NCBI Summary
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015].
Protein
Protein (NP_001292204)
Agrin
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]
AGRN
agrin
Undefined
Low evidence
Laminin G-like
Undefined
b-sandwich / ConA-like
GlcA(b1-3)Xyl(a1-4)GlcA / Matriglycan on alpha-dystroglycan
NP_001292204
375790
O00468
Undefined
O00468
0.176
10.1016/j.sbi.2018.11.007
PFAM, InterPro
Protein sequence and protein families (fasta) (2068 amino acids) Download
MAGRSHPGPLRPLLPLLVVAACVLPGAGGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGTHFTPVPPTPPDACRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVTTPGLLLSQALPAPPGALPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPSPAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPGPPVERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAIVDVHFDPTTAFRAPDVARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPAFITGATSGAIAAGATARATTASRLPSSAVTPRAPHPSHTSQPVAKTTAAPTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGRSFLAFPTLRAYHTLRLALEFRALEPQGLLLYNGNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPNPCHGAAPCRVLPEGGAQCECPLGREGTFCQTASGQDGSGPFLADFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTDGKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQLLTPEHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYVCLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVPETLDSGALHSEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGRHPLHLLEDAVTKPELRPCPTP
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-O00468-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Monomer (By similarity). Interacts (N-terminal subunit) with TGF-beta family members, BMP2 and BMP4; the interactions inhibit the activity of these growth factors. Interacts with TGFB1; the interaction enhances the activity of TGFB1 (By similarity). Component of the AGRN-LRP4 complex that consists of a tetramer of two AGRN-LRP4 heterodimers (PubMed:21969364). Interacts (via the laminin G-like 3 domain) directly with LRP4; the interaction is required for activation of MUSK and clustering of AChR and requires the 'z8' insert present in the z(+8) isoforms (PubMed:21969364). Interacts with DAG1; the interaction is influenced by cell surface glycosaminoglycans and by alternative splicing of AGRN, and is required for up-regulation of SOX9 and cartilage formation (PubMed:22205389, PubMed:26290588)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Autoantibodies to cortactin and agrin in sera of patients with myasthenia gravis. [33962172]
