NCBI Summary
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_036230)
Angiopoietin-related protein 2
Angiopoietin-related protein 2 (Angiopoietin-like protein 2)
ANGPTL2
angiopoietin like 2
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_036230
23452
Q9UKU9
ENSP00000362524.3
Q9UKU9
0.589
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (493 amino acids) Download
MRPLCVTCWWLGLLAAMGAVAGQEDGFEGTEEGSPREFIYLNRYKRAGESQDKCTYTFIVPQQRVTGAICVNSKEPEVLLENRVHKQELELLNNELLKQKRQIETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKDLEHKYQHLATLAHNQSEIIAQLEEHCQRVPSARPVPQPPPAAPPRVYQPPTYNRIINQISTNEIQSDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWRDCLQALEDGHDTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q9UKU9-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for ANGPTL2 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance. [34000514]
  • CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2. [33508120]
  • TGF-beta1 aggravates degenerative nucleus pulposus cells inflammation and fibrosis through the upregulation of angiopoietin-like protein 2 expression. [33336720]
  • Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study. [33197687]
  • Angiopoietin-like 2 is a potential biomarker for diabetic foot patients. [33256685]
  • Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy. [17347581]
  • DNA sequence and analysis of human chromosome 9. [15164053]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Identification of a novel human angiopoietin-like gene expressed mainly in heart. [12624729]
  • Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. [10473614]
UniProt Main References (2 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_012098.3)
NM_012098.3
angiopoietin like 2
All isoforms of ANGPTL2 containing a lectin domain
ENST00000373425.8
371..1852 (or 127088939.. 127108731)
127087348.. 127122635
NCBI Matured mRNA sequence 3443 NTPDownload 
m7G-5')ppp(5'-CAAAUGAGGCUGCUGCGGACGGCCUGAGGAUGGACCCCAAGCCCUGGACCUGCCGAGCGUGGCACUGAGGCAGCGGCUGACGCUACUGUGAGGGAAAGAAGGUUGUGAGCAGCCCCGCAGGACCCCUGGCCAGCCCUGGCCCCAGCCUCUGCCGGAGCCCUCUGUGGAGGCAGAGCCAGUGGAGCCCAGUGAGGCAGGGCUGCUUGGCAGCCACCGGCCUGCAACUCAGGAACCCCUCCAGAGGCCAUGGACAGGCUGCCCCGCUGACGGCCAGGGUGAAGCAUGUGAGGAGCCGCCCCGGAGCCAAGCAGGAGGGAAGAGGCUUUCAUAGAUUCUAUUCACAAAGAAUAACCACCAUUUUGCAAGGACCAUGAGGCCACUGUGCGUGACAUGCUGGUGGCUCGGACUGCUGGCUGCCAUGGGAGCUGUUGCAGGCCAGGAGGACGGUUUUGAGGGCACUGAGGAGGGCUCGCCAAGAGAGUUCAUUUACCUAAACAGGUACAAGCGGGCGGGCGAGUCCCAGGACAAGUGCACCUACACCUUCAUUGUGCCCCAGCAGCGGGUCACGGGUGCCAUCUGCGUCAACUCCAAGGAGCCUGAGGUGCUUCUGGAGAACCGAGUGCAUAAGCAGGAGCUAGAGCUGCUCAACAAUGAGCUGCUCAAGCAGAAGCGGCAGAUCGAGACGCUGCAGCAGCUGGUGGAGGUGGACGGCGGCAUUGUGAGCGAGGUGAAGCUGCUGCGCAAGGAGAGCCGCAACAUGAACUCGCGGGUCACGCAGCUCUACAUGCAGCUCCUGCACGAGAUCAUCCGCAAGCGGGACAACGCGUUGGAGCUCUCCCAGCUGGAGAACAGGAUCCUGAACCAGACAGCCGACAUGCUGCAGCUGGCCAGCAAGUACAAGGACCUGGAGCACAAGUACCAGCACCUGGCCACACUGGCCCACAACCAAUCAGAGAUCAUCGCGCAGCUUGAGGAGCACUGCCAGAGGGUGCCCUCGGCCAGGCCCGUCCCCCAGCCACCCCCCGCUGCCCCGCCCCGGGUCUACCAACCACCCACCUACAACCGCAUCAUCAACCAGAUCUCUACCAACGAGAUCCAGAGUGACCAGAACCUGAAGGUGCUGCCACCCCCUCUGCCCACUAUGCCCACUCUCACCAGCCUCCCAUCUUCCACCGACAAGCCGUCGGGCCCAUGGAGAGACUGCCUGCAGGCCCUGGAGGAUGGCCACGACACCAGCUCCAUCUACCUGGUGAAGCCGGAGAACACCAACCGCCUCAUGCAGGUGUGGUGCGACCAGAGACACGACCCCGGGGGCUGGACCGUCAUCCAGAGACGCCUGGAUGGCUCUGUUAACUUCUUCAGGAACUGGGAGACGUACAAGCAAGGGUUUGGGAACAUUGACGGCGAAUACUGGCUGGGCCUGGAGAACAUUUACUGGCUGACGAACCAAGGCAACUACAAACUCCUGGUGACCAUGGAGGACUGGUCCGGCCGCAAAGUCUUUGCAGAAUACGCCAGUUUCCGCCUGGAACCUGAGAGCGAGUAUUAUAAGCUGCGGCUGGGGCGCUACCAUGGCAAUGCGGGUGACUCCUUUACAUGGCACAACGGCAAGCAGUUCACCACCCUGGACAGAGAUCAUGAUGUCUACACAGGAAACUGUGCCCACUACCAGAAGGGAGGCUGGUGGUAUAACGCCUGUGCCCACUCCAACCUCAACGGGGUCUGGUACCGCGGGGGCCAUUACCGGAGCCGCUACCAGGACGGAGUCUACUGGGCUGAGUUCCGAGGAGGCUCUUACUCACUCAAGAAAGUGGUGAUGAUGAUCCGACCGAACCCCAACACCUUCCACUAAGCCAGCUCCCCCUCCUGACCUCUCGUGGCCAUUGCCAGGAGCCCACCCUGGUCACGCUGGCCACAGCACAAAGAACAACUCCUCACCAGUUCAUCCUGAGGCUGGGAGGACCGGGAUGCUGGAUUCUGUUUUCCGAAGUCACUGCAGCGGAUGAUGGAACUGAAUCGAUACGGUGUUUUCUGUCCCUCCUACUUUCCUUCACACCAGACAGCCCCUCAUGUCUCCAGGACAGGACAGGACUACAGACAACUCUUUCUUUAAAUAAAUUAAGUCUCUACAAUAAAAACACAACUGCAAAGUACCUUCAUAAUAUACAUGUGUAUGAGCCUCCCUUGUGCACGUAUGUGUAUACCACAUAUAUAUGCAUUUAGAUAUACAUCACAUGUGAUAUAUCUAGAUCCAUAUAUAGGUUUGCCUUAGAUACCUAAAUACACAUAUAUUCAGUUCUCAGAUGUUGAAGCUGUCACCAGCAGCUUUGCUCUUAGGAGAAAAGCAUUUCAUUAGUGUUGUAUUACUUGAGUCUAAGGGUAGAUCACAGACUGUGUGGUCUCAACUGAAAGGAUCACCCUUGGCAUCUGUGUGCCUGGAUUCUUCCAGAAUGUCUACAAUGCUAAUCUCUCACAUAGAGGUUCCCAGCUUCUUAAGAACCCCUUUUGGCACCUAAUCAAAUUUCAAAAUCCCUCCCCCCACAUUUUCAUACUUUUCCCCAUUCUCAGGACUUUUCACCAUCCAUCACCCACUUAUCCCUUCAUUUGACACCAUUCAUUAAGUGCCUUCUGUGUGUCAGUCCCUGGCCACUCACUGCAGUUCAAGGCCCCCUUUCCGCUCUGCUGUACUCCUCGCCUACCUACUCCUUGCCUUUUCUGUCGCACAGCCCCUUCUUUCCAGGCGAGAUUCCUCAGCUUCUGAGUAGGAAACACUCCGGGCUCCAGGUUUCUGGUUGGGAAGGGAAGGCCAGGCCAAAAGCUCCACCGGCCGUAUAGAUAAUGUACUCGCAGUUUUGUAUCUUCCAUUCAUACUUUAACCUACAGGUCAUUUGAGUCUUCACACAAAUAAUAACCUAUCUGGCCAGGAGAAUUAUCUCAGAACAGAAGUCAUCAGAUCAUCAGAGCCCCCAGAUGGCUACAGACCAGAGAUUCCACGCUCUCAGGCUGACUAGAGUCCGCAUCUCAUCUCCAAACUACACUUCCCUGGAGAACAAGUGCCACAAAAAUGAAAACAGGCCACUUCUCAGGAGUUGAAUAAUCAGGGGUCACCGGACCCCUUGGUUGAUGCACUGCAGCAUGGUGGCUUUCUGAGUCCUGUUGGCCACCAAGUGUCAGCCUCAGCACUCCCGGGACUAUUGCCAAGAAGGGGCAAGGGAUGAGUCAAGAAGGUGAGACCCUUCCCGGUGGGCACGUGGGCCAGGCUGUGUGAGAUGUUGGAUGUUUGGUACUGUCCAUGUCUGGGUGUGUGCCUAUUACCUCAGCAUUUCUCACAAAGUGUACCAUGUAGCAUGUUUUGUGUAUAUAAAAGGGAGGGUUUUUUUAAAAAUAUAUUCCCAGAUUAUCCUUGUAAUGACACGAAUCUGCAAUAAAAGCCAUCAGUGCUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 23452)
ANGPTL2
angiopoietin like 2
NC_000009.12
9  127088939.. 127108731
127088939.. 127108731
strand -
CCDS6868.1
MGI:1347002
ClinVar, dbVar
ENSG00000136859
ARP2, HARP
uc004bqr.2
INSDC: AF125175
490
605001
OTTHUMG00000020695
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1482 bp)
5'-ATGAGGCCACTGTGCGTGACATGCTGGTGGCTCGGACTGCTGGCTGCCATGGGAGCTGTTGCAGGCCAGGAGGACGGTTTTGAGGGCACTGAGGAGGGCTCGCCAAGAGAGTTCATTTACCTAAACAGGTACAAGCGGGCGGGCGAGTCCCAGGACAAGTGCACCTACACCTTCATTGTGCCCCAGCAGCGGGTCACGGGTGCCATCTGCGTCAACTCCAAGGAGCCTGAGGTGCTTCTGGAGAACCGAGTGCATAAGCAGGAGCTAGAGCTGCTCAACAATGAGCTGCTCAAGCAGAAGCGGCAGATCGAGACGCTGCAGCAGCTGGTGGAGGTGGACGGCGGCATTGTGAGCGAGGTGAAGCTGCTGCGCAAGGAGAGCCGCAACATGAACTCGCGGGTCACGCAGCTCTACATGCAGCTCCTGCACGAGATCATCCGCAAGCGGGACAACGCGTTGGAGCTCTCCCAGCTGGAGAACAGGATCCTGAACCAGACAGCCGACATGCTGCAGCTGGCCAGCAAGTACAAGGACCTGGAGCACAAGTACCAGCACCTGGCCACACTGGCCCACAACCAATCAGAGATCATCGCGCAGCTTGAGGAGCACTGCCAGAGGGTGCCCTCGGCCAGGCCCGTCCCCCAGCCACCCCCCGCTGCCCCGCCCCGGGTCTACCAACCACCCACCTACAACCGCATCATCAACCAGATCTCTACCAACGAGATCCAGAGTGACCAGAACCTGAAGGTGCTGCCACCCCCTCTGCCCACTATGCCCACTCTCACCAGCCTCCCATCTTCCACCGACAAGCCGTCGGGCCCATGGAGAGACTGCCTGCAGGCCCTGGAGGATGGCCACGACACCAGCTCCATCTACCTGGTGAAGCCGGAGAACACCAACCGCCTCATGCAGGTGTGGTGCGACCAGAGACACGACCCCGGGGGCTGGACCGTCATCCAGAGACGCCTGGATGGCTCTGTTAACTTCTTCAGGAACTGGGAGACGTACAAGCAAGGGTTTGGGAACATTGACGGCGAATACTGGCTGGGCCTGGAGAACATTTACTGGCTGACGAACCAAGGCAACTACAAACTCCTGGTGACCATGGAGGACTGGTCCGGCCGCAAAGTCTTTGCAGAATACGCCAGTTTCCGCCTGGAACCTGAGAGCGAGTATTATAAGCTGCGGCTGGGGCGCTACCATGGCAATGCGGGTGACTCCTTTACATGGCACAACGGCAAGCAGTTCACCACCCTGGACAGAGATCATGATGTCTACACAGGAAACTGTGCCCACTACCAGAAGGGAGGCTGGTGGTATAACGCCTGTGCCCACTCCAACCTCAACGGGGTCTGGTACCGCGGGGGCCATTACCGGAGCCGCTACCAGGACGGAGTCTACTGGGCTGAGTTCCGAGGAGGCTCTTACTCACTCAAGAAAGTGGTGATGATGATCCGACCGAACCCCAACACCTTCCACTAA-3'
NCBI CDS gene sequence with introns (location: 127088939.. 127108731) (19793 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 127087348.. 127122635) (35288 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [127087348.. 127122635 + 1000]) (36288 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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