NCBI Summary
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_004458)
Fibrinogen-like protein 1
Fibrinogen-like protein 1 (HP-041) (Hepassocin) (HPS) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1)
FGL1
fibrinogen like 1
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_004458
2267
Q08830
ENSP00000401952.1
Q08830
0.579
Undefined
PFAM, InterPro
Protein sequence and protein families (fasta) (312 amino acids) Download
MAKVFSFILVTTALTMGREISALEDCAQEQMRLRAQVRLLETRVKQQQVKIKQLLQENEVQFLDKGDENTVIDLGSKRQYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVQKHGEYWLGNKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAGNFHPEVQWWASHQRMKFSTWDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKTDNGIVWYTWHGWWYSLKSVVMKIRPNDFIPNVI
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q08830-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Homodimer (PubMed:11470158). Interacts (via the Fibrinogen C-terminal domain) with LAG3 (via Ig-like domains 1 and 2) (PubMed:30580966)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease. [34629811]
  • FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. [33876560]
  • Involvement of LH3 and GLT25D1 for glucosyl-galactosyl-hydroxylation on non-collagen-like domain of FGL1. [33984770]
  • Fibrinogen-Like Protein 1 Modulates Sorafenib Resistance in Human Hepatocellular Carcinoma Cells. [34069373]
  • Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation. [33801246]
  • Genetic variations in humans associated with differences in the course of hepatitis C. [15063762]
  • LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma. [14981537]
  • Identification of a novel human angiopoietin-like gene expressed mainly in heart. [12624729]
  • Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity. [11470158]
  • Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. [8390249]
UniProt Main References (7 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • DNA sequence and analysis of human chromosome 8. [16421571]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant. [18039467]
  • Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure. [19880967]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. [30580966]
All isoforms of this gene containing a lectin domain
NP_004458.3, NP_671736.2, NP_963846.1, NP_963847.1, XP_016868721.1
RNA
RNA (Transcript ID: NM_004467.4)
NM_004467.4
fibrinogen like 1, transcript variant 1
All isoforms of FGL1 containing a lectin domain
ENST00000427924.5
96..1034 (or 17864592.. 17885554)
17864389.. 17895524
NCBI Matured mRNA sequence 1237 NTPDownload 
