NCBI Summary
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_057069)
Angiopoietin-4
Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3)
ANGPT4
angiopoietin 4
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_057069
51378
Q9Y264
ENSP00000371347.3
Q9Y264
0.541
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (503 amino acids) Download
MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPEVSRDSNTLQRESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQQQMAQNQTAPMLELGTSLLNQTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQLLLQRQKLQQLQGQNSALEKRLQALETKQQEELASILSKKAKLLNTLSRQSAALTNIERGLRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAFIMAGEQVFQDCAEIQRSGASASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYKQGFGDPAGEHWLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQSSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIRWHYFKGPSYSLRASRMMIRPLDI
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9Y264-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.37, 1.69] ÅDownload
The location of the lectin domain structural model is: 282-502
We infer [1.37, 1.69] Å as the interval of error of this structural model.
Template 1: 6ZQX chain: A, Q8N539, NP_116232.3, sequence identity: 41.6%, coverage: 96.8%, location in sequence: 239-457, (239-457 in PDB).
Template 2: 2JHK chain: F, O00602, NP_001994.2, sequence identity: 38.5%, coverage: 98.2%, location in sequence: 110-326, (81-297 in PDB).
Template 3: 2J3U chain: B, Q15485, NP_004099.2, sequence identity: 37.6%, coverage: 97.3%, location in sequence: 96-313, (71-288 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for ANGPT4 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Dual functional nanoparticles containing SOX duo and ANGPT4 shRNA for osteoarthritis treatment. [30957437]
  • Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. [25977256]
  • Acute-phase protein alpha1-antitrypsin--a novel regulator of angiopoietin-like protein 4 transcription and secretion. [24760148]
  • Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes. [22267746]
  • Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2. [21603628]
  • The DNA sequence and comparative analysis of human chromosome 20. [11780052]
  • Angiopoietin-3, a novel member of the angiopoietin family. [10218486]
  • Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. [10051567]
  • Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. [10025962]
  • Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping. [10343124]
