HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].

Protein name

Malectin

Synonym(s)

Malectin

HGNC gene name

MLEC

HGNC name

malectin

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

Malectin

Known lectin group

Undefined

Lectin fold

b-sandwich / ConA-like

Glycan specificity

Glc(2)Man(9)GlcNAc(2)

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.925

Reference

10.1091/mbc.E11-03-0201

Either no PDB or existing PDB of non-glycosylated form

Structural models

AlphaFold v2: AF-Q14165-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

SWISS-MODEL structural models

SWISS-MODEL structural model

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for MLEC Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. [31831667]

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. [30021884]

Malectin gene polymorphisms promote cerebral palsy via M2-like macrophage polarization. [28972276]

Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion. [25451265]

Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins. [22988243]

Role of malectin in Glc(2)Man(9)GlcNAc(2)-dependent quality control of alpha1-antitrypsin. [21813736]

MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. [20347265]

Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation. [18524852]

Getting in and out from calnexin/calreticulin cycles. [18303019]

The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. [10929008]

UniProt Main References (5 PubMed Identifiers)

Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. [8590280]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Initial characterization of the human central proteome. [21269460]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]

N-terminome analysis of the human mitochondrial proteome. [25944712]

All isoforms of this gene containing a lectin domain

NP_055545.1, NP_001290556.1, XP_011537333.1, XP_011537334.1, NP_001290557.1

RNA

RNA (Transcript ID: NM_014730.4)

RNA RefSeq ID

NM_014730.4

RNA name

malectin, transcript variant 1

Isoforms

All isoforms of MLEC containing a lectin domain

RNA Ensembl ID

ENST00000228506.8

Coding region

149..1027 (or 120687297.. 120696545)

