NCBI Summary
This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016].
Protein
Protein (NP_001236)
SIGLEC-6
Sialic acid-binding Ig-like lectin 6 (Siglec-6) (CD33 antigen-like 1) (CDw327) (Obesity-binding protein 1) (OB-BP1) (CD antigen CD327)
SIGLEC6
sialic acid binding Ig like lectin 6
CD327
Curated
I-type lectin
I-Type Lectins - CD33-related Siglecs
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)GalNAc
NP_001236
946
O43699
ENSP00000401502.2
O43699
0.487
10.1146/annurev-immunol-102419-035900
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (453 amino acids) Download
MQGAQEASASEMLPLLLPLLWAGALAQERRFQLEGPESLTVQEGLCVLVPCRLPTTLPASYYGYGYWFLEGADVPVATNDPDEEVQEETRGRFHLLWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGHPSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVTFPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDADGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSLFVHWKPEGRAGGVLGAVWGASITTLVFLCVCFIFRVKTRRKKAAQPVQNTDDVNPVMVSGSRGHQHQFQTGIVSDHPAEAGPISEDEQELHYAVLHFHKVQPQEPKVTDTEYSEIKIHK
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-O43699-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.09, 1.33] ÅDownload
The location of the lectin domain structural model is: 28-148
We infer [1.09, 1.33] Å as the interval of error of this structural model.
Template 1: 6D4A chain: B, P20138, NP_001763.3, sequence identity: 58.7%, coverage: 96.7%, location in sequence: 18-141, (18-141 in PDB).
Template 2: 2N7B chain: A, Q9NYZ4, NP_055257.2, sequence identity: 52.1%, coverage: 94.2%, location in sequence: 26-152, (10-136 in PDB).
Template 3: 2G5R chain: A, Q9Y286, NP_055200.1, sequence identity: 47.9%, coverage: 94.2%, location in sequence: 24-144, (24-144 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for SIGLEC6 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas. [32998819]
  • Functional Inhibitory Siglec-6 Is Upregulated in Human Colorectal Cancer-Associated Mast Cells. [30294327]
  • Differentially expressed genes in the pre-eclamptic placenta: a systematic review and meta-analysis. [23874842]
  • Siglec-6 expression is increased in placentas from pregnancies complicated by preterm preeclampsia. [23171684]
  • Siglec-6 is expressed in gestational trophoblastic disease and affects proliferation, apoptosis and invasion. [23089140]
