NCBI Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016].
Protein
Protein (NP_001316028)
Killer cell lectin-like receptor G member 1
Killer cell lectin-like receptor subfamily G member 1 (C-type lectin domain family 15 member A) (ITIM-containing receptor MAFA-L) (MAFA-like receptor) (Mast cell function-associated antigen)
KLRG1
killer cell lectin like receptor G1
Undefined
Low evidence
C-type lectin
CLEC15A
C-type - Natural Killer NK
a/b mixed / C-type lectin-like
Man
NP_001316028
10219
Q96E93
Undefined
Q96E93
0.318
10.1002/eji.1830271014
PFAM, InterPro
Protein sequence and protein families (fasta) (195 amino acids) Download
MTDSVIYSMLELPTATQAQNDYGPQQKSSSSRPSCSCLVAIALGLLTAVLLSVLLYQWILCQGSNYSTCASCPSCPDRWMKYGNHCYYFSVEEKDWNSSLEFCLARDSHLLVITDNQEMSLLQVFLSEAFCWIGLRNNSGWRWEDGSPLNFSRISSNSFVQTCGAINKNGLQASSCEVPLHWVCKKCPFADQALF
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q96E93-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D. Source: UniProt
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Functions and clinical significance of KLRG1 in the development of lung adenocarcinoma and immunotherapy. [34187403]
  • An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics. [32954948]
  • Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. [32814053]
  • KLRG1 and CD103 Expressions Define Distinct Intestinal Tissue-Resident Memory CD8 T Cell Subsets Modulated in Crohn's Disease. [32477365]
  • A reference map of the human binary protein interactome. [32296183]
  • Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1). [12393723]
  • 2F1 antigen, the mouse homolog of the rat 'mast cell function-associated antigen', is a lectin-like type II transmembrane receptor expressed by natural killer cells. [9862378]
  • MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells. [9842918]
  • Human MAFA has alternatively spliced variants. [9765598]
  • Possible interactions between the Fc epsilon receptor and a novel mast cell function-associated antigen. [1831652]
UniProt Main References (5 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. [15879103]
  • Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans. [17617594]
  • Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition. [19604491]
All isoforms of this gene containing a lectin domain
XP_016874171.1, XP_016874172.1, XP_016874173.1, XP_016874174.1, NP_005801.3, NP_001316028.1, NP_001316030.1, NP_001316031.1, NP_001316032.1
RNA
RNA (Transcript ID: NM_001329099.2)
NM_001329099.2
killer cell lectin like receptor G1, transcript variant 1
All isoforms of KLRG1 containing a lectin domain
91..678 (or 8989636.. 9010028)
8989546.. 9010751
NCBI Matured mRNA sequence 1401 NTPDownload 
