HumanLectome - Human Lectin Entry

NCBI Summary

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020].

Protein name

Fibrinogen beta chain

Synonym(s)

Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

HGNC gene name

FGB

HGNC name

fibrinogen beta chain

Protein_CD_name

Undefined

Lectin confidence

Very low evidence

UniLectin class

Ficolin-like

Known lectin group

Undefined

Lectin fold

a/b mixed with b-sheet / Fibrinogen C-ter like

Glycan specificity

Uncharacterised

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.543

Reference

Undefined

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (491 amino acids) Download

MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P02675-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for FGB Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Identification of a novel mutation in congenital afibrinogenemia in Iranian patients. [33901106]

Identification and characterization of novel mutations in Chinese patients with congenital fibrinogen disorders. [32877852]

A Novel Amino Acid Substitution, Fibrinogen Bbetap.Pro234Leu, Associated with Hypofibrinogenemia Causing Impairment of Fibrinogen Assembly and Secretion. [33322044]

Genetic Variants in the FGB and FGG Genes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype. [32610551]

Antimicrobial activity of fibrinogen and fibrinogen-derived peptides--a novel link between coagulation and innate immunity. [23467586]

Fibrinogen and fibrin. [6383194]

Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen. [6688356]

[Temperature-dependent changes in the profile of the sarcoplasmic reticulum membrane hydrophobic zones]. [156564]

Amino acid sequence of the beta chain of human fibrinogen. [420779]

Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments. [891553]

UniProt Main References (29 PubMed Identifiers)

Nucleotide sequences of the three genes coding for human fibrinogen. [2102623]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Cloning of fibrinogen genes and their cDNA. [6575700]

Characterization of the 5'-flanking region for the human fibrinogen beta gene. [3029722]

Disulfide bridges in nh2 -terminal part of human fibrinogen. [936108]

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. [12665801]

Covalent structure of fibrinogen. [6575689]

The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis. [7642629]

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]

A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule. [2143188]

Initial characterization of the human central proteome. [21269460]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]

Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin. [9333233]

Crystal structure of fragment double-D from human fibrin with two different bound ligands. [9628725]

Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide. [10074346]

Crystal structure of human fibrinogen. [19296670]

A polymorphism at B beta 448 of fibrinogen identified during structural studies of fibrinogen Baltimore II. [3194892]

A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine. [2018836]

Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr. [1634610]

Abnormal fibrinogens IJmuiden (B beta Arg14----Cys) and Nijmegen (B beta Arg44----Cys) form disulfide-linked fibrinogen-albumin complexes. [1565641]

Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene. [3156856]

Characterization of single-nucleotide polymorphisms in coding regions of human genes. [10391209]

Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion. [10666208]

The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers. [11468164]

Missense or splicing mutation? The case of a fibrinogen Bbeta-chain mutation causing severe hypofibrinogenemia. [15070683]

Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency. [25427968]

All isoforms of this gene containing a lectin domain

NP_001171670.1, NP_001369688.1, NP_005132.2, NP_001369694.1, NP_001369692.1, NP_001369689.1, NP_001369690.1, NP_001369693.1, NP_001369691.1

RNA

RNA (Transcript ID: NM_005141.5)

RNA RefSeq ID

NM_005141.5

RNA name

fibrinogen beta chain, transcript variant 1

Isoforms

All isoforms of FGB containing a lectin domain

RNA Ensembl ID

ENST00000302068.9

Coding region

9..1484 (or 154563019.. 154570650)

