NCBI Summary
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_006673)
Fibroleukin
Fibroleukin (Fibrinogen-like protein 2) (pT49)
FGL2
fibrinogen like 2
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
MKLANWYWLSSAVLATYGFLVVANNETEEIKDERAKDVCPVRLESRGKCEEAGECPYQVSLPPLTIQLPKQFSRIEEVFKEVQNLKEIVNSLKKSCQDCKLQADDNGDPGRNGLLLPSTGAPGEVGDNRVRELESEVNKLSSELKNAKEEINVLHGRLEKLNLVNMNNIENYVDSKVANLTFVVNSLDGKCSKCPSQEQIQSRPVQHLIYKDCSDYYAIGKRSSETYRVTPDPKNSSFEVYCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRREFWLGNDKIHLLTKSKEMILRIDLEDFNGVELYALYDQFYVANEFLKYRLHVGNYNGTAGDALRFNKHYNHDLKFFTTPDKDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQKYRGVRNGIFWGTWPGVSEAHPGGYKSSFKEAKMMIRPKHFKP
No structure currently available in the PDB RCSB Databank.
Structural models
SWISS-MODEL structural models
The location of the lectin domain structural model is: 204-436
We infer [1.41, 1.76] Å as the interval of error of this structural model.
Template 1: 6ZQX chain: A, Q8N539, NP_116232.3, sequence identity: 38.6%, coverage: 91.8%, location in sequence: 239-457, (239-457 in PDB).
Template 2: 2JHK chain: F, O00602, NP_001994.2, sequence identity: 37.8%, coverage: 93.1%, location in sequence: 110-326, (81-297 in PDB).
Template 3: 2J3U chain: B, Q15485, NP_004099.2, sequence identity: 37.3%, coverage: 93.1%, location in sequence: 96-313, (71-288 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
We infer [1.41, 1.76] Å as the interval of error of this structural model.
Template 1: 6ZQX chain: A, Q8N539, NP_116232.3, sequence identity: 38.6%, coverage: 91.8%, location in sequence: 239-457, (239-457 in PDB).
Template 2: 2JHK chain: F, O00602, NP_001994.2, sequence identity: 37.8%, coverage: 93.1%, location in sequence: 110-326, (81-297 in PDB).
Template 3: 2J3U chain: B, Q15485, NP_004099.2, sequence identity: 37.3%, coverage: 93.1%, location in sequence: 96-313, (71-288 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Oligomerization and Known Interactions
Homotetramer; disulfide-linked
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Soluble fibrinogen-like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function. [34109427]
- Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population. [34154648]
- Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu. [33893391]
- Dabigatran activates inflammation resolution by promoting fibrinogen-like protein 2 shedding and RvD5n-3 DPA production. [33754059]
- Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma. [33323552]
- Identification of a novel human angiopoietin-like gene expressed mainly in heart. [12624729]
- Genomic characterization, localization, and functional expression of FGL2, the human gene encoding fibroleukin: a novel human procoagulant. [11170750]
- Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. [9647217]
- Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. [7642106]
- Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. [1602151]
UniProt Main References (3 PubMed Identifiers)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]
RNA
RNA (Transcript ID: NM_006682.3)
m7G-5')ppp(5'-CUGCUGGGGUGAGCAGCACUGUAAAGAUGAAGCUGGCUAACUGGUACUGGCUGAGCUCAGCUGUUCUUGCCACUUACGGUUUUUUGGUUGUGGCAAACAAUGAAACAGAGGAAAUUAAAGAUGAAAGAGCAAAGGAUGUCUGCCCAGUGAGACUAGAAAGCAGAGGGAAAUGCGAAGAGGCAGGGGAGUGCCCCUACCAGGUAAGCCUGCCCCCCUUGACUAUUCAGCUCCCGAAGCAAUUCAGCAGGAUCGAGGAGGUGUUCAAAGAAGUCCAAAACCUCAAGGAAAUCGUAAAUAGUCUAAAGAAAUCUUGCCAAGACUGCAAGCUGCAGGCUGAUGACAACGGAGACCCAGGCAGAAACGGACUGUUGUUACCCAGUACAGGAGCCCCGGGAGAGGUUGGUGAUAACAGAGUUAGAGAAUUAGAGAGUGAGGUUAACAAGCUGUCCUCUGAGCUAAAGAAUGCCAAAGAGGAGAUCAAUGUACUUCAUGGUCGCCUGGAGAAGCUGAAUCUUGUAAAUAUGAACAACAUAGAAAAUUAUGUUGACAGCAAAGUGGCAAAUCUAACAUUUGUUGUCAAUAGUUUGGAUGGCAAAUGUUCAAAGUGUCCCAGCCAAGAACAAAUACAGUCACGUCCAGUUCAACAUCUAAUAUAUAAAGAUUGCUCUGACUACUACGCAAUAGGCAAAAGAAGCAGUGAGACCUACAGAGUUACACCUGAUCCCAAAAAUAGUAGCUUUGAAGUUUACUGUGACAUGGAGACCAUGGGGGGAGGCUGGACAGUGCUGCAGGCACGUCUCGAUGGGAGCACCAACUUCACCAGAACAUGGCAAGACUACAAAGCAGGCUUUGGAAACCUCAGAAGGGAAUUUUGGCUGGGGAACGAUAAAAUUCAUCUUCUGACCAAGAGUAAGGAAAUGAUUCUGAGAAUAGAUCUUGAAGACUUUAAUGGUGUCGAACUAUAUGCCUUGUAUGAUCAGUUUUAUGUGGCUAAUGAGUUUCUCAAAUAUCGUUUACACGUUGGUAACUAUAAUGGCACAGCUGGAGAUGCAUUACGUUUCAACAAACAUUACAACCACGAUCUGAAGUUUUUCACCACUCCAGAUAAAGACAAUGAUCGAUAUCCUUCUGGGAACUGUGGGCUGUACUACAGUUCAGGCUGGUGGUUUGAUGCAUGUCUUUCUGCAAACUUAAAUGGCAAAUAUUAUCACCAAAAAUACAGAGGUGUCCGUAAUGGGAUUUUCUGGGGUACCUGGCCUGGUGUAAGUGAGGCACACCCUGGUGGCUACAAGUCCUCCUUCAAAGAGGCUAAGAUGAUGAUCAGACCCAAGCACUUUAAGCCAUAAAUCACUCUGUUCAUUCCUCCAGGUAUUCGUUAUCUAAUAGGGCAAUUAAUUCCUUCAGCACUUUAGAAUAUGCCUUGUUUCAUAUUUUUCAUAGCUAAAAAAUGAUGUCUGACGGCUAGGUUCUUAUGCUACACAGCAUUUGAAAUAAAGCUGAAAAACAAUGCAUUUUAAAGGAGUCCUUUGUUGUUAUGCUGUUAUCCAAUGAACACUUGCAAGCAAUUAGCAAUAUUGAGAAUUAUACAUUAGAUUUACAAUUCUUUUAAUUUCUAUUGAAACUUUUUCUAUUGCUUGUAUUACUUGCUGUAUUUAAAAAAUAAUUGUUGGCUGGGUGUGGUAGCUCACGCCUGUAAUCCCAGCACUUUGGAAUGUCAAGGCAGGCAGAUCACUUGAGGUCAGGAGUUUGAGACCAGCCUGGCCAAACAUGUGAAACGCUGUCUCUAUUAAAAAUACAAAAAUUAGCCGGGCAUGGUGGUACAUGCCUGUAAUCCUAGCUACUUGGGAGGCUGAGGCAGGAGAAUCGCUUGAACCUGAGAGGAAGAGGUUGCAGUGAGCCAAGACUGAGCCACUGCACUCCAGCAUGGGUGACAGAGAAAACUCUGUCUCAAACAAAAAAAUAAUAAAAUUUAUUCAGUAGGCUGGAUUCUACACAAAGUAAUCUGUAUUUGGGCCAUGAUUUAAGCACAUCUGAAGGUAUAUCACUCUUUUCAGGCUAUAAUUAUUUGGGUAAUCUUCAUUCUGAGACAAACUUAAUCUAUAUCAUUUACUUUGCAACAGAACAACCCUACAGCAUUUUGGUUCCCAGACUAAGGGAACUAAUAUCUAUAUAAUUAAACUUGUUCAUUUAUCAUUCAUGAAAUAUAAAAUACUUGUCAUUUAAACCGUUUAAAAAUGUGGUAGCAUAAUGUCACCCCAAAAAGCAUUCAGAAAGCAAUGUAACUGUGAAGACCAGGGUUUAAAGGUAAUUCAUUUAUAGUUUAUAACUCCUUAGAUGUUUGAUGUUGAAAACUGCUUUAACAUGAAAAUUAUCUUCCUCUGCUCUGUGUGAACAAUAGCUUUUAAUUUAAGAUUGCUCACUACUGUACUAGACUACUGGUAGGUUUUUUUGGGGGGGGUGGGUAGGGAUAUGUGGGUAAUGAAGCAUUUACUUACAGGCUAUCAUACUCUGAGGCCAAUUUUAUCUCCAAAGCAAUAAUAUCAUUAAGUGAUUCACUUCAUAGAAGGCUAAGUUUCUCUAGGACAGAUAGAAAACAUGAAUUUUGAAAUAUAUAGAACAGUAGUUAAAAUACUAUAUAUUUCAACCCUGGCUGGUAGAUUGCUUAUUUUACUAUCAGAAACUAAAAGAUAGAUUUUUACCCAAACAGAAGUAUCUGUAAUUUUUAUAAUUCAUCAAUUCUGGAAUGCUAUAUAUAAUAUUUAAAAGACUUUUUAAAUGUGUUUAAUUUCAUCAUCGUAAAAAGGGAUCAUCUCAGAGAGAACAGCAGUAUUCUGCGUAUUUUUAAAAAUGCUCUAGAGUAACAUUUGAAGUAAUUCACUGUAGUGUAUGCCAGUCCUAGAAAUAAUUUUUUUAAUUUCUGGUGUCUGUUUCUAAUACACUAACCAAGUUUUCAAAAUAUAUUUACAAAGAUGCAUCUUUACCCAUUAUUUUAAAAUGAUUAAGGAGGAUAGUUGCUUCAGGUAACAAGCUAAUUUUUCAAAUAUUAGGCCCUUACAGAACUAUUUAGUCAAAAAGUAAGAUAUUCCUUUAAAAUAUAUAACCCAAAGCUUUCAGUUAAACAUGAUAUAUCACAAAUACUAUUAAAAUGUUAAAGAGAAAUGCAAAUAGCAUUAAAUGAUGACCAAAAUGUAAAAUAUUGUAGAUUUCAAAAGCUGUGUCUCUAUUAGGUGGGAUACCAAAUGUAAAUGAUGUAACUGACGUUGUUUUUUACUUUUUACUUUUUAAAAAAGACUAAAAACGUUUUGAUAUUAUACAAUGUAUUUGUUUCAGAUAAGGUCAUUGUCAUUUAGUAUAUAUAAUUAAUAUAUGUACAAGUUUAAGUAAAUUCCUGUGAGUAAAAAUGGACUUAUCACAAAACAUAGUUCUAAAGAAAGGUAUAUGCUCAUAUACACGGUGUCCAUUAAUUUAAUGGGAACUAGGUAUAACUUCAGGAGAAUUUGGCAAAUAAUUCAUUAAUCCAUGUAAAUAUUCAAAAGCUUGUUCUAUCCACAUUAUUUCAAGGGAUCACUUUAUUUUUCAUUAUACUUUCACAGCACUUUUCUAGUAAAUUCUGUAACACAGAAAUUCCAUUUUGGAAUCAUUUCAUGUUACCAAUAAUUCUAGACUUUUAUAACAUUUAACAUGUUGAUGGAAAUAGAUUACAUCUGCUAGAACCUUUUGCCUUAACUAUUCACCAAUAUAUGCUAAUAUUCAUAAAUAUGGAUUGACUGUUUACAAACAUUAGAAUCUUGUCUUGGUUCCAUUUUGAUGGCUAAUAUUUGUUAUCUUAAUUAAGACUAUUUCUGAGGUCAUGAUUACUUGAAAAUAUUGACUAAAACUGGGUCCUUAGAAAUUCCAGGUGGAGCUGAUUUACCUAUGACUGAGGGGAAAAAAAAAUCAAAUUUUACUGAUAAUAGUAAUGCUCCAAAUGAAUUAAUGACACAUCUGUUCAAUAAAUAAAGAGCUUAAAUAUACAAAACAUAAGAAAUCUGGGCAACAAAACUUGUGGUCUUUACUUUUGAAUAGCUACCCAAGAAAAGGUUUUAAAGGUAAAAGUUAUGAGUAAUGUCAUCACAAUAAGCUCUUGUUUAAAAUUCUUUUCUUUUAUGUAUAAUUAGGUUUAUGUUUCAUGUCUUUUUAAAACCUUAUAAAAGAUUUAAUUAUCACAUCUAUUCUUCAAUGUGGAAAUAUUAAAUAUUGUUGGUUGUAAAAUAAUA-3'- Poly-A tail - Coding region
DNA
DNA (Gene ID: 10875)
fibrinogen like 2
strand -
pT49, T49
NCBI CDS gene sequence (1320 bp)
5'-ATGAAGCTGGCTAACTGGTACTGGCTGAGCTCAGCTGTTCTTGCCACTTACGGTTTTTTGGTTGTGGCAAACAATGAAACAGAGGAAATTAAAGATGAAAGAGCAAAGGATGTCTGCCCAGTGAGACTAGAAAGCAGAGGGAAATGCGAAGAGGCAGGGGAGTGCCCCTACCAGGTAAGCCTGCCCCCCTTGACTATTCAGCTCCCGAAGCAATTCAGCAGGATCGAGGAGGTGTTCAAAGAAGTCCAAAACCTCAAGGAAATCGTAAATAGTCTAAAGAAATCTTGCCAAGACTGCAAGCTGCAGGCTGATGACAACGGAGACCCAGGCAGAAACGGACTGTTGTTACCCAGTACAGGAGCCCCGGGAGAGGTTGGTGATAACAGAGTTAGAGAATTAGAGAGTGAGGTTAACAAGCTGTCCTCTGAGCTAAAGAATGCCAAAGAGGAGATCAATGTACTTCATGGTCGCCTGGAGAAGCTGAATCTTGTAAATATGAACAACATAGAAAATTATGTTGACAGCAAAGTGGCAAATCTAACATTTGTTGTCAATAGTTTGGATGGCAAATGTTCAAAGTGTCCCAGCCAAGAACAAATACAGTCACGTCCAGTTCAACATCTAATATATAAAGATTGCTCTGACTACTACGCAATAGGCAAAAGAAGCAGTGAGACCTACAGAGTTACACCTGATCCCAAAAATAGTAGCTTTGAAGTTTACTGTGACATGGAGACCATGGGGGGAGGCTGGACAGTGCTGCAGGCACGTCTCGATGGGAGCACCAACTTCACCAGAACATGGCAAGACTACAAAGCAGGCTTTGGAAACCTCAGAAGGGAATTTTGGCTGGGGAACGATAAAATTCATCTTCTGACCAAGAGTAAGGAAATGATTCTGAGAATAGATCTTGAAGACTTTAATGGTGTCGAACTATATGCCTTGTATGATCAGTTTTATGTGGCTAATGAGTTTCTCAAATATCGTTTACACGTTGGTAACTATAATGGCACAGCTGGAGATGCATTACGTTTCAACAAACATTACAACCACGATCTGAAGTTTTTCACCACTCCAGATAAAGACAATGATCGATATCCTTCTGGGAACTGTGGGCTGTACTACAGTTCAGGCTGGTGGTTTGATGCATGTCTTTCTGCAAACTTAAATGGCAAATATTATCACCAAAAATACAGAGGTGTCCGTAATGGGATTTTCTGGGGTACCTGGCCTGGTGTAAGTGAGGCACACCCTGGTGGCTACAAGTCCTCCTTCAAAGAGGCTAAGATGATGATCAGACCCAAGCACTTTAAGCCATAA-3'
By using this site you agree to our privacy policy.
Please confirm you agree with the privacy policy before using the site.
How to cite