m7G-5')ppp(5'-AGAGAUUGGGCUGUUUCCUCACUGAUACAUAUCCCUUCACACUUCUAUAAUUUAACUCUCUCAACUGCAUGUGAAAGAUCUUAGCUGAAGAUGACUGACAGUGUUAUUUAUUCCAUGUUAGAGUUGCCUACGGCAACCCAAGCCCAGAAUGACUAUGGACCACAGCAAAAAUCUUCCUCUUCCAGGCCUUCUUGUUCUUGCCUUGUGGCAAUAGCUUUGGGGCUUCUGACUGCAGUUCUUCUGAGUGUGCUGCUAUACCAGUGGAUCCUGUGCCAGGGCUCCAACUACUCCACUUGUGCCAGCUGUCCUAGCUGCCCAGACCGCUGGAUGAAAUAUGGUAACCAUUGUUAUUAUUUCUCAGUGGAGGAAAAGGACUGGAAUUCUAGUCUGGAAUUCUGCCUAGCCAGAGACUCACACCUCCUUGUGAUAACGGACAAUCAGGAAAUGAGCCUGCUCCAAGUUUUCCUCAGUGAGGCCUUUUGCUGGAUUGGUCUGAGGAACAAUUCUGGCUGGAGGUGGGAAGAUGGAUCACCUCUAAACUUCUCAAGGAUUUCUUCUAAUAGCUUUGUGCAGACAUGCGGUGCCAUCAACAAAAAUGGUCUUCAAGCCUCAAGCUGUGAAGUUCCUUUACACUGGGUGUGUAAGAAGUGUCCCUUUGCAGAUCAAGCUUUAUUCUGAAGAAUAAACCUAGCUGGCAUGCUGGUGUGUACCUGUAGUCCUAGCUAUUUGGGAAGCUGAGGUGGGAGGGUCGCUUGAGCCCAGGAGUUUGAGGCUGCAGUGAGCUAUGAUUGUGCCACUGUACUCCAGCCUGGGAGAUAGAGCAAGACUCCAUCUCUAAAAAAAAAAAAAAAUGCUAAUGUGAGAAUAUAAAUUGUGGGAAAUGAGUGAGGGCAAGGUGGUACUUCCUCCUUCUGAGCUCUUCACACGUAAUGCAAAAACCCGGUCUUAACUGAUUUUGUUUUUUUUCUGAGUAUGCAUAUAUGUGGUUGAAUGAACCAAUGUGUGAUUGUAUCUUUUCCAUUAUGUGACUGUUUGACCUGCAUAUUAAUUUCAAGAUAGCAGUCAAUUCGAUAAGGCAUUUUCAUAGAGGAAAGUUUACAGAAACAGUUUAUGUGGUUGGAUCACCAAAUUAUCUUAGGUACUAAGGCCUCAAAAAUAAGAAAAACUUUAUUAUUUCUCCUCAGUAGAGUUUGGACAUACAUAAGGAGAGAAGGUACAGUGAUGAAGGAGACCAUAAUUCUGUAGUGUUGAUGAUCCUGGAUUAUAAUCUUUUUCUCUUUAUCUUUCAUAGUUUUUUUAAAAACAUGGACUGUAUCUUAUCUACCACUAUAUCCCAAAUACCUAAGAUAGUGCUUACGUUCAGUGACUAUUAAAUAAAUAAAUGGAUGAAUUAAAAAGUAA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 10219)
KLRG1
killer cell lectin like receptor G1
NC_000012.12
12  8989636.. 9010028
8989636.. 9010028
strand +
CCDS86277.1
MGI:1355294
ClinVar, dbVar
ENSG00000139187
MAFA, 2F1, MAFA-L, CLEC15A
uc001qvg.4
INSDC: AF097358
6380
604874
OTTHUMG00000168277
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (588 bp)
5'-ATGACTGACAGTGTTATTTATTCCATGTTAGAGTTGCCTACGGCAACCCAAGCCCAGAATGACTATGGACCACAGCAAAAATCTTCCTCTTCCAGGCCTTCTTGTTCTTGCCTTGTGGCAATAGCTTTGGGGCTTCTGACTGCAGTTCTTCTGAGTGTGCTGCTATACCAGTGGATCCTGTGCCAGGGCTCCAACTACTCCACTTGTGCCAGCTGTCCTAGCTGCCCAGACCGCTGGATGAAATATGGTAACCATTGTTATTATTTCTCAGTGGAGGAAAAGGACTGGAATTCTAGTCTGGAATTCTGCCTAGCCAGAGACTCACACCTCCTTGTGATAACGGACAATCAGGAAATGAGCCTGCTCCAAGTTTTCCTCAGTGAGGCCTTTTGCTGGATTGGTCTGAGGAACAATTCTGGCTGGAGGTGGGAAGATGGATCACCTCTAAACTTCTCAAGGATTTCTTCTAATAGCTTTGTGCAGACATGCGGTGCCATCAACAAAAATGGTCTTCAAGCCTCAAGCTGTGAAGTTCCTTTACACTGGGTGTGTAAGAAGTGTCCCTTTGCAGATCAAGCTTTATTCTGA-3'
NCBI CDS gene sequence with introns (location: 8989636.. 9010028) (20393 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 8989546.. 9010751) (21206 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [8989546 - 1000].. 9010751) (22206 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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