCCGACAGCAUCCAGGGAACCGCCCGCACCCUCAGCCCAGUUCUGGAGAGCCCCCGUGACCUCCAAUUCAGUGAAAUCAGGGAGACCUCAGCCAAGGUCAACUGGAUGCCCCCACCAUCCCGGGCGGACAGCUUCAAAGUCUCCUACCAGCUGGCGGACGGAGGGGAGCCUCAGAGUGUGCAGGUGGAUGGCCAGGCCCGGACCCAGAAACUCCAGGGGCUGAUCCCAGGCGCUCGCUAUGAGGUGACCGUGGUCUCGGUCCGAGGCUUUGAGGAGAGUGAGCCUCUCACAGGCUUCCUCACCACGGUUCCUGACGGUCCCACACAGUUGCGUGCACUGAACUUGACCGAGGGAUUCGCCGUGCUGCACUGGAAGCCCCCCCAGAAUCCUGUGGACACCUAUGACGUCCAGGUCACAGCCCCUGGGGCCCCGCCUCUGCAGGCGGAGACCCCAGGCAGCGCGGUGGACUACCCCCUGCAUGACCUUGUCCUCCACACCAACUACACCGCCACAGUGCGUGGCCUGCGGGGCCCCAACCUCACUUCCCCAGCCAGCAUCACCUUCACCACAGGGCUAGAGGCCCCUCGGGACUUGGAGGCCAAGGAAGUGACCCCCCGCACCGCCCUGCUCACUUGGACUGAGCCCCCAGUCCGGCCCGCAGGCUACCUGCUCAGCUUCCACACCCCUGGUGGACAGAACCAGGAGAUCCUGCUCCCAGGAGGGAUCACAUCUCACCAGCUCCUUGGCCUCUUUCCCUCCACCUCCUACAAUGCACGGCUCCAGGCCAUGUGGGGCCAGAGCCUCCUGCCGCCCGUGUCCACCUCUUUCACCACGGGUGGGCUGCGGAUCCCCUUCCCCAGGGACUGCGGGGAGGAGAUGCAGAACGGAGCCGGUGCCUCCAGGACCAGCACCAUCUUCCUCAACGGCAACCGCGAGCGGCCCCUGAACGUGUUUUGCGACAUGGAGACUGAUGGGGGCGGCUGGCUGGUGUUCCAGCGCCGCAUGGAUGGACAGACAGACUUCUGGAGGGACUGGGAGGACUAUGCCCAUGGUUUUGGGAACAUCUCUGGAGAGUUCUGGCUGGGCAAUGAGGCCCUGCACAGCCUGACACAGGCAGGUGACUACUCCAUGCGCGUGGACCUGCGGGCUGGGGACGAGGCUGUGUUCGCCCAGUACGACUCCUUCCACGUAGACUCGGCUGCGGAGUACUACCGCCUCCACUUGGAGGGCUACCACGGCACCGCAGGGGACUCCAUGAGCUACCACAGCGGCAGUGUCUUCUCUGCCCGUGAUCGGGACCCCAACAGCUUGCUCAUCUCCUGCGCUGUCUCCUACCGAGGGGCCUGGUGGUACAGGAACUGCCACUACGCCAACCUCAACGGGCUCUACGGGAGCACAGUGGACCAUCAGGGAGUGAGCUGGUACCACUGGAAGGGCUUCGAGUUCUCGGUGCCCUUCACGGAAAUGAAGCUGAGACCAAGAAACUUUCGCUCCCCAGCGGGGGGAGGCUGAGCUGCUGCCCACCUCUCUCGCACCCCAGUAUGACUGCCGAGCACUGAGGGGUCGCCCCGAGAGAAGAGCCAGGGUCCUUCACCACCCAGCCGCUGGAGGAAGCCUUCUCUGCCAGCGAUCUCGCAGCACUGUGUUUACAGGGGGGAGGGGAGGGGUUCGUACGGGAGCAAUAAAGGAGAAACUGAGGUACCCGGCU-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 7148)
TNXB
tenascin XB
NC_000006.12
6  32041349.. 32045219
32041349.. 32045219
strand -
CCDS4736.1
MGI:1932137
ClinVar, dbVar
ENSG00000168477
TNXBS, XBS, XB, HXBL, TN-X, TNX
uc063nnw.1
INSDC: X71923
11976
600985
OTTHUMG00000031088
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (2022 bp)
