HumanLectome - Human Lectin Entry

Protein name

Angiopoietin-1

Synonym(s)

Angiopoietin-1 (ANG-1)

HGNC gene name

ANGPT1

HGNC name

angiopoietin 1

Protein_CD_name

Undefined

Lectin confidence

Very low evidence

UniLectin class

Ficolin-like

Known lectin group

Undefined

Lectin fold

a/b mixed with b-sheet / Fibrinogen C-ter like

Glycan specificity

Uncharacterised

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.567

Reference

Undefined

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (498 amino acids) Download

MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q15389-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for ANGPT1 Gene

ProteomicsDB

References

NCBI References (3 PubMed Identifiers)

Rethinking isolated cleft lip and palate as a syndrome. [29500156]

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]

Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system. [11991715]

UniProt Main References (15 PubMed Identifiers)

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. [8980223]

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. [7584026]

The full-ORF clone resource of the German cDNA Consortium. [17974005]

DNA sequence and analysis of human chromosome 8. [16421571]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. [12168954]

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. [9204896]

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. [12427764]

Biological characterization of angiopoietin-3 and angiopoietin-4. [15284220]

Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. [18425120]

All isoforms of this gene containing a lectin domain

NP_001300980.1, NP_001186788.1, NP_001137.2

RNA

RNA (Transcript ID: NM_001135050.2)

RNA RefSeq ID

NM_001135050.2

RNA name

immunoglobulin superfamily member 9, transcript variant 1

Isoforms

All isoforms of ANGPT1 containing a lectin domain

RNA Ensembl ID

ENST00000368094.6

Coding region

216..3755 (or 107251855.. 107497558)

