Protein
Protein (NP_001137)
Angiopoietin-1
Angiopoietin-1 (ANG-1)
ANGPT1
angiopoietin 1
Undefined
Very low evidence
Ficolin-like
Undefined
a/b mixed with b-sheet / Fibrinogen C-ter like
Uncharacterised
NP_001137
284
Q15389
ENSP00000428340.1
Q15389
0.567
Undefined
PFAM, InterPro
Protein sequence and protein families (fasta) (498 amino acids) Download
MTVFLSFAFLAAILTHIGCSNQRRSPENSGRRYNRIQHGQCAYTFILPEHDGNCRESTTDQYNTNALQRDAPHVEPDFSSQKLQHLEHVMENYTQWLQKLENYIVENMKSEMAQIQQNAVQNHTATMLEIGTSLLSQTAEQTRKLTDVETQVLNQTSRLEIQLLENSLSTYKLEKQLLQQTNEILKIHEKNSLLEHKILEMEGKHKEELDTLKEEKENLQGLVTRQTYIIQELEKQLNRATTNNSVLQKQQLELMDTVHNLVNLCTKEGVLLKGGKREEEKPFRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRFHIGNEKQNYRLYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLDF
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q15389-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Homooligomer (PubMed:28601681). Interacts with TEK/TIE2 (PubMed:28601681, PubMed:30689269). Interacts with SVEP1/polydom (By similarity). Interacts with THBD; this interaction significantly inhibits the generation of activated PC and TAFIa/CPB2 by the thrombin/thrombomodulin complex (PubMed:29323190)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (3 PubMed Identifiers)
  • Rethinking isolated cleft lip and palate as a syndrome. [29500156]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Cloning and characterization of Igsf9 in mouse and human: a new member of the immunoglobulin superfamily expressed in the developing nervous system. [11991715]
UniProt Main References (15 PubMed Identifiers)
  • Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. [8980223]
  • Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. [7584026]
  • The full-ORF clone resource of the German cDNA Consortium. [17974005]
  • DNA sequence and analysis of human chromosome 8. [16421571]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. [12168954]
  • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. [9204896]
  • Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. [12427764]
  • Biological characterization of angiopoietin-3 and angiopoietin-4. [15284220]
  • Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. [18425120]
    • Show more