  • New genetic associations detected in a host response study to hepatitis B vaccine. [20237496]
  • Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. [18818296]
  • Human-specific expression of Siglec-6 in the placenta. [17580316]
  • OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. [10428856]
  • Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. [9465907]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_942142.3, NP_942143.3, NP_001236.4, XP_016883000.1, XP_011525840.1, NP_001171019.1, XP_011525836.1, XP_011525835.1, NP_001171018.1, XP_011525839.1, XP_011525841.1, XP_011525838.1, NP_001171020.1, XP_011525837.1
RNA
RNA (Transcript ID: NM_001245.7)
NM_001245.7
sialic acid binding Ig like lectin 6, transcript variant 1
All isoforms of SIGLEC6 containing a lectin domain
ENST00000425629.8
23..1384 (or 51520082.. 51531648)
51517819.. 51531670
NCBI Matured mRNA sequence 3647 NTPDownload 
m7G-5')ppp(5'-ACUCCCUUCCCCUUCUCUGCUCAUGCAGGGAGCCCAGGAAGCCUCCGCCUCAGAGAUGCUACCGCUGCUGCUGCCCCUGCUGUGGGCAGGGGCCCUGGCUCAGGAGCGGAGAUUCCAGCUGGAGGGGCCAGAGUCACUGACGGUGCAGGAGGGUCUGUGCGUCCUCGUACCCUGCAGAUUGCCCACUACCCUUCCAGCCUCGUACUAUGGUUAUGGCUACUGGUUCCUGGAAGGGGCUGAUGUUCCAGUGGCCACAAACGACCCAGACGAAGAAGUGCAGGAGGAGACCCGGGGCCGAUUCCACCUCCUCUGGGAUCCCAGAAGGAAGAACUGCUCCCUGAGCAUCAGAGAUGCCCGGAGGAGGGACAAUGCUGCAUACUUCUUUCGGUUGAAGUCCAAAUGGAUGAAAUACGGUUAUACAUCUUCCAAGCUCUCUGUGCGUGUGAUGGCCCUGACCCACAGGCCCAACAUCUCCAUCCCAGGGACCCUGGAGUCUGGCCAUCCCAGCAAUCUGACCUGCUCUGUGCCCUGGGUCUGUGAGCAGGGGACGCCCCCCAUCUUCUCCUGGAUGUCAGCUGCCCCCACCUCCCUGGGCCCCAGGACCACCCAGUCCUCGGUGCUCACAAUCACCCCACGGCCCCAGGACCACAGCACCAACCUCACCUGUCAGGUGACGUUCCCUGGAGCCGGUGUGACCAUGGAGAGAACCAUCCAGCUCAAUGUCUCCUAUGCUCCACAGAAAGUGGCCAUCAGCAUCUUCCAAGGAAACAGCGCAGCCUUCAAAAUCCUGCAAAACACCUCGUCCCUCCCUGUCCUGGAGGGCCAGGCUCUGCGGCUGCUCUGUGAUGCUGACGGCAACCCCCCUGCACACCUGAGCUGGUUCCAGGGCUUCCCCGCCCUGAACGCCACCCCCAUCUCCAAUACCGGGGUCCUGGAGCUGCCUCAAGUAGGGUCUGCAGAAGAAGGAGAUUUCACCUGCCGUGCUCAGCAUCCUCUGGGCUCCCUGCAAAUCUCUCUGAGUCUCUUUGUGCAUUGGAAACCAGAAGGCAGGGCUGGUGGUGUCCUGGGAGCAGUCUGGGGAGCUAGCAUCACAACCCUGGUUUUCCUCUGUGUUUGCUUCAUCUUCAGAGUGAAGACUAGAAGGAAGAAAGCAGCCCAGCCAGUGCAAAACACGGAUGAUGUGAACCCCGUCAUGGUCUCAGGCUCCAGGGGUCAUCAGCACCAGUUCCAGACAGGCAUAGUUUCAGACCACCCUGCUGAGGCUGGCCCCAUCUCAGAAGAUGAGCAGGAGCUCCACUACGCUGUCCUACACUUCCACAAGGUGCAACCUCAGGAACCAAAGGUCACCGACACUGAGUACUCAGAAAUCAAGAUACACAAGUGAGGAAUUGUCCAAAGCCAUAACCUUGAUUGGAGAGAACAUGGUACCUCUCAGUGUAUUGGUUACUAGGGCUGCCACAGCAAUGUACCACAAACCGAGUGACAUAAACACAGAACUUUAUUUUCGUAUAGUUUCAGAUGUUAGAGGUCUGAGAACAAGGUGUUAUCAGGGUUGGUCCCUUCUAAGGCCUCUCUUGUUGGCUUGUAGAUGGCUGUCUCCUCCUUGUGUCUUCACAUGGUCUUUCCUCUGAGUGUGUUUGUGUCCUAAUCUUCUCUUCUUAUAAAGACACUAGUCAUAUUGGAUUAGGGCCUCCCCAUGACCUAAUUUAAAUAAAUUAACUAUUUAAAGACCCUCCAAAUACAGUAACCUUCUGAGAUAUUGAGAUUUAGGACUUCCAACAUAUGAAUUUUAGAAGGGAACAAUUUAGCCCAUAACACUGUGUCCAAUUCUUUUAAAAUUAAUGUUUUUGUUGUAAAUGGACUAUAUAAAUACCUUCGUAUAUAUGGCAGACCACAGGACUUCUGUCCAAGAGAACUGAGUUCAACUCCAUCUAUGCCAGCUAUUGAGCAAGUCGCUUUAUGUCCCUGCUCUGUAAGGCAGGGAAAUAAUUUCCAUCUAACCAGAUUAUUGUGAAAGGUCAAAGAAAGCAUACAGCUAACAUACAGCUUUGUUAGCUGUAAAACAGCUAACAAAGGCCCUGACACAAAGGUUUUCAUAAAGUCUGUAUAUUUUUGUAAAUGAAUGCCUUGUAUCUGGCUUUGGCUAGCUUUUUUUUUUUUUUUUUUUUUCUGAGAUGGAGUCUUGCUGUAUCUCCCAGGCUGGAGUGCAGUGGUGCGAUCUUGGCUCAGUGCAAGCUUCGCCCCCUGGGUUCACACCAUUCUCCUGCCUCAGCCUCCCAAGUAGCUGGGACUACAGGCACCCACCACCACACCCGGCUAAUUUUUUGUAUUUUUAGUAGAGACGGGGUUUCACCGUGUUAGCCAGGAUGGUCUUGAUCUCCUGACCUCGUGAUCUGCCCUCCUCGGCCUCCCAAAGUGCUGAGAUUACAGGCAUGAGCCACCGCACCCGGCUUUGAUUAGCUGUUUUAACAGACGGUUUCUGCUGGCAAUUUCUUCUAAGGCUGAAAAGGAGUAGGCCCAGAGGCCACAGCACCAGGUGUCUGUGUCACCCCCUGUUCAGAACUCUUCACGACUCCCCAAAAUAAGGUUUCCAUCCAUCAUCUUUCUGCUCAAGGCUCUCUACAUGAUCUUGUCCAUCCAGAUUUCCCCAGAUCAAUUCCUCACCAGUCACCAAUACCCCAUGUCCAUUUCCACAGCUUCCUCUUACAAAUCCCAGUCUCCACUAUUCCAGUGAAAUUGAAGAAAGCAUUUAAUGAAGACCAACUAUUAAGGAAAAUUCUUAAGAGUAGCCAUGAAAAAUAAAAAGAUAGAUUACACUUAAAAGACCACAGUUAGCAGUGGCUCACGCCUGUAAUCCCAGCACUUUGGGAGGCUGAGGUGGGUGGAUCACUGGAGGUCAGGAGUUCGAGACUGGUCUGGCCAACAUGGUGAAACCCCAUCUCUACUAAAAUACAAAAAUUAGCUCGGUGUGGUGGCACUUGCCUGUAAUCCCAGGUACUUCUGCAGGUUGAAGCAGGAGAAUUGCUUGAACCUGGGAGGUGGAGGUUGAAGUGAGCUGAGAUUGCAUCACUGCACUCCAGCCUGGGCAACAGAGCGAGACUCCAACUCAGAAAAAGCAAAACAAAACAAACAAACAAGCAAAAAACCACAAUUAGACUGACAGCUGACUUUUUUAGGAGCAAUAUUGGAAGGCUAAAUGCAAUAGAAAGAUGUCUUUGAUGGCUUAAGAGAAAUAAAUGUUGUUUUAGAAAGCCUACUCAAUGAAAACACAUUUUAAGACUGAAAGUGAAAUAUAGAUAUUUUAAGGAAAACCAAAAUAUGUGAGUGUUAAUAAAGAAAAGAUUUCUCAAAUAAAUUCUAAAACAUAUAAUUCAGGUAUUAGGAAAGUGAUCCCAGAUUAGAUUUUUGAGAUCCAAAAAAAAUGAAAACCUAGGAAAGUAGCAAAUAUGUGAGCAAAAUGAAACAAAUACUUGUUGUAAAAAUGAUGGUUUGUAGAGGGGUCAAACAUCAAAUGUAAUAUUGAAAUACCAAUAUUAUAUAGCCCAGAAACUAUAAUAACAUAAAGUUCAGAAGAGUGUAAAUAGAAUUUAUAUUACAUAAAGUCUUUAUAUUUUUCCAGAGAAAAUUAAAUGUUAUGAUGAAUGUUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 946)