UniProt Main References (4 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Biological characterization of angiopoietin-3 and angiopoietin-4. [15284220]
  • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. [19234476]
All isoforms of this gene containing a lectin domain
XP_011527541.1, NP_057069.1, NP_001309738.1
RNA
RNA (Transcript ID: NM_015985.4)
NM_015985.4
angiopoietin 4, transcript variant 1
All isoforms of ANGPT4 containing a lectin domain
ENST00000381922.5
121..1632 (or 872960.. 916214)
869900.. 916334
NCBI Matured mRNA sequence 4692 NTPDownload 
m7G-5')ppp(5'-AGACAGAGGUUUGUAGCUGCAGCUGCAGGCAAGCCUGGCCACUGUUGGCUGCAGCAGGACAUCCCAGGCACAGCCCCUAGGGCUCUGAGCAGACAUCCCUCGCCAUUGACACAUCUUCAGAUGCUCUCCCAGCUAGCCAUGCUGCAGGGCAGCCUCCUCCUUGUGGUUGCCACCAUGUCUGUGGCUCAACAGACAAGGCAGGAGGCGGAUAGGGGCUGCGAGACACUUGUAGUCCAGCACGGCCACUGUAGCUACACCUUCUUGCUGCCCAAGUCUGAGCCCUGCCCUCCGGGGCCUGAGGUCUCCAGGGACUCCAACACCCUCCAGAGAGAAUCACUGGCCAACCCACUGCACCUGGGGAAGUUGCCCACCCAGCAGGUGAAACAGCUGGAGCAGGCACUGCAGAACAACACGCAGUGGCUGAAGAAGCUAGAGAGGGCCAUCAAGACGAUCUUGAGGUCGAAGCUGGAGCAGGUCCAGCAGCAAAUGGCCCAGAAUCAGACGGCCCCCAUGCUAGAGCUGGGCACCAGCCUCCUGAACCAGACCACUGCCCAGAUCCGCAAGCUGACCGACAUGGAGGCUCAGCUCCUGAACCAGACAUCAAGAAUGGAUGCCCAGAUGCCAGAGACCUUUCUGUCCACCAACAAGCUGGAGAACCAGCUGCUGCUACAGAGGCAGAAGCUCCAGCAGCUUCAGGGCCAAAACAGCGCGCUCGAGAAGCGGUUGCAGGCCCUGGAGACCAAGCAGCAGGAGGAGCUGGCCAGCAUCCUCAGCAAGAAGGCGAAGCUGCUGAACACGCUGAGCCGCCAGAGCGCCGCCCUCACCAACAUCGAGCGCGGCCUGCGCGGUGUCAGGCACAACUCCAGCCUCCUGCAGGACCAGCAGCACAGCCUGCGCCAGCUGCUGGUGUUGUUGCGGCACCUGGUGCAAGAAAGGGCUAACGCCUCGGCCCCGGCCUUCAUAAUGGCAGGUGAGCAGGUGUUCCAGGACUGUGCAGAGAUCCAGCGCUCUGGGGCCAGUGCCAGUGGUGUCUACACCAUCCAGGUGUCCAAUGCAACGAAGCCCAGGAAGGUGUUCUGUGACCUGCAGAGCAGUGGAGGCAGGUGGACCCUCAUCCAGCGCCGUGAGAAUGGCACCGUGAAUUUUCAGCGGAACUGGAAGGAUUACAAACAGGGCUUCGGAGACCCAGCUGGGGAGCACUGGCUGGGCAAUGAAGUGGUGCACCAGCUCACCAGAAGGGCAGCCUACUCUCUGCGUGUGGAGCUGCAAGACUGGGAAGGCCACGAGGCCUAUGCCCAGUACGAACAUUUCCACCUGGGCAGUGAGAACCAGCUAUACAGGCUUUCUGUGGUCGGGUACAGCGGCUCAGCAGGGCGCCAGAGCAGCCUGGUCCUGCAGAACACCAGCUUUAGCACCCUUGACUCAGACAACGACCACUGUCUCUGCAAGUGUGCCCAAGUGAUGUCUGGAGGGUGGUGGUUUGACGCCUGUGGCCUGUCAAACCUCAACGGCGUCUACUACCACGCUCCCGACAACAAGUACAAGAUGGACGGCAUCCGCUGGCACUACUUCAAGGGCCCCAGCUACUCACUGCGUGCCUCUCGCAUGAUGAUACGGCCUUUGGACAUCUAACGAGCAGCUGUGCCAGAGGCUGGACCACACAGGAGAAGCUCGGACUUGGCACUCCUGGACAACCUGGACCCAGAUGCAAGACACUGUGCCACCGCCUUCCCUGACACCCUGGGCUUCCUGAGCCAGCCCUCCUUGACCCAGAAGUCCAGAAGGGUCAUCUGCCCCCCAACUCCCCUCCGUCUGUGACAUGGAGGGUGUUCGGGGCCCAUCCCUCUGAUGUAGUCCUCGCCCCUCUUCUCUCCCUCCCCCUUCAGGGGCUCCCUGCCUGAGGGUCACAGUACCUUGAAUGGGCUGAGAACAGACCAAACUUGAUUCCCAUGACCAAUGGUGGGGUUGCAGGCAGGUGGGAAUGUAUUUGCACAUCGGAAGCUGCCCAGAUGGCCCAGGUUCUCUCCCUUGGAUUGGCAAGAAGGCCAUCUCCCAUUCUAAGCUCCUGUUCCAAGAUUUUCUAGUCUUGAGAUGUCCUUGAACUUUCUUUUCAAGUCUGAAGGGGCUGCAUCCACCCCUUAGUGGGUGGGUUAAUCAUUAUUUCCCCUUCACACUUCACCACUUCUAGGUUCUAAUGACCCUAGAUCUCAGGGUCUUUAGACUUCACCACUUCUAGGCUUUACCACUUCACCACUUCUAGGCUCCAAUGUUUGGAGCUCAGGGUCUUUAGGAGACCCAAAAGGACAUGCUCCUUCACCUCCAGCAUGUCCUAGAGGAUGUGUCACAGGGAAUAACUAUGGCUUGUCUCUAAAAGUACCUAUGAGCAAUGAGAAAAGGAAACAGCAGGUUAAGUCAAAGUGAACAGGCACUCUUCACUGCAGGACUGAUCAGAGCCUUUAAUAUGGCCAAGUGCCUUGUGACUACCCAUGAAGGGGCUAGAGUGGGCAGCUUUCUCCAAAUUUACUUAUUUGAAAAUGGGCUCGGUUUGUCCCAGAGCAUCUCACAGGACUGUAGAUGCUCUUGGACAAAGCUAGUGCUCCCCUGGCAUAAGGAGGAGCCCUACGACCCCAUCCCCACCCCAGCUAUACUCACCCUUUUUGGCUACAAGGGCCACAGUGACAGCCUCAAACAACCUCUAAAAACAACUGGAAAUAACCUUUCAGUUAAAACAGAUACCAUCCCUGAAGAAGGGUCUAGAACUAGGUCCCUGUCUGUGUUAUAGGCUCAUGUCCUCCAAGGCUCCUUCAAGUCCCAGGAAGCUGAUCUCUACCUGGGUGGCUUCCCUUAGGACUCCCUGUAACCUCAACUCCCCCAGGCUCAAUUACAGGGACUGUUAGGCAGGACAUCUGUCUCCAAGUCCAGAUCCUCUCUGCCUCCAAGCCCUAACCCCUAGCCUCCCUCCCUUCCCCAUCCAGCAGUGAUGCUGCCUCUGUGGUGGUAGGUGGGGAGCUGCAGGGGAGGAGAUAAGGCCUCUGCCUGAGUUUGGGAGACCAGGGCCCUCAUAGCUUCUUUCAGAGGAUGGAGUCAGAAAGGAUCCACAGCUACUCUGUCACCUGCCCCCAUCACUGUGUCAUGCUGUCUGCCCUGUUGUCAUCAGCCAACACCCAGGCAUAGCCAGGAGCCCACCUGCCCUACCGCCAGGAUACACCUCUGUCCUCAGAAGGUUUUCUCCUGGAUGAGACUGAGCCAAUGGGAAUGGGACCCCUUCAUCCCCCUGGCUCGCCCCAGCCCUGAGUCCCACUCUCAGCCGAUCCCUGAGUAAACCCAGCACAGACUGACUUUGAUCUCAUUCCUGGGAAUUAGCACUCUUCCCCUUCAAGACUCAAAGGACAUGGUUGCUAAUGGUGGCAUUUCAGGCAUGAUGGGAAAUCUUUAGGGGCAGAUUGCUGCCCAGAGAGCUCAAAUCGCCUUAAGCAGCAUUUGCCCAGCAGACCUUUAUUUAGCCUCUACUGUGUGCAGUGUGGUGUGGUGGGCAGGGCUUUGGAGUCGGACAAACCUGCUCCAGCUCUGACACUUUGGUCCAGUGGCUCAGCCUCUCAAGGCACCAGUUAUCUUCACAUCAUCAAAGCCUCAGUUUUCCCAUCUGUAAAAUGGAGAUGAUAAUAUUCCUUCCUGGCUGGGCUAUGGCAAGGAGGAAAUGAGACCAUGUAUGUCAUCUUCUUAAUAGAGCCUGGCAUGAAGCAGGUGCCUAAUAAAUGUUUGUCCUCAAAGAGGAGAAUGGGGUGAGGAAGGCAUUCCCCAGCACAUGCCGCCCCUUCUCCUGCACUCAGGUGAGGAAAAGGCAUUUUAUUUUUGUAUCCACAUCAUUUAUUUUUCUAUUGUAGUUUCUAGGCUGACUGCAAGCUAGAGAGGAGACAGGGCAAAGCUGUGAGGCCCAGGGACAGAACUCCUCUGGGUGGGUUGAAGGCCCAAGUCCCUCUCUACUCCCAUUUUAUAAGGGGGCAGGAAGCUGAUUUGAGUUAUCCUCAGACACCUGUUCUUUAUGUAAUUUUAUUUUAUUUUUUUGAGACAGAGUCUCACUCUGUCACCCAGGCUGGAGUGCAGUGGCAUGAUCUCAGAUCACUGCAAUCUCUGCCUCCUGGUUCAAGUGAUUCUCCUACCUCAGCCUCCUGAGUAAUGGGAUUACAGACGCCUACCACCACGCCCGGAAAACUUUUGUAUUUUUAGUAGAAACGGGUUUUCACCAUGUUGGCCAGGCUGGUCUCAAACUCCUGGCCUCAUGUGAUCCACCUGCCUCAGCCUCCCAAAGUGCUGGGAUUACAGGCAUGAGCCACCAUACCCAGCCUCAGACACCUGUUCUUAAAUAUUCAUCCUUCUUUCUUACCUUCCUUCCUCUUCCAUGCCAGGACUCAGGUAUAAGGGAUAGAAAUUCUAGCCCUAAGGAAUAAAUUGACUCACAUAACUGGAAAGUCUAAGGGUAAAGGCAAGUGAGGUUAGAUCCAGAGGCUCAAAUGAUGUCAGCUCCACCUCUCAGCCCCUCCAUCUGCCCCGUUGACUUCAUUCUCAGCCAGGAUCUUUCCUCACAAGAAGGCUCUGGCAGCCCCAGGCUCAUGUCCUCCCAGCUCAGCAUCCCUGACCCGGGGAGCUCCCUCGUCUCCAUGAUUCCAGUAAAGGAAUGAUUUUCUGCAGCCA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 