Protein
Protein (NP_001245319)
Layilin
Layilin
LAYN
layilin
Undefined
Curated
C-type lectin
Undefined
C-type - Type I receptors
a/b mixed / C-type lectin-like
Hyaluronan
NP_001245319
143903
Q6UX15
Undefined
Q6UX15
0.31
10.1091/mbc.12.4.891
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (382 amino acids) Download
MRPGTALQAVLLAVLLVGLRAATGRLLSASDLDLRGGQPVCRGGTQRPCYKVIYFHDTSRRLNFEEAKEACRRDGGQLVSIESEDEQKLIEKFIENLLPSDGDFWIGLRRREEKQSNSTACQDLYAWTDGSISQFRNWYVDEPSCGSEVCVVMYHQPSAPAGIGGPYMFQWNDDRCNMKNNFICKYSDEKPAVPSREAEGEETELTTPVLPEETQEEDAKKTFKESREAALNLAYILIPSIPLLLLLVVTTVVCWVWICRKRKREQPDPSTKKQHTIWPSPHQGNSPDLEVYNVIRKQSEADLAETRPDLKNISFRVCSGEATPDDMSCDYDNMAVNPSESGFVTLVSVESGFVTNDIYEFSPDQMGRSKESGWVENEIYGY
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q6UX15-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.55, 1.99] ÅDownload
The location of the lectin domain structural model is: 45-190
We infer [1.55, 1.99] Å as the interval of error of this structural model.
Template 1: 2OX9 chain: A, Q8K4Q8, NP_569716.2, sequence identity: 28.8%, coverage: 83.6%, location in sequence: 606-735, (606-735 in PDB).
Template 2: 2OX8 chain: A, Q5KU26, NP_569057.2, sequence identity: 26.0%, coverage: 82.9%, location in sequence: 606-734, (606-734 in PDB).
Template 3: 7L67 chain: A, P22897, NP_002429.1, sequence identity: 25.3%, coverage: 82.9%, location in sequence: 659-779, (641-761 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LAYN Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells. [33676182]
  • Layilin augments integrin activation to promote antitumor immunity. [32539073]
  • LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers. [30761122]
  • Roles of layilin in TNF-alpha-induced epithelial-mesenchymal transformation of renal tubular epithelial cells. [26410531]
  • Secretion of inflammatory factors from chondrocytes by layilin signaling. [25150153]
  • Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin. [23048036]
  • Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for beta-Pix in negative regulation of focal adhesion maturation. [21423176]
  • Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. [15913605]
  • Layilin, a novel integral membrane protein, is a hyaluronan receptor. [11294894]
  • Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. [9786953]
