NCBI Summary
This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Protein
Protein (NP_055545)
Malectin
Malectin
MLEC
malectin
Undefined
Curated
Malectin
Undefined
b-sandwich / ConA-like
Glc(2)Man(9)GlcNAc(2)
NP_055545
9761
Q14165
ENSP00000228506.3
Q14165
0.925
10.1091/mbc.E11-03-0201
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (292 amino acids) Download
MLGAWAVEGTAVALLRLLLLLLPPAIRGPGLGVAGVAGAAGAGLPESVIWAVNAGGEAHVDVHGIHFRKDPLEGRVGRASDYGMKLPILRSNPEDQILYQTERYNEETFGYEVPIKEEGDYVLVLKFAEVYFAQSQQKVFDVRLNGHVVVKDLDIFDRVGHSTAHDEIIPMSIRKGKLSVQGEVSTFTGKLYIEFVKGYYDNPKVCALYIMAGTVDDVPKLQPHPGLEKKEEEEEEEEYDEGSNLKKQTNKNRVQSGPRTPNPYASDNSSLMFPILVAFGVFIPTLFCLCRL
Mol* PDB structure viewer

Either no PDB or existing PDB of non-glycosylated form

Structural models
AlphaFold v2: AF-Q14165-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for MLEC Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. [31831667]
  • Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. [30021884]
  • Malectin gene polymorphisms promote cerebral palsy via M2-like macrophage polarization. [28972276]
  • Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion. [25451265]
  • Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins. [22988243]
  • Role of malectin in Glc(2)Man(9)GlcNAc(2)-dependent quality control of alpha1-antitrypsin. [21813736]
  • MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. [20347265]
  • Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation. [18524852]
  • Getting in and out from calnexin/calreticulin cycles. [18303019]
  • The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. [10929008]
UniProt Main References (5 PubMed Identifiers)
  • Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. [8590280]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Initial characterization of the human central proteome. [21269460]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • N-terminome analysis of the human mitochondrial proteome. [25944712]
All isoforms of this gene containing a lectin domain