mRNA location

159927041.. 159945613

NCBI Matured mRNA sequence 4059 NTP Download

m⁷G-5')ppp(5'-AUUGUGUAGCGGCGAGAGUGGAGCCGAGCGGUGCGGAGCAGAUCUGGUGGUUCUCCGGAGAGCAGCUUCCUCGGGUGUUACAUGAGCCAAGCCCUCACUGUACAGAAGAGUGAGAGCUGAAACCUGUUCCCUGAGCUGAUCAGAAGGACAUCCCUUGGCCCCUCCAUCUGGGCUCCUGUGGAUAGGAGGGGCUGGGUGAGCAGGCCAGCUGGGCUAUGGUGUGGUGCCUCGGCCUGGCCGUCCUCAGCCUGGUCAUCAGCCAGGGGGCUGACGGUCGAGGGAAGCCUGAGGUGGUAUCGGUGGUGGGCCGGGCUGGGGAGAGUGUGGUGCUGGGCUGUGACCUGCUGCCCCCGGCCGGCCGGCCCCCCCUGCAUGUCAUCGAGUGGCUGCGCUUUGGAUUCCUGCUUCCCAUCUUCAUCCAGUUCGGCCUCUACUCUCCCCGAAUUGACCCUGAUUACGUGGGACGAGUCCGGCUGCAGAAGGGGGCCUCUCUCCAGAUUGAGGGUCUCCGGGUGGAAGACCAGGGCUGGUACGAGUGCCGCGUGUUCUUCCUGGACCAGCACAUCCCUGAAGACGAUUUUGCUAACGGCUCCUGGGUGCAUCUGACAGUCAAUUCACCCCCUCAAUUCCAGGAGACACCUCCUGCUGUGUUGGAAGUGCAGGAACUGGAGCCUGUGACCCUGCGUUGUGUGGCCCGUGGCAGCCCCCUGCCUCAUGUGACGUGGAAGCUCCGAGGAAAGGACCUUGGCCAGGGCCAGGGCCAGGUGCAAGUGCAGAACGGGACGCUGCGGAUCCGCCGGGUAGAGCGAGGCAGCUCUGGGGUCUACACCUGCCAAGCCUCCAGCACUGAGGGCAGCGCCACCCACGCCACCCAGCUGCUAGUGCUAGGACCCCCAGUCAUCGUGGUGCCCCCCAAGAACAGCACAGUCAAUGCCUCCCAGGAUGUUUCAUUGGCCUGCCAUGCUGAGGCAUACCCUGCUAACCUCACCUACAGCUGGUUCCAGGACAACAUCAAUGUCUUCCACAUUAGCCGCCUGCAGCCCCGGGUGCGGAUCCUGGUGGACGGGAGCCUGCGGCUGCUGGCCACCCAGCCUGAUGAUGCCGGCUGCUACACCUGUGUGCCCAGCAAUGGCCUCCUGCAUCCACCCUCAGCCUCUGCCUACCUCACUGUGCUCUACCCAGCCCAGGUGACAGCUAUGCCUCCUGAGACACCCCUGCCCAUAGGCAUGCCGGGGGUGAUCCGCUGCCCGGUUCGUGCCAACCCCCCACUGCUCUUUGUCAGCUGGACCAAGGAUGGAAAGGCCCUGCAGCUGGACAAGUUCCCUGGCUGGUCCCAGGGCACAGAAGGCUCACUGAUCAUCGCCCUGGGGAACGAGGAUGCCCUGGGAGAAUACUCCUGCACCCCCUACAACAGUCUUGGUACCGCCGGGCCCUCUCCUGUGACCCGCGUGCUGCUCAAGGCUCCCCCAGCUUUUAUAGAGCGGCCCAAGGAAGAAUAUUUCCAAGAAGUAGGGCGGGAGCUGCUCAUCCCCUGCUCCGCCCAAGGGGACCCUCCUCCUGUUGUCUCUUGGACCAAGGUGGGCCGGGGGCUGCAAGGCCAGGCCCAGGUGGACAGCAACAGCAGCCUCAUCCUGCGACCAUUGACCAAGGAGGCCCACGGGCACUGGGAAUGCAGUGCCAGCAAUGCUGUGGCCCGAGUGGCCACCUCCACGAACGUCUACGUGCUGGGCACUAGCCCUCAUGUUGUCACCAAUGUGUCCGUGGUGGCUUUGCCCAAGGGUGCCAAUGUCUCCUGGGAGCCUGGCUUUGAUGGUGGUUAUCUGCAGAGAUUCAGUGUCUGGUACACCCCACUGGCCAAGCGUCCUGACCGAAUGCACCAUGACUGGGUGUCCUUGGCAGUGCCUGUGGGGGCUGCUCACCUCCUAGUGCCAGGGCUGCAGCCCCACACCCAGUACCAGUUCAGCGUGCUAGCUCAGAACAAGCUGGGGAGUGGUCCCUUCAGCGAAAUCGUCUUGUCUGCUCCGGAAGGGCUUCCUACCACGCCAGCUGCACCCGGGCUUCCCCCAACAGAGAUACCGCCUCCCCUGUCCCCUCCGCGGGGUCUGGUGGCAGUGAGGACACCCCGGGGGGUACUCCUGCAUUGGGAUCCCCCAGAGCUGGUCCCUAAGAGACUGGAUGGCUACGUCUUGGAAGGCCGGCAAGGCUCCCAGGGCUGGGAGGUGCUGGACCCGGCUGUGGCAGGCACAGAAACAGAGCUGCUGGUGCCAGGCCUCAUCAAGGAUGUUCUCUACGAGUUCCGCCUCGUGGCCUUCGCGGGCAGCUUCGUCAGCGACCCCAGCAACACGGCCAACGUCUCCACUUCCGGUCUGGAGGUCUACCCUUCGCGCACGCAGCUGCCGGGCCUCCUGCCUCAGCCCGUGCUGGCCGGCGUGGUGGGCGGAGUCUGCUUUCUGGGAGUGGCCGUCCUUGUGAGCAUCCUGGCCGGCUGCCUCCUGAACCGGCGCAGGGCUGCCCGCCGCCGCCGCAAGCGCCUCCGCCAAGAUCCACCUCUUAUCUUCUCUCCGACCGGGAAGUCAGCUGCACCCUCUGCUCUGGGCUCAGGCAGUCCUGACAGCGUGGCGAAGCUGAAGCUCCAGGGAUCCCCAGUCCCCAGCCUGCGCCAGAGUCUGCUCUGGGGGGAUCCUGCCGGAACUCCCAGCCCCCACCCGGAUCCUCCAUCUAGCCGGGGACCCUUACCUCUGGAGCCCAUUUGCCGGGGCCCAGACGGGCGCUUUGUGAUGGGGCCCACUGUGGCGGCCCCCCAGGAAAGGUCAGGCCGGGAGCAGGCAGAACCUCGGACUCCAGCCCAGCGUCUGGCCCGGUCCUUUGACUGUAGCAGCAGCAGCCCCAGUGGGGCACCCCAGCCCCUCUGCAUUGAAGACAUCAGCCCUGUGGCACCCCCUCCAGCAGCCCCACCCAGUCCCUUGCCAGGUCCUGGACCCCUGCUCCAGUACCUGAGCCUGCCCUUCUUCCGAGAGAUGAAUGUGGAUGGGGACUGGCCCCCGCUUGAGGAGCCCAGCCCUGCUGCACCCCCAGAUUACAUGGAUACCCGGCGCUGUCCCACCUCAUCUUUCCUUCGUUCUCCAGAAACCCCUCCUGUAUCCCCCAGGGAAUCACUUCCUGGGGCUGUGGUAGGGGCUGGGGCCACUGCAGAGCCCCCUUACACAGCCCUGGCUGACUGGACACUGAGGGAGCGGCUGCUGCCAGGCCUUCUCCCUGCUGCCCCUCGAGGCAGCCUCACCAGCCAGAGCAGUGGGCGAGGCAGCGCUUCGUUCCUGCGGCCCCCCUCCACAGCCCCCUCUGCAGGAGGCAGCUACCUCAGCCCUGCUCCAGGAGACACCAGCAGCUGGGCCAGUGGCCCUGAGAGAUGGCCCCGAAGGGAGCAUGUGGUGACAGUCAGCAAGAGGAGGAACACAUCUGUGGACGAGAACUAUGAGUGGGACUCAGAAUUCCCUGGGGACAUGGAAUUGCUGGAGACUUUGCACCUGGGCUUGGCCAGCUCCCGGCUCAGACCUGAAGCUGAGCCAGAGCUAGGUGUGAAGACUCCAGAGGAGGGCUGCCUCCUGAACACUGCCCAUGUUACUGGCCCUGAGGCCCGCUGUGCUGCCCUUCGGGAGGAAUUCCUGGCCUUCCGCCGCCGCCGAGAUGCUACUAGGGCUCGGCUACCAGCCUAUCGACAGCCAGUCCCCCACCCCGAACAGGCCACUCUGCUGUGAACAUCCCUGAUGUGAGGCUGUGAAAAGGCAUAUGGACCUGCAAAGGAGGCCCCCAACCAGACAGACCUAGUUUCAAACGAGGGCACUGCCCCUGCCUGCCCCUUUGGUGCCCAGGCACAGACCCUGAUAGUGGGUUUGGGUCACCUUGGUAUGGAAUGUAUGUGCUGACCCCCUAGGUGAGUCUGGGGAUUGGAACAGGGAUCUUAGGUCUGCCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUGUGUGUGUGUGUGUGUGUGUGAAGUUUUUUACAGGUGAAUAAACAAAGUUUGAAAGA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 284)