UniProt Main References (4 PubMed Identifiers)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • Human chromosome 11 DNA sequence and analysis including novel gene identification. [16554811]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_849156.1, NP_001245319.1, NP_001305728.1, XP_006718832.1
RNA
RNA (Transcript ID: NM_001258390.2)
NM_001258390.2
layilin, transcript variant 1
All isoforms of LAYN containing a lectin domain
125..1273 (or 111540844.. 111560458)
111540720.. 111561745
NCBI Matured mRNA sequence 2560 NTPDownload 
m7G-5')ppp(5'-GUGCGGUCCGUCGGUGGCCUAGAGAUGCUGCUGCCGCGGUUGCAGUUGUCGCGCACGCCUCUGCCCGCCAGCCCGCUCCACCGCCGUAGCGCCCGAGUGUCGGGGGGCGCACCCGAGUCGGGCCAUGAGGCCGGGAACCGCGCUACAGGCCGUGCUGCUGGCCGUGCUGCUGGUGGGGCUGCGGGCCGCGACGGGUCGCCUGCUGAGUGCCUCGGAUUUGGACCUCAGAGGAGGGCAGCCAGUCUGCCGGGGAGGGACACAGAGGCCUUGUUAUAAAGUCAUUUACUUCCAUGAUACUUCUCGAAGACUGAACUUUGAGGAAGCCAAAGAAGCCUGCAGGAGGGAUGGAGGCCAGCUAGUCAGCAUCGAGUCUGAAGAUGAACAGAAACUGAUAGAAAAGUUCAUUGAAAACCUCUUGCCAUCUGAUGGUGACUUCUGGAUUGGGCUCAGGAGGCGUGAGGAGAAACAAAGCAAUAGCACAGCCUGCCAGGACCUUUAUGCUUGGACUGAUGGCAGCAUAUCACAAUUUAGGAACUGGUAUGUGGAUGAGCCAUCCUGCGGCAGCGAGGUCUGCGUGGUCAUGUACCAUCAGCCAUCGGCACCCGCUGGCAUCGGAGGCCCCUACAUGUUCCAGUGGAAUGAUGACCGGUGCAACAUGAAGAACAAUUUCAUUUGCAAAUAUUCUGAUGAGAAACCAGCAGUUCCUUCUAGAGAAGCUGAAGGUGAGGAAACAGAGCUGACAACACCUGUACUUCCAGAAGAAACACAGGAAGAAGAUGCCAAAAAAACAUUUAAAGAAAGUAGAGAAGCUGCCUUGAAUCUGGCCUACAUCCUAAUCCCCAGCAUUCCCCUUCUCCUCCUCCUUGUGGUCACCACAGUUGUAUGUUGGGUUUGGAUCUGUAGAAAAAGAAAACGGGAGCAGCCAGACCCUAGCACAAAGAAGCAACACACCAUCUGGCCCUCUCCUCACCAGGGAAACAGCCCGGACCUAGAGGUCUACAAUGUCAUAAGAAAACAAAGCGAAGCUGACUUAGCUGAGACCCGGCCAGACCUGAAGAAUAUUUCAUUCCGAGUGUGUUCGGGAGAAGCCACUCCCGAUGACAUGUCUUGUGACUAUGACAACAUGGCUGUGAACCCAUCAGAAAGUGGGUUUGUGACUCUGGUGAGCGUGGAGAGUGGAUUUGUGACCAAUGACAUUUAUGAGUUCUCCCCAGACCAAAUGGGGAGGAGUAAGGAGUCUGGAUGGGUGGAAAAUGAAAUAUAUGGUUAUUAGGACAUAUAAAAAACUGAAACUGACAACAAUGGAAAAGAAAUGAUAAGCAAAAUCCUCUUAUUUUCUAUAAGGAAAAUACACAGAAGGUCUAUGAACAAGCUUAGAUCAGGUCCUGUGGAUGAGCAUGUGGUCCCCACGACCUCCUGUUGGACCCCCACGUUUUGGCUGUAUCCUUUAUCCCAGCCAGUCAUCCAGCUCGACCUUAUGAGAAGGUACCUUGCCCAGGUCUGGCACAUAGUAGAGUCUCAAUAAAUGUCACUUGGUUGGUUGUAUCUAACUUUUAAGGGACAGAGCUUUACCUGGCAGUGAUAAAGAUGGGCUGUGGAGCUUGGAAAACCACCUCUGUUUUCCUUGCUCUAUACAGCAGCACAUAUUAUCAUACAGACAGAAAAUCCAGAAUCUUUUCAAAGCCCACAUAUGGUAGCACAGGCUGGCCUGUGCAUCGGCAAUUCUCAUAUCUGUUUUUUUCAAAGAAUAAUAAAAUCAAAUAAAGAGCAGGAAACAGAGUGUUAGUCUGUGUCUACAGCCCUUCCUCUGCAUGUGGCCACAGGGGACCUUUUUUUGUUUCUCCUGACAUCCAGACUUGGAAAUAUCUAACUACUUGCAAAACUAAAAAUGAGGCCAGGCGCAGUGGCUGACGCCUGUAAUCCCAGAACCUUGGGAGACCAAGAUUGGAGGAUAGCUUGAGUUCAGGAGUUCCAGACCUUCCUGGGCAAAAUAGUGAGACUCUGACUCUACAAAAAAUUUAAAAAUUAGCAGGGCAUGGUGGCAUGCGCCUGCAGUCCCAGCUACUCAGGAGGCCGAGGUGGGGGAAUUGCUUGAGCCCAGGAGGUUGAGGCUGCAGUGAGCUAGGAUCACGCCACUGCUCUCCUGCGUGGGCAACAGAAUGAGACCCUGUCUCUAAACAAAAAUAUUUUUUAAAGAAACUAAAAAUGAAAUUUGAGUCUCAGCUUCUAGGCUUAUGUACUCCCAUCCCUGAUACUACACGUUGUUCUGUUUGCAUGUUUGUUACUGCAGCAUCAACAUAACAUGACUAAUAAUGAUGACAGUUCUACCUUUUGUUGACAGACCUCAUUGUUUCAAUUGUGUUUGGCCUCAAAUUCAGAGAAAAGUUUCUCAGCCCAGCAUCAAUCAUAUACACAUUGGAGGUCUGAAAGCCAUUAUUUAAAUCACCAGCAAUUUCCCUCAAUCAGCUUCAUAAUCUCAUAUUUUAACCUUUCCUCAUAUGUCUUAUUUUUUAAUAGCUCAGCAACUUUGCUUCACAUAUGGAGCCCCAACCUCUAGAGU-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 143903)
LAYN
layilin
NC_000011.10
11  111540844.. 111560458
111540844.. 111560458
strand +
CCDS58178.1
MGI:2685357
ClinVar, dbVar
ENSG00000204381
FLJ30977, FLJ31092
uc001plp.3
INSDC:
29471
618843
OTTHUMG00000166721
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1149 bp)
5'-ATGAGGCCGGGAACCGCGCTACAGGCCGTGCTGCTGGCCGTGCTGCTGGTGGGGCTGCGGGCCGCGACGGGTCGCCTGCTGAGTGCCTCGGATTTGGACCTCAGAGGAGGGCAGCCAGTCTGCCGGGGAGGGACACAGAGGCCTTGTTATAAAGTCATTTACTTCCATGATACTTCTCGAAGACTGAACTTTGAGGAAGCCAAAGAAGCCTGCAGGAGGGATGGAGGCCAGCTAGTCAGCATCGAGTCTGAAGATGAACAGAAACTGATAGAAAAGTTCATTGAAAACCTCTTGCCATCTGATGGTGACTTCTGGATTGGGCTCAGGAGGCGTGAGGAGAAACAAAGCAATAGCACAGCCTGCCAGGACCTTTATGCTTGGACTGATGGCAGCATATCACAATTTAGGAACTGGTATGTGGATGAGCCATCCTGCGGCAGCGAGGTCTGCGTGGTCATGTACCATCAGCCATCGGCACCCGCTGGCATCGGAGGCCCCTACATGTTCCAGTGGAATGATGACCGGTGCAACATGAAGAACAATTTCATTTGCAAATATTCTGATGAGAAACCAGCAGTTCCTTCTAGAGAAGCTGAAGGTGAGGAAACAGAGCTGACAACACCTGTACTTCCAGAAGAAACACAGGAAGAAGATGCCAAAAAAACATTTAAAGAAAGTAGAGAAGCTGCCTTGAATCTGGCCTACATCCTAATCCCCAGCATTCCCCTTCTCCTCCTCCTTGTGGTCACCACAGTTGTATGTTGGGTTTGGATCTGTAGAAAAAGAAAACGGGAGCAGCCAGACCCTAGCACAAAGAAGCAACACACCATCTGGCCCTCTCCTCACCAGGGAAACAGCCCGGACCTAGAGGTCTACAATGTCATAAGAAAACAAAGCGAAGCTGACTTAGCTGAGACCCGGCCAGACCTGAAGAATATTTCATTCCGAGTGTGTTCGGGAGAAGCCACTCCCGATGACATGTCTTGTGACTATGACAACATGGCTGTGAACCCATCAGAAAGTGGGTTTGTGACTCTGGTGAGCGTGGAGAGTGGATTTGTGACCAATGACATTTATGAGTTCTCCCCAGACCAAATGGGGAGGAGTAAGGAGTCTGGATGGGTGGAAAATGAAATATATGGTTATTAG-3'
NCBI CDS gene sequence with introns (location: 111540844.. 111560458) (19615 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 111540720.. 111561745) (21026 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [111540720 - 1000].. 111561745) (22026 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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