Protein
Protein (NP_001192230)
Pikachurin
Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)
EGFLAM
EGF like, fibronectin type III and laminin G domains
Undefined
Low evidence
Laminin G-like
Undefined
b-sandwich / ConA-like
GlcA(b1-3)Xyl(a1-4)GlcA / Matriglycan on alpha-dystroglycan
NP_001192230
133584
Q63HQ2
Undefined
Q63HQ2
0.161
10.1016/j.sbi.2018.11.007
PFAM, InterPro
Protein sequence and protein families (fasta) (1017 amino acids) Download
MDLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRAMNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEEVKPLPATKGGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKNGVAIMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSSGICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKECGNYCLNTIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q63HQ2-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Interacts with DAG1 alpha-dystroglycan. Interacts with GPR158 and GPR179; transsynaptic interaction is required for synaptic organization of photoreceptor cells. Source: UniProt
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (6 PubMed Identifiers)
  • EGFLAM correlates with cell proliferation, migration, invasion and poor prognosis in glioblastoma. [30829611]
  • Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies. [28339009]
  • Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. [22760553]
  • Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression. [21129441]
  • [Model of aberrant DNA methylation patterns and its applications in epithelial ovarian cancer.]. [20078962]
  • Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. [18641643]
UniProt Main References (4 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The full-ORF clone resource of the German cDNA Consortium. [17974005]
  • The DNA sequence and comparative analysis of human chromosome 5. [15372022]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_877950.1, NP_689616.2, NP_001192230.1, NP_877953.1
RNA
RNA (Transcript ID: NM_001205301.2)
NM_001205301.2
EGF like, fibronectin type III and laminin G domains, transcript variant 5
All isoforms of EGFLAM containing a lectin domain