51378)
ANGPT4
angiopoietin 4
NC_000020.11
20  872960.. 916214
872960.. 916214
strand -
CCDS13009.1
MGI:1336887
ClinVar, dbVar
ENSG00000101280
uc002wei.4
INSDC: AF074332
487
603705
OTTHUMG00000031652
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1512 bp)
5'-ATGCTCTCCCAGCTAGCCATGCTGCAGGGCAGCCTCCTCCTTGTGGTTGCCACCATGTCTGTGGCTCAACAGACAAGGCAGGAGGCGGATAGGGGCTGCGAGACACTTGTAGTCCAGCACGGCCACTGTAGCTACACCTTCTTGCTGCCCAAGTCTGAGCCCTGCCCTCCGGGGCCTGAGGTCTCCAGGGACTCCAACACCCTCCAGAGAGAATCACTGGCCAACCCACTGCACCTGGGGAAGTTGCCCACCCAGCAGGTGAAACAGCTGGAGCAGGCACTGCAGAACAACACGCAGTGGCTGAAGAAGCTAGAGAGGGCCATCAAGACGATCTTGAGGTCGAAGCTGGAGCAGGTCCAGCAGCAAATGGCCCAGAATCAGACGGCCCCCATGCTAGAGCTGGGCACCAGCCTCCTGAACCAGACCACTGCCCAGATCCGCAAGCTGACCGACATGGAGGCTCAGCTCCTGAACCAGACATCAAGAATGGATGCCCAGATGCCAGAGACCTTTCTGTCCACCAACAAGCTGGAGAACCAGCTGCTGCTACAGAGGCAGAAGCTCCAGCAGCTTCAGGGCCAAAACAGCGCGCTCGAGAAGCGGTTGCAGGCCCTGGAGACCAAGCAGCAGGAGGAGCTGGCCAGCATCCTCAGCAAGAAGGCGAAGCTGCTGAACACGCTGAGCCGCCAGAGCGCCGCCCTCACCAACATCGAGCGCGGCCTGCGCGGTGTCAGGCACAACTCCAGCCTCCTGCAGGACCAGCAGCACAGCCTGCGCCAGCTGCTGGTGTTGTTGCGGCACCTGGTGCAAGAAAGGGCTAACGCCTCGGCCCCGGCCTTCATAATGGCAGGTGAGCAGGTGTTCCAGGACTGTGCAGAGATCCAGCGCTCTGGGGCCAGTGCCAGTGGTGTCTACACCATCCAGGTGTCCAATGCAACGAAGCCCAGGAAGGTGTTCTGTGACCTGCAGAGCAGTGGAGGCAGGTGGACCCTCATCCAGCGCCGTGAGAATGGCACCGTGAATTTTCAGCGGAACTGGAAGGATTACAAACAGGGCTTCGGAGACCCAGCTGGGGAGCACTGGCTGGGCAATGAAGTGGTGCACCAGCTCACCAGAAGGGCAGCCTACTCTCTGCGTGTGGAGCTGCAAGACTGGGAAGGCCACGAGGCCTATGCCCAGTACGAACATTTCCACCTGGGCAGTGAGAACCAGCTATACAGGCTTTCTGTGGTCGGGTACAGCGGCTCAGCAGGGCGCCAGAGCAGCCTGGTCCTGCAGAACACCAGCTTTAGCACCCTTGACTCAGACAACGACCACTGTCTCTGCAAGTGTGCCCAAGTGATGTCTGGAGGGTGGTGGTTTGACGCCTGTGGCCTGTCAAACCTCAACGGCGTCTACTACCACGCTCCCGACAACAAGTACAAGATGGACGGCATCCGCTGGCACTACTTCAAGGGCCCCAGCTACTCACTGCGTGCCTCTCGCATGATGATACGGCCTTTGGACATCTAA-3'
NCBI CDS gene sequence with introns (location: 872960.. 916214) (43255 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 869900.. 916334) (46435 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [869900.. 916334 + 1000]) (47435 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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