NCBI Summary
This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Protein
Protein (NP_001191047)
Prolectin
C-type lectin domain family 17, member A (Prolectin)
CLEC17A
C-type lectin domain containing 17A
Undefined
Curated
C-type lectin
CLEC17A
C-type - Others
a/b mixed / C-type lectin-like
Man, Fuc / Lewis oligosaccharides
NP_001191047
388512
Q6ZS10
ENSP00000393719.2
Q6ZS10
0.39
10.18632/oncotarget.7476
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (378 amino acids) Download
MHNLYSITGYPDPPGTMEEEEEDDDYENSTPPYKDLPPKPGTMEEEEEDDDYENSTPPYKDLPPKPGTMEEEEEDDDYENSTPPYKDLPPKPGSSAPPRPPRAAKETEKPPLPCKPRNMTGLDLAAVTCPPPQLAVNLEPSPLQPSLAATPVPWLNQRSGGPGCCQKRWMVYLCLLVVTSLFLGCLGLTVTLIKYQELMEELRMLSFQQMTWRTNMTGMAGLAGLKHDIARVRADTNQSLVELWGLLDCRRITCPEGWLPFEGKCYYFSPSTKSWDEARMFCQENYSHLVIINSFAEHNFVAKAHGSPRVYWLGLNDRAQEGDWRWLDGSPVTLSFWEPEEPNNIHDEDCATMNKGGTWNDLSCYKTTYWICERKCSC
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q6ZS10-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.35, 1.66] ÅDownload
The location of the lectin domain structural model is: 251-376
We infer [1.35, 1.66] Å as the interval of error of this structural model.
Template 1: 3WH3 chain: A, Q9ULY5, NP_055173.1, sequence identity: 42.9%, coverage: 97.6%, location in sequence: 79-208, (79-208 in PDB).
Template 2: 1K9J chain: A, Q9H2X3, NP_055072.3, sequence identity: 41.3%, coverage: 97.6%, location in sequence: 267-394, (267-394 in PDB).
Template 3: 6PY1 chain: A, Q8IUN9, NP_878910.1, sequence identity: 41.3%, coverage: 96.8%, location in sequence: 179-308, (179-308 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC17A Gene
ProteomicsDB
References
NCBI References (4 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin). [26908442]
  • Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. [23453885]
  • Prolectin, a glycan-binding receptor on dividing B cells in germinal centers. [19419970]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence and biology of human chromosome 19. [15057824]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
XP_016882279.1, XP_016882274.1, XP_016882275.1, XP_016882276.1, XP_016882277.1, XP_016882278.1, XP_016882280.1, NP_001191047.1, XP_016882281.1, NP_997273.3
RNA
RNA (Transcript ID: NM_001204118.2)
NM_001204118.2
C-type lectin domain containing 17A, transcript variant 1
All isoforms of CLEC17A containing a lectin domain
ENST00000417570.6
78..1214 (or 14583161.. 14610196)
14583084.. 14612035
NCBI Matured mRNA sequence 3053 NTPDownload 
