NCBI Summary
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015].
Protein
Protein (NP_055310)
Angiopoietin-related protein 3
Angiopoietin-related protein 3 (Angiopoietin-5) (ANG-5) (Angiopoietin-like protein 3) [Cleaved into: ANGPTL3(17-221); ANGPTL3(17-224)]
ANGPTL3
angiopoietin like 3
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
MFTIKLLLFIVPLVISSRIDQDNSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELRRTTYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSSKPRAPRTTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHFNCPEGYSGGWWWHDECGENNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Serum Angiopoietin-like Protein 3 Level Is Associated with Peripheral Arterial Stiffness in Patients with Coronary Artery Disease. [34684048]
- Differential Expression of the Host Lipid Regulators ANGPTL-3 and ANGPTL-4 in HCV Infection and Treatment. [34360721]
- Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes. [34293055]
- ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals. [34067751]
- O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids. [20837471]
- Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. [12909640]
- Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes. [12565906]
- Regulation of the angiopoietin-like protein 3 gene by LXR. [12518032]
- ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. [11877390]
- Identification of a mammalian angiopoietin-related protein expressed specifically in liver. [10644446]
UniProt Main References (26 PubMed Identifiers)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
- Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
- ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. [12097324]
- Angptl3 regulates lipid metabolism in mice. [11788823]
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]
- Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. [17110602]
- Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects. [17191020]
- Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin alphaVbeta3. [18535744] Show more
RNA
RNA (Transcript ID: NM_014495.4)
m7G-5')ppp(5'-AGAAGAAAACAGUUCCACGUUGCUUGAAAUUGAAAAUCAAGAUAAAAAUGUUCACAAUUAAGCUCCUUCUUUUUAUUGUUCCUCUAGUUAUUUCCUCCAGAAUUGAUCAAGACAAUUCAUCAUUUGAUUCUCUAUCUCCAGAGCCAAAAUCAAGAUUUGCUAUGUUAGACGAUGUAAAAAUUUUAGCCAAUGGCCUCCUUCAGUUGGGACAUGGUCUUAAAGACUUUGUCCAUAAGACGAAGGGCCAAAUUAAUGACAUAUUUCAAAAACUCAACAUAUUUGAUCAGUCUUUUUAUGAUCUAUCGCUGCAAACCAGUGAAAUCAAAGAAGAAGAAAAGGAACUGAGAAGAACUACAUAUAAACUACAAGUCAAAAAUGAAGAGGUAAAGAAUAUGUCACUUGAACUCAACUCAAAACUUGAAAGCCUCCUAGAAGAAAAAAUUCUACUUCAACAAAAAGUGAAAUAUUUAGAAGAGCAACUAACUAACUUAAUUCAAAAUCAACCUGAAACUCCAGAACACCCAGAAGUAACUUCACUUAAAACUUUUGUAGAAAAACAAGAUAAUAGCAUCAAAGACCUUCUCCAGACCGUGGAAGACCAAUAUAAACAAUUAAACCAACAGCAUAGUCAAAUAAAAGAAAUAGAAAAUCAGCUCAGAAGGACUAGUAUUCAAGAACCCACAGAAAUUUCUCUAUCUUCCAAGCCAAGAGCACCAAGAACUACUCCCUUUCUUCAGUUGAAUGAAAUAAGAAAUGUAAAACAUGAUGGCAUUCCUGCUGAAUGUACCACCAUUUAUAACAGAGGUGAACAUACAAGUGGCAUGUAUGCCAUCAGACCCAGCAACUCUCAAGUUUUUCAUGUCUACUGUGAUGUUAUAUCAGGUAGUCCAUGGACAUUAAUUCAACAUCGAAUAGAUGGAUCACAAAACUUCAAUGAAACGUGGGAGAACUACAAAUAUGGUUUUGGGAGGCUUGAUGGAGAAUUUUGGUUGGGCCUAGAGAAGAUAUACUCCAUAGUGAAGCAAUCUAAUUAUGUUUUACGAAUUGAGUUGGAAGACUGGAAAGACAACAAACAUUAUAUUGAAUAUUCUUUUUACUUGGGAAAUCACGAAACCAACUAUACGCUACAUCUAGUUGCGAUUACUGGCAAUGUCCCCAAUGCAAUCCCGGAAAACAAAGAUUUGGUGUUUUCUACUUGGGAUCACAAAGCAAAAGGACACUUCAACUGUCCAGAGGGUUAUUCAGGAGGCUGGUGGUGGCAUGAUGAGUGUGGAGAAAACAACCUAAAUGGUAAAUAUAACAAACCAAGAGCAAAAUCUAAGCCAGAGAGGAGAAGAGGAUUAUCUUGGAAGUCUCAAAAUGGAAGGUUAUACUCUAUAAAAUCAACCAAAAUGUUGAUCCAUCCAACAGAUUCAGAAAGCUUUGAAUGAACUGAGGCAAAUUUAAAAGGCAAUAAUUUAAACAUUAACCUCAUUCCAAGUUAAUGUGGUCUAAUAAUCUGGUAUUAAAUCCUUAAGAGAAAGCUUGAGAAAUAGAUUUUUUUUAUCUUAAAGUCACUGUCUAUUUAAGAUUAAACAUACAAUCACAUAACCUUAAAGAAUACCGUUUACAUUUCUCAAUCAAAAUUCUUAUAAUACUAUUUGUUUUAAAUUUUGUGAUGUGGGAAUCAAUUUUAGAUGGUCACAAUCUAGAUUAUAAUCAAUAGGUGAACUUAUUAAAUAACUUUUCUAAAUAAAAAAUUUAGAGACUUUUAUUUUAAAAGGCAUCAUAUGAGCUAAUAUCACAACUUUCCCAGUUUAAAAAACUAGUACUCUUGUUAAAACUCUAAACUUGACUAAAUACAGAGGACUGGUAAUUGUACAGUUCUUAAAUGUUGUAGUAUUAAUUUCAAAACUAAAAAUCGUCAGCACAGAGUAUGUGUAAAAAUCUGUAAUACAAAUUUUUAAACUGAUGCUUCAUUUUGCUACAAAAUAAUUUGGAGUAAAUGUUUGAUAUGAUUUAUUUAUGAAACCUAAUGAAGCAGAAUUAAAUACUGUAUUAAAAUAAGUUCGCUGUCUUUAAACAAAUGGAGAUGACUACUAAGUCACAUUGACUUUAACAUGAGGUAUCACUAUACCUUAUUUGUUAAAAUAUAUACUGUAUACAUUUUAUAUAUUUUAACACUUAAUACUAUGAAAACAAAUAAUUGUAAAGGAAUCUUGUCAGAUUACAGUAAGAAUGAACAUAUUUGUGGCAUCGAGUUAAAGUUUAUAUUUCCCCUAAAUAUGCUGUGAUUCUAAUACAUUCGUGUAGGUUUUCAAGUAGAAAUAAACCUCGUAACAAGUUACUGAACGUUUAAACAGCCUGACAAGCAUGUAUAUAUGUUUAAAAUUCAAUAAACAAAGACCCAGUCCCUAAAUUAUAGAAAUUUAAAUUAUUCUUGCAUGUUUAUCGACAUCACAACAGAUCCCUAAAUCCCUAAAUCCCUAAAGAUUAGAUACAAAUUUUUUACCACAGUAUCACUUGUCAGAAUUUAUUUUUAAAUAUGAUUUUUUAAAACUGCCAGUAAGAAAUUUUAAAUUAAACCCAUUUGUUAAAGGAUAUAGUGCCCAAGUUAUAUGGUGACCUACCUUUGUCAAUACUUAGCAUUAUGUAUUUCAAAUUAUCCAAUAUACAUGUCAUAUAUAUUUUUAUAUGUCACAUAUAUAAAAGAUAUGUAUGAUCUAUGUGAAUCCUAAGUAAAUAUUUUGUUCCAGAAAAGUACAAAAUAAUAAAGGUAAAAAUAAUCUAUAAUUUUCAGGACCACAGACUAAGCUGUCGAAAUUAACGCUGAUUUUUUUAGGGCCAGAAUACCAAAAUGGCUCCUCUCUUCCCCCAAAAUUGGACAAUUUCAAAUGCAAAAUAAUUCAUUAUUUAAUAUAUGAGUUGCUUCCUCUAUUUGGUUUCC-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 27329)
angiopoietin like 3
strand +
NCBI CDS gene sequence (1383 bp)
5'-ATGTTCACAATTAAGCTCCTTCTTTTTATTGTTCCTCTAGTTATTTCCTCCAGAATTGATCAAGACAATTCATCATTTGATTCTCTATCTCCAGAGCCAAAATCAAGATTTGCTATGTTAGACGATGTAAAAATTTTAGCCAATGGCCTCCTTCAGTTGGGACATGGTCTTAAAGACTTTGTCCATAAGACGAAGGGCCAAATTAATGACATATTTCAAAAACTCAACATATTTGATCAGTCTTTTTATGATCTATCGCTGCAAACCAGTGAAATCAAAGAAGAAGAAAAGGAACTGAGAAGAACTACATATAAACTACAAGTCAAAAATGAAGAGGTAAAGAATATGTCACTTGAACTCAACTCAAAACTTGAAAGCCTCCTAGAAGAAAAAATTCTACTTCAACAAAAAGTGAAATATTTAGAAGAGCAACTAACTAACTTAATTCAAAATCAACCTGAAACTCCAGAACACCCAGAAGTAACTTCACTTAAAACTTTTGTAGAAAAACAAGATAATAGCATCAAAGACCTTCTCCAGACCGTGGAAGACCAATATAAACAATTAAACCAACAGCATAGTCAAATAAAAGAAATAGAAAATCAGCTCAGAAGGACTAGTATTCAAGAACCCACAGAAATTTCTCTATCTTCCAAGCCAAGAGCACCAAGAACTACTCCCTTTCTTCAGTTGAATGAAATAAGAAATGTAAAACATGATGGCATTCCTGCTGAATGTACCACCATTTATAACAGAGGTGAACATACAAGTGGCATGTATGCCATCAGACCCAGCAACTCTCAAGTTTTTCATGTCTACTGTGATGTTATATCAGGTAGTCCATGGACATTAATTCAACATCGAATAGATGGATCACAAAACTTCAATGAAACGTGGGAGAACTACAAATATGGTTTTGGGAGGCTTGATGGAGAATTTTGGTTGGGCCTAGAGAAGATATACTCCATAGTGAAGCAATCTAATTATGTTTTACGAATTGAGTTGGAAGACTGGAAAGACAACAAACATTATATTGAATATTCTTTTTACTTGGGAAATCACGAAACCAACTATACGCTACATCTAGTTGCGATTACTGGCAATGTCCCCAATGCAATCCCGGAAAACAAAGATTTGGTGTTTTCTACTTGGGATCACAAAGCAAAAGGACACTTCAACTGTCCAGAGGGTTATTCAGGAGGCTGGTGGTGGCATGATGAGTGTGGAGAAAACAACCTAAATGGTAAATATAACAAACCAAGAGCAAAATCTAAGCCAGAGAGGAGAAGAGGATTATCTTGGAAGTCTCAAAATGGAAGGTTATACTCTATAAAATCAACCAAAATGTTGATCCATCCAACAGATTCAGAAAGCTTTGAATGA-3'
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