5'-ATGCGCCTCTCGTGGAGCGTGGCCCAGGGCCCCTTTGATTCCTTCGTGGTCCAGTATGAGGACACGAACGGGCAGCCCCAGGCCTTGCTCGTGGACGGCGACCAGAGCAAGATCCTCATCTCAGGCCTGGAGCCCAGCACCCCCTACAGGTTCCTCCTCTATGGCCTCCATGAAGGGAAGCGCCTGGGGCCCCTCTCAGCTGAGGGCACCACAGGGCTGGCTCCTGCTGGTCAGACCTCAGAGGAGTCAAGGCCCCGCCTGTCCCAGCTGTCTGTGACTGACGTGACCACCAGTTCACTGAGGCTCAACTGGGAGGCCCCACCGGGGGCCTTCGACTCCTTCCTGCTCCGCTTTGGGGTTCCATCACCAAGCACTCTGGAGCCGCATCCGCGTCCACTGCTGCAGCGCGAGCTGATGGTGCCGGGGACGCGGCACTCGGCCGTGCTCCGGGACCTGCGTTCCGGGACTCTGTACAGCCTGACACTGTATGGGCTGCGAGGACCCCACAAGGCCGACAGCATCCAGGGAACCGCCCGCACCCTCAGCCCAGTTCTGGAGAGCCCCCGTGACCTCCAATTCAGTGAAATCAGGGAGACCTCAGCCAAGGTCAACTGGATGCCCCCACCATCCCGGGCGGACAGCTTCAAAGTCTCCTACCAGCTGGCGGACGGAGGGGAGCCTCAGAGTGTGCAGGTGGATGGCCAGGCCCGGACCCAGAAACTCCAGGGGCTGATCCCAGGCGCTCGCTATGAGGTGACCGTGGTCTCGGTCCGAGGCTTTGAGGAGAGTGAGCCTCTCACAGGCTTCCTCACCACGGTTCCTGACGGTCCCACACAGTTGCGTGCACTGAACTTGACCGAGGGATTCGCCGTGCTGCACTGGAAGCCCCCCCAGAATCCTGTGGACACCTATGACGTCCAGGTCACAGCCCCTGGGGCCCCGCCTCTGCAGGCGGAGACCCCAGGCAGCGCGGTGGACTACCCCCTGCATGACCTTGTCCTCCACACCAACTACACCGCCACAGTGCGTGGCCTGCGGGGCCCCAACCTCACTTCCCCAGCCAGCATCACCTTCACCACAGGGCTAGAGGCCCCTCGGGACTTGGAGGCCAAGGAAGTGACCCCCCGCACCGCCCTGCTCACTTGGACTGAGCCCCCAGTCCGGCCCGCAGGCTACCTGCTCAGCTTCCACACCCCTGGTGGACAGAACCAGGAGATCCTGCTCCCAGGAGGGATCACATCTCACCAGCTCCTTGGCCTCTTTCCCTCCACCTCCTACAATGCACGGCTCCAGGCCATGTGGGGCCAGAGCCTCCTGCCGCCCGTGTCCACCTCTTTCACCACGGGTGGGCTGCGGATCCCCTTCCCCAGGGACTGCGGGGAGGAGATGCAGAACGGAGCCGGTGCCTCCAGGACCAGCACCATCTTCCTCAACGGCAACCGCGAGCGGCCCCTGAACGTGTTTTGCGACATGGAGACTGATGGGGGCGGCTGGCTGGTGTTCCAGCGCCGCATGGATGGACAGACAGACTTCTGGAGGGACTGGGAGGACTATGCCCATGGTTTTGGGAACATCTCTGGAGAGTTCTGGCTGGGCAATGAGGCCCTGCACAGCCTGACACAGGCAGGTGACTACTCCATGCGCGTGGACCTGCGGGCTGGGGACGAGGCTGTGTTCGCCCAGTACGACTCCTTCCACGTAGACTCGGCTGCGGAGTACTACCGCCTCCACTTGGAGGGCTACCACGGCACCGCAGGGGACTCCATGAGCTACCACAGCGGCAGTGTCTTCTCTGCCCGTGATCGGGACCCCAACAGCTTGCTCATCTCCTGCGCTGTCTCCTACCGAGGGGCCTGGTGGTACAGGAACTGCCACTACGCCAACCTCAACGGGCTCTACGGGAGCACAGTGGACCATCAGGGAGTGAGCTGGTACCACTGGAAGGGCTTCGAGTTCTCGGTGCCCTTCACGGAAATGAAGCTGAGACCAAGAAACTTTCGCTCCCCAGCGGGGGGAGGCTGA-3'
NCBI CDS gene sequence with introns (location: 32041349.. 32045219) (3871 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 32041153.. 32046128) (4976 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [32041153.. 32046128 + 1000]) (5976 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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