NCBI Summary
This gene belongs to the pentraxin superfamily, whose members encode highly conserved multifunctional proteins. The encoded protein, like other members of this family, contains a conserved pentraxin domain at the C-terminus. The highest levels of expression of the protein were observed in bone marrow, small intestine and testes. [provided by RefSeq, Jun 2016].
Protein
Protein (NP_001315537)
Pentraxin-4
Pentraxin-4
PTX4
pentraxin 4
Undefined
Very low evidence
Pentraxin
Undefined
b-sandwich / ConA-like
Uncharacterised
NP_001315537
390667
Q96A99
ENSP00000445277.2
Q96A99
0.392
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (478 amino acids) Download
MGCSWRKTLSFFLVFVPIYLHGASSQEAAPVGPRKPFFERLRRLEEQFRRFQEVTWTHLQNIASNYNVSYNVDVRFRSLAEESQAVAQAVNRSQASVQGELAQLKAWVRKLQRRGRKVDTRLRALDLTLGERSQQRARERKAHKAQRDALQDSLARLEGLVHSQGARLAALEGRLPVAHPGTAALGPALVPTPTQPEELGPTSLKLQRDRQELRAASEHRGPPQDSSAPLQGRREPPASGSHRVLSGTAPKDPRQQAWSPQVPGEICGVGPTLVFPNASTRNVVFLSPGFVTALRALSFCSWVRTASGRLGTLLSYATEDNDNKLVLHGRDSLLPGSIHFVIGDPAFRELPLQLLLDGQWHHICVIWTSTQGRYWLHVDRRLVATGSRFREGYEIPPGGSLVLGQEQDSVGGGFDSSEAFVGSMSGLAIWDRALVPGEVANLAIGKEFPTGAILTLANAALAGGFVQGANCTCLERCP
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q96A99-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.55, 2.0] ÅDownload
The location of the lectin domain structural model is: 269-473
We infer [1.55, 2.0] Å as the interval of error of this structural model.
Template 1: 1GYK chain: A, P02743, NP_001630.1, sequence identity: 28.3%, coverage: 96.1%, location in sequence: 20-223, (1-204 in PDB).
Template 2: 3PVN chain: A, P02741, NP_000558.2, sequence identity: 27.8%, coverage: 93.7%, location in sequence: 19-224, (1-206 in PDB).
Template 3: 1HAS chain: A, P07629, NP_0NO0REFSEQ0.0, sequence identity: 26.3%, coverage: 96.1%, location in sequence: 23-234, (1-212 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for PTX4 Gene
ProteomicsDB
References
NCBI References (3 PubMed Identifiers)
  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. [22504420]
  • Evolution of the pentraxin family: the new entry PTX4. [20357257]
  • Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. [11157797]
UniProt Main References (2 PubMed Identifiers)
  • The sequence and analysis of duplication-rich human chromosome 16. [15616553]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_001013680.1, NP_001315537.1
RNA
RNA (Transcript ID: NM_001328608.2)
NM_001328608.2
pentraxin 4, transcript variant 1
All isoforms of PTX4 containing a lectin domain
ENST00000447419.7
36..1472 (or 1485939.. 1488909)
1485886.. 1488944
NCBI Matured mRNA sequence 1525 NTPDownload 
m7G-5')ppp(5'-GGAGGGAGACUGCUGGGGCCUUGCCGUCUCUCCGGAUGGGUUGCUCGUGGAGGAAGACCUUGUCUUUCUUCCUUGUUUUUGUGCCUAUAUAUCUACAUGGGGCUUCAUCGCAGGAAGCCGCCCCAGUGGGGCCCAGGAAACCGUUUUUCGAGAGGCUCCGUAGGCUGGAGGAACAGUUCCGGAGAUUCCAGGAGGUGACCUGGACACACCUGCAGAACAUCGCCAGCAACUACAACGUGUCCUACAACGUUGACGUCCGGUUCCGGAGCCUGGCGGAAGAGAGCCAGGCUGUGGCUCAGGCAGUCAACCGGUCACAGGCCUCGGUGCAGGGGGAGCUGGCGCAGCUCAAGGCCUGGGUGAGGAAGCUGCAGCGCCGAGGCCGGAAAGUAGACACGCGGCUGCGGGCCUUGGACCUCACCCUGGGCGAGAGGAGCCAGCAGCGGGCCCGGGAAAGGAAGGCACACAAGGCCCAGAGGGACGCCCUGCAGGACUCACUGGCACGCCUGGAGGGCCUCGUCCACAGCCAGGGCGCCAGGCUGGCUGCUCUGGAGGGGCGGCUGCCCGUGGCCCACCCUGGCACUGCAGCCCUCGGGCCGGCCCUGGUCCCAACCCCAACCCAGCCUGAGGAGCUGGGCCCGACCUCCCUGAAGCUUCAGAGGGACAGGCAGGAGCUCCGAGCUGCCUCUGAGCACAGGGGCCCCCCACAGGACUCCUCGGCCCCUCUCCAAGGGAGGCGGGAGCCUCCAGCCUCAGGCAGCCAUCGGGUACUCAGUGGGACUGCCCCAAAAGACCCUCGGCAGCAGGCAUGGUCCCCCCAGGUGCCAGGAGAGAUUUGCGGCGUGGGCCCCACCCUCGUUUUCCCAAACGCCUCCACCAGGAACGUGGUCUUCCUCAGCCCUGGUUUCGUCACUGCCCUGCGAGCCCUGUCCUUCUGCAGCUGGGUCCGCACGGCCUCCGGCCGCCUGGGCACCCUCCUGUCCUACGCCACCGAGGACAAUGACAACAAGCUGGUGCUGCACGGCCGAGACUCCCUGCUGCCCGGAUCCAUCCACUUCGUGAUCGGGGACCCGGCCUUCAGGGAGCUGCCCUUGCAGCUGCUGCUGGACGGCCAGUGGCACCACAUCUGUGUCAUCUGGACGUCCACCCAGGGCAGGUACUGGCUCCACGUGGAUCGCAGGCUGGUGGCCACCGGCUCCCGCUUCAGGGAGGGCUAUGAGAUCCCCCCCGGAGGGUCCCUCGUGCUGGGCCAGGAACAAGACAGCGUGGGGGGCGGAUUCGACAGCUCCGAGGCCUUCGUGGGGAGCAUGUCUGGCUUGGCUAUCUGGGAUCGGGCGCUGGUUCCCGGGGAAGUUGCAAACCUUGCCAUCGGGAAAGAGUUCCCGACAGGUGCCAUCCUGACGCUGGCCAAUGCUGCACUAGCAGGCGGAUUUGUGCAGGGGGCCAACUGCACCUGCCUGGAACGCUGUCCCUGAGGCCGAGCCGCACGGGGGCUGAGGCCAGCAAGGGCAGCAUGCCCCCAUCCACA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 390667)
PTX4
pentraxin 4
NC_000016.10
16  1485939.. 1488909
1485939.. 1488909
strand -
CCDS86492.1
MGI:1915759
ClinVar, dbVar
ENSG00000251692
uc010uvf.2
INSDC:
14171
613442
OTTHUMG00000044470
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1437 bp)
5'-ATGGGTTGCTCGTGGAGGAAGACCTTGTCTTTCTTCCTTGTTTTTGTGCCTATATATCTACATGGGGCTTCATCGCAGGAAGCCGCCCCAGTGGGGCCCAGGAAACCGTTTTTCGAGAGGCTCCGTAGGCTGGAGGAACAGTTCCGGAGATTCCAGGAGGTGACCTGGACACACCTGCAGAACATCGCCAGCAACTACAACGTGTCCTACAACGTTGACGTCCGGTTCCGGAGCCTGGCGGAAGAGAGCCAGGCTGTGGCTCAGGCAGTCAACCGGTCACAGGCCTCGGTGCAGGGGGAGCTGGCGCAGCTCAAGGCCTGGGTGAGGAAGCTGCAGCGCCGAGGCCGGAAAGTAGACACGCGGCTGCGGGCCTTGGACCTCACCCTGGGCGAGAGGAGCCAGCAGCGGGCCCGGGAAAGGAAGGCACACAAGGCCCAGAGGGACGCCCTGCAGGACTCACTGGCACGCCTGGAGGGCCTCGTCCACAGCCAGGGCGCCAGGCTGGCTGCTCTGGAGGGGCGGCTGCCCGTGGCCCACCCTGGCACTGCAGCCCTCGGGCCGGCCCTGGTCCCAACCCCAACCCAGCCTGAGGAGCTGGGCCCGACCTCCCTGAAGCTTCAGAGGGACAGGCAGGAGCTCCGAGCTGCCTCTGAGCACAGGGGCCCCCCACAGGACTCCTCGGCCCCTCTCCAAGGGAGGCGGGAGCCTCCAGCCTCAGGCAGCCATCGGGTACTCAGTGGGACTGCCCCAAAAGACCCTCGGCAGCAGGCATGGTCCCCCCAGGTGCCAGGAGAGATTTGCGGCGTGGGCCCCACCCTCGTTTTCCCAAACGCCTCCACCAGGAACGTGGTCTTCCTCAGCCCTGGTTTCGTCACTGCCCTGCGAGCCCTGTCCTTCTGCAGCTGGGTCCGCACGGCCTCCGGCCGCCTGGGCACCCTCCTGTCCTACGCCACCGAGGACAATGACAACAAGCTGGTGCTGCACGGCCGAGACTCCCTGCTGCCCGGATCCATCCACTTCGTGATCGGGGACCCGGCCTTCAGGGAGCTGCCCTTGCAGCTGCTGCTGGACGGCCAGTGGCACCACATCTGTGTCATCTGGACGTCCACCCAGGGCAGGTACTGGCTCCACGTGGATCGCAGGCTGGTGGCCACCGGCTCCCGCTTCAGGGAGGGCTATGAGATCCCCCCCGGAGGGTCCCTCGTGCTGGGCCAGGAACAAGACAGCGTGGGGGGCGGATTCGACAGCTCCGAGGCCTTCGTGGGGAGCATGTCTGGCTTGGCTATCTGGGATCGGGCGCTGGTTCCCGGGGAAGTTGCAAACCTTGCCATCGGGAAAGAGTTCCCGACAGGTGCCATCCTGACGCTGGCCAATGCTGCACTAGCAGGCGGATTTGTGCAGGGGGCCAACTGCACCTGCCTGGAACGCTGTCCCTGA-3'
NCBI CDS gene sequence with introns (location: 1485939.. 1488909) (2971 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 1485886.. 1488944) (3059 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [1485886.. 1488944 + 1000]) (4059 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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