SIGLEC6
sialic acid binding Ig like lectin 6
NC_000019.10
19  51520082.. 51531648
51520082.. 51531648
strand -
CCDS12834.3
MGI:2681107
ClinVar, dbVar
ENSG00000105492
OB-BP1, SIGLEC-6, CD327
uc002pwy.4
INSDC: D86358
10875
604405
OTTHUMG00000133571
ENA, DDBJ, Monarch
CDw327
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1362 bp)
5'-ATGCAGGGAGCCCAGGAAGCCTCCGCCTCAGAGATGCTACCGCTGCTGCTGCCCCTGCTGTGGGCAGGGGCCCTGGCTCAGGAGCGGAGATTCCAGCTGGAGGGGCCAGAGTCACTGACGGTGCAGGAGGGTCTGTGCGTCCTCGTACCCTGCAGATTGCCCACTACCCTTCCAGCCTCGTACTATGGTTATGGCTACTGGTTCCTGGAAGGGGCTGATGTTCCAGTGGCCACAAACGACCCAGACGAAGAAGTGCAGGAGGAGACCCGGGGCCGATTCCACCTCCTCTGGGATCCCAGAAGGAAGAACTGCTCCCTGAGCATCAGAGATGCCCGGAGGAGGGACAATGCTGCATACTTCTTTCGGTTGAAGTCCAAATGGATGAAATACGGTTATACATCTTCCAAGCTCTCTGTGCGTGTGATGGCCCTGACCCACAGGCCCAACATCTCCATCCCAGGGACCCTGGAGTCTGGCCATCCCAGCAATCTGACCTGCTCTGTGCCCTGGGTCTGTGAGCAGGGGACGCCCCCCATCTTCTCCTGGATGTCAGCTGCCCCCACCTCCCTGGGCCCCAGGACCACCCAGTCCTCGGTGCTCACAATCACCCCACGGCCCCAGGACCACAGCACCAACCTCACCTGTCAGGTGACGTTCCCTGGAGCCGGTGTGACCATGGAGAGAACCATCCAGCTCAATGTCTCCTATGCTCCACAGAAAGTGGCCATCAGCATCTTCCAAGGAAACAGCGCAGCCTTCAAAATCCTGCAAAACACCTCGTCCCTCCCTGTCCTGGAGGGCCAGGCTCTGCGGCTGCTCTGTGATGCTGACGGCAACCCCCCTGCACACCTGAGCTGGTTCCAGGGCTTCCCCGCCCTGAACGCCACCCCCATCTCCAATACCGGGGTCCTGGAGCTGCCTCAAGTAGGGTCTGCAGAAGAAGGAGATTTCACCTGCCGTGCTCAGCATCCTCTGGGCTCCCTGCAAATCTCTCTGAGTCTCTTTGTGCATTGGAAACCAGAAGGCAGGGCTGGTGGTGTCCTGGGAGCAGTCTGGGGAGCTAGCATCACAACCCTGGTTTTCCTCTGTGTTTGCTTCATCTTCAGAGTGAAGACTAGAAGGAAGAAAGCAGCCCAGCCAGTGCAAAACACGGATGATGTGAACCCCGTCATGGTCTCAGGCTCCAGGGGTCATCAGCACCAGTTCCAGACAGGCATAGTTTCAGACCACCCTGCTGAGGCTGGCCCCATCTCAGAAGATGAGCAGGAGCTCCACTACGCTGTCCTACACTTCCACAAGGTGCAACCTCAGGAACCAAAGGTCACCGACACTGAGTACTCAGAAATCAAGATACACAAGTGA-3'
NCBI CDS gene sequence with introns (location: 51520082.. 51531648) (11567 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 51517819.. 51531670) (13852 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [51517819.. 51531670 + 1000]) (14852 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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