HumanLectome - Human Lectin Entry

NCBI Summary

This locus represents naturally occurring transcripts that splice the 5' exons of the POC1B (POC1 centriolar protein homolog B) gene on chromosome 12 to the GALNT4 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4) gene, which is located within a POC1B intron. Alternative splicing results in two transcript variants, one of which encodes a fusion isoform that shares sequence identity with the products of each individual gene. [provided by RefSeq, Dec 2010].

Protein name

CBM13-ppGalNAc-T4

Synonym(s)

Polypeptide N-acetylgalactosaminyltransferase 4 (EC 2.4.1.41) (Polypeptide GalNAc transferase 4) (GalNAc-T4) (pp-GaNTase 4) (Protein-UDP acetylgalactosaminyltransferase 4) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4)

HGNC gene name

POC1B-GALNT4

HGNC name

POC1B-GALNT4 readthrough

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

Ricin-like

Known lectin group

R-Type Lectins

Lectin fold

b-trefoil

Glycan specificity

GalNAc / Mucin-type glycopeptide

RefSeq accession

NP_001186710

Gene ID

100528030

UniProt accession

Q8N4A0

Ensembl protein ID

Undefined

UniRef cluster ID

Q8N4A0

LectomeXplore score

Undefined

Reference

10.1074/jbc.M111.273722

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (575 amino acids) Download

MASATEDPVLERYFKGHKAAITSLDLSPNGKQLGAGRARELGSRRLSDLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPEQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGRPDVQMRTCDALDKNQIWSFEK

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q8N4A0-F1 Download See the associated sequence to the AlphaFold v2 model, which is different to this entry(NCBI sequence).

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for POC1B-GALNT4 Gene

ProteomicsDB

References

NCBI References (1 PubMed Identifiers)

Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. [20967262]

UniProt Main References (6 PubMed Identifiers)

Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. [9804815]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The finished DNA sequence of human chromosome 12. [16541075]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

The lectin domain of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-T4 directs its glycopeptide specificities. [10984485]

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. [29208955]

All isoforms of this gene containing a lectin domain

NP_001186711.1, NP_001186710.1

RNA

RNA (Transcript ID: NM_001199781.2)

RNA RefSeq ID

NM_001199781.2

RNA name

POC1B-GALNT4 readthrough, transcript variant 1

Isoforms

All isoforms of POC1B-GALNT4 containing a lectin domain

RNA Ensembl ID

Coding region

153..1880 (or 89522813.. 89525895)

