NCBI Summary
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015].
Protein
Protein (NP_055310)
Angiopoietin-related protein 3
Angiopoietin-related protein 3 (Angiopoietin-5) (ANG-5) (Angiopoietin-like protein 3) [Cleaved into: ANGPTL3(17-221); ANGPTL3(17-224)]
ANGPTL3
angiopoietin like 3
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_055310
27329
Q9Y5C1
ENSP00000360170.3
Q9Y5C1
0.491
Undefined
PFAM, InterPro
Protein sequence and protein families (fasta) (460 amino acids) Download
MFTIKLLLFIVPLVISSRIDQDNSSFDSLSPEPKSRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFQKLNIFDQSFYDLSLQTSEIKEEEKELRRTTYKLQVKNEEVKNMSLELNSKLESLLEEKILLQQKVKYLEEQLTNLIQNQPETPEHPEVTSLKTFVEKQDNSIKDLLQTVEDQYKQLNQQHSQIKEIENQLRRTSIQEPTEISLSSKPRAPRTTPFLQLNEIRNVKHDGIPAECTTIYNRGEHTSGMYAIRPSNSQVFHVYCDVISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNYVLRIELEDWKDNKHYIEYSFYLGNHETNYTLHLVAITGNVPNAIPENKDLVFSTWDHKAKGHFNCPEGYSGGWWWHDECGENNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYSIKSTKMLIHPTDSESFE
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9Y5C1-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Interacts with ANGPTL8. Interacts with ITGB3 (By similarity). Source: UniProt
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Serum Angiopoietin-like Protein 3 Level Is Associated with Peripheral Arterial Stiffness in Patients with Coronary Artery Disease. [34684048]
  • Differential Expression of the Host Lipid Regulators ANGPTL-3 and ANGPTL-4 in HCV Infection and Treatment. [34360721]
  • Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes. [34293055]
  • ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals. [34067751]
  • O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids. [20837471]
  • Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. [12909640]
  • Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes. [12565906]
  • Regulation of the angiopoietin-like protein 3 gene by LXR. [12518032]
  • ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. [11877390]
  • Identification of a mammalian angiopoietin-related protein expressed specifically in liver. [10644446]
UniProt Main References (26 PubMed Identifiers)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
  • ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. [12097324]
  • Angptl3 regulates lipid metabolism in mice. [11788823]
  • Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]
  • Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. [17110602]
  • Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects. [17191020]
  • Angiopoietin-like protein 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving phosphatidylinositol-3 kinase/protein kinase B and integrin alphaVbeta3. [18535744]
    • Show more
RNA
RNA (Transcript ID: NM_014495.4)
NM_014495.4
angiopoietin like 3
All isoforms of ANGPTL3 containing a lectin domain
ENST00000371129.4
48..1430 (or 62597567.. 62604817)
62597520.. 62606313
NCBI Matured mRNA sequence 2926 NTPDownload 
m7G-5')ppp(5'-AGAAGAAAACAGUUCCACGUUGCUUGAAAUUGAAAAUCAAGAUAAAAAUGUUCACAAUUAAGCUCCUUCUUUUUAUUGUUCCUCUAGUUAUUUCCUCCAGAAUUGAUCAAGACAAUUCAUCAUUUGAUUCUCUAUCUCCAGAGCCAAAAUCAAGAUUUGCUAUGUUAGACGAUGUAAAAAUUUUAGCCAAUGGCCUCCUUCAGUUGGGACAUGGUCUUAAAGACUUUGUCCAUAAGACGAAGGGCCAAAUUAAUGACAUAUUUCAAAAACUCAACAUAUUUGAUCAGUCUUUUUAUGAUCUAUCGCUGCAAACCAGUGAAAUCAAAGAAGAAGAAAAGGAACUGAGAAGAACUACAUAUAAACUACAAGUCAAAAAUGAAGAGGUAAAGAAUAUGUCACUUGAACUCAACUCAAAACUUGAAAGCCUCCUAGAAGAAAAAAUUCUACUUCAACAAAAAGUGAAAUAUUUAGAAGAGCAACUAACUAACUUAAUUCAAAAUCAACCUGAAACUCCAGAACACCCAGAAGUAACUUCACUUAAAACUUUUGUAGAAAAACAAGAUAAUAGCAUCAAAGACCUUCUCCAGACCGUGGAAGACCAAUAUAAACAAUUAAACCAACAGCAUAGUCAAAUAAAAGAAAUAGAAAAUCAGCUCAGAAGGACUAGUAUUCAAGAACCCACAGAAAUUUCUCUAUCUUCCAAGCCAAGAGCACCAAGAACUACUCCCUUUCUUCAGUUGAAUGAAAUAAGAAAUGUAAAACAUGAUGGCAUUCCUGCUGAAUGUACCACCAUUUAUAACAGAGGUGAACAUACAAGUGGCAUGUAUGCCAUCAGACCCAGCAACUCUCAAGUUUUUCAUGUCUACUGUGAUGUUAUAUCAGGUAGUCCAUGGACAUUAAUUCAACAUCGAAUAGAUGGAUCACAAAACUUCAAUGAAACGUGGGAGAACUACAAAUAUGGUUUUGGGAGGCUUGAUGGAGAAUUUUGGUUGGGCCUAGAGAAGAUAUACUCCAUAGUGAAGCAAUCUAAUUAUGUUUUACGAAUUGAGUUGGAAGACUGGAAAGACAACAAACAUUAUAUUGAAUAUUCUUUUUACUUGGGAAAUCACGAAACCAACUAUACGCUACAUCUAGUUGCGAUUACUGGCAAUGUCCCCAAUGCAAUCCCGGAAAACAAAGAUUUGGUGUUUUCUACUUGGGAUCACAAAGCAAAAGGACACUUCAACUGUCCAGAGGGUUAUUCAGGAGGCUGGUGGUGGCAUGAUGAGUGUGGAGAAAACAACCUAAAUGGUAAAUAUAACAAACCAAGAGCAAAAUCUAAGCCAGAGAGGAGAAGAGGAUUAUCUUGGAAGUCUCAAAAUGGAAGGUUAUACUCUAUAAAAUCAACCAAAAUGUUGAUCCAUCCAACAGAUUCAGAAAGCUUUGAAUGAACUGAGGCAAAUUUAAAAGGCAAUAAUUUAAACAUUAACCUCAUUCCAAGUUAAUGUGGUCUAAUAAUCUGGUAUUAAAUCCUUAAGAGAAAGCUUGAGAAAUAGAUUUUUUUUAUCUUAAAGUCACUGUCUAUUUAAGAUUAAACAUACAAUCACAUAACCUUAAAGAAUACCGUUUACAUUUCUCAAUCAAAAUUCUUAUAAUACUAUUUGUUUUAAAUUUUGUGAUGUGGGAAUCAAUUUUAGAUGGUCACAAUCUAGAUUAUAAUCAAUAGGUGAACUUAUUAAAUAACUUUUCUAAAUAAAAAAUUUAGAGACUUUUAUUUUAAAAGGCAUCAUAUGAGCUAAUAUCACAACUUUCCCAGUUUAAAAAACUAGUACUCUUGUUAAAACUCUAAACUUGACUAAAUACAGAGGACUGGUAAUUGUACAGUUCUUAAAUGUUGUAGUAUUAAUUUCAAAACUAAAAAUCGUCAGCACAGAGUAUGUGUAAAAAUCUGUAAUACAAAUUUUUAAACUGAUGCUUCAUUUUGCUACAAAAUAAUUUGGAGUAAAUGUUUGAUAUGAUUUAUUUAUGAAACCUAAUGAAGCAGAAUUAAAUACUGUAUUAAAAUAAGUUCGCUGUCUUUAAACAAAUGGAGAUGACUACUAAGUCACAUUGACUUUAACAUGAGGUAUCACUAUACCUUAUUUGUUAAAAUAUAUACUGUAUACAUUUUAUAUAUUUUAACACUUAAUACUAUGAAAACAAAUAAUUGUAAAGGAAUCUUGUCAGAUUACAGUAAGAAUGAACAUAUUUGUGGCAUCGAGUUAAAGUUUAUAUUUCCCCUAAAUAUGCUGUGAUUCUAAUACAUUCGUGUAGGUUUUCAAGUAGAAAUAAACCUCGUAACAAGUUACUGAACGUUUAAACAGCCUGACAAGCAUGUAUAUAUGUUUAAAAUUCAAUAAACAAAGACCCAGUCCCUAAAUUAUAGAAAUUUAAAUUAUUCUUGCAUGUUUAUCGACAUCACAACAGAUCCCUAAAUCCCUAAAUCCCUAAAGAUUAGAUACAAAUUUUUUACCACAGUAUCACUUGUCAGAAUUUAUUUUUAAAUAUGAUUUUUUAAAACUGCCAGUAAGAAAUUUUAAAUUAAACCCAUUUGUUAAAGGAUAUAGUGCCCAAGUUAUAUGGUGACCUACCUUUGUCAAUACUUAGCAUUAUGUAUUUCAAAUUAUCCAAUAUACAUGUCAUAUAUAUUUUUAUAUGUCACAUAUAUAAAAGAUAUGUAUGAUCUAUGUGAAUCCUAAGUAAAUAUUUUGUUCCAGAAAAGUACAAAAUAAUAAAGGUAAAAAUAAUCUAUAAUUUUCAGGACCACAGACUAAGCUGUCGAAAUUAACGCUGAUUUUUUUAGGGCCAGAAUACCAAAAUGGCUCCUCUCUUCCCCCAAAAUUGGACAAUUUCAAAUGCAAAAUAAUUCAUUAUUUAAUAUAUGAGUUGCUUCCUCUAUUUGGUUUCC-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 27329)
ANGPTL3
angiopoietin like 3
NC_000001.11
1  62597567.. 62604817
62597567.. 62604817
strand +
CCDS622.1
MGI:1353627
ClinVar, dbVar
ENSG00000132855
uc001das.3
INSDC: AF152562
491
604774
OTTHUMG00000009146
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (1383 bp)
5'-ATGTTCACAATTAAGCTCCTTCTTTTTATTGTTCCTCTAGTTATTTCCTCCAGAATTGATCAAGACAATTCATCATTTGATTCTCTATCTCCAGAGCCAAAATCAAGATTTGCTATGTTAGACGATGTAAAAATTTTAGCCAATGGCCTCCTTCAGTTGGGACATGGTCTTAAAGACTTTGTCCATAAGACGAAGGGCCAAATTAATGACATATTTCAAAAACTCAACATATTTGATCAGTCTTTTTATGATCTATCGCTGCAAACCAGTGAAATCAAAGAAGAAGAAAAGGAACTGAGAAGAACTACATATAAACTACAAGTCAAAAATGAAGAGGTAAAGAATATGTCACTTGAACTCAACTCAAAACTTGAAAGCCTCCTAGAAGAAAAAATTCTACTTCAACAAAAAGTGAAATATTTAGAAGAGCAACTAACTAACTTAATTCAAAATCAACCTGAAACTCCAGAACACCCAGAAGTAACTTCACTTAAAACTTTTGTAGAAAAACAAGATAATAGCATCAAAGACCTTCTCCAGACCGTGGAAGACCAATATAAACAATTAAACCAACAGCATAGTCAAATAAAAGAAATAGAAAATCAGCTCAGAAGGACTAGTATTCAAGAACCCACAGAAATTTCTCTATCTTCCAAGCCAAGAGCACCAAGAACTACTCCCTTTCTTCAGTTGAATGAAATAAGAAATGTAAAACATGATGGCATTCCTGCTGAATGTACCACCATTTATAACAGAGGTGAACATACAAGTGGCATGTATGCCATCAGACCCAGCAACTCTCAAGTTTTTCATGTCTACTGTGATGTTATATCAGGTAGTCCATGGACATTAATTCAACATCGAATAGATGGATCACAAAACTTCAATGAAACGTGGGAGAACTACAAATATGGTTTTGGGAGGCTTGATGGAGAATTTTGGTTGGGCCTAGAGAAGATATACTCCATAGTGAAGCAATCTAATTATGTTTTACGAATTGAGTTGGAAGACTGGAAAGACAACAAACATTATATTGAATATTCTTTTTACTTGGGAAATCACGAAACCAACTATACGCTACATCTAGTTGCGATTACTGGCAATGTCCCCAATGCAATCCCGGAAAACAAAGATTTGGTGTTTTCTACTTGGGATCACAAAGCAAAAGGACACTTCAACTGTCCAGAGGGTTATTCAGGAGGCTGGTGGTGGCATGATGAGTGTGGAGAAAACAACCTAAATGGTAAATATAACAAACCAAGAGCAAAATCTAAGCCAGAGAGGAGAAGAGGATTATCTTGGAAGTCTCAAAATGGAAGGTTATACTCTATAAAATCAACCAAAATGTTGATCCATCCAACAGATTCAGAAAGCTTTGAATGA-3'
NCBI CDS gene sequence with introns (location: 62597567.. 62604817) (7251 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 62597520.. 62606313) (8794 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [62597520 - 1000].. 62606313) (9794 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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