mRNA location

154563011.. 154572807

NCBI Matured mRNA sequence 3641 NTP Download

m⁷G-5')ppp(5'-AAGUCUACAUGAAAAGGAUGGUUUCUUGGAGCUUCCACAAACUUAAAACCAUGAAACAUCUAUUAUUGCUACUAUUGUGUGUUUUUCUAGUUAAGUCCCAAGGUGUCAACGACAAUGAGGAGGGUUUCUUCAGUGCCCGUGGUCAUCGACCCCUUGACAAGAAGAGAGAAGAGGCUCCCAGCCUGAGGCCUGCCCCACCGCCCAUCAGUGGAGGUGGCUAUCGGGCUCGUCCAGCCAAAGCAGCUGCCACUCAAAAGAAAGUAGAAAGAAAAGCCCCUGAUGCUGGAGGCUGUCUUCACGCUGACCCAGACCUGGGGGUGUUGUGUCCUACAGGAUGUCAGUUGCAAGAGGCUUUGCUACAACAGGAAAGGCCAAUCAGAAAUAGUGUUGAUGAGUUAAAUAACAAUGUGGAAGCUGUUUCCCAGACCUCCUCUUCUUCCUUUCAGUACAUGUAUUUGCUGAAAGACCUGUGGCAAAAGAGGCAGAAGCAAGUAAAAGAUAAUGAAAAUGUAGUCAAUGAGUACUCCUCAGAACUGGAAAAGCACCAAUUAUAUAUAGAUGAGACUGUGAAUAGCAAUAUCCCAACUAACCUUCGUGUGCUUCGUUCAAUCCUGGAAAACCUGAGAAGCAAAAUACAAAAGUUAGAAUCUGAUGUCUCAGCUCAAAUGGAAUAUUGUCGCACCCCAUGCACUGUCAGUUGCAAUAUUCCUGUGGUGUCUGGCAAAGAAUGUGAGGAAAUUAUCAGGAAAGGAGGUGAAACAUCUGAAAUGUAUCUCAUUCAACCUGACAGUUCUGUCAAACCGUAUAGAGUAUACUGUGACAUGAAUACAGAAAAUGGAGGAUGGACAGUGAUUCAGAACCGUCAAGACGGUAGUGUUGACUUUGGCAGGAAAUGGGAUCCAUAUAAACAGGGAUUUGGAAAUGUUGCAACCAACACAGAUGGGAAGAAUUACUGUGGCCUACCAGGUGAAUAUUGGCUUGGAAAUGAUAAAAUUAGCCAGCUUACCAGGAUGGGACCCACAGAACUUUUGAUAGAAAUGGAGGACUGGAAAGGAGACAAAGUAAAGGCUCACUAUGGAGGAUUCACUGUACAGAAUGAAGCCAACAAAUACCAGAUCUCAGUGAACAAAUACAGAGGAACAGCCGGUAAUGCCCUCAUGGAUGGAGCAUCUCAGCUGAUGGGAGAAAACAGGACCAUGACCAUUCACAACGGCAUGUUCUUCAGCACGUAUGACAGAGACAAUGACGGCUGGUUAACAUCAGAUCCCAGAAAACAGUGUUCUAAAGAAGACGGUGGUGGAUGGUGGUAUAAUAGAUGUCAUGCAGCCAAUCCAAACGGCAGAUACUACUGGGGUGGACAGUACACCUGGGACAUGGCAAAGCAUGGCACAGAUGAUGGUGUAGUAUGGAUGAAUUGGAAGGGGUCAUGGUACUCAAUGAGGAAGAUGAGUAUGAAGAUCAGGCCCUUCUUCCCACAGCAAUAGUCCCCAAUACGUAGAUUUUUGCUCUUCUGUAUGUGACAACAUUUUUGUACAUUAUGUUAUUGGAAUUUUCUUUCAUACAUUAUAUUCCUCUAAAACUCUCAAGCAGACGUGAGUGUGACUUUUUGAAAAAAGUAUAGGAUAAAUUACAUUAAAAUAGCACAUGAUUUUCUUUUGUUUUCUUCAUUUCUCUUGCUCACCAAGAAGUAACAAAAGUAUAGUUUUGACAGAGUUGGUGUUCAUAAUUUCAGUUCUAGUUGAUUGCGAGAAUUUUCAAAUAAGGAAGAGGGGUCUUUUAUCCUUGUCGUAGGAAAACCAUGACGGAAAGGAAAAACUGAUGUUUAAAAGUCCACUUUUAAAACUAUAUUUAUUUAUGUAGGAUCUGUCAAAGAAAACUUCCAAAAAGAUUUAUUAAUUAAACCAGACUCUGUUGCAAUAAGUUAAUGUUUUCUUGUUUUGUAAUCCACACAUUCAAUGAGUUAGGCUUUGCACUUGUAAGGAAGGAGAAGCGUUCACAACCUCAAAUAGCUAAUAAACCGGUCUUGAAUAUUUGAAGAUUUAAAAUCUGACUCUAGGACGGGCACGGUGGCUCACGACUAUAAUCCCAACACUUUGGGAGGCUGAGGCGGGCGGUCACAAGGUCAGGAGUUCAAGACCAGCCUGACCAAUAUGGUGAAACCCCAUCUCUACUAAAAAUACAAAAAUUAGCCAGGCGUGGUGGCAGGUGCCUGUAGUCCCAGCUACCUGUGAGGUGGAGAUUGCAUUGAGCCAAGAUCUCAACACUGCACUCCAGCCUGGGCAACAGCGUGAGACUCCACCUCAAAAAAAAAAAAAAAAGAAUCUGACUAUAUACCAUGGAAAAGCCACCACUCUGCCACUUAAAUAAACAUCAGGAUCAGAGAUUCCAAGAGGACAAUCUGCAUCAAGUCUUCACCAAGUGUUUUUUAAGCGAAAUAAUGAAAUAGGGAGCAGAAUAUGCCUGUUGCCCAUAGAAACGAGGUCUAUUCUUGUCCUCAAUUAGGCUUUUUUUUCUUCAUAGUUACACCAGAACUAAAGUAAAAGUGGUUUUUCUGUUCUUUCUACUUCUCCCCAUGAAAUGGGCAUAUCAUCUCAACACUUCACUCCAAGUCGCCACGGGCAACCUUAUGACCCUAGGUCCUCCACCCCUAAUGUAUCAUCAUUGCCACCCAUUUUUAUGGUACUUAUUGUUCUUAAGCUUAUCCUCUUAAUCUUUUCAUGUAAGCAAAGCUCAUUAAUUUCUGUCUUGGAAAUGCUACUACUCUCUUUAAUUACUCACCAAAUCCAACUUUAACUUUUGACCUGGUUUCUCUGCCACAAGUUCUGUCCCACUGGAGCCCAUACUCACCUACCGCUUUGCCAUCACAUUUAACAGAAAACUCUUAUCAACUUACUUCCUGCUUAACAUUAGCUCCUUCCUAUCUAUAUCCAAAUUUCUUAAAUUCAAAUUUUUUAGCUGGAGUAAAAAUGGUCCCAGUACCAUUUCCUGUUCCCUUCACUAUAACCUACAUUUUUGUCACAUUAAGUUUUUCCCCAUUCCAGGACAGGUCAGGCCCUUUAAAAAUUUCAACAGCUUUAUUGAGAUAUAAUUGAUAUAAUUUAAAAAAUCCUGCACAUGUGUCAUGCUGGAGCCCUAUUGAUUCCAACAGGGAUGGCGCCUUGUCCAAGAAGAGACCCAGAGCCAGUGAAUGGGACAUAGGGUUUAUUUAGGACUUAAAUACAGAUGUGGUCCAGUGGCAGUGGGCUGGACAGGACCGCUACUAUUUGUAAAGAGUAUGUAGUUUAUAUAACAUUUCUACUUAGCACUCUCCACUUAGCAACCUCCAUUUAACCCAAAAUAAAAGGCCUUGGUUCCUUGCACAUCCUGAGUUCCAACGGACAGGCAGGGAGUUCAAGUGUCCUUCACAGAUAAGAAGUGAAUCUCUCUGGGUUGGCCAUUCCCGGAUUCCUUAGCUUAGACUCUGAACACAUAUUCUUCUUAGACCAUACAGUCAUUCUCAGGGUAUGCUUGAGUUAAUGCUGUCGGAUGCAUCUGUCAUACAAAGUGUUUAACAUAUACGAUUUCAUGAUUUUGGAAAUAUGCAUACACCCAUGAUAUCACUGGCACAGUCAAGAUAUUAAAUAUAUCCAUCACCUCCAAAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 2244)

HGNC Gene symbol

FGB

HGNC Gene name

fibrinogen beta chain

Chr. RefSeq ID

NC_000004.12

Chromosome N°

4 154563019.. 154570650

CDS location

154563019.. 154570650

DNA strand

strand +

CCDS ID

CCDS3786.1

Mouse ortholog gene

MGI:99501

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000171564

HGNC other symbol

UCSC ID

uc003ioa.5

GeneBank

INSDC:

GeneCards

3662

MIM

134830

VEGA ID

OTTHUMG00000150331

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