m7G-5')ppp(5'-AGACGCCUGAGUCGGAGAGACAGGGGGCAGAGGUUGCCAAGCCCUGGCUGCCACUUGUCAGGUUCCCUGUGCUAGACAUGCAUAAUCUGUAUUCCAUCACUGGGUACCCGGACCCACCAGGGACCAUGGAGGAGGAGGAGGAGGAUGAUGACUAUGAGAACUCAACACCUCCCUACAAGGACCUUCCUCCCAAGCCAGGGACCAUGGAGGAGGAGGAGGAGGAUGAUGACUAUGAGAACUCAACACCUCCCUACAAGGACCUUCCUCCCAAGCCAGGGACCAUGGAGGAGGAGGAGGAGGAUGAUGACUAUGAGAACUCAACACCUCCCUACAAGGACCUUCCUCCCAAGCCAGGUUCAAGUGCUCCACCAAGACCUCCAAGGGCAGCAAAGGAAACAGAGAAACCCCCACUUCCUUGCAAGCCCCGGAACAUGACAGGCCUGGACCUCGCCGCUGUCACCUGUCCACCUCCUCAACUGGCUGUGAAUCUUGAGCCUUCUCCAUUGCAGCCAUCCCUGGCCGCAACUCCAGUCCCCUGGCUCAAUCAGAGGUCUGGAGGUCCUGGCUGCUGCCAGAAGAGGUGGAUGGUGUACCUGUGUCUGCUGGUGGUGACUUCCCUGUUCCUGGGCUGCCUUGGUCUCACUGUGACCCUGAUUAAGUACCAGGAGUUGAUGGAAGAACUGAGAAUGUUAAGCUUUCAGCAGAUGACGUGGCGAACAAAUAUGACUGGCAUGGCAGGGCUAGCUGGCCUGAAGCAUGACAUUGCCCGUGUAAGAGCUGACACCAACCAGUCCCUGGUGGAACUUUGGGGCUUAUUAGACUGCCGCCGAAUUACCUGUCCUGAAGGCUGGCUGCCCUUUGAGGGCAAGUGUUACUACUUCUCCCCAAGCACCAAGUCAUGGGAUGAGGCCCGGAUGUUCUGCCAGGAGAAUUACUCUCACUUGGUCAUCAUCAAUAGCUUUGCUGAGCACAAUUUUGUGGCCAAGGCCCAUGGCUCUCCACGGGUGUACUGGCUGGGGCUGAAUGACAGGGCCCAGGAAGGGGACUGGAGGUGGCUGGAUGGGUCUCCUGUGACAUUAAGCUUCUGGGAGCCAGAGGAACCCAAUAACAUCCACGAUGAGGACUGUGCUACCAUGAACAAAGGUGGCACCUGGAAUGAUCUCUCUUGCUACAAAACUACGUAUUGGAUUUGUGAGCGGAAAUGUUCCUGUUGAAGCCCAGGGCCGAGGCUGGGGGUCCAUAUCUGAGUGUCUCUUUGAGAUGAGAAUCUCCUGCCCUUUCGUGGACGGCCUUGCCUCUUCGUGAGUGGACACACAGAUGUGCCUCAAACAGGAUUGGCACCCUGGAUGCAGCAAGUUCCCAGGGGUGCAAGUCAGGCUGUUUCUAGAGUGAGGACUUGGGCUUGCCCUAGUAGAUGGUGAGCUGGGAGGAUGCUCAGAGCUUGGUGGUGGGAGGUCUCCCACUUCUGGGGUUGAAAGGAUCUUCACUAAGUUCCUGAUCAUGACUCUUGGGAAGUGAUACUAGCCCUGAGGACCCUGGGGCUGGUGUUGAACCUGGGAUGAAAUAUCCUGGCGCCUGUGAACCACAAAGAGCUGGGACUGGGCUCCUUUUCCUGCAGCCUCAAACUUCUGGGCUCAGGUGAUCCUCCCAUCUCAGCCUCCUGAGUAGCUGGGACUACACAUGCGCACCACCAUGCCUGGCCAAUUUUUUGUAGCAUUUAAAGAGAGGGAGUCUCACUAUGUUGCCCAGGCCAGUCUCAAACUCCUUGCCUCAAUGGAUCCUCCUACUUGGGCUUCCCAAAUUGUGAGGAUUACAGGUGUGAGCCACUGUGCCUGGCUCAAAAUUAUUAUUAUUAUUUUUAUAGAGAUGAGGUCUCACUCUGUUGCCGAGGCUGGUCUCAAACUCCUGGGGUCAAGCAAUCCUUCCGUGAUGGCCUCCCAAAGUGCUGGGAUUACAGGCAUGUGUCACCGUACCUGGCCGAUAUUUUUAUUUUUAUUUUUACUUUCCCCAUCUUUUCCUUUUUUUUUUUUUUCCAAACAAAAGCUUUGAAAGUGGUGACAGAAAAAUUUCCCUUUGAGCUAGACCUCUAGAUCUGCCUCGCACAGAAAUACAUUAAGUGGGCUGGUCUCAUGUAGUCCCCACAUCAUUGCAAAUUACAAACCUAAAAAUACAGAACAUCAGCGGAGAAGACAGGAGAGCUUCUAUAUUCACCCCAUGUCGUCCUCUCCAGACACUGCUUCCUUCCUGGUCUCAAACAGCACAAAUAACCCAGAAACCAUCAAAAUUAUUUUUGACCAGCAACUUUCUCAAUGUCUUGGGUGAGGUUUGCACAAGCUAAGUGGCAGAAUCAGACUUUUGCCAGAAGACUUGGCCCGUGGAACUUCUAUCCUUUUUUUUUUUUUUUUUUUUUUUUGAGAUAGGGUUUCAUUCUACUACCCAGGCUGGAGUGCAGUGGCACAAUCAUAGCUUACUGCACCCUCUGCCUCCUGGGCUCGAGUGAUCCUCCUGCCUCAGCCUCCCAAGUAGCUGGGACUACAGGCGUUCACCCUCACACCUGGCUGGCCCAUGGAACUUCUAGAAAGGCAUACCAGCUGAAAAGCAAGACCCCUACAUAGUGUGGCCAGGCAGGCCAUAACCUGGUCAUAUCCACACAGGACAACGAUGGACCUAUCUGCCAGCACGUGCCCUUGAGCUAUCUGUGGGUUGUAACGUCUUUGAUGAUAUAAUUCACUUUACUUGCCAGGCACAGUGGCUCACGCCUGUAAUCCCAGCACUCUGGGAGACUGAGGUGGGCUGAUCACCUGGGGUCAGGAUUUCGAGACCAGCCUGGCCAACAUGGUAAAAUCCUAUCUCUACUAAAAAUACAAAAAAAUUAGCUGGGCGUGGUGGCAUGUGCCUGUAAUCCCAGCUACUCAGGAGACUAAGGCACGAGAAUUGCUUGAACCCAGGAGGCGGAGGUUGCAGUGAGCCGAGAUUGUGCCACUGCACUCCAGCCUGGGUGACAGAGCAAGACUCCAUCUCAAAUAAAUAAAUAAAAAUAAAAAUUCACUUUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 388512)
CLEC17A
C-type lectin domain containing 17A
NC_000019.10
19  14583161.. 14610196
14583161.. 14610196
strand +
CCDS56087.1
ClinVar, dbVar
ENSG00000187912
FLJ45910
uc010dzn.3
INSDC: AK127809
34520
616838
OTTHUMG00000169312
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1137 bp)
5'-ATGCATAATCTGTATTCCATCACTGGGTACCCGGACCCACCAGGGACCATGGAGGAGGAGGAGGAGGATGATGACTATGAGAACTCAACACCTCCCTACAAGGACCTTCCTCCCAAGCCAGGGACCATGGAGGAGGAGGAGGAGGATGATGACTATGAGAACTCAACACCTCCCTACAAGGACCTTCCTCCCAAGCCAGGGACCATGGAGGAGGAGGAGGAGGATGATGACTATGAGAACTCAACACCTCCCTACAAGGACCTTCCTCCCAAGCCAGGTTCAAGTGCTCCACCAAGACCTCCAAGGGCAGCAAAGGAAACAGAGAAACCCCCACTTCCTTGCAAGCCCCGGAACATGACAGGCCTGGACCTCGCCGCTGTCACCTGTCCACCTCCTCAACTGGCTGTGAATCTTGAGCCTTCTCCATTGCAGCCATCCCTGGCCGCAACTCCAGTCCCCTGGCTCAATCAGAGGTCTGGAGGTCCTGGCTGCTGCCAGAAGAGGTGGATGGTGTACCTGTGTCTGCTGGTGGTGACTTCCCTGTTCCTGGGCTGCCTTGGTCTCACTGTGACCCTGATTAAGTACCAGGAGTTGATGGAAGAACTGAGAATGTTAAGCTTTCAGCAGATGACGTGGCGAACAAATATGACTGGCATGGCAGGGCTAGCTGGCCTGAAGCATGACATTGCCCGTGTAAGAGCTGACACCAACCAGTCCCTGGTGGAACTTTGGGGCTTATTAGACTGCCGCCGAATTACCTGTCCTGAAGGCTGGCTGCCCTTTGAGGGCAAGTGTTACTACTTCTCCCCAAGCACCAAGTCATGGGATGAGGCCCGGATGTTCTGCCAGGAGAATTACTCTCACTTGGTCATCATCAATAGCTTTGCTGAGCACAATTTTGTGGCCAAGGCCCATGGCTCTCCACGGGTGTACTGGCTGGGGCTGAATGACAGGGCCCAGGAAGGGGACTGGAGGTGGCTGGATGGGTCTCCTGTGACATTAAGCTTCTGGGAGCCAGAGGAACCCAATAACATCCACGATGAGGACTGTGCTACCATGAACAAAGGTGGCACCTGGAATGATCTCTCTTGCTACAAAACTACGTATTGGATTTGTGAGCGGAAATGTTCCTGTTGA-3'
NCBI CDS gene sequence with introns (location: 14583161.. 14610196) (27036 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 14583084.. 14612035) (28952 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [14583084 - 1000].. 14612035) (29952 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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