NCBI Summary
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014].
Protein
Protein (NP_001278789)
Basement membrane-specific heparan sulfate proteoglycan core protein
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]
HSPG2
heparan sulfate proteoglycan 2
Undefined
Low evidence
Laminin G-like
Undefined
b-sandwich / ConA-like
GlcA(b1-3)Xyl(a1-4)GlcA / Matriglycan on alpha-dystroglycan
Undefined
0.181
MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDMLADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRAGPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAASTHTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPGSTPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGNNIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTRPCPS
Mol* PDB structure viewerUniLectin3D
Structural models
No AlphaFold model available for P98160.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Perlecan in Pericellular Mechanosensory Cell-Matrix Communication, Extracellular Matrix Stabilisation and Mechanoregulation of Load-Bearing Connective Tissues. [33800241]
- Perlecan, a modular instructive proteoglycan with diverse functional properties. [32947020]
- HSPG2 overexpression independently predicts poor survival in patients with acute myeloid leukemia. [32606327]
- Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells. [32205445]
- Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. [1569102]
- Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. [1730768]
- Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1----p35 and identification of a BamHI restriction fragment length polymorphism. [1685141]
- Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1. [1679749]
- Matrix-associated heparan sulfate proteoglycan: core protein-specific monoclonal antibodies decorate the pericellular matrix of connective tissue cells and the stromal side of basement membranes. [2687294]
- SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix. [2745554]
UniProt Main References (18 PubMed Identifiers)
- The DNA sequence and biological annotation of human chromosome 1. [16710414]
- Structural characterization of the complete human perlecan gene and its promoter. [8234307]
- Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). [11101850]
- BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. [15591058]
- Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. [12435733]
- Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. [11148217]
- Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene. [11279527]
- The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin. [11956183]
- Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. [12604605]
- Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. [12754519] Show more
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_001291860.2)
heparan sulfate proteoglycan 2, transcript variant 1
m7G-5')ppp(5'-GCUGUCCCGAGCUGGCCGGCGAGCGGGCGGCUGCGGGCGGCGCGGAGCGGGCGGCGCGGAGCGAGCGAGCGAGAGAGCGGCGCGGGCCGGGCCAUGGGGUGGCGGGCGGCGGGCGCGCUGCUGCUGGCGCUGCUGCUGCACGGGCGGCUGCUGGCGGUGACCCAUGGGCUGAGGGCAUACGAUGGCUUGUCUCUGCCUGAGGACAUAGAGACCGUCACAGCAAGCCAAAUGCGCUGGACACAUUCGUACCUUUCUGAUGAUGAGGACAUGCUGGCUGACAGCAUCUCAGGAGACGACCUGGGCAGUGGGGACCUGGGCAGCGGGGACUUCCAGAUGGUUUAUUUCCGAGCCCUGGUGAAUUUCACUCGCUCCAUCGAGUACAGCCCUCAGCUGGAGGAUGCAGGCUCCAGAGAGUUCCGAGAGGUGUCCGAGGCUGUGGUAGACACGCUGGAGUCGGAGUACUUGAAAAUUCCCGGAGACCAGGUUGUCAGUGUGGUGUUCAUCAAGGAGCUGGAUGGCUGGGUUUUUGUGGAGCUGGAUGUGGGCUCGGAAGGGAAUGCGGAUGGGGCUCAGAUUCAGGAGAUGCUGCUCAGGGUCAUCUCCAGCGGCUCUGUGGCCUCCUACGUCACCUCUCCCCAGGGAUUCCAGUUCCGACGCCUGGGCACAGUGCCCCAGUUCCCAAGAGCCUGCACGGAGGCCGAGUUUGCCUGCCACAGCUACAAUGAGUGUGUGGCCCUGGAGUAUCGCUGUGACCGGCGGCCCGACUGCAGGGACAUGUCUGAUGAGCUCAAUUGUGAGGAGCCAGUCCUGGGUAUCAGCCCCACAUUCUCUCUCCUUGUGGAGACGACAUCUUUACCGCCCCGGCCAGAGACAACCAUCAUGCGACAGCCACCAGUCACCCACGCUCCUCAGCCCCUGCUUCCCGGUUCCGUCAGGCCCCUGCCCUGUGGGCCCCAGGAGGCCGCAUGCCGCAAUGGGCACUGCAUCCCCAGAGACUACCUCUGCGACGGACAGGAGGACUGCGAGGACGGCAGCGAUGAGCUAGACUGUGGCCCCCCGCCACCCUGUGAGCCCAACGAGUUCCCCUGCGGGAAUGGACAUUGUGCCCUCAAGCUGUGGCGCUGCGAUGGUGACUUUGACUGUGAGGACCGAACUGAUGAAGCCAACUGCCCCACCAAGCGUCCUGAGGAAGUGUGCGGGCCCACACAGUUCCGAUGCGUCUCUACCAACAUGUGCAUCCCAGCCAGCUUCCACUGUGACGAGGAGAGCGACUGUCCUGACCGGAGCGACGAGUUUGGCUGCAUGCCCCCCCAGGUGGUGACACCUCCCCGGGAGUCCAUCCAGGCUUCCCGGGGCCAGACAGUGACCUUCACCUGCGUGGCCAUUGGCGUCCCCACCCCCAUCAUCAAUUGGAGGCUCAACUGGGGCCACAUCCCCUCUCAUCCCAGGGUGACAGUGACCAGCGAGGGUGGCCGUGGCACACUGAUCAUCCGUGAUGUGAAGGAGUCAGACCAGGGUGCCUACACCUGUGAGGCCAUGAACGCCCGGGGCAUGGUGUUUGGCAUUCCUGACGGUGUCCUUGAGCUCGUCCCACAACGAGCAGGCCCCUGCCCUGACGGCCACUUCUACCUGGAGCACAGCGCCGCCUGCCUGCCCUGCUUCUGCUUUGGCAUCACCAGCGUGUGCCAGAGCACCCGCCGCUUCCGGGACCAGAUCAGGCUGCGCUUUGACCAACCCGAUGACUUCAAGGGUGUGAAUGUGACAAUGCCUGCGCAGCCCGGCACGCCACCCCUCUCCUCCACGCAGCUGCAGAUCGACCCAUCCCUGCACGAGUUCCAGCUAGUCGACCUGUCCCGCCGCUUCCUCGUCCACGACUCCUUCUGGGCUCUGCCUGAACAGUUCCUGGGCAACAAGGUGGACUCCUAUGGCGGCUCCCUGCGUUACAACGUGCGCUACGAGUUGGCCCGUGGCAUGCUGGAGCCAGUGCAGCGGCCGGACGUGGUCCUCAUGGGUGCCGGGUACCGCCUCCUCUCCCGAGGCCACACACCCACCCAACCUGGUGCUCUGAACCAGCGCCAGGUCCAGUUCUCUGAGGAGCACUGGGUCCAUGAGUCUGGCCGGCCGGUGCAGCGCGCGGAGCUGCUGCAGGUGCUGCAGAGCCUGGAGGCCGUGCUCAUCCAGACCGUGUACAACACCAAGAUGGCCAGCGUGGGACUUAGCGACAUCGCCAUGGAUACCACCGUCACCCAUGCCACCAGCCAUGGCCGUGCCCACAGUGUGGAGGAGUGCAGAUGCCCCAUUGGCUAUUCUGGCUUGUCCUGCGAGAGCUGUGAUGCCCACUUCACUCGGGUGCCUGGUGGGCCCUACCUGGGCACCUGCUCUGGUUGCAAUUGCAAUGGCCAUGCCAGCUCCUGUGACCCUGUGUAUGGCCACUGCCUGAAUUGCCAGCACAACACGGAGGGGCCACAGUGCAACAAGUGCAAGGCUGGCUUCUUUGGGGACGCCAUGAAGGCCACGGCCACUUCCUGCCGGCCCUGCCCUUGCCCAUACAUCGAUGCCUCCCGCAGAUUCUCAGACACUUGCUUCCUGGACACGGAUGGCCAAGCCACAUGUGACGCCUGUGCCCCAGGCUACACUGGCCGCCGCUGUGAGAGCUGUGCCCCCGGAUACGAGGGCAACCCCAUCCAGCCCGGCGGGAAGUGCAGGCCCGUCAACCAGGAGAUUGUGCGCUGUGACGAGCGUGGCAGCAUGGGGACCUCCGGGGAGGCCUGCCGCUGUAAGAACAAUGUGGUGGGGCGCUUGUGCAAUGAAUGUGCUGACGGCUCUUUCCACCUGAGUACCCGAAACCCCGAUGGCUGCCUCAAGUGCUUCUGCAUGGGUGUCAGUCGCCACUGCACCAGCUCUUCAUGGAGCCGUGCCCAGUUGCAUGGGGCCUCUGAGGAGCCUGGUCACUUCAGCCUGACCAACGCCGCAAGCACCCACACCACCAACGAGGGCAUCUUCUCCCCCACGCCCGGGGAACUGGGAUUCUCCUCCUUCCACAGACUCUUAUCUGGACCCUACUUCUGGAGCCUCCCUUCACGCUUCCUGGGGGACAAGGUGACCUCCUAUGGAGGAGAGCUGCGCUUCACAGUGACCCAGAGGUCCCAGCCGGGCUCCACACCCCUGCACGGGCAGCCGUUGGUGGUGCUGCAAGGUAACAACAUCAUCCUAGAGCACCAUGUGGCCCAGGAGCCCAGCCCCGGCCAGCCCAGCACCUUCAUUGUGCCUUUCCGGGAGCAAGCAUGGCAGCGGCCCGAUGGGCAGCCAGCCACACGGGAGCACCUGCUGAUGGCACUGGCAGGCAUCGACACCCUCCUGAUCCGAGCAUCCUACGCCCAGCAGCCCGCUGAGAGCAGGGUCUCUGGCAUCAGCAUGGACGUGGCUGUGCCCGAGGAAACCGGCCAGGACCCCGCGCUGGAAGUGGAACAGUGCUCCUGCCCACCCGGGUACCGUGGGCCGUCCUGCCAGGACUGUGACACAGGCUACACACGCACGCCCAGUGGCCUCUACCUGGGUACCUGUGAACGCUGCAGCUGCCAUGGCCACUCAGAGGCCUGCGAGCCAGAAACAGGUGCCUGCCAGGGCUGCCAGCAUCACACGGAGGGCCCUCGGUGUGAGCAGUGCCAGCCAGGAUACUACGGGGACGCCCAGCGGGGGACACCACAGGACUGCCAGCUGUGCCCCUGCUACGGAGACCCUGCUGCCGGCCAGGCUGCCCACACUUGUUUUCUGGACACAGACGGCCACCCCACCUGUGAUGCGUGCUCCCCAGGCCACAGUGGGCGUCACUGUGAGAGGUGCGCCCCUGGCUACUAUGGCAACCCCAGCCAGGGCCAGCCAUGCCAGAGAGACAGCCAGGUGCCAGGGCCCAUAGGCUGCAACUGUGACCCCCAAGGCAGCGUCAGCAGCCAGUGUGAUGCUGCUGGUCAGUGCCAGUGCAAGGCCCAGGUGGAAGGCCUCACUUGCAGCCACUGCCGGCCCCACCACUUCCACCUGAGUGCCAGCAACCCAGACGGCUGCCUGCCCUGCUUCUGUAUGGGCAUCACCCAGCAGUGCGCCAGCUCUGCCUACACACGCCACCUGAUCUCCACCCACUUUGCCCCUGGGGACUUCCAAGGCUUUGCCCUGGUGAACCCACAGCGAAACAGCCGCCUGACAGGAGAAUUCACUGUGGAACCCGUGCCCGAGGGUGCCCAGCUCUCUUUUGGCAACUUUGCCCAACUCGGCCAUGAGUCCUUCUACUGGCAGCUGCCGGAGACAUACCAGGGAGACAAGGUGGCGGCCUACGGUGGGAAGUUGCGAUACACCCUCUCCUACACAGCAGGCCCACAGGGCAGCCCACUCUCUGACCCCGAUGUGCAGAUCACGGGCAACAACAUCAUGCUAGUGGCCUCCCAGCCAGCGCUGCAGGGCCCUGAGAGGAGGAGCUACGAGAUCAUGUUCCGAGAGGAAUUCUGGCGCCGGCCCGAUGGGCAGCCGGCCACACGCGAGCACCUCCUGAUGGCACUGGCCGACCUGGAUGAGCUCCUGAUCCGGGCCACGUUCUCCUCCGUGCCGCUGGCGGCCAGCAUCAGCGCAGUCAGCCUGGAGGUCGCCCAGCCGGGGCCCUCAAACAGACCCCGCGCCCUCGAGGUGGAGGAGUGCCGCUGCCCGCCAGGCUACAUCGGUCUGUCCUGCCAGGACUGUGCCCCCGGCUACACGCGCACCGGGAGUGGGCUCUACCUCGGCCACUGCGAGCUAUGUGAAUGCAAUGGCCACUCAGACCUGUGCCACCCAGAGACUGGGGCCUGCUCGCAAUGCCAGCACAACGCCGCAGGGGAGUUCUGCGAGCUUUGUGCCCCUGGCUACUACGGAGAUGCCACAGCCGGGACGCCUGAGGACUGCCAGCCCUGUGCCUGCCCACUGACCAACCCAGAGAACAUGUUUUCCCGCACCUGUGAGAGCCUGGGAGCCGGCGGGUACCGCUGCACGGCCUGCGAACCCGGCUACACUGGCCAGUACUGUGAGCAGUGUGGCCCAGGUUACGUGGGUAACCCCAGUGUGCAAGGGGGCCAGUGCCUGCCAGAGACAAACCAAGCCCCACUGGUGGUCGAGGUCCAUCCUGCUCGAAGCAUAGUGCCCCAAGGUGGCUCCCACUCCCUGCGGUGUCAGGUCAGUGGGAGCCCACCCCACUACUUCUAUUGGUCCCGUGAGGAUGGGCGGCCUGUGCCCAGCGGCACCCAGCAGCGACAUCAAGGCUCCGAGCUCCACUUCCCCAGCGUCCAGCCCUCGGAUGCUGGGGUCUACAUUUGCACCUGCCGUAAUCUCCACCAAUCCAAUACCAGCCGGGCAGAGCUGCUGGUCACUGAGGCUCCAAGCAAGCCCAUCACAGUGACUGUGGAGGAGCAGCGGAGCCAGAGCGUGCGCCCCGGAGCUGACGUCACCUUCAUCUGCACAGCCAAAAGCAAGUCCCCAGCCUAUACCCUGGUGUGGACCCGCCUGCACAACGGGAAACUGCCCACCCGAGCCAUGGAUUUCAAUGGCAUCCUGACCAUUCGCAACGUCCAGCUGAGUGAUGCAGGCACCUACGUGUGCACCGGCUCCAACAUGUUUGCCAUGGACCAGGGCACAGCCACUCUACAUGUGCAGGCCUCGGGCACCUUGUCCGCCCCCGUGGUCUCCAUCCAUCCGCCACAGCUCACAGUGCAGCCCGGGCAACUGGCGGAGUUCCGCUGCAGCGCCACAGGGAGCCCCACGCCCACCCUCGAGUGGACAGGGGGCCCCGGCGGCCAGCUCCCUGCGAAGGCACAAAUCCACGGCGGCAUCCUGCGCCUGCCAGCUGUCGAGCCCACGGAUCAGGCCCAGUACUUGUGCCGAGCCCACAGCAGCGCUGGGCAGCAGGUGGCCAGGGCUGUGCUCCACGUGCAUGGGGGCGGUGGGCCCAGAGUCCAAGUGAGCCCAGAGAGGACCCAGGUCCACGCAGGCCGCACCGUCAGGCUGUACUGCAGGGCUGCAGGCGUGCCUAGCGCCACCAUCACCUGGAGGAAGGAAGGGGGCAGCCUCCCACCACAGGCCCGGUCAGAGCGCACAGACAUCGCGACACUGCUCAUCCCAGCCAUCACGACUGCUGACGCCGGCUUCUACCUCUGCGUGGCCACCAGCCCUGCAGGCACUGCCCAGGCCCGGAUCCAAGUGGUUGUCCUUUCAGCCUCAGAUGCCAGCCCACCGCCGGUCAAGAUUGAGUCCUCAUCGCCUUCUGUGACAGAAGGGCAAACACUCGACCUCAACUGUGUGGUGGCAGGGUCAGCCCAUGCCCAGGUCACCUGGUACAGGCGAGGGGGUAGCCUGCCUCCCCACACCCAGGUGCACGGCUCCCGUCUGCGGCUCCCCCAGGUCUCACCAGCUGAUUCUGGAGAAUAUGUGUGCCGUGUGGAGAAUGGAUCGGGCCCCAAGGAGGCCUCCAUUACUGUGUCUGUGCUCCACGGCACCCAUUCUGGCCCCAGCUACACCCCAGUGCCCGGCAGCACCCGGCCCAUCCGCAUCGAGCCCUCCUCCUCACACGUGGCGGAAGGGCAGACCCUGGAUCUGAACUGCGUGGUGCCCGGGCAGGCCCACGCCCAGGUCACGUGGCACAAGCGUGGGGGCAGCCUCCCUGCCCGGCACCAGACCCACGGCUCGCUGCUGCGGCUGCACCAGGUGACCCCGGCCGACUCAGGCGAGUAUGUGUGCCAUGUGGUGGGCACCUCCGGCCCCCUAGAGGCCUCAGUCCUGGUCACCAUCGAAGCCUCUGUCAUCCCUGGACCCAUCCCACCUGUCAGGAUCGAGUCUUCAUCCUCCACAGUGGCCGAGGGCCAGACCCUGGAUCUGAGCUGCGUGGUGGCAGGGCAGGCCCACGCCCAGGUCACAUGGUACAAGCGUGGGGGCAGCCUCCCUGCCCGGCACCAGGUUCGUGGCUCCCGCCUGUACAUCUUCCAGGCCUCACCUGCCGAUGCGGGACAGUACGUCUGCCGGGCCAGCAACGGCAUGGAGGCCUCCAUCACGGUCACAGUAACUGGGACCCAGGGGGCCAACUUAGCCUACCCUGCCGGCAGCACCCAGCCCAUCCGCAUCGAGCCCUCCUCCUCGCAAGUGGCGGAAGGGCAGACCCUGGAUCUGAACUGCGUGGUGCCCGGGCAGUCCCAUGCCCAGGUCACGUGGCACAAGCGUGGGGGCAGCCUCCCUGUCCGGCACCAGACCCACGGCUCCCUGCUGAGACUCUACCAAGCGUCCCCCGCCGACUCGGGCGAGUACGUGUGCCGAGUGUUGGGCAGCUCCGUGCCUCUAGAGGCCUCUGUCCUGGUCACCAUUGAGCCUGCGGGCUCAGUGCCUGCACUUGGGGUCACCCCCACGGUCCGGAUCGAGUCAUCGUCUUCGCAAGUGGCCGAGGGGCAGACCCUGGACCUGAACUGCCUCGUUGCUGGUCAGGCCCAUGCCCAGGUCACGUGGCACAAGCGCGGGGGCAGCCUCCCGGCCCGGCACCAGGUGCAUGGCUCGAGGCUACGCCUGCUCCAGGUGACCCCAGCUGAUUCAGGGGAGUACGUGUGCCGUGUGGUCGGCAGCUCAGGUACCCAGGAAGCCUCAGUCCUUGUCACCAUCCAGCAGCGCCUUAGUGGCUCCCACUCCCAGGGUGUGGCGUACCCCGUCCGCAUCGAGUCCUCCUCAGCCUCCCUGGCCAAUGGACACACCCUGGACCUCAACUGCCUGGUUGCCAGCCAGGCUCCCCACACCAUCACCUGGUAUAAGCGUGGAGGCAGCUUACCCAGCCGGCACCAGAUCGUGGGCUCCCGGCUGCGGAUCCCUCAGGUGACUCCGGCAGACUCGGGCGAGUACGUGUGUCACGUCAGUAACGGUGCAGGCUCCCGGGAGACCUCGCUCAUCGUCACCAUCCAGGGCAGCGGUUCCUCCCACGUGCCCAGCGUCUCCCCACCGAUCAGGAUCGAGUCGUCUUCCCCCACGGUGGUGGAAGGGCAGACCUUGGAUCUGAACUGCGUGGUCGCCAGGCAGCCCCAGGCUAUCAUCACAUGGUACAAGCGUGGGGGCAGCCUUCCCUCCCGACACCAGACCCAUGGCUCCCACCUGCGGUUGCACCAAAUGUCUGUGGCUGACUCGGGCGAGUAUGUGUGCCGGGCCAACAACAACAUCGAUGCCCUGGAGGCCUCCAUCGUCAUCUCCGUCUCCCCUAGCGCCGGCAGCCCCUCCGCCCCUGGCAGCUCCAUGCCCAUCAGAAUUGAGUCAUCCUCCUCACACGUGGCCGAAGGGGAGACCCUGGAUCUGAACUGCGUGGUCCCCGGGCAGGCCCAUGCCCAGGUCACUUGGCACAAGCGUGGGGGCAGCCUCCCCAGUCACCAUCAGACCCGCGGCUCACGGCUGCGGCUGCACCAUGUGUCCCCGGCCGACUCGGGUGAAUACGUGUGCCGGGUGAUGGGCAGCUCUGGCCCCCUGGAGGCCUCAGUCCUGGUCACCAUCGAAGCCUCUGGCUCAAGUGCUGUCCACGUCCCCGCCCCAGGUGGAGCCCCACCCAUCCGCAUCGAGCCCUCCUCCUCCCGAGUGGCAGAAGGGCAGACCCUGGAUCUGAAGUGCGUGGUGCCCGGGCAGGCCCACGCCCAGGUCACGUGGCACAAGCGUGGAGGAAACCUCCCUGCCCGGCACCAGGUCCACGGCCCACUGCUGAGGCUGAACCAGGUGUCCCCGGCUGACUCUGGCGAGUACUCGUGCCAAGUGACCGGAAGCUCAGGCACCCUGGAGGCAUCUGUCCUGGUCACAAUUGAGCCCUCCAGCCCAGGACCCAUUCCUGCUCCAGGACUGGCCCAGCCCAUCUACAUCGAGGCCUCCUCUUCACACGUGACUGAAGGGCAGACUCUGGAUCUGAACUGUGUGGUGCCCGGGCAGGCCCAUGCCCAGGUCACGUGGUACAAGCGCGGGGGCAGCCUCCCCGCCCGGCACCAGACCCAUGGCUCCCAGCUGCGGCUCCACCUCGUCUCCCCUGCCGACUCAGGCGAGUAUGUGUGUCGUGCAGCCAGCGGCCCAGGCCCUGAGCAAGAAGCCUCCUUCACAGUCACCGUCCCGCCCAGUGAGGGGUCUUCCUACCGCCUUAGGAGCCCGGUCAUCUCCAUCGACCCGCCCAGCAGCACCGUGCAGCAGGGCCAGGAUGCCAGCUUCAAGUGCCUCAUCCAUGACGGGGCAGCCCCCAUCAGCCUCGAGUGGAAGACCCGGAACCAGGAGCUGGAGGACAACGUCCACAUCAGUCCCAAUGGCUCCAUCAUCACCAUCGUGGGCACCCGGCCCAGCAACCACGGUACCUACCGCUGCGUGGCCUCCAAUGCCUACGGUGUGGCCCAGAGUGUGGUGAACCUCAGUGUGCACGGGCCCCCUACAGUGUCCGUGCUCCCCGAGGGCCCCGUGUGGGUGAAAGUGGGAAAGGCUGUCACCCUGGAGUGUGUCAGUGCCGGGGAGCCCCGCUCCUCUGCUCGUUGGACCCGGAUCAGCAGCACCCCUGCCAAGUUGGAGCAGCGGACAUAUGGGCUCAUGGACAGCCACGCGGUGCUGCAGAUUUCAUCAGCUAAACCAUCAGAUGCGGGCACUUAUGUGUGCCUUGCUCAGAAUGCACUAGGCACAGCACAGAAGCAGGUGGAGGUGAUCGUGGACACGGGCGCCAUGGCCCCAGGGGCCCCUCAGGUCCAAGCUGAAGAAGCUGAGCUGACUGUGGAGGCUGGACACACGGCCACCUUGCGCUGCUCAGCCACAGGCAGCCCCGCGCCCACCAUCCACUGGUCCAAGCUGCGUUCCCCACUGCCCUGGCAGCACCGGCUGGAAGGUGACACACUCAUCAUACCCCGGGUAGCCCAGCAGGACUCGGGCCAGUACAUCUGCAAUGCCACUAGCCCUGCUGGGCACGCUGAGGCCACCAUCAUCCUGCACGUGGAGAGCCCACCAUAUGCCACCACGGUCCCAGAGCACGCUUCGGUGCAGGCAGGGGAGACGGUGCAGCUCCAGUGCCUGGCUCACGGGACACCCCCACUCACCUUCCAGUGGAGCCGCGUGGGCAGCAGCCUUCCUGGGAGGGCGACCGCCAGGAACGAGCUGCUGCACUUUGAGCGUGCAGCCCCUGAGGACUCAGGCCGCUACCGCUGCCGGGUCACCAACAAGGUGGGCUCAGCCGAGGCCUUUGCCCAGCUGCUCGUCCAAGGCCCUCCCGGCUCUCUCCCUGCCACCUCCAUCCCAGCAGGGUCCACGCCCACCGUGCAGGUCACGCCUCAGCUAGAGACCAAGAGCAUUGGGGCCAGCGUUGAGUUCCACUGUGCUGUGCCCAGCGACCGGGGUACCCAGCUCCGUUGGUUCAAGGAAGGGGGUCAGCUGCCUCCGGGUCACAGCGUGCAGGAUGGGGUGCUCCGAAUCCAGAACUUGGACCAGAGCUGCCAAGGGACGUAUAUAUGCCAGGCCCAUGGACCUUGGGGGAAGGCCCAGGCCAGUGCCCAGCUGGUUAUCCAAGCCCUGCCCUCGGUGCUCAUCAACAUCCGGACCUCUGUGCAGACCGUGGUGGUUGGCCACGCCGUGGAGUUCGAAUGCCUGGCACUGGGUGACCCCAAGCCUCAGGUGACAUGGAGCAAAGUUGGAGGGCACCUGCGGCCAGGCAUUGUGCAGAGCGGAGGUGUCGUCAGGAUCGCCCACGUAGAGCUGGCUGAUGCGGGACAGUAUCGCUGCACUGCCACCAACGCAGCUGGCACCACACAAUCCCACGUCCUGCUGCUUGUGCAAGCCUUGCCCCAGAUCUCAAUGCCCCAAGAAGUCCGUGUGCCUGCUGGUUCUGCAGCUGUCUUCCCCUGCAUAGCCUCAGGCUACCCCACUCCUGACAUCAGCUGGAGCAAGCUGGAUGGCAGCCUGCCACCUGACAGCCGCCUGGAGAACAACAUGCUGAUGCUGCCCUCAGUCCGACCCCAGGACGCAGGUACCUACGUCUGCACCGCCACUAACCGCCAGGGCAAGGUCAAAGCCUUUGCCCACCUGCAGGUGCCAGAGCGGGUGGUGCCCUACUUCACGCAGACCCCCUACUCCUUCCUACCGCUGCCCACCAUCAAGGAUGCCUACAGGAAGUUCGAGAUCAAGAUCACCUUCCGGCCCGACUCAGCCGAUGGGAUGCUGCUGUACAAUGGGCAGAAGCGAGUCCCAGGGAGCCCCACCAACCUGGCCAACCGGCAGCCCGACUUCAUCUCCUUCGGCCUCGUGGGGGGAAGGCCCGAGUUCCGGUUCGAUGCAGGCUCAGGCAUGGCCACCAUCCGCCAUCCCACACCACUGGCCCUGGGCCAUUUCCACACCGUGACCCUGCUGCGCAGCCUCACCCAGGGCUCCCUGAUUGUGGGUGACCUGGCCCCGGUCAAUGGGACCUCCCAGGGCAAGUUCCAGGGCCUGGAUCUGAACGAGGAACUCUACCUGGGUGGCUAUCCUGACUAUGGUGCCAUCCCCAAGGCGGGGCUGAGCAGCGGCUUCAUAGGCUGUGUCCGGGAGCUGCGCAUCCAGGGCGAGGAGAUCGUCUUCCAUGACCUCAACCUCACGGCGCACGGCAUCUCCCACUGCCCCACCUGUCGGGACCGGCCCUGCCAGAAUGGCGGUCAGUGCCAUGACUCUGAGAGCAGCAGCUACGUGUGCGUCUGCCCAGCUGGCUUCACCGGGAGCCGCUGUGAGCACUCGCAGGCCCUGCACUGCCAUCCAGAGGCCUGUGGGCCCGACGCCACCUGUGUGAACCGGCCUGACGGUCGAGGCUACACCUGCCGCUGCCACCUGGGCCGCUCGGGGUUGCGGUGUGAGGAAGGUGUGACAGUGACCACCCCCUCGCUGUCGGGUGCUGGCUCCUACCUGGCACUGCCCGCCCUCACCAACACACACCACGAGCUACGCCUGGACGUGGAGUUCAAGCCACUCGCCCCUGACGGGGUCCUGCUGUUCAGCGGGGGGAAGAGCGGGCCUGUGGAGGACUUCGUGUCCCUGGCGAUGGUGGGCGGCCACCUGGAGUUCCGCUAUGAGUUGGGGUCAGGGCUGGCCGUUCUGCGGAGCGCCGAGCCGCUGGCCCUGGGCCGCUGGCACCGUGUGUCUGCAGAGCGUCUCAACAAGGACGGCAGCCUGCGGGUGAAUGGUGGACGCCCUGUGCUGCGCUCCUCGCCCGGCAAGAGCCAGGGCCUCAACCUGCACACCCUGCUCUACCUGGGGGGUGUGGAGCCUUCCGUGCCACUGUCCCCGGCCACCAACAUGAGCGCUCACUUCCGCGGCUGUGUGGGCGAGGUGUCAGUGAAUGGCAAACGGCUGGACCUCACCUACAGUUUCCUAGGCAGCCAGGGCAUCGGGCAAUGCUAUGAUAGCUCCCCAUGUGAGCGCCAGCCUUGCCAACAUGGUGCCACGUGCAUGCCCGCUGGCGAGUAUGAGUUCCAGUGCCUGUGUCGAGAUGGAUUCAAAGGAGACCUGUGUGAGCACGAGGAGAACCCCUGCCAGCUCCGUGAACCCUGUCUGCAUGGGGGCACCUGCCAGGGCACCCGCUGCCUCUGCCUCCCUGGCUUCUCUGGCCCACGCUGCCAACAAGGCUCUGGACAUGGCAUAGCAGAGUCCGACUGGCAUCUUGAAGGCAGCGGGGGCAAUGAUGCCCCUGGGCAGUACGGAGCCUAUUUCCACGAUGAUGGCUUCCUCGCCUUCCCUGGCCAUGUCUUCUCCAGGAGCCUGCCCGAGGUGCCCGAGACCAUCGAGCUGGAGGUUCGGACCAGCACAGCCAGUGGCCUCCUGCUCUGGCAGGGUGUGGAGGUGGGAGAGGCCGGCCAAGGCAAGGACUUCAUCAGCCUCGGGCUUCAAGACGGGCACCUUGUCUUCAGGUACCAGCUGGGUAGUGGGGAGGCCCGCCUGGUCUCUGAGGACCCCAUCAAUGACGGCGAGUGGCACCGGGUGACAGCACUGCGGGAGGGCCGCAGAGGUUCCAUCCAAGUCGACGGUGAGGAGCUGGUCAGCGGCCGGUCCCCAGGUCCCAACGUGGCAGUCAACGCCAAGGGCAGCGUCUACAUCGGCGGAGCCCCUGACGUGGCCACGCUGACCGGGGGCAGAUUCUCCUCAGGCAUCACAGGCUGUGUCAAGAACCUGGUGCUGCACUCGGCCCGACCCGGCGCCCCGCCCCCACAGCCCCUGGACCUGCAGCACCGCGCCCAGGCCGGGGCCAACACACGCCCCUGCCCCUCGUAGGCACCUGCCUGCCCCACACGGACUCCCGGGCCACGCCCCAGCCCGACAAUGUCGAGUAUAUUAUUAUUAAUAUUAUUAUGAAUUUUUGUAAGAAACCGAGGCGAUGCCACGCUUUGCUGCUACCGCCCUGGGCUGGACUGGAGGUGGGCAUGCCACCCUCACACACACAGCUGGGCAAAGCCACAAGGCUGGCCAGCAAGGCAGGUUGGAUGGGAGUGGGCACCUCAGAAAGUCACCAGGACUUGGGGUCAGGAACAGUGGCUGGGUGGGCCCAGAACUGCCCCCACUGUCCCCCUACCCACCGAUGGAGCCCCCAGAUAGAGCUGGGUGGCCUGUUUCUGCAGCCCUUGGGCAGUUCUCACUCCUAGGAGAGCCAACCUCGGCUUGUGGGCUGGUGCCCCACAGCUACCUGAGACGGGCAUCGCAGGAGUCUCUGCCACCCACUCAGGAUUGGGAAUUGUCUUUAGUGCCGGCUGUGGAGCAAAAGGCAGCUCACCCCUGGGCAGGCGGUCCCCAUCCCCACCAGCUCGUUUUUCAGCACCCCCACCCACCUCCACCCAGCCCCUGGCACCUCCUCUGGCAGACUCCCCCUCCUACCACGUCCUCCUGGCCUGCAUUCCCACCCCCUCCUGCCAGCACACAGCCUGGGGUCCCUCCCUCAGGGGCUGUAAGGGAAGGCCCACCCCAACUCUUACCAGGAGCUGCUACAGGCAGAGCCCAGCACUGAUAGGGCCCCGCCCACCGGGCCCCGCCCACCCCAGGCCACAUCCCCACCCAUCUGGAAGUGAAGGCCCAGGGACUCCUCCAACAGACAACGGACGGACGGAUGCCGCUGGUGCUCAGGAAGAGCUAGUGCCUUAGGUGGGGGAAGGCAGGACUCACGACUGAGAGAGAGAGGAGGGGGAUAUGACCACCCUGCCCCAUCUGCAGGAGCCUGAAGAUCCAGCUCAAGUGCCAUCCUGCCAGUGGCCCCCAGACUGUGGGGUUGGGACGCCUGGCCUCUGUGUCCUAGAAGGGACCCUCCUGUGGUCUUUGUCUUGAUUUUUCUUAAUAAACGGUGCUAUCCCCGCCA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 3339)
heparan sulfate proteoglycan 2
strand -
perlecan, PRCAN
NCBI CDS gene sequence (13179 bp)
5'-ATGGGGTGGCGGGCGGCGGGCGCGCTGCTGCTGGCGCTGCTGCTGCACGGGCGGCTGCTGGCGGTGACCCATGGGCTGAGGGCATACGATGGCTTGTCTCTGCCTGAGGACATAGAGACCGTCACAGCAAGCCAAATGCGCTGGACACATTCGTACCTTTCTGATGATGAGGACATGCTGGCTGACAGCATCTCAGGAGACGACCTGGGCAGTGGGGACCTGGGCAGCGGGGACTTCCAGATGGTTTATTTCCGAGCCCTGGTGAATTTCACTCGCTCCATCGAGTACAGCCCTCAGCTGGAGGATGCAGGCTCCAGAGAGTTCCGAGAGGTGTCCGAGGCTGTGGTAGACACGCTGGAGTCGGAGTACTTGAAAATTCCCGGAGACCAGGTTGTCAGTGTGGTGTTCATCAAGGAGCTGGATGGCTGGGTTTTTGTGGAGCTGGATGTGGGCTCGGAAGGGAATGCGGATGGGGCTCAGATTCAGGAGATGCTGCTCAGGGTCATCTCCAGCGGCTCTGTGGCCTCCTACGTCACCTCTCCCCAGGGATTCCAGTTCCGACGCCTGGGCACAGTGCCCCAGTTCCCAAGAGCCTGCACGGAGGCCGAGTTTGCCTGCCACAGCTACAATGAGTGTGTGGCCCTGGAGTATCGCTGTGACCGGCGGCCCGACTGCAGGGACATGTCTGATGAGCTCAATTGTGAGGAGCCAGTCCTGGGTATCAGCCCCACATTCTCTCTCCTTGTGGAGACGACATCTTTACCGCCCCGGCCAGAGACAACCATCATGCGACAGCCACCAGTCACCCACGCTCCTCAGCCCCTGCTTCCCGGTTCCGTCAGGCCCCTGCCCTGTGGGCCCCAGGAGGCCGCATGCCGCAATGGGCACTGCATCCCCAGAGACTACCTCTGCGACGGACAGGAGGACTGCGAGGACGGCAGCGATGAGCTAGACTGTGGCCCCCCGCCACCCTGTGAGCCCAACGAGTTCCCCTGCGGGAATGGACATTGTGCCCTCAAGCTGTGGCGCTGCGATGGTGACTTTGACTGTGAGGACCGAACTGATGAAGCCAACTGCCCCACCAAGCGTCCTGAGGAAGTGTGCGGGCCCACACAGTTCCGATGCGTCTCTACCAACATGTGCATCCCAGCCAGCTTCCACTGTGACGAGGAGAGCGACTGTCCTGACCGGAGCGACGAGTTTGGCTGCATGCCCCCCCAGGTGGTGACACCTCCCCGGGAGTCCATCCAGGCTTCCCGGGGCCAGACAGTGACCTTCACCTGCGTGGCCATTGGCGTCCCCACCCCCATCATCAATTGGAGGCTCAACTGGGGCCACATCCCCTCTCATCCCAGGGTGACAGTGACCAGCGAGGGTGGCCGTGGCACACTGATCATCCGTGATGTGAAGGAGTCAGACCAGGGTGCCTACACCTGTGAGGCCATGAACGCCCGGGGCATGGTGTTTGGCATTCCTGACGGTGTCCTTGAGCTCGTCCCACAACGAGCAGGCCCCTGCCCTGACGGCCACTTCTACCTGGAGCACAGCGCCGCCTGCCTGCCCTGCTTCTGCTTTGGCATCACCAGCGTGTGCCAGAGCACCCGCCGCTTCCGGGACCAGATCAGGCTGCGCTTTGACCAACCCGATGACTTCAAGGGTGTGAATGTGACAATGCCTGCGCAGCCCGGCACGCCACCCCTCTCCTCCACGCAGCTGCAGATCGACCCATCCCTGCACGAGTTCCAGCTAGTCGACCTGTCCCGCCGCTTCCTCGTCCACGACTCCTTCTGGGCTCTGCCTGAACAGTTCCTGGGCAACAAGGTGGACTCCTATGGCGGCTCCCTGCGTTACAACGTGCGCTACGAGTTGGCCCGTGGCATGCTGGAGCCAGTGCAGCGGCCGGACGTGGTCCTCATGGGTGCCGGGTACCGCCTCCTCTCCCGAGGCCACACACCCACCCAACCTGGTGCTCTGAACCAGCGCCAGGTCCAGTTCTCTGAGGAGCACTGGGTCCATGAGTCTGGCCGGCCGGTGCAGCGCGCGGAGCTGCTGCAGGTGCTGCAGAGCCTGGAGGCCGTGCTCATCCAGACCGTGTACAACACCAAGATGGCCAGCGTGGGACTTAGCGACATCGCCATGGATACCACCGTCACCCATGCCACCAGCCATGGCCGTGCCCACAGTGTGGAGGAGTGCAGATGCCCCATTGGCTATTCTGGCTTGTCCTGCGAGAGCTGTGATGCCCACTTCACTCGGGTGCCTGGTGGGCCCTACCTGGGCACCTGCTCTGGTTGCAATTGCAATGGCCATGCCAGCTCCTGTGACCCTGTGTATGGCCACTGCCTGAATTGCCAGCACAACACGGAGGGGCCACAGTGCAACAAGTGCAAGGCTGGCTTCTTTGGGGACGCCATGAAGGCCACGGCCACTTCCTGCCGGCCCTGCCCTTGCCCATACATCGATGCCTCCCGCAGATTCTCAGACACTTGCTTCCTGGACACGGATGGCCAAGCCACATGTGACGCCTGTGCCCCAGGCTACACTGGCCGCCGCTGTGAGAGCTGTGCCCCCGGATACGAGGGCAACCCCATCCAGCCCGGCGGGAAGTGCAGGCCCGTCAACCAGGAGATTGTGCGCTGTGACGAGCGTGGCAGCATGGGGACCTCCGGGGAGGCCTGCCGCTGTAAGAACAATGTGGTGGGGCGCTTGTGCAATGAATGTGCTGACGGCTCTTTCCACCTGAGTACCCGAAACCCCGATGGCTGCCTCAAGTGCTTCTGCATGGGTGTCAGTCGCCACTGCACCAGCTCTTCATGGAGCCGTGCCCAGTTGCATGGGGCCTCTGAGGAGCCTGGTCACTTCAGCCTGACCAACGCCGCAAGCACCCACACCACCAACGAGGGCATCTTCTCCCCCACGCCCGGGGAACTGGGATTCTCCTCCTTCCACAGACTCTTATCTGGACCCTACTTCTGGAGCCTCCCTTCACGCTTCCTGGGGGACAAGGTGACCTCCTATGGAGGAGAGCTGCGCTTCACAGTGACCCAGAGGTCCCAGCCGGGCTCCACACCCCTGCACGGGCAGCCGTTGGTGGTGCTGCAAGGTAACAACATCATCCTAGAGCACCATGTGGCCCAGGAGCCCAGCCCCGGCCAGCCCAGCACCTTCATTGTGCCTTTCCGGGAGCAAGCATGGCAGCGGCCCGATGGGCAGCCAGCCACACGGGAGCACCTGCTGATGGCACTGGCAGGCATCGACACCCTCCTGATCCGAGCATCCTACGCCCAGCAGCCCGCTGAGAGCAGGGTCTCTGGCATCAGCATGGACGTGGCTGTGCCCGAGGAAACCGGCCAGGACCCCGCGCTGGAAGTGGAACAGTGCTCCTGCCCACCCGGGTACCGTGGGCCGTCCTGCCAGGACTGTGACACAGGCTACACACGCACGCCCAGTGGCCTCTACCTGGGTACCTGTGAACGCTGCAGCTGCCATGGCCACTCAGAGGCCTGCGAGCCAGAAACAGGTGCCTGCCAGGGCTGCCAGCATCACACGGAGGGCCCTCGGTGTGAGCAGTGCCAGCCAGGATACTACGGGGACGCCCAGCGGGGGACACCACAGGACTGCCAGCTGTGCCCCTGCTACGGAGACCCTGCTGCCGGCCAGGCTGCCCACACTTGTTTTCTGGACACAGACGGCCACCCCACCTGTGATGCGTGCTCCCCAGGCCACAGTGGGCGTCACTGTGAGAGGTGCGCCCCTGGCTACTATGGCAACCCCAGCCAGGGCCAGCCATGCCAGAGAGACAGCCAGGTGCCAGGGCCCATAGGCTGCAACTGTGACCCCCAAGGCAGCGTCAGCAGCCAGTGTGATGCTGCTGGTCAGTGCCAGTGCAAGGCCCAGGTGGAAGGCCTCACTTGCAGCCACTGCCGGCCCCACCACTTCCACCTGAGTGCCAGCAACCCAGACGGCTGCCTGCCCTGCTTCTGTATGGGCATCACCCAGCAGTGCGCCAGCTCTGCCTACACACGCCACCTGATCTCCACCCACTTTGCCCCTGGGGACTTCCAAGGCTTTGCCCTGGTGAACCCACAGCGAAACAGCCGCCTGACAGGAGAATTCACTGTGGAACCCGTGCCCGAGGGTGCCCAGCTCTCTTTTGGCAACTTTGCCCAACTCGGCCATGAGTCCTTCTACTGGCAGCTGCCGGAGACATACCAGGGAGACAAGGTGGCGGCCTACGGTGGGAAGTTGCGATACACCCTCTCCTACACAGCAGGCCCACAGGGCAGCCCACTCTCTGACCCCGATGTGCAGATCACGGGCAACAACATCATGCTAGTGGCCTCCCAGCCAGCGCTGCAGGGCCCTGAGAGGAGGAGCTACGAGATCATGTTCCGAGAGGAATTCTGGCGCCGGCCCGATGGGCAGCCGGCCACACGCGAGCACCTCCTGATGGCACTGGCCGACCTGGATGAGCTCCTGATCCGGGCCACGTTCTCCTCCGTGCCGCTGGCGGCCAGCATCAGCGCAGTCAGCCTGGAGGTCGCCCAGCCGGGGCCCTCAAACAGACCCCGCGCCCTCGAGGTGGAGGAGTGCCGCTGCCCGCCAGGCTACATCGGTCTGTCCTGCCAGGACTGTGCCCCCGGCTACACGCGCACCGGGAGTGGGCTCTACCTCGGCCACTGCGAGCTATGTGAATGCAATGGCCACTCAGACCTGTGCCACCCAGAGACTGGGGCCTGCTCGCAATGCCAGCACAACGCCGCAGGGGAGTTCTGCGAGCTTTGTGCCCCTGGCTACTACGGAGATGCCACAGCCGGGACGCCTGAGGACTGCCAGCCCTGTGCCTGCCCACTGACCAACCCAGAGAACATGTTTTCCCGCACCTGTGAGAGCCTGGGAGCCGGCGGGTACCGCTGCACGGCCTGCGAACCCGGCTACACTGGCCAGTACTGTGAGCAGTGTGGCCCAGGTTACGTGGGTAACCCCAGTGTGCAAGGGGGCCAGTGCCTGCCAGAGACAAACCAAGCCCCACTGGTGGTCGAGGTCCATCCTGCTCGAAGCATAGTGCCCCAAGGTGGCTCCCACTCCCTGCGGTGTCAGGTCAGTGGGAGCCCACCCCACTACTTCTATTGGTCCCGTGAGGATGGGCGGCCTGTGCCCAGCGGCACCCAGCAGCGACATCAAGGCTCCGAGCTCCACTTCCCCAGCGTCCAGCCCTCGGATGCTGGGGTCTACATTTGCACCTGCCGTAATCTCCACCAATCCAATACCAGCCGGGCAGAGCTGCTGGTCACTGAGGCTCCAAGCAAGCCCATCACAGTGACTGTGGAGGAGCAGCGGAGCCAGAGCGTGCGCCCCGGAGCTGACGTCACCTTCATCTGCACAGCCAAAAGCAAGTCCCCAGCCTATACCCTGGTGTGGACCCGCCTGCACAACGGGAAACTGCCCACCCGAGCCATGGATTTCAATGGCATCCTGACCATTCGCAACGTCCAGCTGAGTGATGCAGGCACCTACGTGTGCACCGGCTCCAACATGTTTGCCATGGACCAGGGCACAGCCACTCTACATGTGCAGGCCTCGGGCACCTTGTCCGCCCCCGTGGTCTCCATCCATCCGCCACAGCTCACAGTGCAGCCCGGGCAACTGGCGGAGTTCCGCTGCAGCGCCACAGGGAGCCCCACGCCCACCCTCGAGTGGACAGGGGGCCCCGGCGGCCAGCTCCCTGCGAAGGCACAAATCCACGGCGGCATCCTGCGCCTGCCAGCTGTCGAGCCCACGGATCAGGCCCAGTACTTGTGCCGAGCCCACAGCAGCGCTGGGCAGCAGGTGGCCAGGGCTGTGCTCCACGTGCATGGGGGCGGTGGGCCCAGAGTCCAAGTGAGCCCAGAGAGGACCCAGGTCCACGCAGGCCGCACCGTCAGGCTGTACTGCAGGGCTGCAGGCGTGCCTAGCGCCACCATCACCTGGAGGAAGGAAGGGGGCAGCCTCCCACCACAGGCCCGGTCAGAGCGCACAGACATCGCGACACTGCTCATCCCAGCCATCACGACTGCTGACGCCGGCTTCTACCTCTGCGTGGCCACCAGCCCTGCAGGCACTGCCCAGGCCCGGATCCAAGTGGTTGTCCTTTCAGCCTCAGATGCCAGCCCACCGCCGGTCAAGATTGAGTCCTCATCGCCTTCTGTGACAGAAGGGCAAACACTCGACCTCAACTGTGTGGTGGCAGGGTCAGCCCATGCCCAGGTCACCTGGTACAGGCGAGGGGGTAGCCTGCCTCCCCACACCCAGGTGCACGGCTCCCGTCTGCGGCTCCCCCAGGTCTCACCAGCTGATTCTGGAGAATATGTGTGCCGTGTGGAGAATGGATCGGGCCCCAAGGAGGCCTCCATTACTGTGTCTGTGCTCCACGGCACCCATTCTGGCCCCAGCTACACCCCAGTGCCCGGCAGCACCCGGCCCATCCGCATCGAGCCCTCCTCCTCACACGTGGCGGAAGGGCAGACCCTGGATCTGAACTGCGTGGTGCCCGGGCAGGCCCACGCCCAGGTCACGTGGCACAAGCGTGGGGGCAGCCTCCCTGCCCGGCACCAGACCCACGGCTCGCTGCTGCGGCTGCACCAGGTGACCCCGGCCGACTCAGGCGAGTATGTGTGCCATGTGGTGGGCACCTCCGGCCCCCTAGAGGCCTCAGTCCTGGTCACCATCGAAGCCTCTGTCATCCCTGGACCCATCCCACCTGTCAGGATCGAGTCTTCATCCTCCACAGTGGCCGAGGGCCAGACCCTGGATCTGAGCTGCGTGGTGGCAGGGCAGGCCCACGCCCAGGTCACATGGTACAAGCGTGGGGGCAGCCTCCCTGCCCGGCACCAGGTTCGTGGCTCCCGCCTGTACATCTTCCAGGCCTCACCTGCCGATGCGGGACAGTACGTCTGCCGGGCCAGCAACGGCATGGAGGCCTCCATCACGGTCACAGTAACTGGGACCCAGGGGGCCAACTTAGCCTACCCTGCCGGCAGCACCCAGCCCATCCGCATCGAGCCCTCCTCCTCGCAAGTGGCGGAAGGGCAGACCCTGGATCTGAACTGCGTGGTGCCCGGGCAGTCCCATGCCCAGGTCACGTGGCACAAGCGTGGGGGCAGCCTCCCTGTCCGGCACCAGACCCACGGCTCCCTGCTGAGACTCTACCAAGCGTCCCCCGCCGACTCGGGCGAGTACGTGTGCCGAGTGTTGGGCAGCTCCGTGCCTCTAGAGGCCTCTGTCCTGGTCACCATTGAGCCTGCGGGCTCAGTGCCTGCACTTGGGGTCACCCCCACGGTCCGGATCGAGTCATCGTCTTCGCAAGTGGCCGAGGGGCAGACCCTGGACCTGAACTGCCTCGTTGCTGGTCAGGCCCATGCCCAGGTCACGTGGCACAAGCGCGGGGGCAGCCTCCCGGCCCGGCACCAGGTGCATGGCTCGAGGCTACGCCTGCTCCAGGTGACCCCAGCTGATTCAGGGGAGTACGTGTGCCGTGTGGTCGGCAGCTCAGGTACCCAGGAAGCCTCAGTCCTTGTCACCATCCAGCAGCGCCTTAGTGGCTCCCACTCCCAGGGTGTGGCGTACCCCGTCCGCATCGAGTCCTCCTCAGCCTCCCTGGCCAATGGACACACCCTGGACCTCAACTGCCTGGTTGCCAGCCAGGCTCCCCACACCATCACCTGGTATAAGCGTGGAGGCAGCTTACCCAGCCGGCACCAGATCGTGGGCTCCCGGCTGCGGATCCCTCAGGTGACTCCGGCAGACTCGGGCGAGTACGTGTGTCACGTCAGTAACGGTGCAGGCTCCCGGGAGACCTCGCTCATCGTCACCATCCAGGGCAGCGGTTCCTCCCACGTGCCCAGCGTCTCCCCACCGATCAGGATCGAGTCGTCTTCCCCCACGGTGGTGGAAGGGCAGACCTTGGATCTGAACTGCGTGGTCGCCAGGCAGCCCCAGGCTATCATCACATGGTACAAGCGTGGGGGCAGCCTTCCCTCCCGACACCAGACCCATGGCTCCCACCTGCGGTTGCACCAAATGTCTGTGGCTGACTCGGGCGAGTATGTGTGCCGGGCCAACAACAACATCGATGCCCTGGAGGCCTCCATCGTCATCTCCGTCTCCCCTAGCGCCGGCAGCCCCTCCGCCCCTGGCAGCTCCATGCCCATCAGAATTGAGTCATCCTCCTCACACGTGGCCGAAGGGGAGACCCTGGATCTGAACTGCGTGGTCCCCGGGCAGGCCCATGCCCAGGTCACTTGGCACAAGCGTGGGGGCAGCCTCCCCAGTCACCATCAGACCCGCGGCTCACGGCTGCGGCTGCACCATGTGTCCCCGGCCGACTCGGGTGAATACGTGTGCCGGGTGATGGGCAGCTCTGGCCCCCTGGAGGCCTCAGTCCTGGTCACCATCGAAGCCTCTGGCTCAAGTGCTGTCCACGTCCCCGCCCCAGGTGGAGCCCCACCCATCCGCATCGAGCCCTCCTCCTCCCGAGTGGCAGAAGGGCAGACCCTGGATCTGAAGTGCGTGGTGCCCGGGCAGGCCCACGCCCAGGTCACGTGGCACAAGCGTGGAGGAAACCTCCCTGCCCGGCACCAGGTCCACGGCCCACTGCTGAGGCTGAACCAGGTGTCCCCGGCTGACTCTGGCGAGTACTCGTGCCAAGTGACCGGAAGCTCAGGCACCCTGGAGGCATCTGTCCTGGTCACAATTGAGCCCTCCAGCCCAGGACCCATTCCTGCTCCAGGACTGGCCCAGCCCATCTACATCGAGGCCTCCTCTTCACACGTGACTGAAGGGCAGACTCTGGATCTGAACTGTGTGGTGCCCGGGCAGGCCCATGCCCAGGTCACGTGGTACAAGCGCGGGGGCAGCCTCCCCGCCCGGCACCAGACCCATGGCTCCCAGCTGCGGCTCCACCTCGTCTCCCCTGCCGACTCAGGCGAGTATGTGTGTCGTGCAGCCAGCGGCCCAGGCCCTGAGCAAGAAGCCTCCTTCACAGTCACCGTCCCGCCCAGTGAGGGGTCTTCCTACCGCCTTAGGAGCCCGGTCATCTCCATCGACCCGCCCAGCAGCACCGTGCAGCAGGGCCAGGATGCCAGCTTCAAGTGCCTCATCCATGACGGGGCAGCCCCCATCAGCCTCGAGTGGAAGACCCGGAACCAGGAGCTGGAGGACAACGTCCACATCAGTCCCAATGGCTCCATCATCACCATCGTGGGCACCCGGCCCAGCAACCACGGTACCTACCGCTGCGTGGCCTCCAATGCCTACGGTGTGGCCCAGAGTGTGGTGAACCTCAGTGTGCACGGGCCCCCTACAGTGTCCGTGCTCCCCGAGGGCCCCGTGTGGGTGAAAGTGGGAAAGGCTGTCACCCTGGAGTGTGTCAGTGCCGGGGAGCCCCGCTCCTCTGCTCGTTGGACCCGGATCAGCAGCACCCCTGCCAAGTTGGAGCAGCGGACATATGGGCTCATGGACAGCCACGCGGTGCTGCAGATTTCATCAGCTAAACCATCAGATGCGGGCACTTATGTGTGCCTTGCTCAGAATGCACTAGGCACAGCACAGAAGCAGGTGGAGGTGATCGTGGACACGGGCGCCATGGCCCCAGGGGCCCCTCAGGTCCAAGCTGAAGAAGCTGAGCTGACTGTGGAGGCTGGACACACGGCCACCTTGCGCTGCTCAGCCACAGGCAGCCCCGCGCCCACCATCCACTGGTCCAAGCTGCGTTCCCCACTGCCCTGGCAGCACCGGCTGGAAGGTGACACACTCATCATACCCCGGGTAGCCCAGCAGGACTCGGGCCAGTACATCTGCAATGCCACTAGCCCTGCTGGGCACGCTGAGGCCACCATCATCCTGCACGTGGAGAGCCCACCATATGCCACCACGGTCCCAGAGCACGCTTCGGTGCAGGCAGGGGAGACGGTGCAGCTCCAGTGCCTGGCTCACGGGACACCCCCACTCACCTTCCAGTGGAGCCGCGTGGGCAGCAGCCTTCCTGGGAGGGCGACCGCCAGGAACGAGCTGCTGCACTTTGAGCGTGCAGCCCCTGAGGACTCAGGCCGCTACCGCTGCCGGGTCACCAACAAGGTGGGCTCAGCCGAGGCCTTTGCCCAGCTGCTCGTCCAAGGCCCTCCCGGCTCTCTCCCTGCCACCTCCATCCCAGCAGGGTCCACGCCCACCGTGCAGGTCACGCCTCAGCTAGAGACCAAGAGCATTGGGGCCAGCGTTGAGTTCCACTGTGCTGTGCCCAGCGACCGGGGTACCCAGCTCCGTTGGTTCAAGGAAGGGGGTCAGCTGCCTCCGGGTCACAGCGTGCAGGATGGGGTGCTCCGAATCCAGAACTTGGACCAGAGCTGCCAAGGGACGTATATATGCCAGGCCCATGGACCTTGGGGGAAGGCCCAGGCCAGTGCCCAGCTGGTTATCCAAGCCCTGCCCTCGGTGCTCATCAACATCCGGACCTCTGTGCAGACCGTGGTGGTTGGCCACGCCGTGGAGTTCGAATGCCTGGCACTGGGTGACCCCAAGCCTCAGGTGACATGGAGCAAAGTTGGAGGGCACCTGCGGCCAGGCATTGTGCAGAGCGGAGGTGTCGTCAGGATCGCCCACGTAGAGCTGGCTGATGCGGGACAGTATCGCTGCACTGCCACCAACGCAGCTGGCACCACACAATCCCACGTCCTGCTGCTTGTGCAAGCCTTGCCCCAGATCTCAATGCCCCAAGAAGTCCGTGTGCCTGCTGGTTCTGCAGCTGTCTTCCCCTGCATAGCCTCAGGCTACCCCACTCCTGACATCAGCTGGAGCAAGCTGGATGGCAGCCTGCCACCTGACAGCCGCCTGGAGAACAACATGCTGATGCTGCCCTCAGTCCGACCCCAGGACGCAGGTACCTACGTCTGCACCGCCACTAACCGCCAGGGCAAGGTCAAAGCCTTTGCCCACCTGCAGGTGCCAGAGCGGGTGGTGCCCTACTTCACGCAGACCCCCTACTCCTTCCTACCGCTGCCCACCATCAAGGATGCCTACAGGAAGTTCGAGATCAAGATCACCTTCCGGCCCGACTCAGCCGATGGGATGCTGCTGTACAATGGGCAGAAGCGAGTCCCAGGGAGCCCCACCAACCTGGCCAACCGGCAGCCCGACTTCATCTCCTTCGGCCTCGTGGGGGGAAGGCCCGAGTTCCGGTTCGATGCAGGCTCAGGCATGGCCACCATCCGCCATCCCACACCACTGGCCCTGGGCCATTTCCACACCGTGACCCTGCTGCGCAGCCTCACCCAGGGCTCCCTGATTGTGGGTGACCTGGCCCCGGTCAATGGGACCTCCCAGGGCAAGTTCCAGGGCCTGGATCTGAACGAGGAACTCTACCTGGGTGGCTATCCTGACTATGGTGCCATCCCCAAGGCGGGGCTGAGCAGCGGCTTCATAGGCTGTGTCCGGGAGCTGCGCATCCAGGGCGAGGAGATCGTCTTCCATGACCTCAACCTCACGGCGCACGGCATCTCCCACTGCCCCACCTGTCGGGACCGGCCCTGCCAGAATGGCGGTCAGTGCCATGACTCTGAGAGCAGCAGCTACGTGTGCGTCTGCCCAGCTGGCTTCACCGGGAGCCGCTGTGAGCACTCGCAGGCCCTGCACTGCCATCCAGAGGCCTGTGGGCCCGACGCCACCTGTGTGAACCGGCCTGACGGTCGAGGCTACACCTGCCGCTGCCACCTGGGCCGCTCGGGGTTGCGGTGTGAGGAAGGTGTGACAGTGACCACCCCCTCGCTGTCGGGTGCTGGCTCCTACCTGGCACTGCCCGCCCTCACCAACACACACCACGAGCTACGCCTGGACGTGGAGTTCAAGCCACTCGCCCCTGACGGGGTCCTGCTGTTCAGCGGGGGGAAGAGCGGGCCTGTGGAGGACTTCGTGTCCCTGGCGATGGTGGGCGGCCACCTGGAGTTCCGCTATGAGTTGGGGTCAGGGCTGGCCGTTCTGCGGAGCGCCGAGCCGCTGGCCCTGGGCCGCTGGCACCGTGTGTCTGCAGAGCGTCTCAACAAGGACGGCAGCCTGCGGGTGAATGGTGGACGCCCTGTGCTGCGCTCCTCGCCCGGCAAGAGCCAGGGCCTCAACCTGCACACCCTGCTCTACCTGGGGGGTGTGGAGCCTTCCGTGCCACTGTCCCCGGCCACCAACATGAGCGCTCACTTCCGCGGCTGTGTGGGCGAGGTGTCAGTGAATGGCAAACGGCTGGACCTCACCTACAGTTTCCTAGGCAGCCAGGGCATCGGGCAATGCTATGATAGCTCCCCATGTGAGCGCCAGCCTTGCCAACATGGTGCCACGTGCATGCCCGCTGGCGAGTATGAGTTCCAGTGCCTGTGTCGAGATGGATTCAAAGGAGACCTGTGTGAGCACGAGGAGAACCCCTGCCAGCTCCGTGAACCCTGTCTGCATGGGGGCACCTGCCAGGGCACCCGCTGCCTCTGCCTCCCTGGCTTCTCTGGCCCACGCTGCCAACAAGGCTCTGGACATGGCATAGCAGAGTCCGACTGGCATCTTGAAGGCAGCGGGGGCAATGATGCCCCTGGGCAGTACGGAGCCTATTTCCACGATGATGGCTTCCTCGCCTTCCCTGGCCATGTCTTCTCCAGGAGCCTGCCCGAGGTGCCCGAGACCATCGAGCTGGAGGTTCGGACCAGCACAGCCAGTGGCCTCCTGCTCTGGCAGGGTGTGGAGGTGGGAGAGGCCGGCCAAGGCAAGGACTTCATCAGCCTCGGGCTTCAAGACGGGCACCTTGTCTTCAGGTACCAGCTGGGTAGTGGGGAGGCCCGCCTGGTCTCTGAGGACCCCATCAATGACGGCGAGTGGCACCGGGTGACAGCACTGCGGGAGGGCCGCAGAGGTTCCATCCAAGTCGACGGTGAGGAGCTGGTCAGCGGCCGGTCCCCAGGTCCCAACGTGGCAGTCAACGCCAAGGGCAGCGTCTACATCGGCGGAGCCCCTGACGTGGCCACGCTGACCGGGGGCAGATTCTCCTCAGGCATCACAGGCTGTGTCAAGAACCTGGTGCTGCACTCGGCCCGACCCGGCGCCCCGCCCCCACAGCCCCTGGACCTGCAGCACCGCGCCCAGGCCGGGGCCAACACACGCCCCTGCCCCTCGTAG-3'
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