Protein
Protein (NP_001138)
Angiopoietin-2
Angiopoietin-2 (ANG-2)
ANGPT2
angiopoietin 2
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_001138
285
O15123
Undefined
O15123
0.54
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (496 amino acids) Download
MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-O15123-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for ANGPT2 Gene
ProteomicsDB
References
NCBI References (3 PubMed Identifiers)
  • Rethinking isolated cleft lip and palate as a syndrome. [29500156]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system. [11991715]
UniProt Main References (13 PubMed Identifiers)
  • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. [9204896]
  • Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. [9927494]
  • Characterization and expression of a novel alternatively spliced human angiopoietin-2. [10766762]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • DNA sequence and analysis of human chromosome 8. [16421571]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. [12427764]
  • Biological characterization of angiopoietin-3 and angiopoietin-4. [15284220]
  • Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells. [19116766]
  • Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. [19223473]
    • Show more
All isoforms of this gene containing a lectin domain
NP_001112360.1, NP_001373264.1, NP_001138.1, NP_001112359.1, NP_001373265.1, NP_001373266.1
RNA
RNA (Transcript ID: NM_001135050.2)
NM_001135050.2
immunoglobulin superfamily member 9, transcript variant 1
All isoforms of ANGPT2 containing a lectin domain
ENST00000368094.6
216..3755 (or 6503101.. 6562934)
159927041.. 159945613
NCBI Matured mRNA sequence 4059 NTPDownload 
m7G-5')ppp(5'-AUUGUGUAGCGGCGAGAGUGGAGCCGAGCGGUGCGGAGCAGAUCUGGUGGUUCUCCGGAGAGCAGCUUCCUCGGGUGUUACAUGAGCCAAGCCCUCACUGUACAGAAGAGUGAGAGCUGAAACCUGUUCCCUGAGCUGAUCAGAAGGACAUCCCUUGGCCCCUCCAUCUGGGCUCCUGUGGAUAGGAGGGGCUGGGUGAGCAGGCCAGCUGGGCUAUGGUGUGGUGCCUCGGCCUGGCCGUCCUCAGCCUGGUCAUCAGCCAGGGGGCUGACGGUCGAGGGAAGCCUGAGGUGGUAUCGGUGGUGGGCCGGGCUGGGGAGAGUGUGGUGCUGGGCUGUGACCUGCUGCCCCCGGCCGGCCGGCCCCCCCUGCAUGUCAUCGAGUGGCUGCGCUUUGGAUUCCUGCUUCCCAUCUUCAUCCAGUUCGGCCUCUACUCUCCCCGAAUUGACCCUGAUUACGUGGGACGAGUCCGGCUGCAGAAGGGGGCCUCUCUCCAGAUUGAGGGUCUCCGGGUGGAAGACCAGGGCUGGUACGAGUGCCGCGUGUUCUUCCUGGACCAGCACAUCCCUGAAGACGAUUUUGCUAACGGCUCCUGGGUGCAUCUGACAGUCAAUUCACCCCCUCAAUUCCAGGAGACACCUCCUGCUGUGUUGGAAGUGCAGGAACUGGAGCCUGUGACCCUGCGUUGUGUGGCCCGUGGCAGCCCCCUGCCUCAUGUGACGUGGAAGCUCCGAGGAAAGGACCUUGGCCAGGGCCAGGGCCAGGUGCAAGUGCAGAACGGGACGCUGCGGAUCCGCCGGGUAGAGCGAGGCAGCUCUGGGGUCUACACCUGCCAAGCCUCCAGCACUGAGGGCAGCGCCACCCACGCCACCCAGCUGCUAGUGCUAGGACCCCCAGUCAUCGUGGUGCCCCCCAAGAACAGCACAGUCAAUGCCUCCCAGGAUGUUUCAUUGGCCUGCCAUGCUGAGGCAUACCCUGCUAACCUCACCUACAGCUGGUUCCAGGACAACAUCAAUGUCUUCCACAUUAGCCGCCUGCAGCCCCGGGUGCGGAUCCUGGUGGACGGGAGCCUGCGGCUGCUGGCCACCCAGCCUGAUGAUGCCGGCUGCUACACCUGUGUGCCCAGCAAUGGCCUCCUGCAUCCACCCUCAGCCUCUGCCUACCUCACUGUGCUCUACCCAGCCCAGGUGACAGCUAUGCCUCCUGAGACACCCCUGCCCAUAGGCAUGCCGGGGGUGAUCCGCUGCCCGGUUCGUGCCAACCCCCCACUGCUCUUUGUCAGCUGGACCAAGGAUGGAAAGGCCCUGCAGCUGGACAAGUUCCCUGGCUGGUCCCAGGGCACAGAAGGCUCACUGAUCAUCGCCCUGGGGAACGAGGAUGCCCUGGGAGAAUACUCCUGCACCCCCUACAACAGUCUUGGUACCGCCGGGCCCUCUCCUGUGACCCGCGUGCUGCUCAAGGCUCCCCCAGCUUUUAUAGAGCGGCCCAAGGAAGAAUAUUUCCAAGAAGUAGGGCGGGAGCUGCUCAUCCCCUGCUCCGCCCAAGGGGACCCUCCUCCUGUUGUCUCUUGGACCAAGGUGGGCCGGGGGCUGCAAGGCCAGGCCCAGGUGGACAGCAACAGCAGCCUCAUCCUGCGACCAUUGACCAAGGAGGCCCACGGGCACUGGGAAUGCAGUGCCAGCAAUGCUGUGGCCCGAGUGGCCACCUCCACGAACGUCUACGUGCUGGGCACUAGCCCUCAUGUUGUCACCAAUGUGUCCGUGGUGGCUUUGCCCAAGGGUGCCAAUGUCUCCUGGGAGCCUGGCUUUGAUGGUGGUUAUCUGCAGAGAUUCAGUGUCUGGUACACCCCACUGGCCAAGCGUCCUGACCGAAUGCACCAUGACUGGGUGUCCUUGGCAGUGCCUGUGGGGGCUGCUCACCUCCUAGUGCCAGGGCUGCAGCCCCACACCCAGUACCAGUUCAGCGUGCUAGCUCAGAACAAGCUGGGGAGUGGUCCCUUCAGCGAAAUCGUCUUGUCUGCUCCGGAAGGGCUUCCUACCACGCCAGCUGCACCCGGGCUUCCCCCAACAGAGAUACCGCCUCCCCUGUCCCCUCCGCGGGGUCUGGUGGCAGUGAGGACACCCCGGGGGGUACUCCUGCAUUGGGAUCCCCCAGAGCUGGUCCCUAAGAGACUGGAUGGCUACGUCUUGGAAGGCCGGCAAGGCUCCCAGGGCUGGGAGGUGCUGGACCCGGCUGUGGCAGGCACAGAAACAGAGCUGCUGGUGCCAGGCCUCAUCAAGGAUGUUCUCUACGAGUUCCGCCUCGUGGCCUUCGCGGGCAGCUUCGUCAGCGACCCCAGCAACACGGCCAACGUCUCCACUUCCGGUCUGGAGGUCUACCCUUCGCGCACGCAGCUGCCGGGCCUCCUGCCUCAGCCCGUGCUGGCCGGCGUGGUGGGCGGAGUCUGCUUUCUGGGAGUGGCCGUCCUUGUGAGCAUCCUGGCCGGCUGCCUCCUGAACCGGCGCAGGGCUGCCCGCCGCCGCCGCAAGCGCCUCCGCCAAGAUCCACCUCUUAUCUUCUCUCCGACCGGGAAGUCAGCUGCACCCUCUGCUCUGGGCUCAGGCAGUCCUGACAGCGUGGCGAAGCUGAAGCUCCAGGGAUCCCCAGUCCCCAGCCUGCGCCAGAGUCUGCUCUGGGGGGAUCCUGCCGGAACUCCCAGCCCCCACCCGGAUCCUCCAUCUAGCCGGGGACCCUUACCUCUGGAGCCCAUUUGCCGGGGCCCAGACGGGCGCUUUGUGAUGGGGCCCACUGUGGCGGCCCCCCAGGAAAGGUCAGGCCGGGAGCAGGCAGAACCUCGGACUCCAGCCCAGCGUCUGGCCCGGUCCUUUGACUGUAGCAGCAGCAGCCCCAGUGGGGCACCCCAGCCCCUCUGCAUUGAAGACAUCAGCCCUGUGGCACCCCCUCCAGCAGCCCCACCCAGUCCCUUGCCAGGUCCUGGACCCCUGCUCCAGUACCUGAGCCUGCCCUUCUUCCGAGAGAUGAAUGUGGAUGGGGACUGGCCCCCGCUUGAGGAGCCCAGCCCUGCUGCACCCCCAGAUUACAUGGAUACCCGGCGCUGUCCCACCUCAUCUUUCCUUCGUUCUCCAGAAACCCCUCCUGUAUCCCCCAGGGAAUCACUUCCUGGGGCUGUGGUAGGGGCUGGGGCCACUGCAGAGCCCCCUUACACAGCCCUGGCUGACUGGACACUGAGGGAGCGGCUGCUGCCAGGCCUUCUCCCUGCUGCCCCUCGAGGCAGCCUCACCAGCCAGAGCAGUGGGCGAGGCAGCGCUUCGUUCCUGCGGCCCCCCUCCACAGCCCCCUCUGCAGGAGGCAGCUACCUCAGCCCUGCUCCAGGAGACACCAGCAGCUGGGCCAGUGGCCCUGAGAGAUGGCCCCGAAGGGAGCAUGUGGUGACAGUCAGCAAGAGGAGGAACACAUCUGUGGACGAGAACUAUGAGUGGGACUCAGAAUUCCCUGGGGACAUGGAAUUGCUGGAGACUUUGCACCUGGGCUUGGCCAGCUCCCGGCUCAGACCUGAAGCUGAGCCAGAGCUAGGUGUGAAGACUCCAGAGGAGGGCUGCCUCCUGAACACUGCCCAUGUUACUGGCCCUGAGGCCCGCUGUGCUGCCCUUCGGGAGGAAUUCCUGGCCUUCCGCCGCCGCCGAGAUGCUACUAGGGCUCGGCUACCAGCCUAUCGACAGCCAGUCCCCCACCCCGAACAGGCCACUCUGCUGUGAACAUCCCUGAUGUGAGGCUGUGAAAAGGCAUAUGGACCUGCAAAGGAGGCCCCCAACCAGACAGACCUAGUUUCAAACGAGGGCACUGCCCCUGCCUGCCCCUUUGGUGCCCAGGCACAGACCCUGAUAGUGGGUUUGGGUCACCUUGGUAUGGAAUGUAUGUGCUGACCCCCUAGGUGAGUCUGGGGAUUGGAACAGGGAUCUUAGGUCUGCCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUGUGUGUGUGUGUGUGUGUGUGAAGUUUUUUACAGGUGAAUAAACAAAGUUUGAAAGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 285)
ANGPT2
angiopoietin 2
NC_000008.11
8  6503101.. 6562934
6503101.. 6562934
strand -
CCDS5958.1
MGI:1202890
ClinVar, dbVar
ENSG00000091879
Ang2
uc003wqj.6
INSDC: AF004327
485
601922
OTTHUMG00000090365
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1491 bp)
5'-ATGTGGCAGATTGTTTTCTTTACTCTGAGCTGTGATCTTGTCTTGGCCGCAGCCTATAACAACTTTCGGAAGAGCATGGACAGCATAGGAAAGAAGCAATATCAGGTCCAGCATGGGTCCTGCAGCTACACTTTCCTCCTGCCAGAGATGGACAACTGCCGCTCTTCCTCCAGCCCCTACGTGTCCAATGCTGTGCAGAGGGACGCGCCGCTCGAATACGATGACTCGGTGCAGAGGCTGCAAGTGCTGGAGAACATCATGGAAAACAACACTCAGTGGCTAATGAAGCTTGAGAATTATATCCAGGACAACATGAAGAAAGAAATGGTAGAGATACAGCAGAATGCAGTACAGAACCAGACGGCTGTGATGATAGAAATAGGGACAAACCTGTTGAACCAAACAGCGGAGCAAACGCGGAAGTTAACTGATGTGGAAGCCCAAGTATTAAATCAGACCACGAGACTTGAACTTCAGCTCTTGGAACACTCCCTCTCGACAAACAAATTGGAAAAACAGATTTTGGACCAGACCAGTGAAATAAACAAATTGCAAGATAAGAACAGTTTCCTAGAAAAGAAGGTGCTAGCTATGGAAGACAAGCACATCATCCAACTACAGTCAATAAAAGAAGAGAAAGATCAGCTACAGGTGTTAGTATCCAAGCAAAATTCCATCATTGAAGAACTAGAAAAAAAAATAGTGACTGCCACGGTGAATAATTCAGTTCTTCAGAAGCAGCAACATGATCTCATGGAGACAGTTAATAACTTACTGACTATGATGTCCACATCAAACTCAGCTAAGGACCCCACTGTTGCTAAAGAAGAACAAATCAGCTTCAGAGACTGTGCTGAAGTATTCAAATCAGGACACACCACGAATGGCATCTACACGTTAACATTCCCTAATTCTACAGAAGAGATCAAGGCCTACTGTGACATGGAAGCTGGAGGAGGCGGGTGGACAATTATTCAGCGACGTGAGGATGGCAGCGTTGATTTTCAGAGGACTTGGAAAGAATATAAAGTGGGATTTGGTAACCCTTCAGGAGAATATTGGCTGGGAAATGAGTTTGTTTCGCAACTGACTAATCAGCAACGCTATGTGCTTAAAATACACCTTAAAGACTGGGAAGGGAATGAGGCTTACTCATTGTATGAACATTTCTATCTCTCAAGTGAAGAACTCAATTATAGGATTCACCTTAAAGGACTTACAGGGACAGCCGGCAAAATAAGCAGCATCAGCCAACCAGGAAATGATTTTAGCACAAAGGATGGAGACAACGACAAATGTATTTGCAAATGTTCACAAATGCTAACAGGAGGCTGGTGGTTTGATGCATGTGGTCCTTCCAACTTGAACGGAATGTACTATCCACAGAGGCAGAACACAAATAAGTTCAACGGCATTAAATGGTACTACTGGAAAGGCTCAGGCTATTCGCTCAAGGCCACAACCATGATGATCCGACCAGCAGATTTCTAA-3'
NCBI CDS gene sequence with introns (location: 6503101.. 6562934) (59834 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 159927041.. 159945613) (18573 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [159927041.. 159945613 + 1000]) (19573 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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