mRNA location

89519412.. 89526047

NCBI Matured mRNA sequence 5281 NTP Download

m⁷G-5')ppp(5'-GACUGGGCCGCCGUUGUUGUAGUGACCGGGAGGCGCUGCCGCUCUGGGCAGACGGUUCCGGGAGCCGCACGGUCCCCUCUCCUUCCCCAUCCUCUCCCCUCCCCUCUCCGGGUUCCCCCACCCACAGGAGCCUUGGGCCGACCACUCCCCCGAUGGCCUCAGCCACGGAGGACCCCGUUCUGGAGCGUUAUUUCAAAGGCCACAAAGCUGCGAUCACCUCCUUGGACCUCAGCCCCAACGGCAAGCAACUUGGAGCCGGCCGUGCCAGGGAGCUGGGGUCAAGAAGGCUCUCAGACCUCCAGAAAAAUACGGAGGAUUUGUCUCGACCGCUUUAUAAGAAGCCCCCUGCAGAUUCCCGUGCACUUGGGGAGUGGGGGAAAGCCAGCAAACUCCAGCUCAACGAGGAUGAACUGAAGCAGCAAGAAGAACUCAUUGAGAGAUACGCCAUCAAUAUUUACCUCAGUGACAGGAUUUCCCUGCAUCGACACAUAGAGGAUAAAAGAAUGUAUGAGUGUAAGUCCCAGAAGUUCAACUAUAGGACACUUCCUACCACCUCUGUUAUCAUUGCUUUCUAUAACGAAGCCUGGUCGACUUUGCUCCGUACCAUUCACAGUGUUUUAGAAACUUCUCCUGCAGUUCUUUUGAAAGAGAUCAUCUUGGUGGAUGACUUGAGUGACAGAGUUUAUUUGAAGACACAACUUGAAACUUACAUCAGCAAUCUUGAUAGAGUACGCUUGAUUAGGACCAAUAAGCGAGAGGGGCUGGUUAGGGCCCGUCUGAUUGGGGCCACUUUCGCCACUGGGGACGUCCUCACUUUCCUGGAUUGUCACUGUGAGUGUAAUUCCGGUUGGCUGGAACCGCUUUUGGAAAGGAUUGGGAGAGAUGAAACAGCAGUUGUGUGUCCUGUUAUAGACACAAUUGAUUGGAAUACUUUUGAAUUCUAUAUGCAGAUAGGGGAGCCCAUGAUUGGUGGGUUUGACUGGCGUUUAACAUUUCAGUGGCAUUCUGUCCCCAAACAGGAAAGGGACAGGCGGAUAUCAAGAAUUGACCCCAUCAGAUCACCUACCAUGGCUGGAGGACUGUUUGCUGUCAGCAAGAAAUAUUUUCAGUACCUUGGAACGUAUGACACAGGAAUGGAAGUGUGGGGAGGUGAAAACCUUGAGCUGUCUUUUAGGGUGUGGCAGUGUGGUGGCAAAUUGGAGAUCCACCCGUGUUCCCACGUGGGCCAUGUGUUCCCCAAGCGGGCACCAUAUGCUCGCCCCAAUUUCCUACAGAAUACUGCUCGGGCAGCAGAAGUUUGGAUGGAUGAAUACAAAGAGCACUUCUACAAUAGAAACCCUCCAGCAAGAAAAGAAGCUUAUGGUGAUAUUUCUGAAAGAAAAUUACUACGAGAGCGGUUGAGAUGCAAGAGCUUUGACUGGUAUUUGAAAAACGUUUUUCCUAAUUUACAUGUUCCAGAGGAUAGACCAGGCUGGCAUGGGGCUAUUCGCAGUAGAGGGAUCUCGUCUGAAUGUUUAGAUUAUAAUUCUCCUGACAACAACCCCACAGGUGCUAACCUUUCACUGUUUGGAUGCCAUGGUCAAGGAGGCAAUCAAUUCUUUGAAUAUACUUCAAACAAAGAAAUAAGGUUUAAUUCUGUGACAGAGUUAUGUGCAGAGGUACCUGAGCAAAAAAAUUAUGUGGGAAUGCAAAAUUGUCCCAAAGAUGGGUUCCCUGUACCAGCAAACAUUAUUUGGCAUUUUAAAGAAGAUGGAACUAUUUUUCACCCACACUCAGGACUGUGUCUUAGUGCUUAUCGGACACCGGAGGGCCGACCUGAUGUACAAAUGAGAACUUGUGAUGCUCUAGAUAAAAAUCAAAUUUGGAGUUUUGAGAAAUAGAGCACAACAGCACUUUCGUCAUGAGCUGACAGUAGUGUCAAGAAAGUCAAAGAGCCUUAAGAGCCUCAGUGAAGAUUGUAUUUUAUUUUAUCAAAAGCCACCUAGCAGUCAUCUGUGGAGCACUGGAAAGCUGGGGUUCAUUUUGGUAUAUCACACUGAAACUGGGUACCCAGAGUGCUGCUGUUUAAUAUUUCACAAUGCCUUACUUAUUGGUUGUUUUAUAUAAGAGUUUUGUCAAUAUGGUCUCUUCUUAAAAGAAGUUGACUAUGAAUUGAAACACACAAAACAUUUAAGUGCCAGACUUAAUAUUAAAGAAUGUAAAGGUCCAAGUAAAAUGAGGUAUGAUUUAUGUUGAUGUGUAAGUUCACCGCACAUCCCACUUUUUAACAAAACUCAUGAAUGUGCAGUUUGAGCCAUUGCUAUUUUGAUUACAUAGAAUUUGUAUUUCUUUUUUAGCCAGCACAUUAAAUUUUAGAUUUUAUUUUUUAAUCUAAUUUUUUUCUAAUCAAAAAGAAAAUUGAGCUUAAGGCAAAAGGCCUGGUUUUAGAGAUAUGUGUAAUUGGAAGAGGGCAUUUGUUUGAGUGUGAGUUUGGAGGCCUUUUUAACAUGCAGACAUACCCAUAUUUAAAUGAAAUGGGGAGAUAUUUACAUUCCGUACUUUGUAAACUUGAGCUAUUGGACUUCACUGAUGUAUAUAUUAAUACCUCAGAUUCCUCUGAUUUUGUAAGCUGUCUUCUCUGUGAACGUGUUUGUGUGUGUAGGGCAUUUUCUGAUUGCACUUCCUUAAGUUAUGAAUGUACUAGAAAGGGACUCAUCCAGAAUACUAUGCCUCCCUUUGUUAAUGCUUAAUCAUUUAAAGUAAACACAAUUGAAGCCUCUCUGAAGUUAAACCCAACUAUGUUUAUUAAAAUGUGUGAAACUGAAAGUGGGCUAGGUUCUACCAAGGCUGUGGAACUCUCCUACGAGUUCUGCUGAUCAGGAAAUUUAAGAAUUUAUCUUAAAAAUGCAAGGAAAAAAGACUGCCUUGGCAAUUGUGAAUGGUGCUUUCAAUCUCCUAGCACCGAGCCUGGCACUUAGGCAGCUUUCAGUAAGUGGGUGAAUGAAUGACUGAAUGAAUGAAUGAAUGGCUCAGCUGAGGAAUGUAACUUUGGUCAAGUUAUUAUGAUGUGUUUGGGCUUAGUUUUCUCAUUGGUAAAAUGUGGGUGCUGGAUUGGAUCUUAAAGAUCCCUUCCAGCUCUGAAAUGCUGAUUGUACAGUAUAUUCUUCCCAGAUUGACUCACUGUGCAAUCUUUACAAUACUUUUUAUCUUUUCACUUUUGACAUAGGUAAUGUUGUUGAGCAGUUGAGCAAUGUUCAGUCCAGUUGUGAAGCUGGAGAAGAGAAAUGGGUUUUAAAAAUUAAGUGAGGGGAGGCCGGGUGCGGUGGCUCACGCAUGUAAUCCCAGCACUUUGGGAGGCCAAGGCAGGUGGAUCACGAGGUCAGGAGAUCCAGACCAUCCUGGCUAACAUGGUGAAACCUCGUCUCUACUAAAAAUACAAAAAAUUAGCCAGCUGUGGUGGCGGGCGCCUGUAGUCCCAGCUACUCAGGAGGCUGAGGCAGGAGAAUGGCGUGAACCUGUGAGGCAGAGCUUACAGUGAGCCGAGAUCGUGCCACUGCACUCCAGCCUGGGCGACAGAGCAAGACUCUGUCUCAAAAAAAAAAAAUAAUAAUAAAAUAAGUGAGCUGAACUCACCUGAAGUGGUUUACUUCUGUGGGUUAAGAAGUUCUAGUCAGUGUUCAUAGUCGUUUCGUUUUGAUAAUUGUUGAACCAAUUUUGUUUUUAAAACCUUUAGACUCUGAAAGUAAUAUUUUGACUAAGAAUGUAAAUAUUUCCAAACUAAAUUACUCGGGAAGUAAACGCUUUUUUUAAAAGUAUUUUUACUGGUUUUAUACCAAUAUUAUAUGCAGAAAUCACAGGAUGAAUUUAGAAUUAAAUCUCAAUUAGUUCACUUUGGCCUAGAUUUAUGAAAAAUGCAUGCCUCGUAAAGAGUCCACUGUAUUCACGAGUAAAGUUGCUUUUAGUGUUCACUUGAUGACUUGGAGAGUAGGAAUUUUGCAAAAUCUGAAUUUAAGGAAAUUCUUUAGGAUAACCAUUUCAAAAAAUAAAAUUGCUAUGCAAUCUUGAAUAUUUUCUCUUUUGCCUCGUAAAAUGAAAAUGCAUUCACAGUUUCUGUAAAUUAUUUAGCAGCCUUAAAGUUUAUCAAAAAAUUGUCCAGAUUCCACGUGCAGCAUGCUUGGCCCUGCAUUUAAUUUAAGAAGGAUUAAUAAUAAUGCUCUGAAUUUUUCGAAAGGGAUUCUCCUAAACCCACCCACUUCUCUUGCCCAGGCUGCUUUUUAAAAAUAUUUUUUUAUUUUUUACUUAUUUUUAAAUUUUCUCUUUUUAUUUAUUUUUGGUUUUCUUGUUAGCCACCUGUUAUAUGGGAGAACGAAAAUUGUUAUAUUUUGAAAGUACUUAUUACAUUAUUUUUAUUUUAGUAUCUUGAUGCUCCUGUCAAAAGGGAAAUGAGGCUUUUAAAAAUAAAGUACCUUAAUUCUUUAUUGACUUUUUGCCCUAAAUUGCUAGGUGUGACCCAGCAAUCUUUUAGGAAGAGAUUUUACAGUGGUGCUUUAUUUAUAUCAAUAAUCCAGUAUAGUUAGGCUGUUCAUUCCUCAUAAUAGAGUACAUAACAGAAAAGUGGGACUUUCACAUUUUCAUAUUUAGGCACGUUCCAAUUUAAUUCCAAAAAUACUCUGUAAUUCUACAUCUAAAAAAACCGAUUCCCUAAUUCGAAUUUAUUGGUACCAAAGCUCUCUUUGGCUAUAGACAAUUAAGAGUUGACCUUUUAAGUUAAUGUAUAUGCUUAAAAACAGUUUUAGGAAAAUAUUUGGUAGACAAAGAGUUUCAACUUUAAAUGUUCACUAUGUCAUUUAGUGUCCAACUUUACGGAUAGGUUGACUAUCUAAAUAGGCAUUUUUAGUCAUUAAAAAAAAUCUAGUCACCAGGAGGAUCCCUAUAACUCAAAAUAACUUGUUUGUAAAAGAAAAUUUGUUUACUUACCCAUUAGUAAGUUCCUGCAUAUUCAUUAUAAGAUGGCAAAUCAAACUUUUCUAGGAUGAAGACAGCUUAUUUUUAAGUUGUAUAGUCUUAGUUGGUUUAGGGUCUCAAUUUUAAUUAAUAAAAUACUUGGUUUUUAUUUGCUUGUCCUUUUGAAUUCCUGUUUUAAUAAUUUUAAAAUGAGCACAAAGAACGUUGAAGUUCAGAUUAAUCUCUUCUGAAUGAUGUUUUUUUCCUCUGUGAUGAGUUGUUUCUGACUUUUUUCCUUUUGUAUUUGUAAUGUUGAUUAAGAUGUAAAAUAAAAAGUGUGCCUGAUUAUUUUUGCAAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 100528030)

HGNC Gene symbol

POC1B-GALNT4

HGNC Gene name

POC1B-GALNT4 readthrough

Chr. RefSeq ID

NC_000012.12

Chromosome N°

12 89522813.. 89525895

CDS location

89522813.. 89525895

DNA strand

strand -

CCDS ID

Mouse ortholog gene

MGI:894692

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000259075

HGNC other symbol

UCSC ID

uc001tbe.4

GeneBank

INSDC:

GeneCards

42957

MIM

VEGA ID

OTTHUMG00000171333