  • AGRN Gene Mutation Leads to Congenital Myasthenia Syndromes: A Pediatric Case Report and Literature Review. [32221959]
  • Congenital myasthenic syndrome-associated agrin variants affect clustering of acetylcholine receptors in a domain-specific manner. [32271162]
  • Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions. [31852835]
  • Clinical significance of nuclear localisation of agrin in lung adenocarcinoma. [31820863]
  • Agrin binds to the nerve-muscle basal lamina via laminin. [9151673]
  • Congenital Myasthenic Syndromes [20301347]
  • Structure and chromosomal localization of the mammalian agrin gene. [1326608]
  • Agrin mediates cell contact-induced acetylcholine receptor clustering. [1659950]
  • Structure and expression of a rat agrin. [1851019]
UniProt Main References (12 PubMed Identifiers)
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • Primary structure and high expression of human agrin in basement membranes of adult lung and kidney. [9652404]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein. [11161480]
  • Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm. [16487930]
  • Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]
  • Proteomics characterization of extracellular space components in the human aorta. [20551380]
  • Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK). [21969364]
  • C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction. [22683512]
  • Identification of an agrin mutation that causes congenital myasthenia and affects synapse function. [19631309]
    • Show more
All isoforms of this gene containing a lectin domain
NP_940978.2, NP_001351656.1, XP_005244806.1, NP_001292204.1, XP_011539731.1
RNA
RNA (Transcript ID: NM_001305275.2)
NM_001305275.2
agrin, transcript variant 1
All isoforms of AGRN containing a lectin domain
54..6260 (or 1020173.. 1054981)
1020120.. 1056116
NCBI Matured mRNA sequence 7395 NTPDownload 
