NCBI Summary
This locus represents naturally occurring transcripts that splice the 5' exons of the POC1B (POC1 centriolar protein homolog B) gene on chromosome 12 to the GALNT4 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4) gene, which is located within a POC1B intron. Alternative splicing results in two transcript variants, one of which encodes a fusion isoform that shares sequence identity with the products of each individual gene. [provided by RefSeq, Dec 2010].
Protein
Protein (NP_001186710)
CBM13-ppGalNAc-T4
Polypeptide N-acetylgalactosaminyltransferase 4 (EC 2.4.1.41) (Polypeptide GalNAc transferase 4) (GalNAc-T4) (pp-GaNTase 4) (Protein-UDP acetylgalactosaminyltransferase 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4)
POC1B-GALNT4
POC1B-GALNT4 readthrough
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_001186710
100528030
Q8N4A0
Undefined
Q8N4A0
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (575 amino acids) Download
MASATEDPVLERYFKGHKAAITSLDLSPNGKQLGAGRARELGSRRLSDLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPEQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGRPDVQMRTCDALDKNQIWSFEK
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q8N4A0-F1DownloadSee the associated sequence to the AlphaFold v2 model, which is different to this entry(NCBI sequence).
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
GalNAc, Glycopeptide
GalNAc
5NQA, 6H0B
5NQA, 6H0B
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for POC1B-GALNT4 Gene
ProteomicsDB
References
NCBI References (1 PubMed Identifiers)
  • Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. [20967262]
UniProt Main References (6 PubMed Identifiers)
  • Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. [9804815]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The finished DNA sequence of human chromosome 12. [16541075]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities. [10984485]
  • The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. [29208955]
All isoforms of this gene containing a lectin domain
NP_001186711.1, NP_001186710.1
RNA
RNA (Transcript ID: NM_001199781.2)
NM_001199781.2
POC1B-GALNT4 readthrough, transcript variant 1
All isoforms of POC1B-GALNT4 containing a lectin domain
153..1880 (or 89522813.. 89525895)
89519412.. 89526047
NCBI Matured mRNA sequence 5281 NTPDownload 
