NCBI Summary
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_004458)
Fibrinogen-like protein 1
Fibrinogen-like protein 1 (HP-041) (Hepassocin) (HPS) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1)
FGL1
fibrinogen like 1
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_004458
2267
Q08830
ENSP00000401952.1
Q08830
0.579
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (312 amino acids) Download
MAKVFSFILVTTALTMGREISALEDCAQEQMRLRAQVRLLETRVKQQQVKIKQLLQENEVQFLDKGDENTVIDLGSKRQYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVQKHGEYWLGNKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAGNFHPEVQWWASHQRMKFSTWDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKTDNGIVWYTWHGWWYSLKSVVMKIRPNDFIPNVI
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q08830-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for FGL1 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn's disease. [34629811]
  • FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer. [33876560]
  • Involvement of LH3 and GLT25D1 for glucosyl-galactosyl-hydroxylation on non-collagen-like domain of FGL1. [33984770]
  • Fibrinogen-Like Protein 1 Modulates Sorafenib Resistance in Human Hepatocellular Carcinoma Cells. [34069373]
  • Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation. [33801246]
  • Genetic variations in humans associated with differences in the course of hepatitis C. [15063762]
  • LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma. [14981537]
  • Identification of a novel human angiopoietin-like gene expressed mainly in heart. [12624729]
  • Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity. [11470158]
  • Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. [8390249]
UniProt Main References (7 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • DNA sequence and analysis of human chromosome 8. [16421571]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant. [18039467]
  • Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure. [19880967]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
  • Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. [30580966]
All isoforms of this gene containing a lectin domain
NP_004458.3, NP_671736.2, NP_963846.1, NP_963847.1, XP_016868721.1
RNA
RNA (Transcript ID: NM_004467.4)
NM_004467.4
fibrinogen like 1, transcript variant 1
All isoforms of FGL1 containing a lectin domain
ENST00000427924.5
96..1034 (or 17864592.. 17885554)
17864389.. 17895524
NCBI Matured mRNA sequence 1237 NTPDownload 
m7G-5')ppp(5'-AAUGCAGUUACAGGAUCCUGGGAAGCAGAGUGUCUGGAUGGAACCUGAGCUGGGUCUCUGACUCACUUCUGACUUUAGUUUUUUCAAGGGGGAACAUGGCAAAGGUGUUCAGUUUCAUCCUUGUUACCACCGCUCUGACAAUGGGCAGGGAAAUUUCGGCGCUCGAGGACUGUGCCCAGGAGCAGAUGCGGCUCAGAGCCCAGGUGCGCCUGCUUGAGACCCGGGUCAAACAGCAACAGGUCAAGAUCAAGCAGCUUUUGCAGGAGAAUGAAGUCCAGUUCCUUGAUAAAGGAGAUGAGAAUACUGUCAUUGAUCUUGGAAGCAAGAGGCAGUAUGCAGAUUGUUCAGAGAUUUUCAAUGAUGGGUAUAAGCUCAGUGGAUUUUACAAAAUCAAACCUCUCCAGAGCCCAGCAGAAUUUUCUGUUUAUUGUGACAUGUCCGAUGGAGGAGGAUGGACUGUAAUUCAGAGACGAUCUGAUGGCAGUGAAAACUUUAACAGAGGAUGGAAAGACUAUGAAAAUGGCUUUGGAAAUUUUGUCCAAAAACAUGGUGAAUAUUGGCUGGGCAAUAAAAAUCUUCACUUCUUGACCACUCAAGAAGACUACACUUUAAAAAUCGACCUUGCAGAUUUUGAAAAAAAUAGCCGUUAUGCACAAUAUAAGAAUUUCAAAGUUGGAGAUGAAAAGAAUUUCUACGAGUUGAAUAUUGGGGAAUAUUCUGGAACAGCUGGAGAUUCCCUUGCGGGGAAUUUUCAUCCUGAGGUGCAGUGGUGGGCUAGUCACCAAAGAAUGAAAUUCAGCACGUGGGACAGAGAUCAUGACAACUAUGAAGGGAACUGCGCAGAAGAAGAUCAGUCUGGCUGGUGGUUUAACAGGUGUCACUCUGCAAACCUGAAUGGUGUAUACUACAGCGGCCCCUACACGGCUAAAACAGACAAUGGGAUUGUCUGGUACACCUGGCAUGGGUGGUGGUAUUCUCUGAAAUCUGUGGUUAUGAAAAUUAGGCCAAAUGAUUUUAUUCCAAAUGUAAUUUAAUUGCUGCUGUUGGGCUUUCGUUUCUGCAAUUCAGCUUUGUUUAAAGUGAUUUGAAAAAUACUCAUUCUGAACAUAUCCAUGCGCAAUCAUGAUAACUGUUGUGAGUAGUGCUUUUCAUUCUUCUCACUUGCCUUUGUUACUUAAUGUGCUUUCAGUACAGCAGAUAUGCAAUAUUCACCAAAUAAAUGUAGACUGUGUUAAUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
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More about the NCBI sViewer.
DNA
DNA (Gene ID: 2267)
FGL1
fibrinogen like 1
NC_000008.11
8  17864592.. 17885554
17864592.. 17885554
strand -
CCDS6004.1
MGI:102795
ClinVar, dbVar
ENSG00000104760
HFREP-1, HPS
uc003wye.4
INSDC: D14446
3695
605776
OTTHUMG00000096989
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (939 bp)
5'-ATGGCAAAGGTGTTCAGTTTCATCCTTGTTACCACCGCTCTGACAATGGGCAGGGAAATTTCGGCGCTCGAGGACTGTGCCCAGGAGCAGATGCGGCTCAGAGCCCAGGTGCGCCTGCTTGAGACCCGGGTCAAACAGCAACAGGTCAAGATCAAGCAGCTTTTGCAGGAGAATGAAGTCCAGTTCCTTGATAAAGGAGATGAGAATACTGTCATTGATCTTGGAAGCAAGAGGCAGTATGCAGATTGTTCAGAGATTTTCAATGATGGGTATAAGCTCAGTGGATTTTACAAAATCAAACCTCTCCAGAGCCCAGCAGAATTTTCTGTTTATTGTGACATGTCCGATGGAGGAGGATGGACTGTAATTCAGAGACGATCTGATGGCAGTGAAAACTTTAACAGAGGATGGAAAGACTATGAAAATGGCTTTGGAAATTTTGTCCAAAAACATGGTGAATATTGGCTGGGCAATAAAAATCTTCACTTCTTGACCACTCAAGAAGACTACACTTTAAAAATCGACCTTGCAGATTTTGAAAAAAATAGCCGTTATGCACAATATAAGAATTTCAAAGTTGGAGATGAAAAGAATTTCTACGAGTTGAATATTGGGGAATATTCTGGAACAGCTGGAGATTCCCTTGCGGGGAATTTTCATCCTGAGGTGCAGTGGTGGGCTAGTCACCAAAGAATGAAATTCAGCACGTGGGACAGAGATCATGACAACTATGAAGGGAACTGCGCAGAAGAAGATCAGTCTGGCTGGTGGTTTAACAGGTGTCACTCTGCAAACCTGAATGGTGTATACTACAGCGGCCCCTACACGGCTAAAACAGACAATGGGATTGTCTGGTACACCTGGCATGGGTGGTGGTATTCTCTGAAATCTGTGGTTATGAAAATTAGGCCAAATGATTTTATTCCAAATGTAATTTAA-3'
NCBI CDS gene sequence with introns (location: 17864592.. 17885554) (20963 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 17864389.. 17895524) (31136 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [17864389.. 17895524 + 1000]) (32136 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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