NCBI Summary
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016].
Protein
Protein (NP_004792)
Neurexin-1
Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha)
NRXN1
neurexin 1
Undefined
Low evidence
Laminin G-like
Undefined
b-sandwich / ConA-like
GlcA(b1-3)Xyl(a1-4)GlcA / Matriglycan on alpha-dystroglycan
NP_004792
9378
Q9ULB1
Undefined
Q9ULB1
0.145
10.1016/j.sbi.2018.11.007
PFAM, InterPro
Protein sequence and protein families (fasta) (1477 amino acids) Download
MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Mol* PDB structure viewer

Either no PDB or existing PDB of non-glycosylated form

Structural models
AlphaFold v2: AF-Q9ULB1-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.63, 2.13] ÅDownload
The location of the lectin domain structural model is: 480-672
We infer [1.63, 2.13] Å as the interval of error of this structural model.
Template: 5IK4 chain: A, Q60675, NP_032507.2, sequence identity: 22.8%, coverage: 88.1%, location in sequence: 2740-3118, (2740-3118 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Oligomerization and Known Interactions
Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer. Also interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN2, NLGN3 and NLGN4L; interactions with NLGN1, NLGN2, NLGN3 and NLGN4L are calcium-dependent. Interacts (via cytoplasmic C-terminal region) with CASK (via the PDZ, SH3 and guanylate kinase-like domains) (By similarity). Interacts (via cytoplasmic C-terminus) with CASKIN1 and APBA1. Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3. Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4 (By similarity). Interacts with SYT13 and SYTL1. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Interacts with CLSTN3 (PubMed:25352602)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Rare NRXN1 missense variants identified in autism interfered protein degradation and Drosophila sleeping. [34487988]
  • miR-196a-2 Promotes Malignant Progression of Thyroid Carcinoma by Targeting NRXN1. [34158819]
  • An increased burden of rare exonic variants in NRXN1 microdeletion carriers is likely to enhance the penetrance for autism spectrum disorder. [33476483]
  • Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia. [32942984]
  • Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators. [25737549]
  • Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. [12036300]
  • Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. [11944992]
  • Neuroligin 1: a splice site-specific ligand for beta-neurexins. [7736595]
  • Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. [7695896]
  • Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. [1621094]
UniProt Main References (8 PubMed Identifiers)
  • Disruption of neurexin 1 associated with autism spectrum disorder. [18179900]
  • Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. [9628581]
  • Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. [12168954]
  • Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. [11230166]
  • Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [15815621]
  • CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila. [19896112]
  • Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. [21424692]
  • Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders. [22892527]
All isoforms of this gene containing a lectin domain
NP_001317025.1, NP_001317016.1, NP_001317017.1, NP_001317024.1, NP_001317014.1, NP_001317012.1, NP_001317013.1, NP_001317011.1, NP_001317006.1, NP_004792.1, NP_001317023.1, NP_001317015.1, NP_001317022.1, NP_001317007.1, NP_001129131.1, NP_001317008.1, NP_001317010.1, NP_001317018.1, NP_001317019.1
RNA
RNA (Transcript ID: NM_004801.6)
NM_004801.6
neurexin 1, transcript variant alpha1
All isoforms of NRXN1 containing a lectin domain
1074..5507 (or 49921944.. 51028273)
49918503.. 51032132
NCBI Matured mRNA sequence 8948 NTPDownload 
m7G-5')ppp(5'-GUUCUCCCCUCCCGCACUCCUGGAGAUAGACGCUCAAGCCUGACGCCUCUGAAAAGGCAGCAGCAGUCGCCUUAUCCAUAGACCUCAGGAAAUUCGCUUUGACCGAUGCAUGCUUCAGGCUCUGGCUCGAGCUGAGGGGAAUAACCGGGCAGAUGUCUGAGUCCUUAAAAAAGACAAGAUAAAACCAAAAUGCAUCACCAACACACAACCAAUUGAUGUGCUGGCAUCUUAGCUUGGCCCUGCAGAGGCAGAGAGAAAAGAAGAGGAGCUGUUGCGAUUUCCACAUCUAACAGCUUCUGGCUAUUUCGCAACUGCUGGGUUUGAGUCCUACUGUUGCCGUGGCUGAAAAGAGAAGUAAAAUCCAACUUGUGAGACCACGCACAAGGAAUUAGGCUUUGGCUGCAGCGGUGCUGAAGCCCAUGCUAUGACAGAAGAAGCAGGCCUUUGAAGCUAUCCUCGGGUUAAGAAAUGGUGCCCUAAAGAGGCAAGCAUCCCUUUCUCCGUUCUGCUGUAAGACACCACAUCUGAAGGAGACAGACUUGAGGCAUUCACAAGCAUCCAAGGAUACUGGCUCACUGCUGGCUUCCUGUACUUUCUUGAGAAAAGUGUUUUCUUUUUACUGACUCUCACUGCUUCCUUUUGGCCUGGUACCACUGGUGGAACCUGGCAGAUAAUGGGAUUUGAGGAGUUAAGUAUCUGUUGACACUGCAGAUACUCUUAAAUUAGUUAAUCAGACUCAAAUGGGUCAGUGCUUUCCCUUGAUCUUUUGUUGAAGCCUUUUCCAGAACGUUGUCUCCAAAGUGCAUCCUCCCUUUGGUCUGGAAGUUCUGUGGCUACCCUGUACCACUGGGGUCAACGUUUUCCAGUUGGAAGAGGACUACAGGGAGAGAGGGCGGGGUUAUUGGAAGAAGAAGAAGAAAAAAAGAACUAGAUAAAGGAGGGCACAUCCCUCUCACUCCCGCCUUUCCCCUUACCUUUCUGUCUCUCGGGACCCUUAUUUCUUCGUCACGGUGUCCAGGACCAUUUUGACCCUGUCGGCCCCGGCACCCCCCCGCCGCACCCCAGCCCCGAGCAUGGGGACGGCGCUGCUCCAGCGCGGGGGCUGUUUUCUUCUGUGCCUCUCGCUGCUGCUCCUGGGCUGCUGGGCGGAGCUGGGCAGCGGGCUGGAGUUUCCGGGCGCCGAGGGCCAAUGGACGCGCUUCCCCAAGUGGAACGCCUGCUGCGAGAGCGAGAUGAGCUUCCAGCUCAAGACUCGCAGCGCCCGCGGCCUCGUGCUCUACUUCGACGACGAGGGCUUCUGCGACUUCCUGGAGCUGAUUCUGACGCGCGGCGGCCGCCUGCAGCUCAGCUUCUCCAUCUUCUGCGCUGAGCCUGCGACGCUCCUGGCCGACACGCCGGUUAACGACGGCGCCUGGCACAGCGUGCGCAUCCGCCGCCAGUUCCGCAACACCACGCUCUUCAUCGACCAGGUGGAGGCCAAGUGGGUGGAGGUCAAGUCCAAGCGCAGGGACAUGACGGUGUUCAGCGGCCUUUUCGUCGGGGGGCUGCCCCCGGAACUGCGCGCCGCGGCGCUCAAGCUCACCCUGGCCUCGGUGAGGGAGCGGGAGCCCUUCAAGGGGUGGAUUCGUGACGUGAGGGUCAACUCCUCGCAGGUCCUGCCCGUGGACAGCGGCGAGGUGAAGCUGGACGAUGAGCCGCCCAACAGCGGCGGGGGAAGCCCGUGCGAGGCGGGCGAGGAGGGCGAGGGCGGGGUGUGCCUCAACGGAGGUGUGUGCUCCGUGGUGGACGACCAGGCCGUGUGCGACUGCUCGCGAACCGGCUUCCGCGGCAAGGACUGCAGCCAAGAAGACAACAAUGUGGAAGGUCUGGCGCACCUGAUGAUGGGCGACCAAGGUAAAAGUAAAGGAAAAGAAGAAUAUAUUGCCACGUUCAAAGGAUCUGAAUACUUCUGCUACGACUUGUCUCAAAACCCCAUUCAAAGCAGCAGUGAUGAAAUAACUCUGUCAUUUAAAACCCUUCAGAGGAAUGGACUGAUGCUUCACACUGGGAAAUCGGCUGAUUAUGUCAAUCUUGCCCUGAAAAAUGGAGCUGUCUCUCUGGUCAUUAAUUUGGGAUCAGGGGCCUUUGAAGCACUAGUGGAGCCUGUGAAUGGAAAGUUUAAUGAUAAUGCCUGGCAUGAUGUGAAAGUCACCAGGAAUCUGCGUCAGCACUCAGGCAUUGGACACGCUAUGGUGACAAUAUCAGUGGAUGGGAUUCUUACCACAACGGGCUACACGCAAGAAGAUUAUACCAUGCUGGGGUCUGAUGACUUUUUCUAUGUUGGAGGCAGUCCCAGCACAGCCGACCUUCCAGGGUCACCAGUCAGUAACAACUUUAUGGGCUGUCUCAAAGAGGUUGUAUAUAAAAAUAAUGAUGUGAGGCUGGAAUUAUCUCGACUUGCCAAGCAAGGAGAUCCUAAGAUGAAGAUCCAUGGAGUGGUGGCAUUUAAAUGUGAGAAUGUUGCAACUUUAGACCCAAUCACCUUUGAAACCCCAGAGUCUUUCAUCUCUUUGCCUAAAUGGAAUGCAAAGAAAACUGGCUCCAUAUCAUUUGAUUUCCGUACAACAGAGCCAAAUGGCCUCAUCUUAUUUAGCCAUGGCAAGCCAAGACAUCAGAAAGAUGCCAAGCACCCACAGAUGAUAAAGGUGGACUUCUUUGCUAUUGAGAUGCUAGAUGGCCACCUCUACCUCCUCCUGGACAUGGGGUCAGGUACUAUAAAAAUAAAAGCCCUGUUGAAGAAAGUGAAUGAUGGAGAAUGGUAUCAUGUGGACUUCCAGAGAGACGGACGGUCAGGUACCAUUUCUGUCAACACGUUGCGUACUCCCUACACUGCUCCUGGUGAGAGUGAGAUUCUGGACCUGGAUGAUGAGUUGUACCUGGGGGGGCUGCCAGAAAAUAAAGCUGGCCUUGUCUUCCCCACCGAGGUGUGGACUGCUCUGCUCAACUAUGGCUACGUGGGCUGCAUCAGGGAUUUGUUCAUCGAUGGCCAAAGCAAAGAUAUCCGGCAAAUGGCUGAAGUUCAAAGUACUGCUGGAGUGAAGCCUUCCUGCUCAAAGGAAACAGCAAAACCGUGCCUUAGCAACCCUUGCAAAAACAAUGGCAUGUGCAGGGAUGGGUGGAACAGAUAUGUCUGUGAUUGUUCCGGAACAGGCUAUCUUGGCAGGUCCUGUGAGAGAGAGGCAACGGUUUUGAGCUAUGAUGGGAGCAUGUUUAUGAAAAUUCAGCUCCCCGUAGUCAUGCAUACGGAGGCUGAGGAUGUUUCCUUACGGUUCCGAUCCCAGCGUGCAUAUGGCAUUCUGAUGGCAACCACUUCUAGAGACUCUGCUGACACCCUCCGCCUGGAGCUAGACGCAGGACGUGUGAAACUGACGGUCAAUCUAGAUUGUAUCAGGAUUAACUGUAAUUCCAGCAAAGGUCCCGAGACUCUUUUUGCUGGCUAUAACCUCAAUGAUAACGAGUGGCACACAGUGCGUGUAGUUCGGCGUGGAAAAAGUUUAAAGUUAACAGUGGAUGACCAACAGGCCAUGACAGGUCAAAUGGCAGGUGAUCAUACUAGGCUGGAGUUCCAUAACAUAGAGACUGGCAUCAUCACAGAACGACGGUAUCUUUCUUCUGUCCCCUCCAACUUCAUUGGACACCUGCAGAGCUUGACAUUUAAUGGAAUGGCAUACAUUGACCUGUGUAAAAAUGGCGACAUAGAUUACUGUGAGCUUAAUGCCAGAUUUGGCUUCAGGAACAUCAUAGCAGAUCCUGUCACCUUCAAGACCAAAUCGAGCUAUGUUGCCUUAGCUACCUUGCAAGCCUACACUUCUAUGCAUCUUUUUUUCCAGUUCAAGACAACAUCCCUAGAUGGAUUAAUUCUAUAUAACAGUGGGGAUGGAAAUGACUUUAUUGUGGUUGAAUUAGUUAAAGGGUACUUACAUUACGUGUUUGAUUUGGGAAAUGGUGCUAACCUCAUCAAAGGAAGCUCAAAUAAACCUCUCAAUGACAAUCAGUGGCACAACGUGAUGAUAUCAAGGGACACCAGCAACCUCCACACUGUAAAGAUUGACACAAAAAUCACAACGCAAAUCACCGCCGGAGCCAGGAACUUAGACCUCAAGAGUGACUUAUAUAUAGGAGGAGUAGCUAAAGAAACAUACAAAUCCUUACCAAAACUUGUACAUGCCAAAGAAGGCUUUCAAGGCUGCCUGGCAUCAGUUGAUUUAAAUGGACGGCUUCCGGACCUCAUCUCCGAUGCUCUUUUCUGCAACGGACAGAUCGAGAGAGGAUGUGAAGGGCCCAGCACAACCUGCCAAGAGGACUCAUGUUCCAAUCAAGGUGUGUGCUUGCAACAAUGGGAUGGCUUCAGCUGUGACUGUAGUAUGACUUCCUUCAGUGGACCACUCUGCAAUGACCCUGGGACGACAUAUAUCUUUAGCAAAGGUGGUGGACAAAUCACGUAUAAGUGGCCUCCUAAUGACCGACCCAGUACACGAGCAGACAGACUGGCCAUAGGUUUUAGCACUGUUCAGAAAGAAGCCGUAUUGGUGCGAGUGGACAGUUCUUCAGGCUUGGGUGACUACCUAGAACUGCAUAUACACCAGGGAAAAAUUGGAGUUAAGUUUAAUGUUGGGACAGAUGACAUCGCCAUUGAAGAAUCCAAUGCAAUCAUUAAUGAUGGGAAAUACCAUGUAGUUCGUUUCACGAGGAGUGGUGGCAAUGCCACGUUGCAGGUGGACAGCUGGCCAGUGAUCGAGCGCUACCCUGCAGGGCGUCAGCUCACAAUCUUCAAUAGCCAAGCAACCAUAAUAAUUGGCGGGAAAGAGCAGGGCCAGCCCUUCCAGGGCCAGCUCUCUGGGCUGUACUACAAUGGCUUGAAAGUUCUGAAUAUGGCAGCCGAAAACGAUGCCAACAUCGCCAUAGUGGGAAAUGUGAGACUGGUUGGUGAAGUGCCUUCCUCUAUGACAACUGAGUCAACAGCCACUGCCAUGCAAUCAGAGAUGUCCACAUCAAUUAUGGAGACUACCACGACCCUGGCUACUAGCACAGCCAGAAGAGGAAAGCCCCCGACAAAAGAACCCAUUAGCCAGACCACAGAUGACAUCCUUGUGGCCUCAGCAGAGUGUCCCAGCGAUGAUGAGGACAUUGACCCCUGUGAGCCGAGCUCAGGUGGGUUAGCCAACCCAACCCGAGCAGGCGGCAGAGAGCCGUAUCCAGGCUCAGCAGAAGUGAUCCGGGAGUCCAGCAGCACCACGGGUAUGGUCGUUGGGAUAGUAGCCGCUGCCGCCCUGUGCAUCCUUAUCCUCCUCUAUGCCAUGUACAAGUACAGAAACCGGGAUGAAGGCUCAUACCAUGUGGACGAGAGUCGAAACUACAUCAGUAACUCAGCACAGUCCAAUGGGGCUGUUGUAAAGGAGAAACAACCCAGCAGUGCGAAAAGCUCCAACAAAAAUAAGAAAAACAAGGAUAAAGAGUAUUAUGUCUGAUCCCAAGAUCUUAAAUGGACACUUGUAUAGAAAUAGUCUUCAUUUUAUCUGAGACAUAAUAUAAACUUAUUUACUUUCCUUUUUAUGAAGCACAUACAAAAGAAGACAGGGAAUGCAAUCAGGAAGGAAAGACUUUUUAAAAAAUAAAAACAAGUAUCUCAUGCUCUUGUUUCUCAAAAAAGAAAAACAAAAAACAAAAAACAGGGGCCAAUAAAUUCCCUAACAUCCACAGUGUUUUCAUUUACUCUGCUUGUCUUUAUGUUGCUGGAACAUUUCUAAAAGACAGUGAUGACCGCACGCAUUCAUAAAGCAAAGGAGUACUACAGCAUCAAGGCACAACACAAAAACCAACACAAAACAUAACACAAAAAAGAAGCUACCUAUGAUCCUGGAUUUAGCCAAAGUGCUAGCGCUUUCCUGAGAAGUCAGUCCAAUUGCCAGAGAAGACUGUCCUUUUGAGUGACUCAACCUGCAAACCUUUAAGAGUUUGCCGCCUGGUGCAACUGGAGCAGUGGUUGGAACUUGCAUUUGAAACAAAGUGCUGGCUUUUUUGAAGACUUGUGUAGGAACACAUUCAAAAAGCCCCUUUCUGGUUGUGAGAGAGGAAAAAAAAGUAUGGAGGCCUUAUUUUCAAAAAUGUGAAAUAUAAGGCACGUUUUCACACAAAAUUUCAAAACAAAAACAAGAGGGCAUAGAUGCAAUCAUUGGGAAAUUUUCAUGCACGCUUAUUAUGUUAUUACAUAUGUUUAUAUAAAAUCCAUCUCUGUGUGCUUUCUGGACUGUGAUAAGUGACGUUUUAUAGCCUGUUGUAUAGAAAAUGCAAAAUAUAUCUCUGCUCUUCAGCCAUUUUUGGUAAAUUCAAUGUUAUAAGUGUUGCUAAGUAUAGGGAGUUUUAUGACAUCAGAGCAACAAUUAUUUCAGUUGGGUUUUUCUUUUUUUUUGCCACCAUUAUAAAUUGCCACAAUUACUUUUAUUUUUUAAAGAAAUUACAGUGUAGUGUUUAUUCUAAGGAAGAUAUGUAUGAAUGUAUAUACAAAGACUCAGCUACUUCUUUUCUUAUAUGUACAGCCUUCAUUCUGUUGCAAUUAAGUUUUAGUACUUGUAUGAAAGGUGUGAAUUAGAAAGUCACAUAUAUACAUAUGUAUCUUAUAAUCUUUUCUCCCUGAAAUACUCACAUUCCCACAUACAUUCACUAUUUUCACACACACACACACACACACACACACACACACACACACACACACACGAAUCCACAGCAAUCCAUCAGAUAUGCUGGAAGAUCCAAACGUGCAUACAGUAGCAAAUAUUUAUUGACAAAUUGAAAAGCAGGAAGGAAGAGGGUUGUGCCAAGGUAUUGAUGACAAAUGGGGUGAUUUGCUUCAUUGAGAUCUUGCUCCCAGGUAACCUUAAGAAGAUUUUAGUCCCUAAAGAAAUGAACCUUUCCUUAUCAAAUAGAAUAUCACUGAUAUACUGCUGCAUGAAUAAGAACCAUUAUGUGGGCAGGUUAUGGAAGCAAAAUUGGUUAAUCUACACCUUAACUCUGGCUGCUGCAAUUGAAAACUUUCUUUCUAAUAAAAUAAUAUAUAUAUCUCUGAAUCUGAUGUGCAUGAUGAACAUUUCUGGAAAGUAAACACUUUCUCUCGACUAAGAAAGUAUUUUUCAGUAAUUUUUGAUUCUGUAUUACUACCCACUUAAAAAAUCAUUCUCUGUUAAUUAUUGACUAUGUUUUAACUUUUCUGGUUUUACAUAUAUAUCAUUAAAUAUAGUUUUAGUUUAACACAUUAAGUAGUGGAAAAGUAUAGAUUAUACACUUGUUUUGCAUAUUAUUCAAUGAUGUUCACAGCAAUAAAUUACUAAUAUGAGAAGGUAGUGCAAAAAAUGCAUUAUUACAUUGCAAGUUGAUGUUUCAGGAAAAAUUGGUUGCAUUACUUGAAUACCUUCUAAAAGAACGAUAAAAAAUUUUGUAGAAGAGAAGAAUAUCUUUCCAAUUAGCUUUAAUCAGCAAAGGCAAAAAAUGCAAAACAUCUUUUGUGAUACUUUAGUUGAUGAAAAAAAAGCCAAGAAGUGGCCUGGAUUUCAGACAUACAGCACCUUAGAAAUAUGUAUAAUUCAUAGCAAAUCACCACUAUCUAUGGUUGCCAAGUAAUUGUUGUGUACAAAGAAAUUUAGUGGCUUUUUAUGACCCAGAAAGUAGAAGGUAUAAAAUGAAAAUUUAAUAUCCAUUGCUUCUUUUCUAGAUUUUCAUUUUUUUUAAUUUGCCACAUUAAAUAAUUCACGAGUCUUUUCUUUUCCCCCGUCUCAUUCAGUCUUACUCAGGGAAAGCCAGUUAAAUAAGAAGGGAAGUGUAAAACUACUAAUUUACAGCUUGAAGGGUUUUUUUUUUUAAGAUUGCUUUUCUAUUUUAUCUAUUAAGCUUGAACCAGUUUCCAUCUGGAAAGAUUCUAAAAUAUAAUAGAAAAUAAAUUGAAUAAUGGUAAUUUUAAGCAGUAUAUCUAUGAAAUGUGUUGUUUGGGAUUGAUUUCAAUGUUUCUCCCCAGCGUAAAUUUUAAAGUUACAUGCAAUGAUUGAUAUAGUUUAUUAUCAGCAAAAUUAUUUCUAAUAUUAUUGGCUUACACAAACUCUAGCAAAAAUUAUUUUUUCCUCAAUGGAAAAAGAAAAGAGAGGAACAGAGUUAGAAAGAGAAAAUGACUUGAAUCCCAAGUAUCUUCAUACCAAACAUAUCAGGGUUCCCUGCAUAGUUUGCAGUUGAUUGAGGAUUUCACACGACUUGGCAUAAAUUUGAUUACAUCUCUAGACUGUAACUUUUCUGAUUGAUUAUGCUUCUUUUUUAUCCAUGUAAUGUGUUGCCUUUUUUAAAAGAACAAAUACUACAAUAACGUGUGAAGUGGUCAAUCCCUAAGACAUCAAAGAAAGGCCACAUAACCCUACCCUUCUAGUGCUUUGUGUGAUUGGGUAUCAAAGGGGUUUUCUUCUUCUUUUUUUGUUUGUUUGUUUUUCUGUUGCAAGGCCAAUUUAUCCAUUAUUGGAAAUGCUAAGCAAGUGGAAUUUACUGUUUUGUUAAUAAAAUAUUUCUUAAUACAACUGUGAUUUAUUGAUUUUAAAAAUUAUAUGCGGCACCAUUUCGUGCUUAAGUGGGAAAGUAAAGAAGGCUGCAUUUGAAGGGAAGACCCAUCCUUAUAUUAUAGAGGAAGAAUGUUGACUCUCUUUUUUCUGGAUUUAACUAGUCAUUAAAGACCUCUAUAUUCAUACACUUAAAGAUGUAGCCAUUAAAUGUACUUUUGUUAUAUUUGUUCAUCUUGAUAUGCCAGAAACCAUAAACUCAUACAGUAUUAGUUGCAAACAAUAUUAAAAUACUAAUUUCAUAAAUAUGCUUUUUCUCUAUAAAAGACAAUGGAAUCCAAGUUAAGUAAACCUGUGAUUAAAUUCCAACACUAUCACAUA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 9378)
NRXN1
neurexin 1
NC_000002.12
2  49921944.. 51028273
49921944.. 51028273
strand -
CCDS54360.1
MGI:1096391
ClinVar, dbVar
ENSG00000179915
KIAA0578, Hs.22998
uc061jbg.1
INSDC: AB011150
8008
600565
OTTHUMG00000129263
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (4434 bp)