m7G-5')ppp(5'-GACUGGGCCGCCGUUGUUGUAGUGACCGGGAGGCGCUGCCGCUCUGGGCAGACGGUUCCGGGAGCCGCACGGUCCCCUCUCCUUCCCCAUCCUCUCCCCUCCCCUCUCCGGGUUCCCCCACCCACAGGAGCCUUGGGCCGACCACUCCCCCGAUGGCCUCAGCCACGGAGGACCCCGUUCUGGAGCGUUAUUUCAAAGGCCACAAAGCUGCGAUCACCUCCUUGGACCUCAGCCCCAACGGCAAGCAACUUGGAGCCGGCCGUGCCAGGGAGCUGGGGUCAAGAAGGCUCUCAGACCUCCAGAAAAAUACGGAGGAUUUGUCUCGACCGCUUUAUAAGAAGCCCCCUGCAGAUUCCCGUGCACUUGGGGAGUGGGGGAAAGCCAGCAAACUCCAGCUCAACGAGGAUGAACUGAAGCAGCAAGAAGAACUCAUUGAGAGAUACGCCAUCAAUAUUUACCUCAGUGACAGGAUUUCCCUGCAUCGACACAUAGAGGAUAAAAGAAUGUAUGAGUGUAAGUCCCAGAAGUUCAACUAUAGGACACUUCCUACCACCUCUGUUAUCAUUGCUUUCUAUAACGAAGCCUGGUCGACUUUGCUCCGUACCAUUCACAGUGUUUUAGAAACUUCUCCUGCAGUUCUUUUGAAAGAGAUCAUCUUGGUGGAUGACUUGAGUGACAGAGUUUAUUUGAAGACACAACUUGAAACUUACAUCAGCAAUCUUGAUAGAGUACGCUUGAUUAGGACCAAUAAGCGAGAGGGGCUGGUUAGGGCCCGUCUGAUUGGGGCCACUUUCGCCACUGGGGACGUCCUCACUUUCCUGGAUUGUCACUGUGAGUGUAAUUCCGGUUGGCUGGAACCGCUUUUGGAAAGGAUUGGGAGAGAUGAAACAGCAGUUGUGUGUCCUGUUAUAGACACAAUUGAUUGGAAUACUUUUGAAUUCUAUAUGCAGAUAGGGGAGCCCAUGAUUGGUGGGUUUGACUGGCGUUUAACAUUUCAGUGGCAUUCUGUCCCCAAACAGGAAAGGGACAGGCGGAUAUCAAGAAUUGACCCCAUCAGAUCACCUACCAUGGCUGGAGGACUGUUUGCUGUCAGCAAGAAAUAUUUUCAGUACCUUGGAACGUAUGACACAGGAAUGGAAGUGUGGGGAGGUGAAAACCUUGAGCUGUCUUUUAGGGUGUGGCAGUGUGGUGGCAAAUUGGAGAUCCACCCGUGUUCCCACGUGGGCCAUGUGUUCCCCAAGCGGGCACCAUAUGCUCGCCCCAAUUUCCUACAGAAUACUGCUCGGGCAGCAGAAGUUUGGAUGGAUGAAUACAAAGAGCACUUCUACAAUAGAAACCCUCCAGCAAGAAAAGAAGCUUAUGGUGAUAUUUCUGAAAGAAAAUUACUACGAGAGCGGUUGAGAUGCAAGAGCUUUGACUGGUAUUUGAAAAACGUUUUUCCUAAUUUACAUGUUCCAGAGGAUAGACCAGGCUGGCAUGGGGCUAUUCGCAGUAGAGGGAUCUCGUCUGAAUGUUUAGAUUAUAAUUCUCCUGACAACAACCCCACAGGUGCUAACCUUUCACUGUUUGGAUGCCAUGGUCAAGGAGGCAAUCAAUUCUUUGAAUAUACUUCAAACAAAGAAAUAAGGUUUAAUUCUGUGACAGAGUUAUGUGCAGAGGUACCUGAGCAAAAAAAUUAUGUGGGAAUGCAAAAUUGUCCCAAAGAUGGGUUCCCUGUACCAGCAAACAUUAUUUGGCAUUUUAAAGAAGAUGGAACUAUUUUUCACCCACACUCAGGACUGUGUCUUAGUGCUUAUCGGACACCGGAGGGCCGACCUGAUGUACAAAUGAGAACUUGUGAUGCUCUAGAUAAAAAUCAAAUUUGGAGUUUUGAGAAAUAGAGCACAACAGCACUUUCGUCAUGAGCUGACAGUAGUGUCAAGAAAGUCAAAGAGCCUUAAGAGCCUCAGUGAAGAUUGUAUUUUAUUUUAUCAAAAGCCACCUAGCAGUCAUCUGUGGAGCACUGGAAAGCUGGGGUUCAUUUUGGUAUAUCACACUGAAACUGGGUACCCAGAGUGCUGCUGUUUAAUAUUUCACAAUGCCUUACUUAUUGGUUGUUUUAUAUAAGAGUUUUGUCAAUAUGGUCUCUUCUUAAAAGAAGUUGACUAUGAAUUGAAACACACAAAACAUUUAAGUGCCAGACUUAAUAUUAAAGAAUGUAAAGGUCCAAGUAAAAUGAGGUAUGAUUUAUGUUGAUGUGUAAGUUCACCGCACAUCCCACUUUUUAACAAAACUCAUGAAUGUGCAGUUUGAGCCAUUGCUAUUUUGAUUACAUAGAAUUUGUAUUUCUUUUUUAGCCAGCACAUUAAAUUUUAGAUUUUAUUUUUUAAUCUAAUUUUUUUCUAAUCAAAAAGAAAAUUGAGCUUAAGGCAAAAGGCCUGGUUUUAGAGAUAUGUGUAAUUGGAAGAGGGCAUUUGUUUGAGUGUGAGUUUGGAGGCCUUUUUAACAUGCAGACAUACCCAUAUUUAAAUGAAAUGGGGAGAUAUUUACAUUCCGUACUUUGUAAACUUGAGCUAUUGGACUUCACUGAUGUAUAUAUUAAUACCUCAGAUUCCUCUGAUUUUGUAAGCUGUCUUCUCUGUGAACGUGUUUGUGUGUGUAGGGCAUUUUCUGAUUGCACUUCCUUAAGUUAUGAAUGUACUAGAAAGGGACUCAUCCAGAAUACUAUGCCUCCCUUUGUUAAUGCUUAAUCAUUUAAAGUAAACACAAUUGAAGCCUCUCUGAAGUUAAACCCAACUAUGUUUAUUAAAAUGUGUGAAACUGAAAGUGGGCUAGGUUCUACCAAGGCUGUGGAACUCUCCUACGAGUUCUGCUGAUCAGGAAAUUUAAGAAUUUAUCUUAAAAAUGCAAGGAAAAAAGACUGCCUUGGCAAUUGUGAAUGGUGCUUUCAAUCUCCUAGCACCGAGCCUGGCACUUAGGCAGCUUUCAGUAAGUGGGUGAAUGAAUGACUGAAUGAAUGAAUGAAUGGCUCAGCUGAGGAAUGUAACUUUGGUCAAGUUAUUAUGAUGUGUUUGGGCUUAGUUUUCUCAUUGGUAAAAUGUGGGUGCUGGAUUGGAUCUUAAAGAUCCCUUCCAGCUCUGAAAUGCUGAUUGUACAGUAUAUUCUUCCCAGAUUGACUCACUGUGCAAUCUUUACAAUACUUUUUAUCUUUUCACUUUUGACAUAGGUAAUGUUGUUGAGCAGUUGAGCAAUGUUCAGUCCAGUUGUGAAGCUGGAGAAGAGAAAUGGGUUUUAAAAAUUAAGUGAGGGGAGGCCGGGUGCGGUGGCUCACGCAUGUAAUCCCAGCACUUUGGGAGGCCAAGGCAGGUGGAUCACGAGGUCAGGAGAUCCAGACCAUCCUGGCUAACAUGGUGAAACCUCGUCUCUACUAAAAAUACAAAAAAUUAGCCAGCUGUGGUGGCGGGCGCCUGUAGUCCCAGCUACUCAGGAGGCUGAGGCAGGAGAAUGGCGUGAACCUGUGAGGCAGAGCUUACAGUGAGCCGAGAUCGUGCCACUGCACUCCAGCCUGGGCGACAGAGCAAGACUCUGUCUCAAAAAAAAAAAAUAAUAAUAAAAUAAGUGAGCUGAACUCACCUGAAGUGGUUUACUUCUGUGGGUUAAGAAGUUCUAGUCAGUGUUCAUAGUCGUUUCGUUUUGAUAAUUGUUGAACCAAUUUUGUUUUUAAAACCUUUAGACUCUGAAAGUAAUAUUUUGACUAAGAAUGUAAAUAUUUCCAAACUAAAUUACUCGGGAAGUAAACGCUUUUUUUAAAAGUAUUUUUACUGGUUUUAUACCAAUAUUAUAUGCAGAAAUCACAGGAUGAAUUUAGAAUUAAAUCUCAAUUAGUUCACUUUGGCCUAGAUUUAUGAAAAAUGCAUGCCUCGUAAAGAGUCCACUGUAUUCACGAGUAAAGUUGCUUUUAGUGUUCACUUGAUGACUUGGAGAGUAGGAAUUUUGCAAAAUCUGAAUUUAAGGAAAUUCUUUAGGAUAACCAUUUCAAAAAAUAAAAUUGCUAUGCAAUCUUGAAUAUUUUCUCUUUUGCCUCGUAAAAUGAAAAUGCAUUCACAGUUUCUGUAAAUUAUUUAGCAGCCUUAAAGUUUAUCAAAAAAUUGUCCAGAUUCCACGUGCAGCAUGCUUGGCCCUGCAUUUAAUUUAAGAAGGAUUAAUAAUAAUGCUCUGAAUUUUUCGAAAGGGAUUCUCCUAAACCCACCCACUUCUCUUGCCCAGGCUGCUUUUUAAAAAUAUUUUUUUAUUUUUUACUUAUUUUUAAAUUUUCUCUUUUUAUUUAUUUUUGGUUUUCUUGUUAGCCACCUGUUAUAUGGGAGAACGAAAAUUGUUAUAUUUUGAAAGUACUUAUUACAUUAUUUUUAUUUUAGUAUCUUGAUGCUCCUGUCAAAAGGGAAAUGAGGCUUUUAAAAAUAAAGUACCUUAAUUCUUUAUUGACUUUUUGCCCUAAAUUGCUAGGUGUGACCCAGCAAUCUUUUAGGAAGAGAUUUUACAGUGGUGCUUUAUUUAUAUCAAUAAUCCAGUAUAGUUAGGCUGUUCAUUCCUCAUAAUAGAGUACAUAACAGAAAAGUGGGACUUUCACAUUUUCAUAUUUAGGCACGUUCCAAUUUAAUUCCAAAAAUACUCUGUAAUUCUACAUCUAAAAAAACCGAUUCCCUAAUUCGAAUUUAUUGGUACCAAAGCUCUCUUUGGCUAUAGACAAUUAAGAGUUGACCUUUUAAGUUAAUGUAUAUGCUUAAAAACAGUUUUAGGAAAAUAUUUGGUAGACAAAGAGUUUCAACUUUAAAUGUUCACUAUGUCAUUUAGUGUCCAACUUUACGGAUAGGUUGACUAUCUAAAUAGGCAUUUUUAGUCAUUAAAAAAAAUCUAGUCACCAGGAGGAUCCCUAUAACUCAAAAUAACUUGUUUGUAAAAGAAAAUUUGUUUACUUACCCAUUAGUAAGUUCCUGCAUAUUCAUUAUAAGAUGGCAAAUCAAACUUUUCUAGGAUGAAGACAGCUUAUUUUUAAGUUGUAUAGUCUUAGUUGGUUUAGGGUCUCAAUUUUAAUUAAUAAAAUACUUGGUUUUUAUUUGCUUGUCCUUUUGAAUUCCUGUUUUAAUAAUUUUAAAAUGAGCACAAAGAACGUUGAAGUUCAGAUUAAUCUCUUCUGAAUGAUGUUUUUUUCCUCUGUGAUGAGUUGUUUCUGACUUUUUUCCUUUUGUAUUUGUAAUGUUGAUUAAGAUGUAAAAUAAAAAGUGUGCCUGAUUAUUUUUGCAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 100528030)