m7G-5')ppp(5'-AAUGCAGUUACAGGAUCCUGGGAAGCAGAGUGUCUGGAUGGAACCUGAGCUGGGUCUCUGACUCACUUCUGACUUUAGUUUUUUCAAGGGGGAACAUGGCAAAGGUGUUCAGUUUCAUCCUUGUUACCACCGCUCUGACAAUGGGCAGGGAAAUUUCGGCGCUCGAGGACUGUGCCCAGGAGCAGAUGCGGCUCAGAGCCCAGGUGCGCCUGCUUGAGACCCGGGUCAAACAGCAACAGGUCAAGAUCAAGCAGCUUUUGCAGGAGAAUGAAGUCCAGUUCCUUGAUAAAGGAGAUGAGAAUACUGUCAUUGAUCUUGGAAGCAAGAGGCAGUAUGCAGAUUGUUCAGAGAUUUUCAAUGAUGGGUAUAAGCUCAGUGGAUUUUACAAAAUCAAACCUCUCCAGAGCCCAGCAGAAUUUUCUGUUUAUUGUGACAUGUCCGAUGGAGGAGGAUGGACUGUAAUUCAGAGACGAUCUGAUGGCAGUGAAAACUUUAACAGAGGAUGGAAAGACUAUGAAAAUGGCUUUGGAAAUUUUGUCCAAAAACAUGGUGAAUAUUGGCUGGGCAAUAAAAAUCUUCACUUCUUGACCACUCAAGAAGACUACACUUUAAAAAUCGACCUUGCAGAUUUUGAAAAAAAUAGCCGUUAUGCACAAUAUAAGAAUUUCAAAGUUGGAGAUGAAAAGAAUUUCUACGAGUUGAAUAUUGGGGAAUAUUCUGGAACAGCUGGAGAUUCCCUUGCGGGGAAUUUUCAUCCUGAGGUGCAGUGGUGGGCUAGUCACCAAAGAAUGAAAUUCAGCACGUGGGACAGAGAUCAUGACAACUAUGAAGGGAACUGCGCAGAAGAAGAUCAGUCUGGCUGGUGGUUUAACAGGUGUCACUCUGCAAACCUGAAUGGUGUAUACUACAGCGGCCCCUACACGGCUAAAACAGACAAUGGGAUUGUCUGGUACACCUGGCAUGGGUGGUGGUAUUCUCUGAAAUCUGUGGUUAUGAAAAUUAGGCCAAAUGAUUUUAUUCCAAAUGUAAUUUAAUUGCUGCUGUUGGGCUUUCGUUUCUGCAAUUCAGCUUUGUUUAAAGUGAUUUGAAAAAUACUCAUUCUGAACAUAUCCAUGCGCAAUCAUGAUAACUGUUGUGAGUAGUGCUUUUCAUUCUUCUCACUUGCCUUUGUUACUUAAUGUGCUUUCAGUACAGCAGAUAUGCAAUAUUCACCAAAUAAAUGUAGACUGUGUUAAUA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 2267)
FGL1
fibrinogen like 1
NC_000008.11
8  17864592.. 17885554
17864592.. 17885554
strand -
CCDS6004.1
MGI:102795
ClinVar, dbVar
ENSG00000104760
HFREP-1, HPS
uc003wye.4
INSDC: D14446
3695
605776
OTTHUMG00000096989
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (939 bp)
5'-ATGGCAAAGGTGTTCAGTTTCATCCTTGTTACCACCGCTCTGACAATGGGCAGGGAAATTTCGGCGCTCGAGGACTGTGCCCAGGAGCAGATGCGGCTCAGAGCCCAGGTGCGCCTGCTTGAGACCCGGGTCAAACAGCAACAGGTCAAGATCAAGCAGCTTTTGCAGGAGAATGAAGTCCAGTTCCTTGATAAAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGGCAGTATGCAGATTGTTCAGAGATTTTCAATGATGGGTATAAGCTCAGTGGATTTTACAAAATCAAACCTCTCCAGAGCCCAGCAGAATTTTCTGTTTATTGTGACATGTCCGATGGAGGAGGATGGACTGTAATTCAGAGACGATCTGATGGCAGTGAAAACTTTAACAGAGGATGGAAAGACTATGAAAATGGCTTTGGAAATTTTGTCCAAAAACATGGTGAATATTGGCTGGGCAATAAAAATCTTCACTTCTTGACCACTCAAGAAGACTACACTTTAAAAATCGACCTTGCAGATTTTGAAAAAAATAGCCGTTATGCACAATATAAGAATTTCAAAGTTGGAGATGAAAAGAATTTCTACGAGTTGAATATTGGGGAATATTCTGGAACAGCTGGAGATTCCCTTGCGGGGAATTTTCATCCTGAGGTGCAGTGGTGGGCTAGTCACCAAAGAATGAAATTCAGCACGTGGGACAGAGATCATGACAACTATGAAGGGAACTGCGCAGAAGAAGATCAGTCTGGCTGGTGGTTTAACAGGTGTCACTCTGCAAACCTGAATGGTGTATACTACAGCGGCCCCTACACGGCTAAAACAGACAATGGGATTGTCTGGTACACCTGGCATGGGTGGTGGTATTCTCTGAAATCTGTGGTTATGAAAATTAGGCCAAATGATTTTATTCCAAATGTAATTTAA-3'
NCBI CDS gene sequence with introns (location: 17864592.. 17885554) (20963 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 17864389.. 17895524) (31136 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [17864389.. 17895524 + 1000]) (32136 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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