197..3250 (or 38258755.. 38463986)
38258559.. 38465480
NCBI Matured mRNA sequence 4744 NTPDownload 
m7G-5')ppp(5'-ACUCGCGCACGCCGACCUCCCGGCUGCAGUCCUACCUCUUGGAACUACCCGUGUUUCCGGGCCCAGCCCUCGCAGCCCCCCACCUCCUCGCCCCGGCCCGGGGAUCCGUUGGGGCCGCGUCCCCCACGCGCCCCCGGAGACGCCCUUUCCGUGUGCGCCCGGGACUUGGUGAAACUUUGCAGGCGCCGGCUGCGAAAUGGAUUUAAUCCGAGGCGUCUUGCUCCGGCUCCUGCUCCUGGCUUCCAGCCUCGGACCCGGCGCGGUGUCGCUCCGAGCGGCCAUCCGAAAACCAGGCAAGGUAGGGCCUCCUCUUGACAUCAAGCUGGGCGCAUUGAACUGUACGGCUUUCAGCAUCCAGUGGAAAAUGCCAAGGCAUCCUGGAAGUCCCAUCCUUGGGUACACUGUCUUUUACUCUGAGGUUGGCGCAGAUAAAUCCCUGCAGGAGCAGUUGCACAGCGUGCCUCUCAGCCGGGACAUCCCGACCACGGAGGAAGUGAUUGGAGAUUUGAAACCAGGCACUGAAUAUCGUGUGAGCAUAGCAGCUUACAGCCAGGCUGGCAAAGGGCGGCUGAGCUCUCCUCGGCAUGUCACCACUUUGUCCCAAGAUUCCUGCCUGCCUCCUGCAGCUCCCCAGCAGCCACAUGUCAUUGUGGUUUCGGAUUCUGAGGUGGCCCUGUCUUGGAAACCUGGAGCGAGUGAAGGAAGCGCCCCUAUUCAGUACUAUUCUGUGGAAUUCAUCAGGCCAGAUUUCGACAAGAAGUGGACCUCAAUCCAUGAGCGGAUCCAGAUGGACUCCAUGGUUAUCAAGGGCCUCGAUCCAGAUACCAACUACCAGUUUGCCGUGAGGGCAAUGAAUUCCCAUGGCCCCAGCCCCCGCAGCUGGCCCAGUGACAUCAUCCGGACCCUCUGCCCUGAGGAGGCGGGAAGUGGCCGCUAUGGACCCCGUUAUAUCACCGACAUGGGAGCUGGUGAGGAUGAUGAAGGAUUUGAAGACGACUUAGAUUUGGAUAUUUCCUUUGAGGAGGUUAAACCACUUCCUGCUACCAAAGGAGGGAAUAAGAAAUUUUUGGUGGAAAGCAAGAAGAUGUCUAUAUCUAACCCAAAGACCAUUUCUAGGCUCAUCCCCCCUACCUCAGCAUCUCUCCCUGUGACCACGGUGGCUCCCCAGCCCAUUCCCAUACAGAGAAAGGGGAAGAAUGGUGUGGCCAUAAUGUCAAGGCUCUUUGACAUGCCUUGUGAUGAAACUCUCUGCUCUGCUGACAGCUUCUGUGUCAAUGACUACACCUGGGGGGGCUCGCGAUGCCAGUGCACCCUGGGCAAAGGUGGUGAGAGCUGCUCAGAAGAUAUUGUUAUCCAGUAUCCUCAGUUCUUUGGCCACUCCUAUGUAACGUUUGAACCUCUGAAGAAUUCUUAUCAGGCAUUUCAAAUUACUCUUGAAUUUAGGGCGGAGGCAGAGGAUGGCUUACUGCUCUACUGUGGGGAGAACGAACACGGGAGGGGGGAUUUCAUGUCCCUGGCUAUCAUCCGACGCUCCCUGCAGUUCAGGUUUAAUUGUGGAACUGGGGUUGCCAUCAUCGUAAGUGAGACCAAAAUCAAACUAGGGGGUUGGCACACGGUUAUGCUCUACAGAGAUGGGCUGAACGGGCUGCUGCAGCUGAACAAUGGCACCCCAGUGACAGGCCAGUCUCAGGGCCAAUACAGUAAAAUUACUUUCCGGACACCUCUCUAUCUUGGUGGCGCUCCCAGCGCUUACUGGUUGGUUAGAGCAACAGGGACAAACCGAGGCUUUCAAGGCUGUGUGCAGUCGCUCGCUGUGAAUGGGAGGAGAAUUGACAUGAGGCCCUGGCCCCUGGGAAAAGCACUCAGUGGGGCUGAUGUGGGGGAAUGCAGCAGUGGAAUCUGUGAUGAGGCCUCGUGCAUCCAUGGUGGCACCUGCACAGCAAUCAAAGCCGACUCCUACAUUUGCCUCUGUCCCCUUGGGUUUAAAGGUCGACACUGUGAAGAUGCUUUCACCUUGACCAUUCCUCAGUUCAGAGAGUCUCUGAGAUCUUACGCUGCAACUCCCUGGCCACUGGAGCCCCAGCAUUACCUUUCCUUCAUGGAAUUUGAGAUCACAUUUCGGCCAGACUCAGGAGAUGGUGUCCUCCUGUACAGCUAUGACACAGGCAGCAAAGACUUCCUGUCCAUCAACUUGGCAGGGGGCCACGUGGAGUUCCGCUUUGACUGUGGCUCUGGGACCGGUGUCCUCAGGAGUGAAGAUCCCCUCACCCUGGGCAACUGGCACGAGCUUCGUGUAUCUCGCACAGCAAAGAAUGGAAUCUUACAGGUGGAUAAGCAGAAGAUAGUGGAGGGAAUGGCAGAGGGAGGCUUCACACAGAUUAAGUGCAACACAGACAUUUUCAUUGGCGGAGUCCCCAAUUAUGAUGAUGUGAAGAAGAACUCGGGUGUCCUGAAGCCUUUCAGCGGGAGCAUCCAGAAGAUCAUCCUGAAUGACCGAACCAUCCAUGUGAAGCAUGACUUCACCUCCGGAGUGAAUGUGGAGAAUGCGGCCCACCCCUGUGUGAGAGCCCCUUGUGCCCAUGGGGGCAGCUGCCGGCCCAGGAAGGAGGGCUAUGACUGUGACUGCCCCUUGGGCUUUGAGGGGCUUCACUGCCAGAAAGAGUGUGGGAACUACUGCCUCAAUACGAUCAUAGAAGCCAUUGAGAUCCCGCAGUUUAUCGGCCGCAGUUACCUGACGUAUGACAACCCAGAUAUCUUGAAGAGGGUGUCAGGAUCAAGAUCAAAUGUGUUCAUGAGGUUUAAAACAACUGCCAAGGAUGGCCUUUUGCUGUGGAGGGGAGACAGCCCCAUGAGACCCAACAGCGACUUCAUUUCCUUGGGCCUUCGGGAUGGAGCCCUCGUGUUCAGCUAUAACCUGGGCAGUGGUGUGGCAUCCAUCAUGGUGAAUGGCUCCUUCAACGAUGGUCGGUGGCACCGAGUUAAGGCCGUUAGGGAUGGCCAGUCAGGAAAGAUAACCGUGGAUGACUAUGGAGCCAGAACAGGCAAAUCCCCAGGCAUGAUGCGGCAGCUUAACAUCAAUGGAGCUCUGUAUGUGGGUGGAAUGAAGGAAAUUGCUCUGCACACUAACAGGCAAUAUAUGAGAGGGCUCGUGGGCUGUAUCUCUCACUUCACCCUGUCCACCGAUUACCACAUUUCCCUCGUGGAAGAUGCCGUGGAUGGGAAAAACAUCAACACUUGUGGAGCCAAGUAACACCAGCUGGCCUUGUCCAAGGGACAGAGCCUUCUAUUCUGAGAAUCCCAGGGGCCCUCAGACCCUGCCUGAUGCUAUAUGCAGAGGCCCAGGGACCAGGUGUGUUUCCUCUCACCAAGAAGAAAGUACACACUGAUGAGAAACUGAGAACCAAGACAGGCAUCCCUGGGUGGCCUUUCCUGCUGACACUCCACGAGCUGACCCAGCAGAAUUCUCUGUGUAGGAAGCAUCGGACUUUGUCCAUUGAAUAUGUAGCGGCUGCCAGAGAUCACACAUCAAUGCAAAUUCCAGAGCCUGUCUGCUAUAGCUCAGUGACUGUGUUGUGAUUCAUAGUACAUUAAAAAGAGAGAGAGAGAGAAAGAAUCCCACAGGGCACUAUUAAAAUACUUCUCUCCUUCCCUGACUCAUGACACUCUUCCUGACAGCAGAAUGACUGUGUGACCUUGAACUUCACAUUUCCCACAUUGGCCCUUGGAUUGUUCGGAUUAACCCCUUCCACUCCUCACUGGCUGGUUCACUGUGUUCUGACUAGUCCAUAAAAAUAAAGAUGGAAGGAGAUCAAACACAGAAUCAUAAUCAUAAUGCGGCCCCCUUCCCCAGAGCUUACCUCGAAUGUGAAAUCCCUACUUCUUAUAAUGCAGAGUUAAGGAGCUGAGCCCCCAUGAUUUUGUAGCUGUACUUUUGUAUGUGUAUAUUUUUAUAGCUGCAGAUUGUCCACACAGUAUACUUUUGGAAGUUUGGGUGGAUGACUCUGAAUUCUUGCACACCUUUCCUAAAAAUUUCUCCCAAGAGAGACUUGUUUGGGCCUUUUGUGGUGUCAGUGGAAUGGAUAGGUAACUUGGGUGGGCAACUUGGGGAGCUGACCAUUCUCUUUUGGUAAAUGUUGACGGCUCAAGAGGAUGAAUAUGAAGCUUUCCAAGAUAAGCAGAUUAAAAGGAACAUGUGUUACCGAGGUAGGUCACUGUCAUUUUUGUUUUAAGAGUUGGGGGGAGUAUCUAUAGUAAACUUGAAUAAAGGGGACAAAGCUAGAACUUAUUCAUUCAUUCAUUCACUUAUGGAGUUGUUACUGAUUUUGCGGAGGUCAGGUUCAUACCAAUGGACACUAAUACAAUCAGUGUUCCCAAGGCUGUGCAGGGGUGGGGGGACAUGCUGUCAGGAUGGUCUGAGCAUCUGGGUGAGAACCAGAGAAACAGGACUUCUUCCUUCUGUACCAUGAGCUGUGUCCCUUUACUAUGCAAGCACAUGACCCCAGAGACAGCUGGUUCACUGGCAGAUCCCCAUGAUGGACUUACUAAGGGAAAGGUGAGAUGAACACUGCCCCCAAGGAGGGGGUGAAAUAUGAUCUAACUUAUGCAAGAGCCUAUAAUUAGUCCCAGUCUCGACUCUACAUUUGUUUGUGCAGCAUUCAUUCAGCAAAGACUUUUGGGGUUUGUGCAAGGCACAGUUUUAAGCACAUAAUGUAAUUCUAAAAGAUGAAUAAACUAGAGAGGUUCA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 133584)
EGFLAM
EGF like, fibronectin type III and laminin G domains
NC_000005.10
5  38258755.. 38463986
38258755.. 38463986
strand +
CCDS56363.1
MGI:2146149
ClinVar, dbVar
ENSG00000164318
FLJ39155, AGRINL, AGRNL, PIKA
uc003jlb.3
INSDC: AK097549
26810
617683
OTTHUMG00000131139
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (3054 bp)
5'-ATGGATTTAATCCGAGGCGTCTTGCTCCGGCTCCTGCTCCTGGCTTCCAGCCTCGGACCCGGCGCGGTGTCGCTCCGAGCGGCCATCCGAAAACCAGGCAAGGTAGGGCCTCCTCTTGACATCAAGCTGGGCGCATTGAACTGTACGGCTTTCAGCATCCAGTGGAAAATGCCAAGGCATCCTGGAAGTCCCATCCTTGGGTACACTGTCTTTTACTCTGAGGTTGGCGCAGATAAATCCCTGCAGGAGCAGTTGCACAGCGTGCCTCTCAGCCGGGACATCCCGACCACGGAGGAAGTGATTGGAGATTTGAAACCAGGCACTGAATATCGTGTGAGCATAGCAGCTTACAGCCAGGCTGGCAAAGGGCGGCTGAGCTCTCCTCGGCATGTCACCACTTTGTCCCAAGATTCCTGCCTGCCTCCTGCAGCTCCCCAGCAGCCACATGTCATTGTGGTTTCGGATTCTGAGGTGGCCCTGTCTTGGAAACCTGGAGCGAGTGAAGGAAGCGCCCCTATTCAGTACTATTCTGTGGAATTCATCAGGCCAGATTTCGACAAGAAGTGGACCTCAATCCATGAGCGGATCCAGATGGACTCCATGGTTATCAAGGGCCTCGATCCAGATACCAACTACCAGTTTGCCGTGAGGGCAATGAATTCCCATGGCCCCAGCCCCCGCAGCTGGCCCAGTGACATCATCCGGACCCTCTGCCCTGAGGAGGCGGGAAGTGGCCGCTATGGACCCCGTTATATCACCGACATGGGAGCTGGTGAGGATGATGAAGGATTTGAAGACGACTTAGATTTGGATATTTCCTTTGAGGAGGTTAAACCACTTCCTGCTACCAAAGGAGGGAATAAGAAATTTTTGGTGGAAAGCAAGAAGATGTCTATATCTAACCCAAAGACCATTTCTAGGCTCATCCCCCCTACCTCAGCATCTCTCCCTGTGACCACGGTGGCTCCCCAGCCCATTCCCATACAGAGAAAGGGGAAGAATGGTGTGGCCATAATGTCAAGGCTCTTTGACATGCCTTGTGATGAAACTCTCTGCTCTGCTGACAGCTTCTGTGTCAATGACTACACCTGGGGGGGCTCGCGATGCCAGTGCACCCTGGGCAAAGGTGGTGAGAGCTGCTCAGAAGATATTGTTATCCAGTATCCTCAGTTCTTTGGCCACTCCTATGTAACGTTTGAACCTCTGAAGAATTCTTATCAGGCATTTCAAATTACTCTTGAATTTAGGGCGGAGGCAGAGGATGGCTTACTGCTCTACTGTGGGGAGAACGAACACGGGAGGGGGGATTTCATGTCCCTGGCTATCATCCGACGCTCCCTGCAGTTCAGGTTTAATTGTGGAACTGGGGTTGCCATCATCGTAAGTGAGACCAAAATCAAACTAGGGGGTTGGCACACGGTTATGCTCTACAGAGATGGGCTGAACGGGCTGCTGCAGCTGAACAATGGCACCCCAGTGACAGGCCAGTCTCAGGGCCAATACAGTAAAATTACTTTCCGGACACCTCTCTATCTTGGTGGCGCTCCCAGCGCTTACTGGTTGGTTAGAGCAACAGGGACAAACCGAGGCTTTCAAGGCTGTGTGCAGTCGCTCGCTGTGAATGGGAGGAGAATTGACATGAGGCCCTGGCCCCTGGGAAAAGCACTCAGTGGGGCTGATGTGGGGGAATGCAGCAGTGGAATCTGTGATGAGGCCTCGTGCATCCATGGTGGCACCTGCACAGCAATCAAAGCCGACTCCTACATTTGCCTCTGTCCCCTTGGGTTTAAAGGTCGACACTGTGAAGATGCTTTCACCTTGACCATTCCTCAGTTCAGAGAGTCTCTGAGATCTTACGCTGCAACTCCCTGGCCACTGGAGCCCCAGCATTACCTTTCCTTCATGGAATTTGAGATCACATTTCGGCCAGACTCAGGAGATGGTGTCCTCCTGTACAGCTATGACACAGGCAGCAAAGACTTCCTGTCCATCAACTTGGCAGGGGGCCACGTGGAGTTCCGCTTTGACTGTGGCTCTGGGACCGGTGTCCTCAGGAGTGAAGATCCCCTCACCCTGGGCAACTGGCACGAGCTTCGTGTATCTCGCACAGCAAAGAATGGAATCTTACAGGTGGATAAGCAGAAGATAGTGGAGGGAATGGCAGAGGGAGGCTTCACACAGATTAAGTGCAACACAGACATTTTCATTGGCGGAGTCCCCAATTATGATGATGTGAAGAAGAACTCGGGTGTCCTGAAGCCTTTCAGCGGGAGCATCCAGAAGATCATCCTGAATGACCGAACCATCCATGTGAAGCATGACTTCACCTCCGGAGTGAATGTGGAGAATGCGGCCCACCCCTGTGTGAGAGCCCCTTGTGCCCATGGGGGCAGCTGCCGGCCCAGGAAGGAGGGCTATGACTGTGACTGCCCCTTGGGCTTTGAGGGGCTTCACTGCCAGAAAGAGTGTGGGAACTACTGCCTCAATACGATCATAGAAGCCATTGAGATCCCGCAGTTTATCGGCCGCAGTTACCTGACGTATGACAACCCAGATATCTTGAAGAGGGTGTCAGGATCAAGATCAAATGTGTTCATGAGGTTTAAAACAACTGCCAAGGATGGCCTTTTGCTGTGGAGGGGAGACAGCCCCATGAGACCCAACAGCGACTTCATTTCCTTGGGCCTTCGGGATGGAGCCCTCGTGTTCAGCTATAACCTGGGCAGTGGTGTGGCATCCATCATGGTGAATGGCTCCTTCAACGATGGTCGGTGGCACCGAGTTAAGGCCGTTAGGGATGGCCAGTCAGGAAAGATAACCGTGGATGACTATGGAGCCAGAACAGGCAAATCCCCAGGCATGATGCGGCAGCTTAACATCAATGGAGCTCTGTATGTGGGTGGAATGAAGGAAATTGCTCTGCACACTAACAGGCAATATATGAGAGGGCTCGTGGGCTGTATCTCTCACTTCACCCTGTCCACCGATTACCACATTTCCCTCGTGGAAGATGCCGTGGATGGGAAAAACATCAACACTTGTGGAGCCAAGTAA-3'
NCBI CDS gene sequence with introns (location: 38258755.. 38463986) (205232 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 38258559.. 38465480) (206922 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [38258559 - 1000].. 38465480) (207922 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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