POC1B-GALNT4
POC1B-GALNT4 readthrough
NC_000012.12
12  89522813.. 89525895
89522813.. 89525895
strand -
MGI:894692
ClinVar, dbVar
ENSG00000259075
uc001tbe.4
INSDC:
42957
OTTHUMG00000171333
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1728 bp)
5'-ATGGCCTCAGCCACGGAGGACCCCGTTCTGGAGCGTTATTTCAAAGGCCACAAAGCTGCGATCACCTCCTTGGACCTCAGCCCCAACGGCAAGCAACTTGGAGCCGGCCGTGCCAGGGAGCTGGGGTCAAGAAGGCTCTCAGACCTCCAGAAAAATACGGAGGATTTGTCTCGACCGCTTTATAAGAAGCCCCCTGCAGATTCCCGTGCACTTGGGGAGTGGGGGAAAGCCAGCAAACTCCAGCTCAACGAGGATGAACTGAAGCAGCAAGAAGAACTCATTGAGAGATACGCCATCAATATTTACCTCAGTGACAGGATTTCCCTGCATCGACACATAGAGGATAAAAGAATGTATGAGTGTAAGTCCCAGAAGTTCAACTATAGGACACTTCCTACCACCTCTGTTATCATTGCTTTCTATAACGAAGCCTGGTCGACTTTGCTCCGTACCATTCACAGTGTTTTAGAAACTTCTCCTGCAGTTCTTTTGAAAGAGATCATCTTGGTGGATGACTTGAGTGACAGAGTTTATTTGAAGACACAACTTGAAACTTACATCAGCAATCTTGATAGAGTACGCTTGATTAGGACCAATAAGCGAGAGGGGCTGGTTAGGGCCCGTCTGATTGGGGCCACTTTCGCCACTGGGGACGTCCTCACTTTCCTGGATTGTCACTGTGAGTGTAATTCCGGTTGGCTGGAACCGCTTTTGGAAAGGATTGGGAGAGATGAAACAGCAGTTGTGTGTCCTGTTATAGACACAATTGATTGGAATACTTTTGAATTCTATATGCAGATAGGGGAGCCCATGATTGGTGGGTTTGACTGGCGTTTAACATTTCAGTGGCATTCTGTCCCCAAACAGGAAAGGGACAGGCGGATATCAAGAATTGACCCCATCAGATCACCTACCATGGCTGGAGGACTGTTTGCTGTCAGCAAGAAATATTTTCAGTACCTTGGAACGTATGACACAGGAATGGAAGTGTGGGGAGGTGAAAACCTTGAGCTGTCTTTTAGGGTGTGGCAGTGTGGTGGCAAATTGGAGATCCACCCGTGTTCCCACGTGGGCCATGTGTTCCCCAAGCGGGCACCATATGCTCGCCCCAATTTCCTACAGAATACTGCTCGGGCAGCAGAAGTTTGGATGGATGAATACAAAGAGCACTTCTACAATAGAAACCCTCCAGCAAGAAAAGAAGCTTATGGTGATATTTCTGAAAGAAAATTACTACGAGAGCGGTTGAGATGCAAGAGCTTTGACTGGTATTTGAAAAACGTTTTTCCTAATTTACATGTTCCAGAGGATAGACCAGGCTGGCATGGGGCTATTCGCAGTAGAGGGATCTCGTCTGAATGTTTAGATTATAATTCTCCTGACAACAACCCCACAGGTGCTAACCTTTCACTGTTTGGATGCCATGGTCAAGGAGGCAATCAATTCTTTGAATATACTTCAAACAAAGAAATAAGGTTTAATTCTGTGACAGAGTTATGTGCAGAGGTACCTGAGCAAAAAAATTATGTGGGAATGCAAAATTGTCCCAAAGATGGGTTCCCTGTACCAGCAAACATTATTTGGCATTTTAAAGAAGATGGAACTATTTTTCACCCACACTCAGGACTGTGTCTTAGTGCTTATCGGACACCGGAGGGCCGACCTGATGTACAAATGAGAACTTGTGATGCTCTAGATAAAAATCAAATTTGGAGTTTTGAGAAATAG-3'
NCBI CDS gene sequence with introns (location: 89522813.. 89525895) (3083 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 89519412.. 89526047) (6636 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [89519412.. 89526047 + 1000]) (7636 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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