NP_055545.1, NP_001290556.1, XP_011537333.1, XP_011537334.1, NP_001290557.1
RNA
RNA (Transcript ID: NM_014730.4)
NM_014730.4
malectin, transcript variant 1
All isoforms of MLEC containing a lectin domain
ENST00000228506.8
149..1027 (or 120687297.. 120696545)
120687149.. 120701859
NCBI Matured mRNA sequence 6341 NTPDownload 
m7G-5')ppp(5'-GUGGCUGAGAAGAAGGAGGCCUGAGAGCGACAUGUCCCCGGCGGCUCAGGCGGAGCGGCCCGUGGCGCUGUUUUUCUGAGUCCGGGGUGGCCUGGCAGCCGGCCGAGGACGAGGGUCGGCGGGGGCUGCCCCCGUGGUGGUGGCCGCCAUGCUGGGAGCCUGGGCGGUUGAGGGAACCGCUGUGGCGCUCCUGCGACUGCUGCUGCUGCUGCUGCCGCCGGCGAUCCGGGGACCCGGGCUCGGCGUGGCCGGCGUGGCCGGCGCGGCGGGGGCCGGGCUGCCCGAGAGCGUCAUUUGGGCGGUCAACGCGGGUGGAGAGGCGCAUGUGGACGUGCACGGGAUCCACUUCCGCAAGGACCCUUUGGAAGGCCGGGUGGGCCGAGCCUCAGACUAUGGCAUGAAACUGCCAAUCCUGCGUUCCAACCCUGAGGACCAGAUCCUGUAUCAAACUGAGCGGUACAAUGAGGAGACCUUUGGCUACGAAGUGCCCAUCAAAGAGGAGGGGGACUACGUGCUGGUCUUGAAAUUUGCAGAGGUCUACUUUGCACAGUCCCAGCAAAAGGUAUUUGAUGUACGAUUGAAUGGCCACGUCGUGGUGAAGGACUUGGAUAUCUUUGAUCGUGUUGGGCAUAGCACAGCUCACGAUGAAAUUAUACCUAUGAGCAUCAGAAAGGGGAAGCUGAGUGUCCAGGGGGAGGUGUCCACCUUCACAGGGAAACUCUACAUUGAGUUUGUCAAGGGGUACUAUGACAAUCCCAAGGUCUGUGCACUCUACAUCAUGGCUGGGACAGUGGAUGAUGUACCAAAGCUUCAGCCUCAUCCGGGAUUGGAGAAGAAAGAAGAGGAAGAAGAAGAAGAAGAAUAUGAUGAAGGGUCUAAUCUCAAAAAACAGACCAAUAAGAACCGGGUGCAGUCAGGCCCCCGCACACCCAACCCCUAUGCCUCGGACAACAGCAGCCUCAUGUUUCCCAUCCUGGUGGCCUUCGGAGUCUUCAUUCCAACCCUCUUCUGCCUCUGCCGGUUGUGAGAACAAAUGACUAUCCUGAACAGGGUGGAGGGGUGUGGGAAAGAAACCAGCCAUAUUGGUUUUGGUUUCUGUAUUUUUCACAAUGAUUAAUGAACAAAAACAAAGAGAAAAAAACACACAUCAAUUAAAGGAGACAAAAAGAGGCAGAGCGAGUAGAGAGCAGCCCUCAUUCACCACCUGGUCCCAGACGUGCUUCAGUCCUCGUCCUCUCUUUGUGGCUGGCUCCCAGCCUUCUCUUUCCUCUUGAGGAUACUUAGGGUAAACUGGAUCCUUCCUGCUCAAGGAUCCUCAUUUGUAUACCUAGUGGAAAGGACUCUGAACUCAGAGGAGUCACUGUUCCUUUUUUUAGGUUAGAAAUUAACAGCAGGGAAAUGCCAUCUUAUUACCUGAGACGACCAGCACUGGGAGUUAGGUACGGUCUGAAGUUAUGUCUAGAUAAGACUUCAGACGUCCUGGGAUUGAAAGAAUGUGUGUGAAGGGGUAGAAUUUGUGCGGUAAAGACUUAAAAAAAAAAGUAGGGAGAUUAAAAAAAAAGAAAGAAAAUGCUUCCUUAUCUGGAAGCCUUUCUGGAUUAAUCCAGUGAUGGUCCCACCUUUAGUGUUUGAGCUUUGUCAUUGCUUGUCUCCCUGGCAUGUGCCAGUUAUAGACUGUCCAGCAUCCAAGACGUUUCGGUUAUGUCGGGUCCUCAGAUCGCCUCUGACUUGUUACCACAACAAAUCAUUUUGAUUUCAGUGCCUGUUGGGGACUUGAUUUCUUCUCAGUUUUGUUUGUUUGUUUGUUUCCUUAAUCUGGCUCAUUUGAAAUUUCUUCUCCCUCUCAACCAUCCCACUAAGUUAUAGCCAAGAAGGGAAGGAGACACGGGGAUUUGGGGUUCUCUGCUUGAAUGUCUUCUCCUUUACCACCUCACCUUGUUGGUACCUCCCUCCCUGGAUCUCUGAGCCAGCAGCCAGGAGGACCUGACCCAGCAGUUCUUUACUGGCCCCUUUGUAGGGCCUUGCUGCCAGGGGGCAGGGAUGCUUUCCAGCCUGCAGCAACAGAACACUUGACCUUAAAAGUCUCUUCUGGUCUUUGGAUUAGAAAAGGCUUAUGUUAGCAUAGCUUAAGAGCAACCUCAGAGAUUUGAGCCCUACUAAGUGACUGACCACUGUUUAGAGUGUCUGGUAUCUGAUGUUCAUUUAUUCCCAUGUUCUUGUGUGUCACAGUUCAGCCAGUUUUGGUUUAUGCCUAGAGCUACUUCAAGGAACUAGACUAAUUAGCUAUAUAGGCCCAGCGAUGCUUCUUAUUGAUCUUAAUAGUAUGCCCCUCCUUCCCCUGUCCUUUCAUUUCUCUAUCCAAGUAGCAGUCAGGUUCUUGGUGUGAUGGGACUGAAAGAAUUCCAGUCAGCCAGAGCCUUGGCAGCUCUGAAGCUAACCUUAGCAUCUAAGUGUCGAUCUUGAAUUCCCUGAAAAAAUUUCUAUAGGAAAUGAAGCUUCCCUGGUCCCCUCCUUUCUGGCCAUUGUCAUCCAUUUCCCAGUUAGGGCAACAAUGAAGGAGGACCCAGCCAAGCUAGAAGGAAUUUUGUGGAUGGGAGACAGCAGGAUUAGCUUCAGCUUGGGCUGGAGCAGUCAAUAUAGGAUCUCAGGCCAGGCCCGCUUUUCUAGAAUGUGUUUAAUUUUGAGUUUGCUUUAUUAGAUAUGUUUUUUAAGAGCUCUGUAUAUUUGAACUGCUCCUUAUGUGACAAAAUAGGUAGCUCUUGGGCUCAUGUCCUGGGUUUUGGCUCUUUAAUGAUUACUCCAGGCCAGCAUUUAGUCGUUUGAGAAUUGUAGCCUGUUGUUUUCGCUGUGACUUGGGUCUCAGUGCUAGGGUAUUGAGUCAGGCAGCUGGAGGGUUGUGGCCCGAGGCUGCAGUCAGAGGUAUACUUCCCAUAGUGCUUCACACAGCUCCCCUGCUUCUAAAGGAUAAGGUACUGUAGCCUUGGUCCUGGGGACCACCUGCCUGGGGCAGUGGACAUCCUAACUAAACAGGCUUCUGGCAGUAGCUUUGGUUCCUAUCCCAUCGAAAUUCCCCAAAGCCCUGGGCCACUGCCAUUGGGUUAGUCAAGAUGAAGGAGGAGGACUGGCUGCCUCCAUUUUGCCUUGUUUGUUAGUUUGCCUGGGUCUGUCUGAGGAAGGAGGGGGUCCCGCCUUCCACCUCAACACAUCCCUUCAGUGACUCAGAGUCUCAGAAGGAAACCCUGACUCCUGGGGCCAUUUCCUAAUGGUACUGUAAGCCAAGCAGCUUUGCUUCUGCCUCUGUUUCCAAGCCCACCCUUUUCCCCUGAGCUCAGGGUUAGGGAUGGGCGCUUUCCUCUCUGGUUGUGAACGAAAGGAAGGAACAUCUUUCUAUGGCUAACAAAAACUAAAGGGGAAGUGAGGAAACAGGAAGAAGUAUGGUGGGGGCUGGGGUAGACUCCCCUGGAGCCAAGCCUAUCCAGCUAACAAGAGCUCCCUGGGGCUGGUCACAGCUGGCUCAUGAUGCUGAACUUGAAAGUUUUUUUGUUUUUGUUUUUGUUUUGUGGCUCCUCCAAGAUAUAGGUACAUGAAGUUUAGGUUAAAGGGGUGGGAUUCUUUAUUUUUAUUUUUGUAUUGUAUGUGUCAAGAAUUACUCUGUUGUUCACCUUUUGCUUUUUGCACUGUUUGUUCUCUUAUCUGUAUUUUGAGCUUAGUGCUAGGACUGAGAGGCUGCACCAUAGGGAAUGUAUGGGAGAUGGUGAGGGGUGCCAGUGAGGGGUGCGUGGAGGAGAGGCCUGGGCUCCUCUACUGGAUCUACACUCUGUCCCAGGUUUUUAGAUCCCACUGAGCCCAGCUGACUGAAAACAAGGACAGUCAGGGUGAAACUUCUUUUGCCAGAAGUGUGGCCUGAGUUGAAUUUCUGGGAGGAUGACGCAGAUGUCUGCUGCAGAGCUGGGCUGAGAGUUCUGCAGUCUAGCUCUGACUUAGGUCAGGGGCCUGUUGGUCUCUCAUUGGACGUUUUUGGGUCUCACUCAUGCUUACUGAAACAUUGUGCCAAGAAACUCUGUGGGAUUUGUGUCCCUUAAACCAGACUCACUUUUCUGAAAAAUCUCCAUUGUUGAGGAGAGGCUGCUCAAUCGACACCCCGAGUUCUCAUGACUGGGAAGAUAGUUUUCUUCAGGUGUCAAUGGCGUUAGACUCCCAGGAAGACUAGCCCUGCCCACAGGGCCACCUGUUGGUUUGAGAGCGUGUUCGUGUUCUCUUGCCCUCCCUGCCUAAGAGCUACUGGGAUCACGUUAGCGGGCAUUUAGGCUUUGAUGAGAGGGCACAGUUUGAGUUAGGUUUACCUCCCCCUUUCUGUGCCUGGGAACUGUUUGGUCCAGCUUUAGAACUGUGGUUUUGACUUCCUUAUCUCUUGGGAGAAGCUUCUGUUUUAAGGAAUUUCUCUUCCUUCUUCUCCUGCCUCUAGCCUCUCCUGGAAAGGCCUGGAUAUGGUUUCUAAAAUCUCAGCUGAGAACUUCAGAAAACAGCAGCAGUAUUUUCCUUUUCCUAGUGCUAAAAUCCCUUUCCCUAGAAAUUGGCUCACCUUGGGAAACCCAGGGAAAGAAUCAGCAGGUUCUCUGCCCUCCCUAGGGGUUGGGGAAGGACCCACCCCGGUCAGCACAGUGCCUUUUCCUCUCCUGCUCUGAGCCAGGGUGGGGCAUUCCCUCUAGAUUCAGGUUUGGGCAGGGGUCCUAUAGUCCCUGCCAUGGGGCUGCUUCCCUGUCCCUUCCCUCCCCUUUGCUGGCCUACUCUGGCAUAAUUCAAGUGUCUUCUUGCCUUGGGGAUCCUUAGUGGCAUCAAAUGGCAACAUGGAAUAUUGUCCUCCAUGCCCCUCCAGAAGGACCUAGGAGAGUAGGUGAGCUUUCCAAAGUGAGAGACGAAUCUUUCUUUCUUUUUUUUUUUAAAGGGCAGGAUGGGUAUGCUUUGGGCUUUCUCCUUCUGUGGCCCCGGAGGAAGGAGAGACUGAGGCAAGGCAAAGUGAUAGUACACGGAAGCAGAACCGGAAACACCCAGGAACUGUUCAGAAAUCUCAGAAGAAAUCUGCUUCUCUUCGAUGGAAAGAUAUAAUUAACGAUCAAAGAGCUCUAAGAAAAUUGCAAAGAAGCCUUAAUGUUCAAGCUUUAGAAAGAUCAGAGCAAUUUUUCUCUUUCAGUCCAAACUAAGACUCUCUGUAUUUAAAUCUCUCUGGGGCAAGAGGGCUAGAUUUCCUCAUUUUGUUAUGAGACUAGAUUGGUACCAGUAGAUCAGCUGCCUAGCGAGGGCAGGUUUCUUCUUUGCAUCUGUGUGGCUUGCUUCCAGUCUGGCCUGUCCUUUCCAGCUGCCUUUUGUCUAGCCUGCUAUGGGGGGCCAGAUUAUCUUGAUAAGAGCAGGUGAUUUGGGGACUAGCUGGGUUGGCAGGAAAAGAGCAGGAUGGAUCUCUUGGGACAGGUUCCCCCAGGAGUAUAAACACAAGGAGCCAGGAUUGUGCUGGCAGCCAAGGAAACAGUAGUGCCUGUUUGAGUUGGCAGAGAGGGCCUUGGCACCUCUUGCAUCCAGGCAGUCUUGUGAGAUGGGGGCACAUAGCACUGGGGAAAGCAGAACUCCAUUCUCACCUCUAUUUUGAGCUUCAGUGCUUUAUUUCAGUAUGAGGAAAAACAACAACAAACUGAAGUGCGCUUUCCGUCCUUUCAAAGGACAACUGUCGGGAAGGGAGAGCCGAGUUGCGAGGUAGGAGGGGAGCACUGGCAGGGAGAGACAUUCUUGACUCCUCUCUUCCCUGGUGUGUUGUGAUCCAGGGAAUGAAAAGAAAUUUGACCCUGGAUUGGUUCUCUCCUUGGACUUAAGGAAUCUUACCUUUUCCUUCCACAAAGUUCUCCCAGGCAAGGACCAGCUGCCCAUUCUGAGCCCAGGGCAGCCUCUUCAACCAUUAUUGGUCUAACCUGGCUUGUCAGGAAACCAAGCCCACCCUUCCACAUUGGGCCUGGCUGCUCUAUUCUGUACCAAGUACUGGAGAAAAAGCAUCAAGUUCUUAGCCCUUGUAGCUUCUACCCUAGUUUCCCAUCCUCUCUCUGUGGAGGCCAAACCAACUCUUUGCCAGCAGCCACAACAUGCAUUGACAGCGGCACAGUGAGAUAUAACUGAUGGGCUUUGAACCUGGUUGGCCGGGGAAGCUGUAGGGGUGGAUAGAGCUGGCUUUCCUUCUGGGCUGUCUCCAUCUGACCCUACCCCUUCCAUGUCCCACCCCACUCCCACCAAAAAGUACAAAAUCAGGAUGUUUUUCACUGUCCAUUGCUUUGUGUUUUAAUAAACAAUUUGCAGUGACA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 9761)
MLEC
malectin
NC_000012.12
12  120687297.. 120696545
120687297.. 120696545
strand +
CCDS9206.1
MGI:1924015
ClinVar, dbVar
ENSG00000110917
uc001tyy.2
INSDC: BC000371
28973
613802
OTTHUMG00000169187
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (879 bp)
5'-ATGCTGGGAGCCTGGGCGGTTGAGGGAACCGCTGTGGCGCTCCTGCGACTGCTGCTGCTGCTGCTGCCGCCGGCGATCCGGGGACCCGGGCTCGGCGTGGCCGGCGTGGCCGGCGCGGCGGGGGCCGGGCTGCCCGAGAGCGTCATTTGGGCGGTCAACGCGGGTGGAGAGGCGCATGTGGACGTGCACGGGATCCACTTCCGCAAGGACCCTTTGGAAGGCCGGGTGGGCCGAGCCTCAGACTATGGCATGAAACTGCCAATCCTGCGTTCCAACCCTGAGGACCAGATCCTGTATCAAACTGAGCGGTACAATGAGGAGACCTTTGGCTACGAAGTGCCCATCAAAGAGGAGGGGGACTACGTGCTGGTCTTGAAATTTGCAGAGGTCTACTTTGCACAGTCCCAGCAAAAGGTATTTGATGTACGATTGAATGGCCACGTCGTGGTGAAGGACTTGGATATCTTTGATCGTGTTGGGCATAGCACAGCTCACGATGAAATTATACCTATGAGCATCAGAAAGGGGAAGCTGAGTGTCCAGGGGGAGGTGTCCACCTTCACAGGGAAACTCTACATTGAGTTTGTCAAGGGGTACTATGACAATCCCAAGGTCTGTGCACTCTACATCATGGCTGGGACAGTGGATGATGTACCAAAGCTTCAGCCTCATCCGGGATTGGAGAAGAAAGAAGAGGAAGAAGAAGAAGAAGAATATGATGAAGGGTCTAATCTCAAAAAACAGACCAATAAGAACCGGGTGCAGTCAGGCCCCCGCACACCCAACCCCTATGCCTCGGACAACAGCAGCCTCATGTTTCCCATCCTGGTGGCCTTCGGAGTCTTCATTCCAACCCTCTTCTGCCTCTGCCGGTTGTGA-3'
NCBI CDS gene sequence with introns (location: 120687297.. 120696545) (9249 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 120687149.. 120701859) (14711 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [120687149 - 1000].. 120701859) (15711 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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