HGNC Gene symbol

ANGPT1

HGNC Gene name

angiopoietin 1

Chr. RefSeq ID

NC_000008.11

Chromosome N°

8 107251855.. 107497558

CDS location

107251855.. 107497558

DNA strand

strand -

CCDS ID

CCDS6306.1

Mouse ortholog gene

MGI:108448

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000154188

HGNC other symbol

KIAA0003, Ang1, AGPT-1

UCSC ID

uc003ymn.4

GeneBank

INSDC: D13628

GeneCards

484

MIM

601667

VEGA ID

OTTHUMG00000164812

Other links

ENA, DDBJ, Monarch

NCBI CDS Gene viewer

More about the NCBI sViewer.

NCBI CDS gene sequence (1497 bp)

5'-ATGACAGTTTTCCTTTCCTTTGCTTTCCTCGCTGCCATTCTGACTCACATAGGGTGCAGCAATCAGCGCCGAAGTCCAGAAAACAGTGGGAGAAGATATAACCGGATTCAACATGGGCAATGTGCCTACACTTTCATTCTTCCAGAACACGATGGCAACTGTCGTGAGAGTACGACAGACCAGTACAACACAAACGCTCTGCAGAGAGATGCTCCACACGTGGAACCGGATTTCTCTTCCCAGAAACTTCAACATCTGGAACATGTGATGGAAAATTATACTCAGTGGCTGCAAAAACTTGAGAATTACATTGTGGAAAACATGAAGTCGGAGATGGCCCAGATACAGCAGAATGCAGTTCAGAACCACACGGCTACCATGCTGGAGATAGGAACCAGCCTCCTCTCTCAGACTGCAGAGCAGACCAGAAAGCTGACAGATGTTGAGACCCAGGTACTAAATCAAACTTCTCGACTTGAGATACAGCTGCTGGAGAATTCATTATCCACCTACAAGCTAGAGAAGCAACTTCTTCAACAGACAAATGAAATCTTGAAGATCCATGAAAAAAACAGTTTATTAGAACATAAAATCTTAGAAATGGAAGGAAAACACAAGGAAGAGTTGGACACCTTAAAGGAAGAGAAAGAGAACCTTCAAGGCTTGGTTACTCGTCAAACATATATAATCCAGGAGCTGGAAAAGCAATTAAACAGAGCTACCACCAACAACAGTGTCCTTCAGAAGCAGCAACTGGAGCTGATGGACACAGTCCACAACCTTGTCAATCTTTGCACTAAAGAAGGTGTTTTACTAAAGGGAGGAAAAAGAGAGGAAGAGAAACCATTTAGAGACTGTGCAGATGTATATCAAGCTGGTTTTAATAAAAGTGGAATCTACACTATTTATATTAATAATATGCCAGAACCCAAAAAGGTGTTTTGCAATATGGATGTCAATGGGGGAGGTTGGACTGTAATACAACATCGTGAAGATGGAAGTCTAGATTTCCAAAGAGGCTGGAAGGAATATAAAATGGGTTTTGGAAATCCCTCCGGTGAATATTGGCTGGGGAATGAGTTTATTTTTGCCATTACCAGTCAGAGGCAGTACATGCTAAGAATTGAGTTAATGGACTGGGAAGGGAACCGAGCCTATTCACAGTATGACAGATTCCACATAGGAAATGAAAAGCAAAACTATAGGTTGTATTTAAAAGGTCACACTGGGACAGCAGGAAAACAGAGCAGCCTGATCTTACACGGTGCTGATTTCAGCACTAAAGATGCTGATAATGACAACTGTATGTGCAAATGTGCCCTCATGTTAACAGGAGGATGGTGGTTTGATGCTTGTGGCCCCTCCAATCTAAATGGAATGTTCTATACTGCGGGACAAAACCATGGAAAACTGAATGGGATAAAGTGGCACTACTTCAAAGGGCCCAGTTACTCCTTACGTTCCACAACTATGATGATTCGACCTTTAGATTTTTGA-3'

NCBI CDS gene sequence with introns (location: 107251855.. 107497558) (245704 bp)Download

NCBI Gene Viewer (CDS + introns)

NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 159927041.. 159945613) (18573 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions)

NCBI gene sequence (location: [159927041.. 159945613 + 1000]) (19573 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)

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