NCBI Summary
This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_004659)
Maltase-glucoamylase
Maltase-glucoamylase (Alpha-1,4-glucosidase) (EC 3.2.1.20)
MGAM
maltase-glucoamylase
Undefined
Very low evidence
Trefoil Factor
Undefined
peptide
MARKKLKKFTTLEIVLSVLLLVLFIISIVLIVLLAKESLKSTAPDPGTTGTPDPGTTGTPDPGTTGTTHARTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQRGCCWNPQGAVSVPWCYYSKNHSYHVEGNLVNTNAGFTARLKNLPSSPVFGSNVDNVLLTAEYQTSNRFHFKLTDQTNNRFEVPHEHVQSFSGNAAASLTYQVEISRQPFSIKVTRRSNNRVLFDSSIGPLLFADQFLQLSTRLPSTNVYGLGEHVHQQYRHDMNWKTWPIFNRDTTPNGNGTNLYGAQTFFLCLEDASGLSFGVFLMNSNAMEVVLQPAPAITYRTIGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDNMREVVERNRAAQLPYDVQHADIDYMDERRDFTYDSVDFKGFPEFVNELHNNGQKLVIIVDPAISNNSSSSKPYGPYDRGSDMKIWVNSSDGVTPLIGEVWPGQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFTPRILDGYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAAHWLGDNTATWDDLRWSIPGVLEFNLFGIPMVGPDICGFALDTPEELCRRWMQLGAFYPFSRNHNGQGYKDQDPASFGADSLLLNSSRHYLNIRYTLLPYLYTLFFRAHSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVLDEGAEKVMAYVPDAVWYDYETGSQVRWRKQKVEMELPGDKIGLHLRGGYIFPTQQPNTTTLASRKNPLGLIIALDENKEAKGELFWDNGETKDTVANKVYLLCEFSVTQNRLEVNISQSTYKDPNNLAFNEIKILGTEEPSNVTVKHNGVPSQTSPTVTYDSNLKVAIITDIDLLLGEAYTVEWSIKIRDEEKIDCYPDENGASAENCTARGCIWEASNSSGVPFCYFVNDLYSVSDVQYNSHGATADISLKSSVYANAFPSTPVNPLRLDVTYHKNEMLQFKIYDPNKNRYEVPVPLNIPSMPSSTPEGQLYDVLIKKNPFGIEIRRKSTGTIIWDSQLLGFTFSDMFIRISTRLPSKYLYGFGETEHRSYRRDLEWHTWGMFSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGVLLLNSNAMDVTFQPLPALTYRTTGGVLDFYVFLGPTPELVTQQYTELIGRPVMVPYWSLGFQLCRYGYQNDSEIASLYDEMVAAQIPYDVQYSDIDYMERQLDFTLSPKFAGFPALINRMKADGMRVILILDPAISGNETQPYPAFTRGVEDDVFIKYPNDGDIVWGKVWPDFPDVVVNGSLDWDSQVELYRAYVAFPDFFRNSTAKWWKREIEELYNNPQNPERSLKFDGMWIDMNEPSSFVNGAVSPGCRDASLNHPPYMPHLESRDRGLSSKTLCMESQQILPDGSLVQHYNVHNLYGWSQTRPTYEAVQEVTGQRGVVITRSTFPSSGRWAGHWLGDNTAAWDQLKKSIIGMMEFSLFGISYTGADICGFFQDAEYEMCVRWMQLGAFYPFSRNHNTIGTRRQDPVSWDVAFVNISRTVLQTRYTLLPYLYTLMHKAHTEGVTVVRPLLHEFVSDQVTWDIDSQFLLGPAFLVSPVLERNARNVTAYFPRARWYDYYTGVDINARGEWKTLPAPLDHINLHVRGGYILPWQEPALNTHLSRQKFMGFKIALDDEGTAGGWLFWDDGQSIDTYGKGLYYLASFSASQNTMQSHIIFNNYITGTNPLKLGYIEIWGVGSVPVTSVSISVSGMVITPSFNNDPTTQVLSIDVTDRNISLHNFTSLTWISTL