m7G-5')ppp(5'-AGUCCCGUCCCCGGCGCGGCCCGCGCGCUCCUCCGCCGCCUCUCGCCUGCGCCAUGGCCGGCCGGUCCCACCCGGGCCCGCUGCGGCCGCUGCUGCCGCUCCUUGUGGUGGCCGCGUGCGUCCUGCCCGGAGCCGGCGGGACAUGCCCGGAGCGCGCGCUGGAGCGGCGCGAGGAGGAGGCGAACGUGGUGCUCACCGGGACGGUGGAGGAGAUCCUCAACGUGGACCCGGUGCAGCACACGUACUCCUGCAAGGUUCGGGUCUGGCGGUACUUGAAGGGCAAAGACCUGGUGGCCCGGGAGAGCCUGCUGGACGGCGGCAACAAGGUGGUGAUCAGCGGCUUUGGAGACCCCCUCAUCUGUGACAACCAGGUGUCCACUGGGGACACCAGGAUCUUCUUUGUGAACCCUGCACCCCCAUACCUGUGGCCAGCCCACAAGAACGAGCUGAUGCUCAACUCCAGCCUCAUGCGGAUCACCCUGCGGAACCUGGAGGAGGUGGAGUUCUGUGUGGAAGAUAAACCCGGGACCCACUUCACUCCAGUGCCUCCGACGCCUCCUGAUGCGUGCCGGGGAAUGCUGUGCGGCUUCGGCGCCGUGUGCGAGCCCAACGCGGAGGGGCCGGGCCGGGCGUCCUGCGUCUGCAAGAAGAGCCCGUGCCCCAGCGUGGUGGCGCCUGUGUGUGGGUCGGACGCCUCCACCUACAGCAACGAAUGCGAGCUGCAGCGGGCGCAGUGCAGCCAGCAGCGCCGCAUCCGCCUGCUCAGCCGCGGGCCGUGCGGCUCGCGGGACCCCUGCUCCAACGUGACCUGCAGCUUCGGCAGCACCUGUGCGCGCUCGGCCGACGGGCUGACGGCCUCGUGCCUGUGCCCCGCGACCUGCCGUGGCGCCCCCGAGGGGACCGUCUGCGGCAGCGACGGCGCCGACUACCCCGGCGAGUGCCAGCUCCUGCGCCGCGCCUGCGCCCGCCAGGAGAAUGUCUUCAAGAAGUUCGACGGCCCUUGUGACCCCUGUCAGGGCGCCCUCCCUGACCCGAGCCGCAGCUGCCGUGUGAACCCGCGCACGCGGCGCCCUGAGAUGCUCCUACGGCCCGAGAGCUGCCCUGCCCGGCAGGCGCCAGUGUGUGGGGACGACGGAGUCACCUACGAAAACGACUGUGUCAUGGGCCGAUCGGGGGCCGCCCGGGGUCUCCUCCUGCAGAAAGUGCGCUCCGGCCAGUGCCAGGGUCGAGACCAGUGCCCGGAGCCCUGCCGGUUCAAUGCCGUGUGCCUGUCCCGCCGUGGCCGUCCCCGCUGCUCCUGCGACCGCGUCACCUGUGACGGGGCCUACAGGCCCGUGUGUGCCCAGGACGGGCGCACGUAUGACAGUGAUUGCUGGCGGCAGCAGGCUGAGUGCCGGCAGCAGCGUGCCAUCCCCAGCAAGCACCAGGGCCCGUGUGACCAGGCCCCGUCCCCAUGCCUCGGGGUGCAGUGUGCAUUUGGGGCGACGUGUGCUGUGAAGAACGGGCAGGCAGCGUGUGAAUGCCUGCAGGCGUGCUCGAGCCUCUACGAUCCUGUGUGCGGCAGCGACGGCGUCACAUACGGCAGCGCGUGCGAGCUGGAGGCCACGGCCUGUACCCUCGGGCGGGAGAUCCAGGUGGCGCGCAAAGGACCCUGUGACCGCUGCGGGCAGUGCCGCUUUGGAGCCCUGUGCGAGGCCGAGACCGGGCGCUGCGUGUGCCCCUCUGAAUGCGUGGCUUUGGCCCAGCCCGUGUGUGGCUCCGACGGGCACACGUACCCCAGCGAGUGCAUGCUGCACGUGCACGCCUGCACACACCAGAUCAGCCUGCACGUGGCCUCAGCUGGACCCUGUGAGACCUGUGGAGAUGCCGUGUGUGCUUUUGGGGCUGUGUGCUCCGCAGGGCAGUGUGUGUGUCCCCGGUGUGAGCACCCCCCGCCCGGCCCCGUGUGUGGCAGCGACGGUGUCACCUACGGCAGUGCCUGCGAGCUACGGGAAGCCGCCUGCCUCCAGCAGACACAGAUCGAGGAGGCCCGGGCAGGGCCGUGCGAGCAGGCCGAGUGCGGUUCCGGAGGCUCUGGCUCUGGGGAGGACGGUGACUGUGAGCAGGAGCUGUGCCGGCAGCGCGGUGGCAUCUGGGACGAGGACUCGGAGGACGGGCCGUGUGUCUGUGACUUCAGCUGCCAGAGUGUCCCAGGCAGCCCGGUGUGCGGCUCAGAUGGGGUCACCUACAGCACCGAGUGUGAGCUGAAGAAGGCCAGGUGUGAGUCACAGCGAGGGCUCUACGUAGCGGCCCAGGGAGCCUGCCGAGGCCCCACCUUCGCCCCGCUGCCGCCUGUGGCCCCCUUACACUGUGCCCAGACGCCCUACGGCUGCUGCCAGGACAAUAUCACCGCAGCCCGGGGCGUGGGCCUGGCUGGCUGCCCCAGUGCCUGCCAGUGCAACCCCCAUGGCUCUUACGGCGGCACCUGUGACCCAGCCACAGGCCAGUGCUCCUGCCGCCCAGGUGUGGGGGGCCUCAGGUGUGACCGCUGUGAGCCUGGCUUCUGGAACUUUCGAGGCAUCGUCACCGAUGGCCGGAGUGGCUGUACACCCUGCAGCUGUGAUCCCCAAGGCGCCGUGCGGGAUGACUGUGAGCAGAUGACGGGGCUGUGCUCGUGUAAGCCCGGGGUGGCUGGACCCAAGUGUGGGCAGUGUCCAGACGGCCGUGCCCUGGGCCCCGCGGGCUGUGAAGCUGACGCUUCUGCGCCUGCGACCUGUGCGGAGAUGCGCUGUGAGUUCGGUGCGCGGUGCGUGGAGGAGUCUGGCUCAGCCCACUGUGUCUGCCCGAUGCUCACCUGUCCAGAGGCCAACGCUACCAAGGUCUGUGGGUCAGAUGGAGUCACAUACGGCAACGAGUGUCAGCUGAAGACCAUCGCCUGCCGCCAGGGCCUGCAAAUCUCUAUCCAGAGCCUGGGCCCGUGCCAGGAGGCUGUUGCUCCCAGCACUCACCCGACAUCUGCCUCCGUGACUGUGACCACCCCAGGGCUCCUCCUGAGCCAGGCACUGCCGGCCCCCCCCGGCGCCCUCCCCCUGGCUCCCAGCAGUACCGCACACAGCCAGACCACCCCUCCGCCCUCAUCACGACCUCGGACCACUGCCAGCGUCCCCAGGACCACCGUGUGGCCCGUGCUGACGGUGCCCCCCACGGCACCCUCCCCUGCACCCAGCCUGGUGGCGUCCGCCUUUGGUGAAUCUGGCAGCACUGAUGGAAGCAGCGAUGAGGAACUGAGCGGGGACCAGGAGGCCAGUGGGGGUGGCUCUGGGGGGCUCGAGCCCUUGGAGGGCAGCAGCGUGGCCACCCCUGGGCCACCUGUCGAGAGGGCUUCCUGCUACAACUCCGCGUUGGGCUGCUGCUCUGAUGGGAAGACGCCCUCGCUGGACGCAGAGGGCUCCAACUGCCCCGCCACCAAGGUGUUCCAGGGCGUCCUGGAGCUGGAGGGCGUCGAGGGCCAGGAGCUGUUCUACACGCCCGAGAUGGCUGACCCCAAGUCAGAACUGUUCGGGGAGACAGCCAGGAGCAUUGAGAGCACCCUGGACGACCUCUUCCGGAAUUCAGACGUCAAGAAGGAUUUUCGGAGUGUCCGCUUGCGGGACCUGGGGCCCGGCAAAUCCGUCCGCGCCAUUGUGGAUGUGCACUUUGACCCCACCACAGCCUUCAGGGCACCCGACGUGGCCCGGGCCCUGCUCCGGCAGAUCCAGGUGUCCAGGCGCCGGUCCUUGGGGGUGAGGCGGCCGCUGCAGGAGCACGUGCGAUUUAUGGACUUUGACUGGUUUCCUGCGUUUAUCACGGGGGCCACGUCAGGAGCCAUUGCUGCGGGAGCCACGGCCAGAGCCACCACUGCAUCGCGCCUGCCGUCCUCUGCUGUGACCCCUCGGGCCCCGCACCCCAGUCACACAAGCCAGCCCGUUGCCAAGACCACGGCAGCCCCCACCACACGUCGGCCCCCCACCACUGCCCCCAGCCGUGUGCCCGGACGUCGGCCCCCGGCCCCCCAGCAGCCUCCAAAGCCCUGUGACUCACAGCCCUGCUUCCACGGGGGGACCUGCCAGGACUGGGCAUUGGGCGGGGGCUUCACCUGCAGCUGCCCGGCAGGCAGGGGAGGCGCCGUCUGUGAGAAGGUGCUUGGCGCCCCUGUGCCGGCCUUCGAGGGCCGCUCCUUCCUGGCCUUCCCCACUCUCCGCGCCUACCACACGCUGCGCCUGGCACUGGAAUUCCGGGCGCUGGAGCCUCAGGGGCUGCUGCUGUACAAUGGCAACGCCCGGGGCAAGGACUUCCUGGCAUUGGCGCUGCUAGAUGGCCGCGUGCAGCUCAGGUUUGACACAGGUUCGGGGCCGGCGGUGCUGACCAGUGCCGUGCCGGUAGAGCCGGGCCAGUGGCACCGCCUGGAGCUGUCCCGGCACUGGCGCCGGGGCACCCUCUCGGUGGAUGGUGAGACCCCUGUUCUGGGCGAGAGUCCCAGUGGCACCGACGGCCUCAACCUGGACACAGACCUCUUUGUGGGCGGCGUACCCGAGGACCAGGCUGCCGUGGCGCUGGAGCGGACCUUCGUGGGCGCCGGCCUGAGGGGGUGCAUCCGUUUGCUGGACGUCAACAACCAGCGCCUGGAGCUUGGCAUUGGGCCGGGGGCUGCCACCCGAGGCUCUGGCGUGGGCGAGUGCGGGGACCACCCCUGCCUGCCCAACCCCUGCCAUGGCGGGGCCCCAUGCCAGAACCUGGAGGCUGGAAGGUUCCAUUGCCAGUGCCCGCCCGGCCGCGUCGGACCAACCUGUGCCGAUGAGAAGAGCCCCUGCCAGCCCAACCCCUGCCAUGGGGCGGCGCCCUGCCGUGUGCUGCCCGAGGGUGGUGCUCAGUGCGAGUGCCCCCUGGGGCGUGAGGGCACCUUCUGCCAGACAGCCUCGGGGCAGGACGGCUCUGGGCCCUUCCUGGCUGACUUCAACGGCUUCUCCCACCUGGAGCUGAGAGGCCUGCACACCUUUGCACGGGACCUGGGGGAGAAGAUGGCGCUGGAGGUCGUGUUCCUGGCACGAGGCCCCAGCGGCCUCCUGCUCUACAACGGGCAGAAGACGGACGGCAAGGGGGACUUCGUGUCGCUGGCACUGCGGGACCGCCGCCUGGAGUUCCGCUACGACCUGGGCAAGGGGGCAGCGGUCAUCAGGAGCAGGGAGCCAGUCACCCUGGGAGCCUGGACCAGGGUCUCACUGGAGCGAAACGGCCGCAAGGGUGCCCUGCGUGUGGGCGACGGCCCCCGUGUGUUGGGGGAGUCCCCGAAAUCCCGCAAGGUUCCGCACACCGUCCUCAACCUGAAGGAGCCGCUCUACGUAGGGGGCGCUCCCGACUUCAGCAAGCUGGCCCGUGCUGCUGCCGUGUCCUCUGGCUUCGACGGUGCCAUCCAGCUGGUCUCCCUCGGAGGCCGCCAGCUGCUGACCCCGGAGCACGUGCUGCGGCAGGUGGACGUCACGUCCUUUGCAGGUCACCCCUGCACCCGGGCCUCAGGCCACCCCUGCCUCAAUGGGGCCUCCUGCGUCCCGAGGGAGGCUGCCUAUGUGUGCCUGUGUCCCGGGGGAUUCUCAGGACCGCACUGCGAGAAGGGGCUGGUGGAGAAGUCAGCGGGGGACGUGGAUACCUUGGCCUUUGACGGGCGGACCUUUGUCGAGUACCUCAACGCUGUGACCGAGAGCGAACUGGCCAAUGAGAUCCCCGUCCCCGAAACUCUGGAUUCCGGGGCCCUUCACAGCGAGAAGGCACUGCAGAGCAACCACUUUGAACUGAGCCUGCGCACUGAGGCCACGCAGGGGCUGGUGCUCUGGAGUGGCAAGGCCACGGAGCGGGCAGACUAUGUGGCACUGGCCAUUGUGGACGGGCACCUGCAACUGAGCUACAACCUGGGCUCCCAGCCCGUGGUGCUGCGUUCCACCGUGCCCGUCAACACCAACCGCUGGUUGCGGGUCGUGGCACAUAGGGAGCAGAGGGAAGGUUCCCUGCAGGUGGGCAAUGAGGCCCCUGUGACCGGCUCCUCCCCGCUGGGCGCCACGCAGCUGGACACUGAUGGAGCCCUGUGGCUUGGGGGCCUGCCGGAGCUGCCCGUGGGCCCAGCACUGCCCAAGGCCUACGGCACAGGCUUUGUGGGCUGCUUGCGGGACGUGGUGGUGGGCCGGCACCCGCUGCACCUGCUGGAGGACGCCGUCACCAAGCCAGAGCUGCGGCCCUGCCCCACCCCAUGAGCUGGCACCAGAGCCCCGCGCCCGCUGUAAUUAUUUUCUAUUUUUGUAAACUUGUUGCUUUUUGAUAUGAUUUUCUUGCCUGAGUGUUGGCCGGAGGGACUGCUGGCCCGGCCUCCCUUCCGUCCAGGCAGCCGUGCUGCAGACAGACCUAGUGCCGAGGGAUGGACAGGCGAGGUGGCAGCGUGGAGGGCUCGGCGUGGAUGGCAGCCUCAGGACACACACCCCUGCCUCAAGGUGCUGAGCCCCCGCCUUGCACUGCGCCUGCCCCACGGUGUCCCCGCCGGGAAGCAGCCCCGGCUCCUGAAUCACCCUCGCUCCGUCAGGCGGGACUCGUGUCCCAGAGAGGAAGGGGCUGCUGAGGUCUGAUGGGGCCCUUCCUCCGGGUGACCCCACAGGGCCUUUCCAAGCCCCCAUUUGAGCUGCUCCUUCCUGUGUGUGCUCUGGGCCCUGCCUCGGCCUCCUGCGCCAAUACUGUGACUUCCAAACAAUGUUACUGCUGGGCACAGCUCUGCGUUGCUCCCGUGCUGCCUGCGCCAGCCCCAGGCUGCUGAGGAGCAGAGGCCAGACCAGGGCCGAUCUGGGUGUCCUGACCCUCAGCUGGCCCUGCCCAGCCACCCUGGACGUGACCGUAUCCCUCUGCCACACCCCAGGCCCUGCGAGGGGCUAUCGAGAGGAGCUCACUGUGGGAUGGGGUUGACCUCUGCCGCCUGCCUGGGUAUCUGGGCCUGGCCAUGGCUGUGUUCUUCAUGUGUUGAUUUUAUUUGACCCCUGGAGUGGUGGGUCUCAUCUUUCCCAUCUCGCCUGAGAGCGGCUGAGGGCUGCCUCACUGCAAAUCCUCCCCACAGCGUCAGUGAAAGUCGUCCUUGUCUCAGAAUGACCAGGGGCCAGCCAGUGUCUGACCAAGGUCAAGGGGCAGGUGCAGAGGUGGCAGGGAUGGCUCCGAAGCCAGAAAUGCCUUAAACUGCAACGUCCCGUCCCUUCCCCACCCCCAUCCCAUCCCCACCCCCAGCCCCAGCCCAGUCCUCCUAGGAGCAGGACCCGAUGAAGCGGGCGGCGGUGGGGCUGGGUGCCGUGUUACUAACUCUAGUAUGUUUCUGUGUCAAUCGCUGUGAAAUAAAGUCUGAAAACUUUAAAA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 375790)
AGRN
agrin
NC_000001.11
1  1020173.. 1054981
1020173.. 1054981
strand +
MGI:87961
ClinVar, dbVar
ENSG00000188157
uc001ack.3
INSDC:
329
103320
OTTHUMG00000040778
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (6207 bp)
5'-ATGGCCGGCCGGTCCCACCCGGGCCCGCTGCGGCCGCTGCTGCCGCTCCTTGTGGTGGCCGCGTGCGTCCTGCCCGGAGCCGGCGGGACATGCCCGGAGCGCGCGCTGGAGCGGCGCGAGGAGGAGGCGAACGTGGTGCTCACCGGGACGGTGGAGGAGATCCTCAACGTGGACCCGGTGCAGCACACGTACTCCTGCAAGGTTCGGGTCTGGCGGTACTTGAAGGGCAAAGACCTGGTGGCCCGGGAGAGCCTGCTGGACGGCGGCAACAAGGTGGTGATCAGCGGCTTTGGAGACCCCCTCATCTGTGACAACCAGGTGTCCACTGGGGACACCAGGATCTTCTTTGTGAACCCTGCACCCCCATACCTGTGGCCAGCCCACAAGAACGAGCTGATGCTCAACTCCAGCCTCATGCGGATCACCCTGCGGAACCTGGAGGAGGTGGAGTTCTGTGTGGAAGATAAACCCGGGACCCACTTCACTCCAGTGCCTCCGACGCCTCCTGATGCGTGCCGGGGAATGCTGTGCGGCTTCGGCGCCGTGTGCGAGCCCAACGCGGAGGGGCCGGGCCGGGCGTCCTGCGTCTGCAAGAAGAGCCCGTGCCCCAGCGTGGTGGCGCCTGTGTGTGGGTCGGACGCCTCCACCTACAGCAACGAATGCGAGCTGCAGCGGGCGCAGTGCAGCCAGCAGCGCCGCATCCGCCTGCTCAGCCGCGGGCCGTGCGGCTCGCGGGACCCCTGCTCCAACGTGACCTGCAGCTTCGGCAGCACCTGTGCGCGCTCGGCCGACGGGCTGACGGCCTCGTGCCTGTGCCCCGCGACCTGCCGTGGCGCCCCCGAGGGGACCGTCTGCGGCAGCGACGGCGCCGACTACCCCGGCGAGTGCCAGCTCCTGCGCCGCGCCTGCGCCCGCCAGGAGAATGTCTTCAAGAAGTTCGACGGCCCTTGTGACCCCTGTCAGGGCGCCCTCCCTGACCCGAGCCGCAGCTGCCGTGTGAACCCGCGCACGCGGCGCCCTGAGATGCTCCTACGGCCCGAGAGCTGCCCTGCCCGGCAGGCGCCAGTGTGTGGGGACGACGGAGTCACCTACGAAAACGACTGTGTCATGGGCCGATCGGGGGCCGCCCGGGGTCTCCTCCTGCAGAAAGTGCGCTCCGGCCAGTGCCAGGGTCGAGACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTCCTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACAGTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCGTGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAACGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACGGCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTGGCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGGGCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGTACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCTGGACCCTGTGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGTGTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTGCCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGCGAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTGCCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCCAGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAGAAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCACCTTCGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATATCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCTTACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTGTGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACACCCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGTAAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTGTGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGGAGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTCTGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCTGCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCACTCACCCGACATCTGCCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCCCCCGGCGCCCTCCCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATCACGACCTCGGACCACTGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGGCACCCTCCCCTGCACCCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGCGGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCACCCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACTCCGCGTTGGGCTGCTGCTCTGATGGGAAGACGCCCTCGCTGGACGCAGAGGGCTCCAACTGCCCCGCCACCAAGGTGTTCCAGGGCGTCCTGGAGCTGGAGGGCGTCGAGGGCCAGGAGCTGTTCTACACGCCCGAGATGGCTGACCCCAAGTCAGAACTGTTCGGGGAGACAGCCAGGAGCATTGAGAGCACCCTGGACGACCTCTTCCGGAATTCAGACGTCAAGAAGGATTTTCGGAGTGTCCGCTTGCGGGACCTGGGGCCCGGCAAATCCGTCCGCGCCATTGTGGATGTGCACTTTGACCCCACCACAGCCTTCAGGGCACCCGACGTGGCCCGGGCCCTGCTCCGGCAGATCCAGGTGTCCAGGCGCCGGTCCTTGGGGGTGAGGCGGCCGCTGCAGGAGCACGTGCGATTTATGGACTTTGACTGGTTTCCTGCGTTTATCACGGGGGCCACGTCAGGAGCCATTGCTGCGGGAGCCACGGCCAGAGCCACCACTGCATCGCGCCTGCCGTCCTCTGCTGTGACCCCTCGGGCCCCGCACCCCAGTCACACAAGCCAGCCCGTTGCCAAGACCACGGCAGCCCCCACCACACGTCGGCCCCCCACCACTGCCCCCAGCCGTGTGCCCGGACGTCGGCCCCCGGCCCCCCAGCAGCCTCCAAAGCCCTGTGACTCACAGCCCTGCTTCCACGGGGGGACCTGCCAGGACTGGGCATTGGGCGGGGGCTTCACCTGCAGCTGCCCGGCAGGCAGGGGAGGCGCCGTCTGTGAGAAGGTGCTTGGCGCCCCTGTGCCGGCCTTCGAGGGCCGCTCCTTCCTGGCCTTCCCCACTCTCCGCGCCTACCACACGCTGCGCCTGGCACTGGAATTCCGGGCGCTGGAGCCTCAGGGGCTGCTGCTGTACAATGGCAACGCCCGGGGCAAGGACTTCCTGGCATTGGCGCTGCTAGATGGCCGCGTGCAGCTCAGGTTTGACACAGGTTCGGGGCCGGCGGTGCTGACCAGTGCCGTGCCGGTAGAGCCGGGCCAGTGGCACCGCCTGGAGCTGTCCCGGCACTGGCGCCGGGGCACCCTCTCGGTGGATGGTGAGACCCCTGTTCTGGGCGAGAGTCCCAGTGGCACCGACGGCCTCAACCTGGACACAGACCTCTTTGTGGGCGGCGTACCCGAGGACCAGGCTGCCGTGGCGCTGGAGCGGACCTTCGTGGGCGCCGGCCTGAGGGGGTGCATCCGTTTGCTGGACGTCAACAACCAGCGCCTGGAGCTTGGCATTGGGCCGGGGGCTGCCACCCGAGGCTCTGGCGTGGGCGAGTGCGGGGACCACCCCTGCCTGCCCAACCCCTGCCATGGCGGGGCCCCATGCCAGAACCTGGAGGCTGGAAGGTTCCATTGCCAGTGCCCGCCCGGCCGCGTCGGACCAACCTGTGCCGATGAGAAGAGCCCCTGCCAGCCCAACCCCTGCCATGGGGCGGCGCCCTGCCGTGTGCTGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCCCTGGGGCGTGAGGGCACCTTCTGCCAGACAGCCTCGGGGCAGGACGGCTCTGGGCCCTTCCTGGCTGACTTCAACGGCTTCTCCCACCTGGAGCTGAGAGGCCTGCACACCTTTGCACGGGACCTGGGGGAGAAGATGGCGCTGGAGGTCGTGTTCCTGGCACGAGGCCCCAGCGGCCTCCTGCTCTACAACGGGCAGAAGACGGACGGCAAGGGGGACTTCGTGTCGCTGGCACTGCGGGACCGCCGCCTGGAGTTCCGCTACGACCTGGGCAAGGGGGCAGCGGTCATCAGGAGCAGGGAGCCAGTCACCCTGGGAGCCTGGACCAGGGTCTCACTGGAGCGAAACGGCCGCAAGGGTGCCCTGCGTGTGGGCGACGGCCCCCGTGTGTTGGGGGAGTCCCCGAAATCCCGCAAGGTTCCGCACACCGTCCTCAACCTGAAGGAGCCGCTCTACGTAGGGGGCGCTCCCGACTTCAGCAAGCTGGCCCGTGCTGCTGCCGTGTCCTCTGGCTTCGACGGTGCCATCCAGCTGGTCTCCCTCGGAGGCCGCCAGCTGCTGACCCCGGAGCACGTGCTGCGGCAGGTGGACGTCACGTCCTTTGCAGGTCACCCCTGCACCCGGGCCTCAGGCCACCCCTGCCTCAATGGGGCCTCCTGCGTCCCGAGGGAGGCTGCCTATGTGTGCCTGTGTCCCGGGGGATTCTCAGGACCGCACTGCGAGAAGGGGCTGGTGGAGAAGTCAGCGGGGGACGTGGATACCTTGGCCTTTGACGGGCGGACCTTTGTCGAGTACCTCAACGCTGTGACCGAGAGCGAACTGGCCAATGAGATCCCCGTCCCCGAAACTCTGGATTCCGGGGCCCTTCACAGCGAGAAGGCACTGCAGAGCAACCACTTTGAACTGAGCCTGCGCACTGAGGCCACGCAGGGGCTGGTGCTCTGGAGTGGCAAGGCCACGGAGCGGGCAGACTATGTGGCACTGGCCATTGTGGACGGGCACCTGCAACTGAGCTACAACCTGGGCTCCCAGCCCGTGGTGCTGCGTTCCACCGTGCCCGTCAACACCAACCGCTGGTTGCGGGTCGTGGCACATAGGGAGCAGAGGGAAGGTTCCCTGCAGGTGGGCAATGAGGCCCCTGTGACCGGCTCCTCCCCGCTGGGCGCCACGCAGCTGGACACTGATGGAGCCCTGTGGCTTGGGGGCCTGCCGGAGCTGCCCGTGGGCCCAGCACTGCCCAAGGCCTACGGCACAGGCTTTGTGGGCTGCTTGCGGGACGTGGTGGTGGGCCGGCACCCGCTGCACCTGCTGGAGGACGCCGTCACCAAGCCAGAGCTGCGGCCCTGCCCCACCCCATGA-3'
NCBI CDS gene sequence with introns (location: 1020173.. 1054981) (34809 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 1020120.. 1056116) (35997 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [1020120 - 1000].. 1056116) (36997 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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