NCBI Summary
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].
Protein
Protein (NP_001292204)
Agrin
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]
AGRN
agrin
Undefined
Low evidence
Laminin G-like
Undefined
b-sandwich / ConA-like
GlcA(b1-3)Xyl(a1-4)GlcA / Matriglycan on alpha-dystroglycan
NP_001292204
375790
O00468
Undefined
O00468
0.176
10.1016/j.sbi.2018.11.007
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (2068 amino acids) Download
MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-O00468-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for AGRN Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis. [33962172]
  • AGRN Gene Mutation Leads to Congenital Myasthenia Syndromes: A Pediatric Case Report and Literature Review. [32221959]
  • Congenital myasthenic syndrome-associated agrin variants affect clustering of acetylcholine receptors in a domain-specific manner. [32271162]
  • Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions. [31852835]
  • Clinical significance of nuclear localisation of agrin in lung adenocarcinoma. [31820863]
  • Agrin binds to the nerve-muscle basal lamina via laminin. [9151673]
  • Congenital Myasthenic Syndromes [20301347]
  • Structure and chromosomal localization of the mammalian agrin gene. [1326608]
  • Agrin mediates cell contact-induced acetylcholine receptor clustering. [1659950]
  • Structure and expression of a rat agrin. [1851019]
UniProt Main References (12 PubMed Identifiers)
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • Primary structure and high expression of human agrin in basement membranes of adult lung and kidney. [9652404]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein. [11161480]
  • Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm. [16487930]
  • Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]
  • Proteomics characterization of extracellular space components in the human aorta. [20551380]
  • Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK). [21969364]
  • C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction. [22683512]
  • Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. [19631309]
    • Show more
All isoforms of this gene containing a lectin domain
NP_940978.2, NP_001351656.1, XP_005244806.1, NP_001292204.1, XP_011539731.1
RNA
RNA (Transcript ID: NM_001305275.2)
NM_001305275.2
agrin, transcript variant 1
