NCBI Summary
This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Protein
Protein (NP_001335293)
SIGLEC-16
Sialic acid-binding Ig-like lectin 16 (Siglec-16) (Siglec-P16)
SIGLEC16
sialic acid binding Ig like lectin 16
Undefined
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-8)Neu5Ac(a2-3)Gal
NP_001335293
400709
A6NMB1
Undefined
A6NMB1
0.495
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (481 amino acids) Download
MLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGWTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFVNNLFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVASLELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLRNGTSLRVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPRVQMEHEGEFTCHARHPLGSQRVSLSFSVHCKSGPMTGVVLVAVGEVAMKILLLCLCLILLRVRSCRRKAARAALGMEAADAVTD
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-A6NMB1-F1DownloadSee the associated sequence to the AlphaFold v2 model, which is different to this entry(NCBI sequence).
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.26, 1.53] ÅDownload
The location of the lectin domain structural model is: 19-147
We infer [1.26, 1.53] Å as the interval of error of this structural model.
Template 1: 2N7B chain: A, Q9NYZ4, NP_055257.2, sequence identity: 48.8%, coverage: 93.8%, location in sequence: 26-152, (10-136 in PDB).
Template 2: 2ZG1 chain: A, O15389, NP_003821.1, sequence identity: 47.3%, coverage: 94.6%, location in sequence: 20-141, (25-146 in PDB).
Template 3: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 41.9%, coverage: 96.1%, location in sequence: 18-141, (18-141 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for SIGLEC16 Gene
ProteomicsDB
References
NCBI References (7 PubMed Identifiers)
  • Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. [28100677]
  • Evolution of siglec-11 and siglec-16 genes in hominins. [22383531]
  • SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. [18629938]
  • A human-specific gene in microglia. [16151003]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. [11986327]
  • A second uniquely human mutation affecting sialic acid biology. [11546777]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_001348364.2)
NM_001348364.2
sialic acid binding Ig like lectin 16, transcript variant 1
All isoforms of SIGLEC16 containing a lectin domain
39..1484 (or 49969702.. 49973115)
49969664.. 49975814
NCBI Matured mRNA sequence 3805 NTPDownload 