5'-ATGGGGACGGCGCTGCTCCAGCGCGGGGGCTGTTTTCTTCTGTGCCTCTCGCTGCTGCTCCTGGGCTGCTGGGCGGAGCTGGGCAGCGGGCTGGAGTTTCCGGGCGCCGAGGGCCAATGGACGCGCTTCCCCAAGTGGAACGCCTGCTGCGAGAGCGAGATGAGCTTCCAGCTCAAGACTCGCAGCGCCCGCGGCCTCGTGCTCTACTTCGACGACGAGGGCTTCTGCGACTTCCTGGAGCTGATTCTGACGCGCGGCGGCCGCCTGCAGCTCAGCTTCTCCATCTTCTGCGCTGAGCCTGCGACGCTCCTGGCCGACACGCCGGTTAACGACGGCGCCTGGCACAGCGTGCGCATCCGCCGCCAGTTCCGCAACACCACGCTCTTCATCGACCAGGTGGAGGCCAAGTGGGTGGAGGTCAAGTCCAAGCGCAGGGACATGACGGTGTTCAGCGGCCTTTTCGTCGGGGGGCTGCCCCCGGAACTGCGCGCCGCGGCGCTCAAGCTCACCCTGGCCTCGGTGAGGGAGCGGGAGCCCTTCAAGGGGTGGATTCGTGACGTGAGGGTCAACTCCTCGCAGGTCCTGCCCGTGGACAGCGGCGAGGTGAAGCTGGACGATGAGCCGCCCAACAGCGGCGGGGGAAGCCCGTGCGAGGCGGGCGAGGAGGGCGAGGGCGGGGTGTGCCTCAACGGAGGTGTGTGCTCCGTGGTGGACGACCAGGCCGTGTGCGACTGCTCGCGAACCGGCTTCCGCGGCAAGGACTGCAGCCAAGAAGACAACAATGTGGAAGGTCTGGCGCACCTGATGATGGGCGACCAAGGTAAAAGTAAAGGAAAAGAAGAATATATTGCCACGTTCAAAGGATCTGAATACTTCTGCTACGACTTGTCTCAAAACCCCATTCAAAGCAGCAGTGATGAAATAACTCTGTCATTTAAAACCCTTCAGAGGAATGGACTGATGCTTCACACTGGGAAATCGGCTGATTATGTCAATCTTGCCCTGAAAAATGGAGCTGTCTCTCTGGTCATTAATTTGGGATCAGGGGCCTTTGAAGCACTAGTGGAGCCTGTGAATGGAAAGTTTAATGATAATGCCTGGCATGATGTGAAAGTCACCAGGAATCTGCGTCAGCACTCAGGCATTGGACACGCTATGGTGACAATATCAGTGGATGGGATTCTTACCACAACGGGCTACACGCAAGAAGATTATACCATGCTGGGGTCTGATGACTTTTTCTATGTTGGAGGCAGTCCCAGCACAGCCGACCTTCCAGGGTCACCAGTCAGTAACAACTTTATGGGCTGTCTCAAAGAGGTTGTATATAAAAATAATGATGTGAGGCTGGAATTATCTCGACTTGCCAAGCAAGGAGATCCTAAGATGAAGATCCATGGAGTGGTGGCATTTAAATGTGAGAATGTTGCAACTTTAGACCCAATCACCTTTGAAACCCCAGAGTCTTTCATCTCTTTGCCTAAATGGAATGCAAAGAAAACTGGCTCCATATCATTTGATTTCCGTACAACAGAGCCAAATGGCCTCATCTTATTTAGCCATGGCAAGCCAAGACATCAGAAAGATGCCAAGCACCCACAGATGATAAAGGTGGACTTCTTTGCTATTGAGATGCTAGATGGCCACCTCTACCTCCTCCTGGACATGGGGTCAGGTACTATAAAAATAAAAGCCCTGTTGAAGAAAGTGAATGATGGAGAATGGTATCATGTGGACTTCCAGAGAGACGGACGGTCAGGTACCATTTCTGTCAACACGTTGCGTACTCCCTACACTGCTCCTGGTGAGAGTGAGATTCTGGACCTGGATGATGAGTTGTACCTGGGGGGGCTGCCAGAAAATAAAGCTGGCCTTGTCTTCCCCACCGAGGTGTGGACTGCTCTGCTCAACTATGGCTACGTGGGCTGCATCAGGGATTTGTTCATCGATGGCCAAAGCAAAGATATCCGGCAAATGGCTGAAGTTCAAAGTACTGCTGGAGTGAAGCCTTCCTGCTCAAAGGAAACAGCAAAACCGTGCCTTAGCAACCCTTGCAAAAACAATGGCATGTGCAGGGATGGGTGGAACAGATATGTCTGTGATTGTTCCGGAACAGGCTATCTTGGCAGGTCCTGTGAGAGAGAGGCAACGGTTTTGAGCTATGATGGGAGCATGTTTATGAAAATTCAGCTCCCCGTAGTCATGCATACGGAGGCTGAGGATGTTTCCTTACGGTTCCGATCCCAGCGTGCATATGGCATTCTGATGGCAACCACTTCTAGAGACTCTGCTGACACCCTCCGCCTGGAGCTAGACGCAGGACGTGTGAAACTGACGGTCAATCTAGATTGTATCAGGATTAACTGTAATTCCAGCAAAGGTCCCGAGACTCTTTTTGCTGGCTATAACCTCAATGATAACGAGTGGCACACAGTGCGTGTAGTTCGGCGTGGAAAAAGTTTAAAGTTAACAGTGGATGACCAACAGGCCATGACAGGTCAAATGGCAGGTGATCATACTAGGCTGGAGTTCCATAACATAGAGACTGGCATCATCACAGAACGACGGTATCTTTCTTCTGTCCCCTCCAACTTCATTGGACACCTGCAGAGCTTGACATTTAATGGAATGGCATACATTGACCTGTGTAAAAATGGCGACATAGATTACTGTGAGCTTAATGCCAGATTTGGCTTCAGGAACATCATAGCAGATCCTGTCACCTTCAAGACCAAATCGAGCTATGTTGCCTTAGCTACCTTGCAAGCCTACACTTCTATGCATCTTTTTTTCCAGTTCAAGACAACATCCCTAGATGGATTAATTCTATATAACAGTGGGGATGGAAATGACTTTATTGTGGTTGAATTAGTTAAAGGGTACTTACATTACGTGTTTGATTTGGGAAATGGTGCTAACCTCATCAAAGGAAGCTCAAATAAACCTCTCAATGACAATCAGTGGCACAACGTGATGATATCAAGGGACACCAGCAACCTCCACACTGTAAAGATTGACACAAAAATCACAACGCAAATCACCGCCGGAGCCAGGAACTTAGACCTCAAGAGTGACTTATATATAGGAGGAGTAGCTAAAGAAACATACAAATCCTTACCAAAACTTGTACATGCCAAAGAAGGCTTTCAAGGCTGCCTGGCATCAGTTGATTTAAATGGACGGCTTCCGGACCTCATCTCCGATGCTCTTTTCTGCAACGGACAGATCGAGAGAGGATGTGAAGGGCCCAGCACAACCTGCCAAGAGGACTCATGTTCCAATCAAGGTGTGTGCTTGCAACAATGGGATGGCTTCAGCTGTGACTGTAGTATGACTTCCTTCAGTGGACCACTCTGCAATGACCCTGGGACGACATATATCTTTAGCAAAGGTGGTGGACAAATCACGTATAAGTGGCCTCCTAATGACCGACCCAGTACACGAGCAGACAGACTGGCCATAGGTTTTAGCACTGTTCAGAAAGAAGCCGTATTGGTGCGAGTGGACAGTTCTTCAGGCTTGGGTGACTACCTAGAACTGCATATACACCAGGGAAAAATTGGAGTTAAGTTTAATGTTGGGACAGATGACATCGCCATTGAAGAATCCAATGCAATCATTAATGATGGGAAATACCATGTAGTTCGTTTCACGAGGAGTGGTGGCAATGCCACGTTGCAGGTGGACAGCTGGCCAGTGATCGAGCGCTACCCTGCAGGGCGTCAGCTCACAATCTTCAATAGCCAAGCAACCATAATAATTGGCGGGAAAGAGCAGGGCCAGCCCTTCCAGGGCCAGCTCTCTGGGCTGTACTACAATGGCTTGAAAGTTCTGAATATGGCAGCCGAAAACGATGCCAACATCGCCATAGTGGGAAATGTGAGACTGGTTGGTGAAGTGCCTTCCTCTATGACAACTGAGTCAACAGCCACTGCCATGCAATCAGAGATGTCCACATCAATTATGGAGACTACCACGACCCTGGCTACTAGCACAGCCAGAAGAGGAAAGCCCCCGACAAAAGAACCCATTAGCCAGACCACAGATGACATCCTTGTGGCCTCAGCAGAGTGTCCCAGCGATGATGAGGACATTGACCCCTGTGAGCCGAGCTCAGGTGGGTTAGCCAACCCAACCCGAGCAGGCGGCAGAGAGCCGTATCCAGGCTCAGCAGAAGTGATCCGGGAGTCCAGCAGCACCACGGGTATGGTCGTTGGGATAGTAGCCGCTGCCGCCCTGTGCATCCTTATCCTCCTCTATGCCATGTACAAGTACAGAAACCGGGATGAAGGCTCATACCATGTGGACGAGAGTCGAAACTACATCAGTAACTCAGCACAGTCCAATGGGGCTGTTGTAAAGGAGAAACAACCCAGCAGTGCGAAAAGCTCCAACAAAAATAAGAAAAACAAGGATAAAGAGTATTATGTCTGA-3'
NCBI CDS gene sequence with introns (location: 49921944.. 51028273) (1106330 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 49918503.. 51032132) (1113630 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [49918503.. 51032132 + 1000]) (1114630 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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