All isoforms of this gene containing a lectin domain
NP_001300980.1, NP_001186788.1, NP_001137.2
RNA
RNA (Transcript ID: NM_001135050.2)
NM_001135050.2
immunoglobulin superfamily member 9, transcript variant 1
All isoforms of ANGPT1 containing a lectin domain
ENST00000368094.6
216..3755 (or 107251855.. 107497558)
159927041.. 159945613
NCBI Matured mRNA sequence 4059 NTPDownload 
m7G-5')ppp(5'-AUUGUGUAGCGGCGAGAGUGGAGCCGAGCGGUGCGGAGCAGAUCUGGUGGUUCUCCGGAGAGCAGCUUCCUCGGGUGUUACAUGAGCCAAGCCCUCACUGUACAGAAGAGUGAGAGCUGAAACCUGUUCCCUGAGCUGAUCAGAAGGACAUCCCUUGGCCCCUCCAUCUGGGCUCCUGUGGAUAGGAGGGGCUGGGUGAGCAGGCCAGCUGGGCUAUGGUGUGGUGCCUCGGCCUGGCCGUCCUCAGCCUGGUCAUCAGCCAGGGGGCUGACGGUCGAGGGAAGCCUGAGGUGGUAUCGGUGGUGGGCCGGGCUGGGGAGAGUGUGGUGCUGGGCUGUGACCUGCUGCCCCCGGCCGGCCGGCCCCCCCUGCAUGUCAUCGAGUGGCUGCGCUUUGGAUUCCUGCUUCCCAUCUUCAUCCAGUUCGGCCUCUACUCUCCCCGAAUUGACCCUGAUUACGUGGGACGAGUCCGGCUGCAGAAGGGGGCCUCUCUCCAGAUUGAGGGUCUCCGGGUGGAAGACCAGGGCUGGUACGAGUGCCGCGUGUUCUUCCUGGACCAGCACAUCCCUGAAGACGAUUUUGCUAACGGCUCCUGGGUGCAUCUGACAGUCAAUUCACCCCCUCAAUUCCAGGAGACACCUCCUGCUGUGUUGGAAGUGCAGGAACUGGAGCCUGUGACCCUGCGUUGUGUGGCCCGUGGCAGCCCCCUGCCUCAUGUGACGUGGAAGCUCCGAGGAAAGGACCUUGGCCAGGGCCAGGGCCAGGUGCAAGUGCAGAACGGGACGCUGCGGAUCCGCCGGGUAGAGCGAGGCAGCUCUGGGGUCUACACCUGCCAAGCCUCCAGCACUGAGGGCAGCGCCACCCACGCCACCCAGCUGCUAGUGCUAGGACCCCCAGUCAUCGUGGUGCCCCCCAAGAACAGCACAGUCAAUGCCUCCCAGGAUGUUUCAUUGGCCUGCCAUGCUGAGGCAUACCCUGCUAACCUCACCUACAGCUGGUUCCAGGACAACAUCAAUGUCUUCCACAUUAGCCGCCUGCAGCCCCGGGUGCGGAUCCUGGUGGACGGGAGCCUGCGGCUGCUGGCCACCCAGCCUGAUGAUGCCGGCUGCUACACCUGUGUGCCCAGCAAUGGCCUCCUGCAUCCACCCUCAGCCUCUGCCUACCUCACUGUGCUCUACCCAGCCCAGGUGACAGCUAUGCCUCCUGAGACACCCCUGCCCAUAGGCAUGCCGGGGGUGAUCCGCUGCCCGGUUCGUGCCAACCCCCCACUGCUCUUUGUCAGCUGGACCAAGGAUGGAAAGGCCCUGCAGCUGGACAAGUUCCCUGGCUGGUCCCAGGGCACAGAAGGCUCACUGAUCAUCGCCCUGGGGAACGAGGAUGCCCUGGGAGAAUACUCCUGCACCCCCUACAACAGUCUUGGUACCGCCGGGCCCUCUCCUGUGACCCGCGUGCUGCUCAAGGCUCCCCCAGCUUUUAUAGAGCGGCCCAAGGAAGAAUAUUUCCAAGAAGUAGGGCGGGAGCUGCUCAUCCCCUGCUCCGCCCAAGGGGACCCUCCUCCUGUUGUCUCUUGGACCAAGGUGGGCCGGGGGCUGCAAGGCCAGGCCCAGGUGGACAGCAACAGCAGCCUCAUCCUGCGACCAUUGACCAAGGAGGCCCACGGGCACUGGGAAUGCAGUGCCAGCAAUGCUGUGGCCCGAGUGGCCACCUCCACGAACGUCUACGUGCUGGGCACUAGCCCUCAUGUUGUCACCAAUGUGUCCGUGGUGGCUUUGCCCAAGGGUGCCAAUGUCUCCUGGGAGCCUGGCUUUGAUGGUGGUUAUCUGCAGAGAUUCAGUGUCUGGUACACCCCACUGGCCAAGCGUCCUGACCGAAUGCACCAUGACUGGGUGUCCUUGGCAGUGCCUGUGGGGGCUGCUCACCUCCUAGUGCCAGGGCUGCAGCCCCACACCCAGUACCAGUUCAGCGUGCUAGCUCAGAACAAGCUGGGGAGUGGUCCCUUCAGCGAAAUCGUCUUGUCUGCUCCGGAAGGGCUUCCUACCACGCCAGCUGCACCCGGGCUUCCCCCAACAGAGAUACCGCCUCCCCUGUCCCCUCCGCGGGGUCUGGUGGCAGUGAGGACACCCCGGGGGGUACUCCUGCAUUGGGAUCCCCCAGAGCUGGUCCCUAAGAGACUGGAUGGCUACGUCUUGGAAGGCCGGCAAGGCUCCCAGGGCUGGGAGGUGCUGGACCCGGCUGUGGCAGGCACAGAAACAGAGCUGCUGGUGCCAGGCCUCAUCAAGGAUGUUCUCUACGAGUUCCGCCUCGUGGCCUUCGCGGGCAGCUUCGUCAGCGACCCCAGCAACACGGCCAACGUCUCCACUUCCGGUCUGGAGGUCUACCCUUCGCGCACGCAGCUGCCGGGCCUCCUGCCUCAGCCCGUGCUGGCCGGCGUGGUGGGCGGAGUCUGCUUUCUGGGAGUGGCCGUCCUUGUGAGCAUCCUGGCCGGCUGCCUCCUGAACCGGCGCAGGGCUGCCCGCCGCCGCCGCAAGCGCCUCCGCCAAGAUCCACCUCUUAUCUUCUCUCCGACCGGGAAGUCAGCUGCACCCUCUGCUCUGGGCUCAGGCAGUCCUGACAGCGUGGCGAAGCUGAAGCUCCAGGGAUCCCCAGUCCCCAGCCUGCGCCAGAGUCUGCUCUGGGGGGAUCCUGCCGGAACUCCCAGCCCCCACCCGGAUCCUCCAUCUAGCCGGGGACCCUUACCUCUGGAGCCCAUUUGCCGGGGCCCAGACGGGCGCUUUGUGAUGGGGCCCACUGUGGCGGCCCCCCAGGAAAGGUCAGGCCGGGAGCAGGCAGAACCUCGGACUCCAGCCCAGCGUCUGGCCCGGUCCUUUGACUGUAGCAGCAGCAGCCCCAGUGGGGCACCCCAGCCCCUCUGCAUUGAAGACAUCAGCCCUGUGGCACCCCCUCCAGCAGCCCCACCCAGUCCCUUGCCAGGUCCUGGACCCCUGCUCCAGUACCUGAGCCUGCCCUUCUUCCGAGAGAUGAAUGUGGAUGGGGACUGGCCCCCGCUUGAGGAGCCCAGCCCUGCUGCACCCCCAGAUUACAUGGAUACCCGGCGCUGUCCCACCUCAUCUUUCCUUCGUUCUCCAGAAACCCCUCCUGUAUCCCCCAGGGAAUCACUUCCUGGGGCUGUGGUAGGGGCUGGGGCCACUGCAGAGCCCCCUUACACAGCCCUGGCUGACUGGACACUGAGGGAGCGGCUGCUGCCAGGCCUUCUCCCUGCUGCCCCUCGAGGCAGCCUCACCAGCCAGAGCAGUGGGCGAGGCAGCGCUUCGUUCCUGCGGCCCCCCUCCACAGCCCCCUCUGCAGGAGGCAGCUACCUCAGCCCUGCUCCAGGAGACACCAGCAGCUGGGCCAGUGGCCCUGAGAGAUGGCCCCGAAGGGAGCAUGUGGUGACAGUCAGCAAGAGGAGGAACACAUCUGUGGACGAGAACUAUGAGUGGGACUCAGAAUUCCCUGGGGACAUGGAAUUGCUGGAGACUUUGCACCUGGGCUUGGCCAGCUCCCGGCUCAGACCUGAAGCUGAGCCAGAGCUAGGUGUGAAGACUCCAGAGGAGGGCUGCCUCCUGAACACUGCCCAUGUUACUGGCCCUGAGGCCCGCUGUGCUGCCCUUCGGGAGGAAUUCCUGGCCUUCCGCCGCCGCCGAGAUGCUACUAGGGCUCGGCUACCAGCCUAUCGACAGCCAGUCCCCCACCCCGAACAGGCCACUCUGCUGUGAACAUCCCUGAUGUGAGGCUGUGAAAAGGCAUAUGGACCUGCAAAGGAGGCCCCCAACCAGACAGACCUAGUUUCAAACGAGGGCACUGCCCCUGCCUGCCCCUUUGGUGCCCAGGCACAGACCCUGAUAGUGGGUUUGGGUCACCUUGGUAUGGAAUGUAUGUGCUGACCCCCUAGGUGAGUCUGGGGAUUGGAACAGGGAUCUUAGGUCUGCCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUCUGUGUGUGUGUGUGUGUGUGUGAAGUUUUUUACAGGUGAAUAAACAAAGUUUGAAAGA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 284)