All isoforms of AGRN containing a lectin domain
54..6260 (or 1020173.. 1054981)
1020120.. 1056116
NCBI Matured mRNA sequence 7395 NTPDownload 
m7G-5')ppp(5'-AGUCCCGUCCCCGGCGCGGCCCGCGCGCUCCUCCGCCGCCUCUCGCCUGCGCCAUGGCCGGCCGGUCCCACCCGGGCCCGCUGCGGCCGCUGCUGCCGCUCCUUGUGGUGGCCGCGUGCGUCCUGCCCGGAGCCGGCGGGACAUGCCCGGAGCGCGCGCUGGAGCGGCGCGAGGAGGAGGCGAACGUGGUGCUCACCGGGACGGUGGAGGAGAUCCUCAACGUGGACCCGGUGCAGCACACGUACUCCUGCAAGGUUCGGGUCUGGCGGUACUUGAAGGGCAAAGACCUGGUGGCCCGGGAGAGCCUGCUGGACGGCGGCAACAAGGUGGUGAUCAGCGGCUUUGGAGACCCCCUCAUCUGUGACAACCAGGUGUCCACUGGGGACACCAGGAUCUUCUUUGUGAACCCUGCACCCCCAUACCUGUGGCCAGCCCACAAGAACGAGCUGAUGCUCAACUCCAGCCUCAUGCGGAUCACCCUGCGGAACCUGGAGGAGGUGGAGUUCUGUGUGGAAGAUAAACCCGGGACCCACUUCACUCCAGUGCCUCCGACGCCUCCUGAUGCGUGCCGGGGAAUGCUGUGCGGCUUCGGCGCCGUGUGCGAGCCCAACGCGGAGGGGCCGGGCCGGGCGUCCUGCGUCUGCAAGAAGAGCCCGUGCCCCAGCGUGGUGGCGCCUGUGUGUGGGUCGGACGCCUCCACCUACAGCAACGAAUGCGAGCUGCAGCGGGCGCAGUGCAGCCAGCAGCGCCGCAUCCGCCUGCUCAGCCGCGGGCCGUGCGGCUCGCGGGACCCCUGCUCCAACGUGACCUGCAGCUUCGGCAGCACCUGUGCGCGCUCGGCCGACGGGCUGACGGCCUCGUGCCUGUGCCCCGCGACCUGCCGUGGCGCCCCCGAGGGGACCGUCUGCGGCAGCGACGGCGCCGACUACCCCGGCGAGUGCCAGCUCCUGCGCCGCGCCUGCGCCCGCCAGGAGAAUGUCUUCAAGAAGUUCGACGGCCCUUGUGACCCCUGUCAGGGCGCCCUCCCUGACCCGAGCCGCAGCUGCCGUGUGAACCCGCGCACGCGGCGCCCUGAGAUGCUCCUACGGCCCGAGAGCUGCCCUGCCCGGCAGGCGCCAGUGUGUGGGGACGACGGAGUCACCUACGAAAACGACUGUGUCAUGGGCCGAUCGGGGGCCGCCCGGGGUCUCCUCCUGCAGAAAGUGCGCUCCGGCCAGUGCCAGGGUCGAGACCAGUGCCCGGAGCCCUGCCGGUUCAAUGCCGUGUGCCUGUCCCGCCGUGGCCGUCCCCGCUGCUCCUGCGACCGCGUCACCUGUGACGGGGCCUACAGGCCCGUGUGUGCCCAGGACGGGCGCACGUAUGACAGUGAUUGCUGGCGGCAGCAGGCUGAGUGCCGGCAGCAGCGUGCCAUCCCCAGCAAGCACCAGGGCCCGUGUGACCAGGCCCCGUCCCCAUGCCUCGGGGUGCAGUGUGCAUUUGGGGCGACGUGUGCUGUGAAGAACGGGCAGGCAGCGUGUGAAUGCCUGCAGGCGUGCUCGAGCCUCUACGAUCCUGUGUGCGGCAGCGACGGCGUCACAUACGGCAGCGCGUGCGAGCUGGAGGCCACGGCCUGUACCCUCGGGCGGGAGAUCCAGGUGGCGCGCAAAGGACCCUGUGACCGCUGCGGGCAGUGCCGCUUUGGAGCCCUGUGCGAGGCCGAGACCGGGCGCUGCGUGUGCCCCUCUGAAUGCGUGGCUUUGGCCCAGCCCGUGUGUGGCUCCGACGGGCACACGUACCCCAGCGAGUGCAUGCUGCACGUGCACGCCUGCACACACCAGAUCAGCCUGCACGUGGCCUCAGCUGGACCCUGUGAGACCUGUGGAGAUGCCGUGUGUGCUUUUGGGGCUGUGUGCUCCGCAGGGCAGUGUGUGUGUCCCCGGUGUGAGCACCCCCCGCCCGGCCCCGUGUGUGGCAGCGACGGUGUCACCUACGGCAGUGCCUGCGAGCUACGGGAAGCCGCCUGCCUCCAGCAGACACAGAUCGAGGAGGCCCGGGCAGGGCCGUGCGAGCAGGCCGAGUGCGGUUCCGGAGGCUCUGGCUCUGGGGAGGACGGUGACUGUGAGCAGGAGCUGUGCCGGCAGCGCGGUGGCAUCUGGGACGAGGACUCGGAGGACGGGCCGUGUGUCUGUGACUUCAGCUGCCAGAGUGUCCCAGGCAGCCCGGUGUGCGGCUCAGAUGGGGUCACCUACAGCACCGAGUGUGAGCUGAAGAAGGCCAGGUGUGAGUCACAGCGAGGGCUCUACGUAGCGGCCCAGGGAGCCUGCCGAGGCCCCACCUUCGCCCCGCUGCCGCCUGUGGCCCCCUUACACUGUGCCCAGACGCCCUACGGCUGCUGCCAGGACAAUAUCACCGCAGCCCGGGGCGUGGGCCUGGCUGGCUGCCCCAGUGCCUGCCAGUGCAACCCCCAUGGCUCUUACGGCGGCACCUGUGACCCAGCCACAGGCCAGUGCUCCUGCCGCCCAGGUGUGGGGGGCCUCAGGUGUGACCGCUGUGAGCCUGGCUUCUGGAACUUUCGAGGCAUCGUCACCGAUGGCCGGAGUGGCUGUACACCCUGCAGCUGUGAUCCCCAAGGCGCCGUGCGGGAUGACUGUGAGCAGAUGACGGGGCUGUGCUCGUGUAAGCCCGGGGUGGCUGGACCCAAGUGUGGGCAGUGUCCAGACGGCCGUGCCCUGGGCCCCGCGGGCUGUGAAGCUGACGCUUCUGCGCCUGCGACCUGUGCGGAGAUGCGCUGUGAGUUCGGUGCGCGGUGCGUGGAGGAGUCUGGCUCAGCCCACUGUGUCUGCCCGAUGCUCACCUGUCCAGAGGCCAACGCUACCAAGGUCUGUGGGUCAGAUGGAGUCACAUACGGCAACGAGUGUCAGCUGAAGACCAUCGCCUGCCGCCAGGGCCUGCAAAUCUCUAUCCAGAGCCUGGGCCCGUGCCAGGAGGCUGUUGCUCCCAGCACUCACCCGACAUCUGCCUCCGUGACUGUGACCACCCCAGGGCUCCUCCUGAGCCAGGCACUGCCGGCCCCCCCCGGCGCCCUCCCCCUGGCUCCCAGCAGUACCGCACACAGCCAGACCACCCCUCCGCCCUCAUCACGACCUCGGACCACUGCCAGCGUCCCCAGGACCACCGUGUGGCCCGUGCUGACGGUGCCCCCCACGGCACCCUCCCCUGCACCCAGCCUGGUGGCGUCCGCCUUUGGUGAAUCUGGCAGCACUGAUGGAAGCAGCGAUGAGGAACUGAGCGGGGACCAGGAGGCCAGUGGGGGUGGCUCUGGGGGGCUCGAGCCCUUGGAGGGCAGCAGCGUGGCCACCCCUGGGCCACCUGUCGAGAGGGCUUCCUGCUACAACUCCGCGUUGGGCUGCUGCUCUGAUGGGAAGACGCCCUCGCUGGACGCAGAGGGCUCCAACUGCCCCGCCACCAAGGUGUUCCAGGGCGUCCUGGAGCUGGAGGGCGUCGAGGGCCAGGAGCUGUUCUACACGCCCGAGAUGGCUGACCCCAAGUCAGAACUGUUCGGGGAGACAGCCAGGAGCAUUGAGAGCACCCUGGACGACCUCUUCCGGAAUUCAGACGUCAAGAAGGAUUUUCGGAGUGUCCGCUUGCGGGACCUGGGGCCCGGCAAAUCCGUCCGCGCCAUUGUGGAUGUGCACUUUGACCCCACCACAGCCUUCAGGGCACCCGACGUGGCCCGGGCCCUGCUCCGGCAGAUCCAGGUGUCCAGGCGCCGGUCCUUGGGGGUGAGGCGGCCGCUGCAGGAGCACGUGCGAUUUAUGGACUUUGACUGGUUUCCUGCGUUUAUCACGGGGGCCACGUCAGGAGCCAUUGCUGCGGGAGCCACGGCCAGAGCCACCACUGCAUCGCGCCUGCCGUCCUCUGCUGUGACCCCUCGGGCCCCGCACCCCAGUCACACAAGCCAGCCCGUUGCCAAGACCACGGCAGCCCCCACCACACGUCGGCCCCCCACCACUGCCCCCAGCCGUGUGCCCGGACGUCGGCCCCCGGCCCCCCAGCAGCCUCCAAAGCCCUGUGACUCACAGCCCUGCUUCCACGGGGGGACCUGCCAGGACUGGGCAUUGGGCGGGGGCUUCACCUGCAGCUGCCCGGCAGGCAGGGGAGGCGCCGUCUGUGAGAAGGUGCUUGGCGCCCCUGUGCCGGCCUUCGAGGGCCGCUCCUUCCUGGCCUUCCCCACUCUCCGCGCCUACCACACGCUGCGCCUGGCACUGGAAUUCCGGGCGCUGGAGCCUCAGGGGCUGCUGCUGUACAAUGGCAACGCCCGGGGCAAGGACUUCCUGGCAUUGGCGCUGCUAGAUGGCCGCGUGCAGCUCAGGUUUGACACAGGUUCGGGGCCGGCGGUGCUGACCAGUGCCGUGCCGGUAGAGCCGGGCCAGUGGCACCGCCUGGAGCUGUCCCGGCACUGGCGCCGGGGCACCCUCUCGGUGGAUGGUGAGACCCCUGUUCUGGGCGAGAGUCCCAGUGGCACCGACGGCCUCAACCUGGACACAGACCUCUUUGUGGGCGGCGUACCCGAGGACCAGGCUGCCGUGGCGCUGGAGCGGACCUUCGUGGGCGCCGGCCUGAGGGGGUGCAUCCGUUUGCUGGACGUCAACAACCAGCGCCUGGAGCUUGGCAUUGGGCCGGGGGCUGCCACCCGAGGCUCUGGCGUGGGCGAGUGCGGGGACCACCCCUGCCUGCCCAACCCCUGCCAUGGCGGGGCCCCAUGCCAGAACCUGGAGGCUGGAAGGUUCCAUUGCCAGUGCCCGCCCGGCCGCGUCGGACCAACCUGUGCCGAUGAGAAGAGCCCCUGCCAGCCCAACCCCUGCCAUGGGGCGGCGCCCUGCCGUGUGCUGCCCGAGGGUGGUGCUCAGUGCGAGUGCCCCCUGGGGCGUGAGGGCACCUUCUGCCAGACAGCCUCGGGGCAGGACGGCUCUGGGCCCUUCCUGGCUGACUUCAACGGCUUCUCCCACCUGGAGCUGAGAGGCCUGCACACCUUUGCACGGGACCUGGGGGAGAAGAUGGCGCUGGAGGUCGUGUUCCUGGCACGAGGCCCCAGCGGCCUCCUGCUCUACAACGGGCAGAAGACGGACGGCAAGGGGGACUUCGUGUCGCUGGCACUGCGGGACCGCCGCCUGGAGUUCCGCUACGACCUGGGCAAGGGGGCAGCGGUCAUCAGGAGCAGGGAGCCAGUCACCCUGGGAGCCUGGACCAGGGUCUCACUGGAGCGAAACGGCCGCAAGGGUGCCCUGCGUGUGGGCGACGGCCCCCGUGUGUUGGGGGAGUCCCCGAAAUCCCGCAAGGUUCCGCACACCGUCCUCAACCUGAAGGAGCCGCUCUACGUAGGGGGCGCUCCCGACUUCAGCAAGCUGGCCCGUGCUGCUGCCGUGUCCUCUGGCUUCGACGGUGCCAUCCAGCUGGUCUCCCUCGGAGGCCGCCAGCUGCUGACCCCGGAGCACGUGCUGCGGCAGGUGGACGUCACGUCCUUUGCAGGUCACCCCUGCACCCGGGCCUCAGGCCACCCCUGCCUCAAUGGGGCCUCCUGCGUCCCGAGGGAGGCUGCCUAUGUGUGCCUGUGUCCCGGGGGAUUCUCAGGACCGCACUGCGAGAAGGGGCUGGUGGAGAAGUCAGCGGGGGACGUGGAUACCUUGGCCUUUGACGGGCGGACCUUUGUCGAGUACCUCAACGCUGUGACCGAGAGCGAACUGGCCAAUGAGAUCCCCGUCCCCGAAACUCUGGAUUCCGGGGCCCUUCACAGCGAGAAGGCACUGCAGAGCAACCACUUUGAACUGAGCCUGCGCACUGAGGCCACGCAGGGGCUGGUGCUCUGGAGUGGCAAGGCCACGGAGCGGGCAGACUAUGUGGCACUGGCCAUUGUGGACGGGCACCUGCAACUGAGCUACAACCUGGGCUCCCAGCCCGUGGUGCUGCGUUCCACCGUGCCCGUCAACACCAACCGCUGGUUGCGGGUCGUGGCACAUAGGGAGCAGAGGGAAGGUUCCCUGCAGGUGGGCAAUGAGGCCCCUGUGACCGGCUCCUCCCCGCUGGGCGCCACGCAGCUGGACACUGAUGGAGCCCUGUGGCUUGGGGGCCUGCCGGAGCUGCCCGUGGGCCCAGCACUGCCCAAGGCCUACGGCACAGGCUUUGUGGGCUGCUUGCGGGACGUGGUGGUGGGCCGGCACCCGCUGCACCUGCUGGAGGACGCCGUCACCAAGCCAGAGCUGCGGCCCUGCCCCACCCCAUGAGCUGGCACCAGAGCCCCGCGCCCGCUGUAAUUAUUUUCUAUUUUUGUAAACUUGUUGCUUUUUGAUAUGAUUUUCUUGCCUGAGUGUUGGCCGGAGGGACUGCUGGCCCGGCCUCCCUUCCGUCCAGGCAGCCGUGCUGCAGACAGACCUAGUGCCGAGGGAUGGACAGGCGAGGUGGCAGCGUGGAGGGCUCGGCGUGGAUGGCAGCCUCAGGACACACACCCCUGCCUCAAGGUGCUGAGCCCCCGCCUUGCACUGCGCCUGCCCCACGGUGUCCCCGCCGGGAAGCAGCCCCGGCUCCUGAAUCACCCUCGCUCCGUCAGGCGGGACUCGUGUCCCAGAGAGGAAGGGGCUGCUGAGGUCUGAUGGGGCCCUUCCUCCGGGUGACCCCACAGGGCCUUUCCAAGCCCCCAUUUGAGCUGCUCCUUCCUGUGUGUGCUCUGGGCCCUGCCUCGGCCUCCUGCGCCAAUACUGUGACUUCCAAACAAUGUUACUGCUGGGCACAGCUCUGCGUUGCUCCCGUGCUGCCUGCGCCAGCCCCAGGCUGCUGAGGAGCAGAGGCCAGACCAGGGCCGAUCUGGGUGUCCUGACCCUCAGCUGGCCCUGCCCAGCCACCCUGGACGUGACCGUAUCCCUCUGCCACACCCCAGGCCCUGCGAGGGGCUAUCGAGAGGAGCUCACUGUGGGAUGGGGUUGACCUCUGCCGCCUGCCUGGGUAUCUGGGCCUGGCCAUGGCUGUGUUCUUCAUGUGUUGAUUUUAUUUGACCCCUGGAGUGGUGGGUCUCAUCUUUCCCAUCUCGCCUGAGAGCGGCUGAGGGCUGCCUCACUGCAAAUCCUCCCCACAGCGUCAGUGAAAGUCGUCCUUGUCUCAGAAUGACCAGGGGCCAGCCAGUGUCUGACCAAGGUCAAGGGGCAGGUGCAGAGGUGGCAGGGAUGGCUCCGAAGCCAGAAAUGCCUUAAACUGCAACGUCCCGUCCCUUCCCCACCCCCAUCCCAUCCCCACCCCCAGCCCCAGCCCAGUCCUCCUAGGAGCAGGACCCGAUGAAGCGGGCGGCGGUGGGGCUGGGUGCCGUGUUACUAACUCUAGUAUGUUUCUGUGUCAAUCGCUGUGAAAUAAAGUCUGAAAACUUUAAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 375790)
AGRN
agrin
NC_000001.11
1  1020173.. 1054981
1020173.. 1054981
strand +
MGI:87961
ClinVar, dbVar
ENSG00000188157
uc001ack.3
INSDC:
329
103320
OTTHUMG00000040778
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (6207 bp)
5'-ATGGCCGGCCGGTCCCACCCGGGCCCGCTGCGGCCGCTGCTGCCGCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGACATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAGGAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAAGGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTGGAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCACCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCTGCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAGTGCCTCCGACGCCTCCTGATGCGTGCCGGGGAATGCTGTGCGGCTTCGGCGCCGTGTGCGAGCCCAACGCGGAGGGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGCCCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGGGTCGGACGCCTCCACCTACAGCAACGAATGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCATCCGCCTGCTCAGCCGCGGGCCGTGCGGCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGCAGCACCTGTGCGCGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGCCCCCGAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGCCGCGCCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTGACCCCTGTCAGGGCGCCCTCCCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCTGAGATGCTCCTACGGCCCGAGAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGACGGAGTCACCTACGAAAACGACTGTGTCATGGGCCGATCGGGGGCCGCCCGGGGTCTCCTCCTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGAGACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTCCTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACAGTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCGTGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAACGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACGGCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTGGCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGGGCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGTACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCTGGACCCTGTGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGTGTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTGCCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGCGAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTGCCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCCAGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAGAAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCACCTTCGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATATCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCTTACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTGTGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACACCCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGTAAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTGTGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGGAGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTCTGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCTGCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCACTCACCCGACATCTGCCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCCCCCGGCGCCCTCCCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATCACGACCTCGGACCACTGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGGCACCCTCCCCTGCACCCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGCGGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCACCCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACTCCGCGTTGGGCTGCTGCTCTGATGGGAAGACGCCCTCGCTGGACGCAGAGGGCTCCAACTGCCCCGCCACCAAGGTGTTCCAGGGCGTCCTGGAGCTGGAGGGCGTCGAGGGCCAGGAGCTGTTCTACACGCCCGAGATGGCTGACCCCAAGTCAGAACTGTTCGGGGAGACAGCCAGGAGCATTGAGAGCACCCTGGACGACCTCTTCCGGAATTCAGACGTCAAGAAGGATTTTCGGAGTGTCCGCTTGCGGGACCTGGGGCCCGGCAAATCCGTCCGCGCCATTGTGGATGTGCACTTTGACCCCACCACAGCCTTCAGGGCACCCGACGTGGCCCGGGCCCTGCTCCGGCAGATCCAGGTGTCCAGGCGCCGGTCCTTGGGGGTGAGGCGGCCGCTGCAGGAGCACGTGCGATTTATGGACTTTGACTGGTTTCCTGCGTTTATCACGGGGGCCACGTCAGGAGCCATTGCTGCGGGAGCCACGGCCAGAGCCACCACTGCATCGCGCCTGCCGTCCTCTGCTGTGACCCCTCGGGCCCCGCACCCCAGTCACACAAGCCAGCCCGTTGCCAAGACCACGGCAGCCCCCACCACACGTCGGCCCCCCACCACTGCCCCCAGCCGTGTGCCCGGACGTCGGCCCCCGGCCCCCCAGCAGCCTCCAAAGCCCTGTGACTCACAGCCCTGCTTCCACGGGGGGACCTGCCAGGACTGGGCATTGGGCGGGGGCTTCACCTGCAGCTGCCCGGCAGGCAGGGGAGGCGCCGTCTGTGAGAAGGTGCTTGGCGCCCCTGTGCCGGCCTTCGAGGGCCGCTCCTTCCTGGCCTTCCCCACTCTCCGCGCCTACCACACGCTGCGCCTGGCACTGGAATTCCGGGCGCTGGAGCCTCAGGGGCTGCTGCTGTACAATGGCAACGCCCGGGGCAAGGACTTCCTGGCATTGGCGCTGCTAGATGGCCGCGTGCAGCTCAGGTTTGACACAGGTTCGGGGCCGGCGGTGCTGACCAGTGCCGTGCCGGTAGAGCCGGGCCAGTGGCACCGCCTGGAGCTGTCCCGGCACTGGCGCCGGGGCACCCTCTCGGTGGATGGTGAGACCCCTGTTCTGGGCGAGAGTCCCAGTGGCACCGACGGCCTCAACCTGGACACAGACCTCTTTGTGGGCGGCGTACCCGAGGACCAGGCTGCCGTGGCGCTGGAGCGGACCTTCGTGGGCGCCGGCCTGAGGGGGTGCATCCGTTTGCTGGACGTCAACAACCAGCGCCTGGAGCTTGGCATTGGGCCGGGGGCTGCCACCCGAGGCTCTGGCGTGGGCGAGTGCGGGGACCACCCCTGCCTGCCCAACCCCTGCCATGGCGGGGCCCCATGCCAGAACCTGGAGGCTGGAAGGTTCCATTGCCAGTGCCCGCCCGGCCGCGTCGGACCAACCTGTGCCGATGAGAAGAGCCCCTGCCAGCCCAACCCCTGCCATGGGGCGGCGCCCTGCCGTGTGCTGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCCCTGGGGCGTGAGGGCACCTTCTGCCAGACAGCCTCGGGGCAGGACGGCTCTGGGCCCTTCCTGGCTGACTTCAACGGCTTCTCCCACCTGGAGCTGAGAGGCCTGCACACCTTTGCACGGGACCTGGGGGAGAAGATGGCGCTGGAGGTCGTGTTCCTGGCACGAGGCCCCAGCGGCCTCCTGCTCTACAACGGGCAGAAGACGGACGGCAAGGGGGACTTCGTGTCGCTGGCACTGCGGGACCGCCGCCTGGAGTTCCGCTACGACCTGGGCAAGGGGGCAGCGGTCATCAGGAGCAGGGAGCCAGTCACCCTGGGAGCCTGGACCAGGGTCTCACTGGAGCGAAACGGCCGCAAGGGTGCCCTGCGTGTGGGCGACGGCCCCCGTGTGTTGGGGGAGTCCCCGAAATCCCGCAAGGTTCCGCACACCGTCCTCAACCTGAAGGAGCCGCTCTACGTAGGGGGCGCTCCCGACTTCAGCAAGCTGGCCCGTGCTGCTGCCGTGTCCTCTGGCTTCGACGGTGCCATCCAGCTGGTCTCCCTCGGAGGCCGCCAGCTGCTGACCCCGGAGCACGTGCTGCGGCAGGTGGACGTCACGTCCTTTGCAGGTCACCCCTGCACCCGGGCCTCAGGCCACCCCTGCCTCAATGGGGCCTCCTGCGTCCCGAGGGAGGCTGCCTATGTGTGCCTGTGTCCCGGGGGATTCTCAGGACCGCACTGCGAGAAGGGGCTGGTGGAGAAGTCAGCGGGGGACGTGGATACCTTGGCCTTTGACGGGCGGACCTTTGTCGAGTACCTCAACGCTGTGACCGAGAGCGAACTGGCCAATGAGATCCCCGTCCCCGAAACTCTGGATTCCGGGGCCCTTCACAGCGAGAAGGCACTGCAGAGCAACCACTTTGAACTGAGCCTGCGCACTGAGGCCACGCAGGGGCTGGTGCTCTGGAGTGGCAAGGCCACGGAGCGGGCAGACTATGTGGCACTGGCCATTGTGGACGGGCACCTGCAACTGAGCTACAACCTGGGCTCCCAGCCCGTGGTGCTGCGTTCCACCGTGCCCGTCAACACCAACCGCTGGTTGCGGGTCGTGGCACATAGGGAGCAGAGGGAAGGTTCCCTGCAGGTGGGCAATGAGGCCCCTGTGACCGGCTCCTCCCCGCTGGGCGCCACGCAGCTGGACACTGATGGAGCCCTGTGGCTTGGGGGCCTGCCGGAGCTGCCCGTGGGCCCAGCACTGCCCAAGGCCTACGGCACAGGCTTTGTGGGCTGCTTGCGGGACGTGGTGGTGGGCCGGCACCCGCTGCACCTGCTGGAGGACGCCGTCACCAAGCCAGAGCTGCGGCCCTGCCCCACCCCATGA-3'
NCBI CDS gene sequence with introns (location: 1020173.. 1054981) (34809 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 1020120.. 1056116) (35997 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [1020120 - 1000].. 1056116) (36997 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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