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- A reference map of the human binary protein interactome. [32296183]
- Mechanistic Pathway on Human alpha-Glucosidase Maltase-Glucoamylase Unveiled by QM/MM Calculations. [29548257]
- A genome-wide study of inherited deletions identified two regions associated with nonsyndromic isolated oral clefts. [25776870]
- Branch pattern of starch internal structure influences the glucogenesis by mucosal Nt-maltase-glucoamylase. [25037326]
- An atlas of genetic influences on human blood metabolites. [24816252]
- Evidence of native starch degradation with human small intestinal maltase-glucoamylase (recombinant). [17485087]
- The maltase-glucoamylase gene: common ancestry to sucrase-isomaltase with complementary starch digestion activities. [12547908]
- Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. [9446624]
- Structure, biosynthesis, and glycosylation of human small intestinal maltase-glucoamylase. [3143729]
- Tyrosine sulfation, a post-translational modification of microvillar enzymes in the small intestinal enterocyte. [3121301]
UniProt Main References (7 PubMed Identifiers)
- The DNA sequence of human chromosome 7. [12853948]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. [24309898]
- Luminal starch substrate 'brake' on maltase-glucoamylase activity is located within the glucoamylase subunit. [18356321]
- Structural insight into substrate specificity of human intestinal maltase-glucoamylase. [22058037]
- Contribution of the Individual Small Intestinal alpha-Glucosidases to Digestion of Unusual alpha-Linked Glycemic Disaccharides. [27480812]
- Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity. [18036614]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_004668.3)
maltase-glucoamylase, transcript variant 2