mRNA location

120687149.. 120701859

NCBI Matured mRNA sequence 6341 NTP Download

m⁷G-5')ppp(5'-GUGGCUGAGAAGAAGGAGGCCUGAGAGCGACAUGUCCCCGGCGGCUCAGGCGGAGCGGCCCGUGGCGCUGUUUUUCUGAGUCCGGGGUGGCCUGGCAGCCGGCCGAGGACGAGGGUCGGCGGGGGCUGCCCCCGUGGUGGUGGCCGCCAUGCUGGGAGCCUGGGCGGUUGAGGGAACCGCUGUGGCGCUCCUGCGACUGCUGCUGCUGCUGCUGCCGCCGGCGAUCCGGGGACCCGGGCUCGGCGUGGCCGGCGUGGCCGGCGCGGCGGGGGCCGGGCUGCCCGAGAGCGUCAUUUGGGCGGUCAACGCGGGUGGAGAGGCGCAUGUGGACGUGCACGGGAUCCACUUCCGCAAGGACCCUUUGGAAGGCCGGGUGGGCCGAGCCUCAGACUAUGGCAUGAAACUGCCAAUCCUGCGUUCCAACCCUGAGGACCAGAUCCUGUAUCAAACUGAGCGGUACAAUGAGGAGACCUUUGGCUACGAAGUGCCCAUCAAAGAGGAGGGGGACUACGUGCUGGUCUUGAAAUUUGCAGAGGUCUACUUUGCACAGUCCCAGCAAAAGGUAUUUGAUGUACGAUUGAAUGGCCACGUCGUGGUGAAGGACUUGGAUAUCUUUGAUCGUGUUGGGCAUAGCACAGCUCACGAUGAAAUUAUACCUAUGAGCAUCAGAAAGGGGAAGCUGAGUGUCCAGGGGGAGGUGUCCACCUUCACAGGGAAACUCUACAUUGAGUUUGUCAAGGGGUACUAUGACAAUCCCAAGGUCUGUGCACUCUACAUCAUGGCUGGGACAGUGGAUGAUGUACCAAAGCUUCAGCCUCAUCCGGGAUUGGAGAAGAAAGAAGAGGAAGAAGAAGAAGAAGAAUAUGAUGAAGGGUCUAAUCUCAAAAAACAGACCAAUAAGAACCGGGUGCAGUCAGGCCCCCGCACACCCAACCCCUAUGCCUCGGACAACAGCAGCCUCAUGUUUCCCAUCCUGGUGGCCUUCGGAGUCUUCAUUCCAACCCUCUUCUGCCUCUGCCGGUUGUGAGAACAAAUGACUAUCCUGAACAGGGUGGAGGGGUGUGGGAAAGAAACCAGCCAUAUUGGUUUUGGUUUCUGUAUUUUUCACAAUGAUUAAUGAACAAAAACAAAGAGAAAAAAACACACAUCAAUUAAAGGAGACAAAAAGAGGCAGAGCGAGUAGAGAGCAGCCCUCAUUCACCACCUGGUCCCAGACGUGCUUCAGUCCUCGUCCUCUCUUUGUGGCUGGCUCCCAGCCUUCUCUUUCCUCUUGAGGAUACUUAGGGUAAACUGGAUCCUUCCUGCUCAAGGAUCCUCAUUUGUAUACCUAGUGGAAAGGACUCUGAACUCAGAGGAGUCACUGUUCCUUUUUUUAGGUUAGAAAUUAACAGCAGGGAAAUGCCAUCUUAUUACCUGAGACGACCAGCACUGGGAGUUAGGUACGGUCUGAAGUUAUGUCUAGAUAAGACUUCAGACGUCCUGGGAUUGAAAGAAUGUGUGUGAAGGGGUAGAAUUUGUGCGGUAAAGACUUAAAAAAAAAAGUAGGGAGAUUAAAAAAAAAGAAAGAAAAUGCUUCCUUAUCUGGAAGCCUUUCUGGAUUAAUCCAGUGAUGGUCCCACCUUUAGUGUUUGAGCUUUGUCAUUGCUUGUCUCCCUGGCAUGUGCCAGUUAUAGACUGUCCAGCAUCCAAGACGUUUCGGUUAUGUCGGGUCCUCAGAUCGCCUCUGACUUGUUACCACAACAAAUCAUUUUGAUUUCAGUGCCUGUUGGGGACUUGAUUUCUUCUCAGUUUUGUUUGUUUGUUUGUUUCCUUAAUCUGGCUCAUUUGAAAUUUCUUCUCCCUCUCAACCAUCCCACUAAGUUAUAGCCAAGAAGGGAAGGAGACACGGGGAUUUGGGGUUCUCUGCUUGAAUGUCUUCUCCUUUACCACCUCACCUUGUUGGUACCUCCCUCCCUGGAUCUCUGAGCCAGCAGCCAGGAGGACCUGACCCAGCAGUUCUUUACUGGCCCCUUUGUAGGGCCUUGCUGCCAGGGGGCAGGGAUGCUUUCCAGCCUGCAGCAACAGAACACUUGACCUUAAAAGUCUCUUCUGGUCUUUGGAUUAGAAAAGGCUUAUGUUAGCAUAGCUUAAGAGCAACCUCAGAGAUUUGAGCCCUACUAAGUGACUGACCACUGUUUAGAGUGUCUGGUAUCUGAUGUUCAUUUAUUCCCAUGUUCUUGUGUGUCACAGUUCAGCCAGUUUUGGUUUAUGCCUAGAGCUACUUCAAGGAACUAGACUAAUUAGCUAUAUAGGCCCAGCGAUGCUUCUUAUUGAUCUUAAUAGUAUGCCCCUCCUUCCCCUGUCCUUUCAUUUCUCUAUCCAAGUAGCAGUCAGGUUCUUGGUGUGAUGGGACUGAAAGAAUUCCAGUCAGCCAGAGCCUUGGCAGCUCUGAAGCUAACCUUAGCAUCUAAGUGUCGAUCUUGAAUUCCCUGAAAAAAUUUCUAUAGGAAAUGAAGCUUCCCUGGUCCCCUCCUUUCUGGCCAUUGUCAUCCAUUUCCCAGUUAGGGCAACAAUGAAGGAGGACCCAGCCAAGCUAGAAGGAAUUUUGUGGAUGGGAGACAGCAGGAUUAGCUUCAGCUUGGGCUGGAGCAGUCAAUAUAGGAUCUCAGGCCAGGCCCGCUUUUCUAGAAUGUGUUUAAUUUUGAGUUUGCUUUAUUAGAUAUGUUUUUUAAGAGCUCUGUAUAUUUGAACUGCUCCUUAUGUGACAAAAUAGGUAGCUCUUGGGCUCAUGUCCUGGGUUUUGGCUCUUUAAUGAUUACUCCAGGCCAGCAUUUAGUCGUUUGAGAAUUGUAGCCUGUUGUUUUCGCUGUGACUUGGGUCUCAGUGCUAGGGUAUUGAGUCAGGCAGCUGGAGGGUUGUGGCCCGAGGCUGCAGUCAGAGGUAUACUUCCCAUAGUGCUUCACACAGCUCCCCUGCUUCUAAAGGAUAAGGUACUGUAGCCUUGGUCCUGGGGACCACCUGCCUGGGGCAGUGGACAUCCUAACUAAACAGGCUUCUGGCAGUAGCUUUGGUUCCUAUCCCAUCGAAAUUCCCCAAAGCCCUGGGCCACUGCCAUUGGGUUAGUCAAGAUGAAGGAGGAGGACUGGCUGCCUCCAUUUUGCCUUGUUUGUUAGUUUGCCUGGGUCUGUCUGAGGAAGGAGGGGGUCCCGCCUUCCACCUCAACACAUCCCUUCAGUGACUCAGAGUCUCAGAAGGAAACCCUGACUCCUGGGGCCAUUUCCUAAUGGUACUGUAAGCCAAGCAGCUUUGCUUCUGCCUCUGUUUCCAAGCCCACCCUUUUCCCCUGAGCUCAGGGUUAGGGAUGGGCGCUUUCCUCUCUGGUUGUGAACGAAAGGAAGGAACAUCUUUCUAUGGCUAACAAAAACUAAAGGGGAAGUGAGGAAACAGGAAGAAGUAUGGUGGGGGCUGGGGUAGACUCCCCUGGAGCCAAGCCUAUCCAGCUAACAAGAGCUCCCUGGGGCUGGUCACAGCUGGCUCAUGAUGCUGAACUUGAAAGUUUUUUUGUUUUUGUUUUUGUUUUGUGGCUCCUCCAAGAUAUAGGUACAUGAAGUUUAGGUUAAAGGGGUGGGAUUCUUUAUUUUUAUUUUUGUAUUGUAUGUGUCAAGAAUUACUCUGUUGUUCACCUUUUGCUUUUUGCACUGUUUGUUCUCUUAUCUGUAUUUUGAGCUUAGUGCUAGGACUGAGAGGCUGCACCAUAGGGAAUGUAUGGGAGAUGGUGAGGGGUGCCAGUGAGGGGUGCGUGGAGGAGAGGCCUGGGCUCCUCUACUGGAUCUACACUCUGUCCCAGGUUUUUAGAUCCCACUGAGCCCAGCUGACUGAAAACAAGGACAGUCAGGGUGAAACUUCUUUUGCCAGAAGUGUGGCCUGAGUUGAAUUUCUGGGAGGAUGACGCAGAUGUCUGCUGCAGAGCUGGGCUGAGAGUUCUGCAGUCUAGCUCUGACUUAGGUCAGGGGCCUGUUGGUCUCUCAUUGGACGUUUUUGGGUCUCACUCAUGCUUACUGAAACAUUGUGCCAAGAAACUCUGUGGGAUUUGUGUCCCUUAAACCAGACUCACUUUUCUGAAAAAUCUCCAUUGUUGAGGAGAGGCUGCUCAAUCGACACCCCGAGUUCUCAUGACUGGGAAGAUAGUUUUCUUCAGGUGUCAAUGGCGUUAGACUCCCAGGAAGACUAGCCCUGCCCACAGGGCCACCUGUUGGUUUGAGAGCGUGUUCGUGUUCUCUUGCCCUCCCUGCCUAAGAGCUACUGGGAUCACGUUAGCGGGCAUUUAGGCUUUGAUGAGAGGGCACAGUUUGAGUUAGGUUUACCUCCCCCUUUCUGUGCCUGGGAACUGUUUGGUCCAGCUUUAGAACUGUGGUUUUGACUUCCUUAUCUCUUGGGAGAAGCUUCUGUUUUAAGGAAUUUCUCUUCCUUCUUCUCCUGCCUCUAGCCUCUCCUGGAAAGGCCUGGAUAUGGUUUCUAAAAUCUCAGCUGAGAACUUCAGAAAACAGCAGCAGUAUUUUCCUUUUCCUAGUGCUAAAAUCCCUUUCCCUAGAAAUUGGCUCACCUUGGGAAACCCAGGGAAAGAAUCAGCAGGUUCUCUGCCCUCCCUAGGGGUUGGGGAAGGACCCACCCCGGUCAGCACAGUGCCUUUUCCUCUCCUGCUCUGAGCCAGGGUGGGGCAUUCCCUCUAGAUUCAGGUUUGGGCAGGGGUCCUAUAGUCCCUGCCAUGGGGCUGCUUCCCUGUCCCUUCCCUCCCCUUUGCUGGCCUACUCUGGCAUAAUUCAAGUGUCUUCUUGCCUUGGGGAUCCUUAGUGGCAUCAAAUGGCAACAUGGAAUAUUGUCCUCCAUGCCCCUCCAGAAGGACCUAGGAGAGUAGGUGAGCUUUCCAAAGUGAGAGACGAAUCUUUCUUUCUUUUUUUUUUUAAAGGGCAGGAUGGGUAUGCUUUGGGCUUUCUCCUUCUGUGGCCCCGGAGGAAGGAGAGACUGAGGCAAGGCAAAGUGAUAGUACACGGAAGCAGAACCGGAAACACCCAGGAACUGUUCAGAAAUCUCAGAAGAAAUCUGCUUCUCUUCGAUGGAAAGAUAUAAUUAACGAUCAAAGAGCUCUAAGAAAAUUGCAAAGAAGCCUUAAUGUUCAAGCUUUAGAAAGAUCAGAGCAAUUUUUCUCUUUCAGUCCAAACUAAGACUCUCUGUAUUUAAAUCUCUCUGGGGCAAGAGGGCUAGAUUUCCUCAUUUUGUUAUGAGACUAGAUUGGUACCAGUAGAUCAGCUGCCUAGCGAGGGCAGGUUUCUUCUUUGCAUCUGUGUGGCUUGCUUCCAGUCUGGCCUGUCCUUUCCAGCUGCCUUUUGUCUAGCCUGCUAUGGGGGGCCAGAUUAUCUUGAUAAGAGCAGGUGAUUUGGGGACUAGCUGGGUUGGCAGGAAAAGAGCAGGAUGGAUCUCUUGGGACAGGUUCCCCCAGGAGUAUAAACACAAGGAGCCAGGAUUGUGCUGGCAGCCAAGGAAACAGUAGUGCCUGUUUGAGUUGGCAGAGAGGGCCUUGGCACCUCUUGCAUCCAGGCAGUCUUGUGAGAUGGGGGCACAUAGCACUGGGGAAAGCAGAACUCCAUUCUCACCUCUAUUUUGAGCUUCAGUGCUUUAUUUCAGUAUGAGGAAAAACAACAACAAACUGAAGUGCGCUUUCCGUCCUUUCAAAGGACAACUGUCGGGAAGGGAGAGCCGAGUUGCGAGGUAGGAGGGGAGCACUGGCAGGGAGAGACAUUCUUGACUCCUCUCUUCCCUGGUGUGUUGUGAUCCAGGGAAUGAAAAGAAAUUUGACCCUGGAUUGGUUCUCUCCUUGGACUUAAGGAAUCUUACCUUUUCCUUCCACAAAGUUCUCCCAGGCAAGGACCAGCUGCCCAUUCUGAGCCCAGGGCAGCCUCUUCAACCAUUAUUGGUCUAACCUGGCUUGUCAGGAAACCAAGCCCACCCUUCCACAUUGGGCCUGGCUGCUCUAUUCUGUACCAAGUACUGGAGAAAAAGCAUCAAGUUCUUAGCCCUUGUAGCUUCUACCCUAGUUUCCCAUCCUCUCUCUGUGGAGGCCAAACCAACUCUUUGCCAGCAGCCACAACAUGCAUUGACAGCGGCACAGUGAGAUAUAACUGAUGGGCUUUGAACCUGGUUGGCCGGGGAAGCUGUAGGGGUGGAUAGAGCUGGCUUUCCUUCUGGGCUGUCUCCAUCUGACCCUACCCCUUCCAUGUCCCACCCCACUCCCACCAAAAAGUACAAAAUCAGGAUGUUUUUCACUGUCCAUUGCUUUGUGUUUUAAUAAACAAUUUGCAGUGACA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 9761)

HGNC Gene symbol

MLEC

HGNC Gene name

malectin

Chr. RefSeq ID

NC_000012.12

Chromosome N°

12 120687297.. 120696545

CDS location

120687297.. 120696545

DNA strand

strand +

CCDS ID

CCDS9206.1

Mouse ortholog gene

MGI:1924015

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000110917

HGNC other symbol

UCSC ID

uc001tyy.2

GeneBank

INSDC: BC000371

GeneCards

28973

MIM

613802

VEGA ID

OTTHUMG00000169187