ANGPT1
angiopoietin 1
NC_000008.11
8  107251855.. 107497558
107251855.. 107497558
strand -
CCDS6306.1
MGI:108448
ClinVar, dbVar
ENSG00000154188
KIAA0003, Ang1, AGPT-1
uc003ymn.4
INSDC: D13628
484
601667
OTTHUMG00000164812
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (1497 bp)
5'-ATGACAGTTTTCCTTTCCTTTGCTTTCCTCGCTGCCATTCTGACTCACATAGGGTGCAGCAATCAGCGCCGAAGTCCAGAAAACAGTGGGAGAAGATATAACCGGATTCAACATGGGCAATGTGCCTACACTTTCATTCTTCCAGAACACGATGGCAACTGTCGTGAGAGTACGACAGACCAGTACAACACAAACGCTCTGCAGAGAGATGCTCCACACGTGGAACCGGATTTCTCTTCCCAGAAACTTCAACATCTGGAACATGTGATGGAAAATTATACTCAGTGGCTGCAAAAACTTGAGAATTACATTGTGGAAAACATGAAGTCGGAGATGGCCCAGATACAGCAGAATGCAGTTCAGAACCACACGGCTACCATGCTGGAGATAGGAACCAGCCTCCTCTCTCAGACTGCAGAGCAGACCAGAAAGCTGACAGATGTTGAGACCCAGGTACTAAATCAAACTTCTCGACTTGAGATACAGCTGCTGGAGAATTCATTATCCACCTACAAGCTAGAGAAGCAACTTCTTCAACAGACAAATGAAATCTTGAAGATCCATGAAAAAAACAGTTTATTAGAACATAAAATCTTAGAAATGGAAGGAAAACACAAGGAAGAGTTGGACACCTTAAAGGAAGAGAAAGAGAACCTTCAAGGCTTGGTTACTCGTCAAACATATATAATCCAGGAGCTGGAAAAGCAATTAAACAGAGCTACCACCAACAACAGTGTCCTTCAGAAGCAGCAACTGGAGCTGATGGACACAGTCCACAACCTTGTCAATCTTTGCACTAAAGAAGGTGTTTTACTAAAGGGAGGAAAAAGAGAGGAAGAGAAACCATTTAGAGACTGTGCAGATGTATATCAAGCTGGTTTTAATAAAAGTGGAATCTACACTATTTATATTAATAATATGCCAGAACCCAAAAAGGTGTTTTGCAATATGGATGTCAATGGGGGAGGTTGGACTGTAATACAACATCGTGAAGATGGAAGTCTAGATTTCCAAAGAGGCTGGAAGGAATATAAAATGGGTTTTGGAAATCCCTCCGGTGAATATTGGCTGGGGAATGAGTTTATTTTTGCCATTACCAGTCAGAGGCAGTACATGCTAAGAATTGAGTTAATGGACTGGGAAGGGAACCGAGCCTATTCACAGTATGACAGATTCCACATAGGAAATGAAAAGCAAAACTATAGGTTGTATTTAAAAGGTCACACTGGGACAGCAGGAAAACAGAGCAGCCTGATCTTACACGGTGCTGATTTCAGCACTAAAGATGCTGATAATGACAACTGTATGTGCAAATGTGCCCTCATGTTAACAGGAGGATGGTGGTTTGATGCTTGTGGCCCCTCCAATCTAAATGGAATGTTCTATACTGCGGGACAAAACCATGGAAAACTGAATGGGATAAAGTGGCACTACTTCAAAGGGCCCAGTTACTCCTTACGTTCCACAACTATGATGATTCGACCTTTAGATTTTTGA-3'
NCBI CDS gene sequence with introns (location: 107251855.. 107497558) (245704 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 159927041.. 159945613) (18573 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [159927041.. 159945613 + 1000]) (19573 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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