m7G-5')ppp(5'-AUUGCUAAGCCAUCCUUCAGACAGAGAGGGAGCGGCUGCAAGAGGUAAUGAGAGAUGGCAAGAAAGAAGCUGAAAAAAUUUACUACUUUGGAGAUUGUGCUCAGUGUUCUUCUGCUUGUGUUGUUUAUCAUCAGUAUUGUUCUAAUUGUGCUUUUAGCCAAAGAGUCACUGAAAUCAACAGCCCCAGAUCCUGGGACAACUGGUACCCCAGAUCCUGGGACAACUGGUACCCCAGAUCCUGGAACAACUGGUACCACACAUGCUAGGACAACGGGUCCCCCAGAUCCUGGAACAACUGGUACCACUCCUGUUUCUGCUGAAUGUCCAGUGGUAAAUGAAUUGGAACGAAUUAAUUGCAUCCCUGACCAGCCGCCAACAAAGGCCACAUGUGACCAACGUGGCUGUUGCUGGAAUCCCCAGGGAGCUGUAAGUGUUCCCUGGUGCUACUAUUCCAAGAAUCAUAGCUACCAUGUAGAGGGCAACCUUGUCAACACAAAUGCAGGAUUCACAGCCCGGUUGAAAAAUCUGCCUUCUUCACCAGUGUUUGGAAGCAAUGUUGACAAUGUUCUUCUCACAGCAGAAUAUCAGACAUCUAAUCGUUUCCACUUUAAGUUGACUGACCAAACCAAUAACAGGUUUGAAGUGCCCCACGAACACGUGCAGUCCUUCAGUGGAAAUGCUGCUGCUUCUUUGACCUACCAAGUUGAAAUCUCCAGACAGCCAUUUAGCAUCAAAGUGACCAGAAGAAGCAACAAUCGUGUUUUGUUUGACUCGAGCAUUGGGCCCCUACUGUUUGCUGACCAGUUCUUGCAGCUCUCCACUCGACUGCCUAGCACUAACGUGUAUGGCCUGGGAGAGCAUGUGCACCAGCAGUAUCGGCAUGAUAUGAAUUGGAAGACCUGGCCCAUAUUUAACAGAGACACAACUCCCAAUGGAAACGGAACUAAUUUGUAUGGUGCGCAGACAUUCUUCUUGUGCCUUGAAGAUGCUAGUGGAUUGUCCUUUGGGGUGUUUCUGAUGAACAGCAAUGCCAUGGAGGUUGUCCUUCAGCCUGCGCCAGCCAUCACUUACCGCACCAUUGGGGGCAUUCUCGACUUCUAUGUGUUCUUGGGAAACACUCCAGAGCAAGUUGUUCAAGAAUAUCUAGAGCUCAUUGGGCGGCCAGCCCUUCCCUCCUACUGGGCGCUUGGAUUUCACCUCAGUCGUUACGAAUAUGGAACCUUAGACAACAUGAGGGAAGUCGUGGAGAGAAAUCGCGCAGCACAGCUCCCUUAUGAUGUUCAGCAUGCUGAUAUUGAUUAUAUGGAUGAGAGAAGGGACUUCACUUAUGAUUCAGUGGAUUUUAAAGGCUUCCCUGAAUUUGUCAACGAGUUACACAAUAAUGGACAGAAGCUUGUCAUCAUUGUGGAUCCAGCCAUCUCCAACAACUCUUCCUCAAGUAAACCCUAUGGCCCAUAUGACAGGGGUUCAGAUAUGAAGAUAUGGGUGAAUAGUUCAGAUGGAGUGACUCCACUCAUUGGGGAGGUCUGGCCUGGACAAACUGUGUUUCCUGAUUAUACCAAUCCCAACUGUGCUGUUUGGUGGACAAAGGAAUUUGAGCUUUUUCACAAUCAAGUAGAGUUUGAUGGAAUCUGGAUUGAUAUGAAUGAAGUCUCCAACUUUGUUGAUGGUUCGGUCUCAGGAUGUUCCACAAACAACCUAAAUAAUCCCCCAUUCACUCCCAGAAUCCUGGAUGGGUACCUGUUCUGCAAGACUCUCUGUAUGGAUGCAGUGCAGCACUGGGGCAAGCAGUAUGACAUUCACAAUCUGUAUGGCUACUCCAUGGCGGUCGCCACAGCAGAAGCUGCCAAGACUGUGUUCCCUAAUAAGAGAAGCUUCAUUCUGACCCGUUCUACCUUUGCGGGCUCUGGCAAGUUUGCAGCACAUUGGUUAGGAGACAACACUGCCACCUGGGAUGACCUGAGAUGGUCCAUCCCUGGCGUGCUUGAGUUCAACCUUUUUGGCAUCCCAAUGGUGGGUCCUGACAUAUGUGGCUUUGCUUUGGACACCCCUGAGGAGCUCUGUAGGCGGUGGAUGCAGUUGGGUGCAUUUUAUCCGUUUUCUAGAAAUCACAAUGGCCAAGGCUACAAGGACCAGGAUCCUGCCUCCUUUGGAGCUGACUCCCUGCUGUUGAAUUCCUCCAGGCACUACCUUAACAUCCGCUAUACUCUAUUGCCCUACCUAUACACCCUCUUCUUCCGUGCUCACAGCCGAGGGGACACGGUGGCCAGGCCCCUUUUGCAUGAGUUCUACGAGGACAACAGCACUUGGGAUGUGCACCAACAGUUCUUAUGGGGGCCCGGCCUCCUCAUCACUCCAGUUCUGGAUGAAGGUGCAGAGAAAGUGAUGGCAUAUGUGCCUGAUGCUGUCUGGUAUGACUACGAGACUGGGAGCCAAGUGAGAUGGAGGAAGCAAAAAGUCGAGAUGGAACUUCCUGGAGACAAAAUUGGACUUCACCUUCGAGGAGGCUACAUCUUCCCCACACAGCAGCCAAAUACAACCACUCUGGCCAGUCGAAAGAACCCUCUUGGUCUUAUCAUUGCCCUAGAUGAGAACAAAGAAGCAAAAGGAGAACUUUUCUGGGAUAAUGGGGAAACGAAGGAUACUGUGGCCAAUAAAGUGUAUCUUUUAUGUGAGUUUUCUGUCACUCAAAACCGCUUGGAGGUGAAUAUUUCACAAUCAACCUACAAGGACCCCAAUAAUUUAGCAUUUAAUGAGAUUAAAAUUCUUGGGACGGAGGAACCUAGCAAUGUUACAGUGAAACACAAUGGUGUCCCAAGUCAGACUUCUCCUACAGUCACUUAUGAUUCUAACCUGAAGGUUGCCAUUAUCACAGAUAUUGAUCUUCUCCUGGGAGAAGCAUACACAGUGGAAUGGAGCAUAAAGAUAAGGGAUGAAGAAAAAAUAGACUGUUACCCUGAUGAGAAUGGUGCUUCUGCCGAAAACUGCACUGCCCGUGGCUGUAUCUGGGAGGCAUCCAAUUCUUCUGGAGUCCCUUUUUGCUAUUUUGUCAACGACCUAUACUCUGUCAGUGAUGUUCAGUAUAAUUCCCAUGGGGCCACAGCUGACAUCUCCUUAAAGUCUUCCGUUUAUGCCAAUGCCUUCCCCUCCACACCCGUGAACCCCCUUCGCCUGGAUGUCACUUACCAUAAGAAUGAAAUGCUGCAGUUCAAGAUUUAUGAUCCCAACAAGAAUCGGUAUGAAGUUCCAGUCCCUCUGAACAUACCCAGCAUGCCAUCCAGCACCCCUGAGGGUCAACUCUAUGAUGUGCUCAUUAAGAAGAAUCCAUUUGGGAUUGAAAUUCGCCGGAAGAGUACAGGCACUAUAAUUUGGGACUCUCAGCUCCUUGGCUUUACCUUCAGUGACAUGUUUAUCCGCAUCUCCACCCGCCUUCCCUCCAAGUACCUCUAUGGCUUUGGGGAAACUGAGCACAGGUCCUAUAGGAGAGACUUGGAGUGGCACACUUGGGGGAUGUUCUCCCGAGACCAGCCCCCAGGGUACAAGAAGAAUUCCUAUGGUGUCCACCCCUACUACAUGGGGCUGGAGGAGGACGGCAGUGCCCAUGGAGUGCUCCUGCUGAACAGCAAUGCCAUGGAUGUGACGUUCCAGCCCCUGCCUGCCUUGACAUACCGCACCACAGGGGGAGUUCUGGACUUUUAUGUGUUCUUGGGGCCGACUCCAGAGCUUGUCACCCAGCAGUACACUGAGUUGAUUGGCCGGCCUGUGAUGGUACCUUACUGGUCUUUGGGGUUCCAGCUGUGUCGCUAUGGCUACCAGAAUGACUCUGAGAUCGCCAGCUUGUAUGAUGAGAUGGUGGCUGCCCAGAUCCCUUAUGAUGUGCAGUACUCAGACAUCGACUACAUGGAGCGGCAGCUGGACUUCACCCUCAGCCCCAAGUUUGCUGGGUUUCCAGCUCUGAUCAAUCGCAUGAAGGCUGAUGGGAUGCGGGUCAUCCUCAUUCUGGAUCCAGCCAUUUCUGGCAAUGAGACACAGCCUUAUCCUGCCUUCACUCGGGGCGUGGAGGAUGACGUCUUCAUCAAAUACCCAAAUGAUGGAGACAUUGUCUGGGGAAAGGUCUGGCCUGAUUUUCCUGAUGUUGUUGUGAAUGGGUCUCUAGACUGGGACAGCCAAGUGGAGCUAUAUCGAGCUUAUGUGGCCUUCCCAGACUUUUUCCGUAAUUCAACUGCCAAGUGGUGGAAGAGGGAAAUAGAAGAACUAUACAACAAUCCACAGAAUCCAGAGAGGAGCUUGAAGUUUGAUGGCAUGUGGAUUGAUAUGAAUGAACCAUCAAGCUUCGUGAAUGGGGCAGUUUCUCCAGGCUGCAGGGACGCCUCUCUGAACCACCCUCCCUACAUGCCACAUUUGGAGUCCAGGGACAGGGGCCUGAGCAGCAAGACCCUUUGUAUGGAGAGUCAGCAGAUCCUCCCAGACGGCUCCCUGGUGCAGCACUACAACGUGCACAACCUGUAUGGGUGGUCCCAGACCAGACCCACAUACGAAGCCGUGCAGGAGGUGACGGGACAGCGAGGGGUCGUCAUCACCCGCUCCACAUUUCCCUCUUCUGGCCGCUGGGCAGGACAUUGGCUGGGAGACAACACGGCCGCAUGGGAUCAGCUGAAGAAGUCUAUCAUUGGCAUGAUGGAGUUCAGCCUCUUCGGCAUAUCCUAUACGGGAGCAGAUAUCUGUGGGUUCUUUCAAGAUGCUGAAUAUGAGAUGUGUGUUCGCUGGAUGCAGCUGGGGGCCUUUUACCCCUUCUCAAGAAACCACAACACCAUUGGGACCAGGAGACAAGACCCUGUGUCCUGGGAUGUUGCUUUUGUGAAUAUUUCCAGAACUGUCCUGCAGACCAGAUACACCCUGUUGCCAUAUCUGUAUACCUUGAUGCAUAAGGCCCACACGGAGGGCGUCACUGUUGUGCGGCCUCUGCUCCAUGAGUUUGUGUCAGACCAGGUGACAUGGGACAUAGACAGUCAGUUCCUGCUGGGCCCAGCCUUCCUGGUCAGCCCUGUCCUGGAGCGUAAUGCCAGAAAUGUCACUGCAUAUUUCCCUAGAGCCCGCUGGUAUGAUUACUACACGGGUGUGGAUAUUAAUGCAAGAGGAGAGUGGAAGACCUUGCCAGCCCCUCUUGACCACAUUAAUCUUCAUGUCCGUGGGGGCUACAUCCUGCCCUGGCAAGAGCCUGCACUGAACACCCACUUAAGCCGCCAGAAAUUCAUGGGCUUCAAAAUUGCCUUGGAUGAUGAAGGAACUGCUGGGGGCUGGCUCUUCUGGGAUGAUGGGCAAAGCAUUGAUACCUAUGGGAAAGGACUCUAUUACUUGGCCAGCUUUUCUGCCAGCCAGAAUACGAUGCAAAGCCAUAUAAUUUUCAACAAUUACAUCACUGGUACAAAUCCUUUGAAACUGGGCUACAUUGAAAUCUGGGGAGUGGGCAGUGUCCCCGUUACCAGUGUCAGCAUCUCUGUGAGUGGCAUGGUCAUAACACCCUCCUUCAACAAUGACCCCACGACACAGGUAUUAAGCAUCGAUGUGACUGACAGAAACAUCAGCCUACAUAAUUUUACUUCAUUGACGUGGAUAAGCACUCUGUGAAUUUUUACAGCAAGAUUCUAACUAACUAUGAAUGACUUUGAAACUACUUAUACUUCAUACUCAUAAAAAUUAUUGUGUGUUGCUAAUUUGUUCAUACCCACUAUUGGUGAAAUAUUUCUGUUAAUUUUGUUAUAUGUUUUUUGUGUGAACCCUAAAGGUUAAACCUUAGCCCUGUGGGAUAGGCAGUUAGGGAGGUGUGGAAAAUCUAUGCAUUACCUUAAUGUCUCUGUGUGGUUAGUAUGGUAGUGACUGUUCAUCAUAUGACAUUUACUGAAGAUGAACUGGGUCCAUGAUGAAGUGUGUGUAUGUCCACGUUUGUAAUCAUAGAAUGGACCCCAUUCUUUUGUUAAAUACACAAGAGAAAGCUUUCUGUGACAGUUCCAGGUCUUGAAGCUAAUCAGCAUCUCAAGAAAGUAUCCAGAAAGAACAUCUGCUAGUUGGUUAUAGGCGGUGGGAGGAAUAAUAUACCUAAUUGGUUAUAGGUGGGGGGAGCAUGAUAAGCAAAGAAAAGGCAAACACAAGGAAAGAUCAGAUGAAACAGAAGAUGAUAGUAAAAGUGAUCCUAAGUAAGAACAUAAUGUAAAAUUGUCAGCAGCCUCAUGGGGAGGAAAAAGGAAGAGUCAACUCACUUGAAGAAGAGGGUCUUGAGAAAUCCUUAGCAUAAAGGGCUACUGGUGAGAUUGAGAUCUGAGCAGGCAAAGCUCAAAAGAGAGUUUGGAGGUUAAAAAUAAUUUAUUUUUGCAGUAGUGUGCUUUGAAAUGUGUAAAUCUUAUUUCUAAUGUAUACAACCACAUUUCACAUAAAAAUAUGCAAUUUAUAUGCCAGAUAAAAAUAAAACAAGUGAAUUUGCAAGUGA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 8972)
maltase-glucoamylase
strand +
NCBI CDS gene sequence (5574 bp)
5'-ATGGCAAGAAAGAAGCTGAAAAAATTTACTACTTTGGAGATTGTGCTCAGTGTTCTTCTGCTTGTGTTGTTTATCATCAGTATTGTTCTAATTGTGCTTTTAGCCAAAGAGTCACTGAAATCAACAGCCCCAGATCCTGGGACAACTGGTACCCCAGATCCTGGGACAACTGGTACCCCAGATCCTGGAACAACTGGTACCACACATGCTAGGACAACGGGTCCCCCAGATCCTGGAACAACTGGTACCACTCCTGTTTCTGCTGAATGTCCAGTGGTAAATGAATTGGAACGAATTAATTGCATCCCTGACCAGCCGCCAACAAAGGCCACATGTGACCAACGTGGCTGTTGCTGGAATCCCCAGGGAGCTGTAAGTGTTCCCTGGTGCTACTATTCCAAGAATCATAGCTACCATGTAGAGGGCAACCTTGTCAACACAAATGCAGGATTCACAGCCCGGTTGAAAAATCTGCCTTCTTCACCAGTGTTTGGAAGCAATGTTGACAATGTTCTTCTCACAGCAGAATATCAGACATCTAATCGTTTCCACTTTAAGTTGACTGACCAAACCAATAACAGGTTTGAAGTGCCCCACGAACACGTGCAGTCCTTCAGTGGAAATGCTGCTGCTTCTTTGACCTACCAAGTTGAAATCTCCAGACAGCCATTTAGCATCAAAGTGACCAGAAGAAGCAACAATCGTGTTTTGTTTGACTCGAGCATTGGGCCCCTACTGTTTGCTGACCAGTTCTTGCAGCTCTCCACTCGACTGCCTAGCACTAACGTGTATGGCCTGGGAGAGCATGTGCACCAGCAGTATCGGCATGATATGAATTGGAAGACCTGGCCCATATTTAACAGAGACACAACTCCCAATGGAAACGGAACTAATTTGTATGGTGCGCAGACATTCTTCTTGTGCCTTGAAGATGCTAGTGGATTGTCCTTTGGGGTGTTTCTGATGAACAGCAATGCCATGGAGGTTGTCCTTCAGCCTGCGCCAGCCATCACTTACCGCACCATTGGGGGCATTCTCGACTTCTATGTGTTCTTGGGAAACACTCCAGAGCAAGTTGTTCAAGAATATCTAGAGCTCATTGGGCGGCCAGCCCTTCCCTCCTACTGGGCGCTTGGATTTCACCTCAGTCGTTACGAATATGGAACCTTAGACAACATGAGGGAAGTCGTGGAGAGAAATCGCGCAGCACAGCTCCCTTATGATGTTCAGCATGCTGATATTGATTATATGGATGAGAGAAGGGACTTCACTTATGATTCAGTGGATTTTAAAGGCTTCCCTGAATTTGTCAACGAGTTACACAATAATGGACAGAAGCTTGTCATCATTGTGGATCCAGCCATCTCCAACAACTCTTCCTCAAGTAAACCCTATGGCCCATATGACAGGGGTTCAGATATGAAGATATGGGTGAATAGTTCAGATGGAGTGACTCCACTCATTGGGGAGGTCTGGCCTGGACAAACTGTGTTTCCTGATTATACCAATCCCAACTGTGCTGTTTGGTGGACAAAGGAATTTGAGCTTTTTCACAATCAAGTAGAGTTTGATGGAATCTGGATTGATATGAATGAAGTCTCCAACTTTGTTGATGGTTCGGTCTCAGGATGTTCCACAAACAACCTAAATAATCCCCCATTCACTCCCAGAATCCTGGATGGGTACCTGTTCTGCAAGACTCTCTGTATGGATGCAGTGCAGCACTGGGGCAAGCAGTATGACATTCACAATCTGTATGGCTACTCCATGGCGGTCGCCACAGCAGAAGCTGCCAAGACTGTGTTCCCTAATAAGAGAAGCTTCATTCTGACCCGTTCTACCTTTGCGGGCTCTGGCAAGTTTGCAGCACATTGGTTAGGAGACAACACTGCCACCTGGGATGACCTGAGATGGTCCATCCCTGGCGTGCTTGAGTTCAACCTTTTTGGCATCCCAATGGTGGGTCCTGACATATGTGGCTTTGCTTTGGACACCCCTGAGGAGCTCTGTAGGCGGTGGATGCAGTTGGGTGCATTTTATCCGTTTTCTAGAAATCACAATGGCCAAGGCTACAAGGACCAGGATCCTGCCTCCTTTGGAGCTGACTCCCTGCTGTTGAATTCCTCCAGGCACTACCTTAACATCCGCTATACTCTATTGCCCTACCTATACACCCTCTTCTTCCGTGCTCACAGCCGAGGGGACACGGTGGCCAGGCCCCTTTTGCATGAGTTCTACGAGGACAACAGCACTTGGGATGTGCACCAACAGTTCTTATGGGGGCCCGGCCTCCTCATCACTCCAGTTCTGGATGAAGGTGCAGAGAAAGTGATGGCATATGTGCCTGATGCTGTCTGGTATGACTACGAGACTGGGAGCCAAGTGAGATGGAGGAAGCAAAAAGTCGAGATGGAACTTCCTGGAGACAAAATTGGACTTCACCTTCGAGGAGGCTACATCTTCCCCACACAGCAGCCAAATACAACCACTCTGGCCAGTCGAAAGAACCCTCTTGGTCTTATCATTGCCCTAGATGAGAACAAAGAAGCAAAAGGAGAACTTTTCTGGGATAATGGGGAAACGAAGGATACTGTGGCCAATAAAGTGTATCTTTTATGTGAGTTTTCTGTCACTCAAAACCGCTTGGAGGTGAATATTTCACAATCAACCTACAAGGACCCCAATAATTTAGCATTTAATGAGATTAAAATTCTTGGGACGGAGGAACCTAGCAATGTTACAGTGAAACACAATGGTGTCCCAAGTCAGACTTCTCCTACAGTCACTTATGATTCTAACCTGAAGGTTGCCATTATCACAGATATTGATCTTCTCCTGGGAGAAGCATACACAGTGGAATGGAGCATAAAGATAAGGGATGAAGAAAAAATAGACTGTTACCCTGATGAGAATGGTGCTTCTGCCGAAAACTGCACTGCCCGTGGCTGTATCTGGGAGGCATCCAATTCTTCTGGAGTCCCTTTTTGCTATTTTGTCAACGACCTATACTCTGTCAGTGATGTTCAGTATAATTCCCATGGGGCCACAGCTGACATCTCCTTAAAGTCTTCCGTTTATGCCAATGCCTTCCCCTCCACACCCGTGAACCCCCTTCGCCTGGATGTCACTTACCATAAGAATGAAATGCTGCAGTTCAAGATTTATGATCCCAACAAGAATCGGTATGAAGTTCCAGTCCCTCTGAACATACCCAGCATGCCATCCAGCACCCCTGAGGGTCAACTCTATGATGTGCTCATTAAGAAGAATCCATTTGGGATTGAAATTCGCCGGAAGAGTACAGGCACTATAATTTGGGACTCTCAGCTCCTTGGCTTTACCTTCAGTGACATGTTTATCCGCATCTCCACCCGCCTTCCCTCCAAGTACCTCTATGGCTTTGGGGAAACTGAGCACAGGTCCTATAGGAGAGACTTGGAGTGGCACACTTGGGGGATGTTCTCCCGAGACCAGCCCCCAGGGTACAAGAAGAATTCCTATGGTGTCCACCCCTACTACATGGGGCTGGAGGAGGACGGCAGTGCCCATGGAGTGCTCCTGCTGAACAGCAATGCCATGGATGTGACGTTCCAGCCCCTGCCTGCCTTGACATACCGCACCACAGGGGGAGTTCTGGACTTTTATGTGTTCTTGGGGCCGACTCCAGAGCTTGTCACCCAGCAGTACACTGAGTTGATTGGCCGGCCTGTGATGGTACCTTACTGGTCTTTGGGGTTCCAGCTGTGTCGCTATGGCTACCAGAATGACTCTGAGATCGCCAGCTTGTATGATGAGATGGTGGCTGCCCAGATCCCTTATGATGTGCAGTACTCAGACATCGACTACATGGAGCGGCAGCTGGACTTCACCCTCAGCCCCAAGTTTGCTGGGTTTCCAGCTCTGATCAATCGCATGAAGGCTGATGGGATGCGGGTCATCCTCATTCTGGATCCAGCCATTTCTGGCAATGAGACACAGCCTTATCCTGCCTTCACTCGGGGCGTGGAGGATGACGTCTTCATCAAATACCCAAATGATGGAGACATTGTCTGGGGAAAGGTCTGGCCTGATTTTCCTGATGTTGTTGTGAATGGGTCTCTAGACTGGGACAGCCAAGTGGAGCTATATCGAGCTTATGTGGCCTTCCCAGACTTTTTCCGTAATTCAACTGCCAAGTGGTGGAAGAGGGAAATAGAAGAACTATACAACAATCCACAGAATCCAGAGAGGAGCTTGAAGTTTGATGGCATGTGGATTGATATGAATGAACCATCAAGCTTCGTGAATGGGGCAGTTTCTCCAGGCTGCAGGGACGCCTCTCTGAACCACCCTCCCTACATGCCACATTTGGAGTCCAGGGACAGGGGCCTGAGCAGCAAGACCCTTTGTATGGAGAGTCAGCAGATCCTCCCAGACGGCTCCCTGGTGCAGCACTACAACGTGCACAACCTGTATGGGTGGTCCCAGACCAGACCCACATACGAAGCCGTGCAGGAGGTGACGGGACAGCGAGGGGTCGTCATCACCCGCTCCACATTTCCCTCTTCTGGCCGCTGGGCAGGACATTGGCTGGGAGACAACACGGCCGCATGGGATCAGCTGAAGAAGTCTATCATTGGCATGATGGAGTTCAGCCTCTTCGGCATATCCTATACGGGAGCAGATATCTGTGGGTTCTTTCAAGATGCTGAATATGAGATGTGTGTTCGCTGGATGCAGCTGGGGGCCTTTTACCCCTTCTCAAGAAACCACAACACCATTGGGACCAGGAGACAAGACCCTGTGTCCTGGGATGTTGCTTTTGTGAATATTTCCAGAACTGTCCTGCAGACCAGATACACCCTGTTGCCATATCTGTATACCTTGATGCATAAGGCCCACACGGAGGGCGTCACTGTTGTGCGGCCTCTGCTCCATGAGTTTGTGTCAGACCAGGTGACATGGGACATAGACAGTCAGTTCCTGCTGGGCCCAGCCTTCCTGGTCAGCCCTGTCCTGGAGCGTAATGCCAGAAATGTCACTGCATATTTCCCTAGAGCCCGCTGGTATGATTACTACACGGGTGTGGATATTAATGCAAGAGGAGAGTGGAAGACCTTGCCAGCCCCTCTTGACCACATTAATCTTCATGTCCGTGGGGGCTACATCCTGCCCTGGCAAGAGCCTGCACTGAACACCCACTTAAGCCGCCAGAAATTCATGGGCTTCAAAATTGCCTTGGATGATGAAGGAACTGCTGGGGGCTGGCTCTTCTGGGATGATGGGCAAAGCATTGATACCTATGGGAAAGGACTCTATTACTTGGCCAGCTTTTCTGCCAGCCAGAATACGATGCAAAGCCATATAATTTTCAACAATTACATCACTGGTACAAATCCTTTGAAACTGGGCTACATTGAAATCTGGGGAGTGGGCAGTGTCCCCGTTACCAGTGTCAGCATCTCTGTGAGTGGCATGGTCATAACACCCTCCTTCAACAATGACCCCACGACACAGGTATTAAGCATCGATGTGACTGACAGAAACATCAGCCTACATAATTTTACTTCATTGACGTGGATAAGCACTCTGTGA-3'
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