m7G-5')ppp(5'-AGAUGGUCCCGGGACAGGCCCAGCCCCAGAGCCCAGAGAUGCUGCUGCUGCCCCUGCUGCUGCCCGUGCUGGGGGCGGGGUCCCUGAACAAGGAUCCCAGUUACAGUCUUCAAGUGCAGAGGCAGGUGCCGGUGCCGGAGGGCCUGUGUGUCAUCGUGUCUUGCAACCUCUCCUACCCCCGGGAUGGCUGGGACGAGUCUACUGCUGCUUAUGGCUACUGGUUCAAAGGAUGGACCAGCCCAAAGACGGGUGCUCCUGUGGCCACUAACAACCAGAGUCGAGAGGUGGAAAUGAGCACCCGGGACCGAUUCCAGCUCACUGGGGAUCCCGGCAAAGGGAGCUGCUCCUUGGUGAUCAGAGACGCGCAGAGGGAGGAUGAGGCAUGGUACUUCUUUCGGGUGGAGAGAGGAAGCCGUGUGAGACAUAGUUUCGUGAACAAUUUGUUAAAAGUAACAGCCCUGACUCAGAAGCCUGAUGUCUACAUCCCCGAGACCCUGGAGCCCGGGCAGCCGGUGACGGUCAUCUGUGUGUUUAACUGGGCUUUCAAGAAAUGUCCAGCCCCUUCUUUCUCCUGGACGGGGGCUGCCCUCUCCCCUAGAAGAACCAGACCAAGCACCUCCCACUUCUCAGUGCUCAGCUUCACGCCCAGCCCCCAGGACCACGACACCGACCUCACCUGCCAUGUGGACUUCUCCAGAAAGGGUGUGAGCGCACAGAGGACCGUCCGACUCCGUGUGGCCUCCCUGGAACUCCAGGGAAACGUCAUAUAUCUGGAAGUUCAGAAAGGCCAGUUCCUGCGGCUCCUCUGUGCUGCUGACAGCCAGCCCCCUGCCACGCUGAGCUGGGUCCUGCAGGACAGAGUCCUCUCCUCGUCCCACCCCUGGGGCCCCAGAACCCUGGGGCUGGAGCUGCGUGGGGUAAGGGCCGGGGAUUCAGGGCGCUACACCUGCCGAGCGGAGAACAGGCUUGGCUCCCAGCAGCGAGCCCUGGACCUCUCUGUGCAGUAUCCUCCAGAGAACCUGAGAGUGAUGGUUUCCCAAGCAAACAGGACAGUCCUGGAAAACCUGAGGAACGGCACAUCCCUCCGGGUCCUGGAGGGCCAAAGCCUGCGUCUGGUCUGUGUCACACACAGCAGCCCCCCAGCCAGGCUGAGCUGGACCCGGUGGGGACAGACCGUGGGCCCCUCCCAGCCCUCAGACCCUGGGGUCCUGGAGCUGCCUCGGGUUCAAAUGGAGCACGAAGGAGAGUUCACCUGCCACGCUCGGCACCCGCUGGGCUCCCAGCGCGUCUCUCUCAGCUUCUCCGUGCACUGCAAAUCAGGGCCCAUGACGGGGGUGGUUCUGGUGGCUGUUGGGGAGGUGGCUAUGAAGAUCCUGCUUCUCUGCCUCUGCCUCAUCCUCCUCAGAGUGAGGUCUUGCAGGAGGAAGGCAGCAAGGGCAGCAUUGGGCAUGGAGGCUGCAGACGCUGUCACGGACUAAUCUCCAGACUCCAGACUGCUUCCAGAUGCCUCCUCAUCCAGUUCCUCCACAGUCUGAGCGGCCGUGUUUCCUCUGCAGGCUUUGCAUGGUCUGUCCCCUGCUGGACUCUCCUGAUCCCUCCUUUCCCUGUCACCCAACAUCUCCCCAAACCCUCCGGGCCAAGGACUCUGCGGCUCUUGACACUUUGCACGUGUAGUUUCUUCUCCUGAAACACCCUUCCCUCCUGCCAAACCACGUCUGGACCCUCCUUCAGGUUCACUUUUUUUUUUUUUUUUUGAGACACAGUCUCACUUUGUCACCCAGGCUGGAGUGCAGUGGCGCGAUCUCGGCUCACUGCAACCUCUGUCUCCCAGGUUCAAGCGAUUCUCAUGUCUCAGCCUCCUGAGUAGCUGGGAUUAUAGGCGCCCGCCACCACGCCUGGCUCAUUUUUGUAUUUUUGGUAGAGACAGGGUUUCACCAUGUCGGCCAGGCUGGUCUUGAACUCCCGACUUCAGGUGAUCCGCCAGCCUCGGCCUCCCAAAGUGGUGGGGUUACAUGUGUGAGCCACCGUGCCCAGCCAGCUGUGUCUUCUUUUUGCAGGAUUUACUUACAAAAUUCCUUGCAGCUGCAGUCUGCGUUCCACCCACAUCCUAAUAUGGUGUUUGCGGUGGUCACAUCCAACUUCCUUCCUCCUCCAUCCAUGGAACGUGCAUUAGGGAGGAACCACACGCACCACGUGCAAGAUGAGCCAGUUCCCUGAACGGCCGGCCACGGCGUUAACCGCGCUGCUCUGGGCUCUGCACGUCUCAUCUGCUGAGGCGCAUUACUGCAUCUUUCAUGCAGAACUUGCUUUCCAUGCCUCACAUCUCCACAUGUGUGGGGAUAUGUCCUGAGAAAUGCACGGUUAGGUGAUUCUGUCGUGUGAGCAUCCUUGAAUGUGCUUACACAGUCAUAAAUGGUACAGCCUACCACACGCCGAGGCUAUACGGUAUAGCCCAUUGCUCCUAGACUAUACACCUGCACGGCAUGUUCCUGUAGUGAAAGCUGUAGGCAAUUAUAACGCAAUGGAUAGGUUAAAGACAGAGUUUUAGUAAAAAUAUGGCAUAAUAGGCCAGGCGUGGUGGCUCAUGCCUGUAAUCCCAGCACUUUGGGAGGCCAAGGCAGGCAGAUCACAAGGUCAGGAGUUUGAGACCAGCCUGGCCAAUAUGGUGAAACCCAGUCUCUACUAAAAAUACAAAAAUUAGCCGGGUGUGGUGGCGGGCGCCUGUAGUCCCAGCUACUCGGGAGGCUGAGGCAGAAGAAUCAUUUGAACCAGGAGGUGGAGGUUGCAGUGAGCCGAGAUCGCAUCACUGCACUCCAGCCUGGGCGACAGAGCAAGACUGUCUCAAAAACUAAAACAAAAAAACACCACCACCACCACCAAUGUCUGAUUAAAUCUAAGCCACGGUUCCAUUUUGGGGCAAGGGGCAGGGUGUGGGUGUGGUGGACAGAGAACGGGCUCCAGCCACCAUCAGCUGCACGUCCUGGUAGCACCUGAGCCAUUCCCAGUCUCCUGUGCUGGGAGAUCAUCAUCUAAUCCUGAUGAUGACGCCCUCCUCUCAGAGCUCGGGGGAUGAGCUGCCAAAACCCAUGGAGGUUCAAAACCCGGGCUCUGGAGACAGAAGACACUGGGCUCAGAGACAUGGGGCCACUGUCCAGGCUUUCCCUGGGCCUGGACCUGGGCUCCUUCCACUGUCUGAGCAGGGUCAGCCUGGGCUGGCUGUGCUGGUUCAAGAGAUGAGGGAGGAGGACACAGCGGUUGCCAGGACCCUGAGGCACUGGACUGGGCACUGCCCCAAGGGGCAGAGGAUGGAACCCGGUGUUGAUAUUGUGAUGCUGACCCGUCUGCUCACCUGAUUUGGGUGCUGAAGGGCAGCUGACCCCCCUAAUCUUUUAUAGACUUGUGAAACGAAAAUAAAUAAAAGUCAAGCUGGGAACAGCUUAGGGCAAACCUGCCUCCCAUUCUAUUCAAAGCCACCCCUCUGCUCACUGAGAUAGAUGCAUGUCUGAUCACCUCAGUUGGGAAAGGCUAAUCAGAAACUCCAAAGAAUGCAUCUGUUCAUCUCUCACCCAUCUGUGACCUGGAAGCCCCCUCCCCACUUCGAGUCUUCCUGCCUUUGCUUCAAGUUUUCCCGCCUUUCCAAAUGGAACCAAAGUACUUCUUACAUAUAGUGACUCAUGUCUCAAGUCUCCCUAAAACGUAUAAAACUAAGCUGUGCCCCAACCACGCUGACCAUGUCAUCAGGACCUCCUGAGGCUGUGUCACGGCCUGUGUCCUCAACCUUGGCAAAAUAAACUUUCUAAAUUAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 400709)
SIGLEC16
sialic acid binding Ig like lectin 16
NC_000019.10
19  49969702.. 49973115
49969702.. 49973115
strand +
MGI:2443630
ClinVar, dbVar
ENSG00000161643
Siglec-P16
INSDC: BC030222
24851
OTTHUMG00000183074
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1440 bp)
5'-ATGCTGCTGCTGCCCCTGCTGCTGCCCGTGCTGGGGGCGGGGTCCCTGAACAAGGATCCCAGTTACAGTCTTCAAGTGCAGAGGCAGGTGCCGGTGCCGGAGGGCCTGTGTGTCATCGTGTCTTGCAACCTCTCCTACCCCCGGGATGGCTGGGACGAGTCTACTGCTGCTTATGGCTACTGGTTCAAAGGATGGACCAGCCCAAAGACGGGTGCTCCTGTGGCCACTAACAACCAGAGTCGAGAGGTGGAAATGAGCACCCGGGACCGATTCCAGCTCACTGGGGATCCCGGCAAAGGGAGCTGCTCCTTGGTGATCAGAGACGCGCAGAGGGAGGATGAGGCATGGTACTTCTTTCGGGTGGAGAGAGGAAGCCGTGTGAGACATAGTTTCGTGAACAATTTGTTAAAAGTAACAGCCCTGACTCAGAAGCCTGATGTCTACATCCCCGAGACCCTGGAGCCCGGGCAGCCGGTGACGGTCATCTGTGTGTTTAACTGGGCTTTCAAGAAATGTCCAGCCCCTTCTTTCTCCTGGACGGGGGCTGCCCTCTCCCCTAGAAGAACCAGACCAAGCACCTCCCACTTCTCAGTGCTCAGCTTCACGCCCAGCCCCCAGGACCACGACACCGACCTCACCTGCCATGTGGACTTCTCCAGAAAGGGTGTGAGCGCACAGAGGACCGTCCGACTCCGTGTGGCCTCCCTGGAACTCCAGGGAAACGTCATATATCTGGAAGTTCAGAAAGGCCAGTTCCTGCGGCTCCTCTGTGCTGCTGACAGCCAGCCCCCTGCCACGCTGAGCTGGGTCCTGCAGGACAGAGTCCTCTCCTCGTCCCACCCCTGGGGCCCCAGAACCCTGGGGCTGGAGCTGCGTGGGGTAAGGGCCGGGGATTCAGGGCGCTACACCTGCCGAGCGGAGAACAGGCTTGGCTCCCAGCAGCGAGCCCTGGACCTCTCTGTGCAGTATCCTCCAGAGAACCTGAGAGTGATGGTTTCCCAAGCAAACAGGACAGTCCTGGAAAACCTGAGGAACGGCACATCCCTCCGGGTCCTGGAGGGCCAAAGCCTGCGTCTGGTCTGTGTCACACACAGCAGCCCCCCAGCCAGGCTGAGCTGGACCCGGTGGGGACAGACCGTGGGCCCCTCCCAGCCCTCAGACCCTGGGGTCCTGGAGCTGCCTCGGGTTCAAATGGAGCACGAAGGAGAGTTCACCTGCCACGCTCGGCACCCGCTGGGCTCCCAGCGCGTCTCTCTCAGCTTCTCCGTGCACTGCAAATCAGGGCCCATGACGGGGGTGGTTCTGGTGGCTGTTGGGGAGGTGGCTATGAAGATCCTGCTTCTCTGCCTCTGCCTCATCCTCCTCAGAGTGAGGTCTTGCAGGAGGAAGGCAGCAAGGGCAGCATTGGGCATGGAGGCTGCAGACGCTGTCACGGACTAA-3'
NCBI CDS gene sequence with introns (location: 49969702.. 49973115) (3414 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 49969664.. 49975814) (6151 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [49969664 - 1000].. 49975814) (7151 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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