Protein
Protein (NP_998767)
SIGLEC-15
Sialic acid-binding Ig-like lectin 15 (Siglec-15) (CD33 antigen-like 3)
SIGLEC15
sialic acid binding Ig like lectin 15
Undefined
Curated
I-type lectin
I-Type Lectins - Siglecs common to mammals
b-sandwich / Ig-like
NeuAc / Neu5Ac(a2-6)GalNAc
NP_998767
284266
Q6ZMC9
ENSP00000374125.2
Q6ZMC9
0.182
10.1146/annurev-immunol-102419-035900
PFAM, InterPro
Protein sequence and protein families (fasta) (328 amino acids) Download
MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRWSMQVPPEVSAEAGDAAVLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNPRRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNISVLPSPAHAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAANSLGRSEASVYLFRFHGASGASTVALLLGALGFKALLLLGVLAARAARRRPEHLDTPDTPPRSQAQESNYENLSQMNPRSPPATMCSP
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q6ZMC9-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
Interacts with TYROBP and HCST. Source: UniProt
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Siglec-15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44. [34328657]
  • Sialic acid-binding immunoglobulin-like lectin (Sigelac)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells. [33951750]
  • Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters. [33666065]
  • Sialic acid-binding immunoglobulin-like lectin-15 expression on peritumoral macrophages is a favorable prognostic factor for primary central nervous system lymphoma patients. [33441719]
  • Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer. [33537076]
  • The diverse functions of Siglec-15 in bone remodeling and antitumor responses. [32112821]
  • Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases. [31900164]
  • Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. [30833750]
  • The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-beta secretion from monocytes/macrophages through the DAP12-Syk pathway. [23035012]
  • Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. [17483134]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • DNA sequence and analysis of human chromosome 18. [16177791]
  • An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]
RNA
RNA (Transcript ID: NM_213602.3)
NM_213602.3
sialic acid binding Ig like lectin 15
All isoforms of SIGLEC15 containing a lectin domain
ENST00000389474.8
55..1041 (or 45825729.. 45842187)
45825675.. 45844094
NCBI Matured mRNA sequence 2948 NTPDownload 
m7G-5')ppp(5'-ACUGGGGAGGUGGCCGAGAGCGGGUCUGGCCUGGGGUGUUCAGAUGCUCACAGCAUGGAAAAGUCCAUCUGGCUGCUGGCCUGCUUGGCGUGGGUUCUCCCGACAGGCUCAUUUGUGAGAACUAAAAUAGAUACUACGGAGAACUUGCUCAACACAGAGGUGCACAGCUCGCCAGCGCAGCGCUGGUCCAUGCAGGUGCCACCCGAGGUGAGCGCGGAGGCAGGCGACGCGGCAGUGCUGCCCUGCACCUUCACGCACCCGCACCGCCACUACGACGGGCCGCUGACGGCCAUCUGGCGCGCGGGCGAGCCCUAUGCGGGCCCGCAGGUGUUCCGCUGCGCUGCGGCGCGGGGCAGCGAGCUCUGCCAGACGGCGCUGAGCCUGCACGGCCGCUUCCGGCUGCUGGGCAACCCGCGCCGCAACGACCUCUCGCUGCGCGUCGAGCGCCUCGCCCUGGCUGACGACCGCCGCUACUUCUGCCGCGUCGAGUUCGCCGGCGACGUCCAUGACCGCUACGAGAGCCGCCACGGCGUCCGGCUGCACGUGACAGCCGCGCCGCGGAUCGUCAACAUCUCGGUGCUGCCCAGUCCGGCUCACGCCUUCCGCGCGCUCUGCACUGCCGAAGGGGAGCCGCCGCCCGCCCUCGCCUGGUCCGGCCCGGCCCUGGGCAACAGCUUGGCAGCCGUGCGGAGCCCGCGUGAGGGUCACGGCCACCUAGUGACCGCCGAACUGCCCGCACUGACCCAUGACGGCCGCUACACGUGUACGGCCGCCAACAGCCUGGGCCGCUCCGAGGCCAGCGUCUACCUGUUCCGCUUCCAUGGCGCCAGCGGGGCCUCGACGGUCGCCCUCCUGCUCGGCGCUCUCGGCUUCAAGGCGCUGCUGCUGCUCGGGGUCCUGGCCGCCCGCGCUGCCCGCCGCCGCCCAGAGCAUCUGGACACCCCGGACACCCCACCACGGUCCCAGGCCCAGGAGUCCAAUUAUGAAAAUUUGAGCCAGAUGAACCCCCGGAGCCCACCAGCCACCAUGUGCUCACCGUGAGGAGUCCCUCAGCCACCAACAUCCAUUUCAGCACUGUAAAGAACAAAGGCCAGUGCGAGGCUUGGCUGGCACAGCCAGUCCUGGUUCUCGGGCACCUUGGCAGCCCCCAGCUGGGUGGCUCCUCCCCUGCUCAAGGUCAAGACCCUGCUCAAGGAGGCUCAUCUGGCCUCCUAUGUGGACAACCAUUUCGGAGCUCCCUGAUAUUUUUGCCAGCAUUUCGUAAAUGUGCAUACGUCUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAGUACACGCAUUAGCUUGAGCGUGAAACUUCCAGAAAUGUUCCCUUGCCCUUUCUUACCUAGAACACCUGCUAUAGUAAAGCAGACAGGAAACUGUUUACAGGGCCUGGAGGCCCAGUCUUGUCCUCCUCUGUCACCGACUUGCUGUGUGGACCUGGGACACUCUCUUCACUUCUCUGGGUCUCAAUUCAUUUACUGUUGAACACGGACAAUCAUAUUCUUCCCUCCUGGCUGGGAGGACUACAAAGAUCUGAGGAAAUAAUGGAUAUGAAGGGGCUUUGGAAAGUACAAAGCCAUCUUCUCAUGAGGGGCAUGACAGAACCCUCUUUGCAGAGUGACCUUUGGACGUGCAGUCAGUUCUUGGAGAAGUGUGGCCCCUGCAGCAGUGUCACGGAGAACACAGAGUUCCAGAGAGCAAGCCUGGGGCAGGGGCUGUGCAAACGUGUGGUCAGAGGAACAUCAAAUCCUGGAAACUUGGUGGCAGGGAGAGGCCUGGGGCCUUUACCCCAUGCCCCCUGGGAUCUCCACUGUGACUGUCCCACACCCUCUGCCCAACUCUUGCCCCAUCAGCUGCCCUGCAUUGCCUUGAGCUGGGACCCCUAGGAAAUGGAAACCAGGCUCCCCUCUCUCAAGGUAUCUGGGAACCACUGUCUCAGGAGCUGAAGCCGGGAGACCUGAGGGGAGGUCUGGCCGGAGAGUCCGUGCGUAAAGCAGCUACAGCUCUGACCUCUCUGACCUGCAGCCUCUCAGGGCGUGCGAAGUCCAAACGCACUGGCAACUUCACCCCCUUUGCCCUAACGCGGGCAGGCUGACUUGGAGGGGUGCUUCCCUAUUUACACCUCAGGGUGAAUUUGUUGAUCACCUUAGCUCCUGUGGUCCUUGGGGCUUAGGGAGAGGAGGGAGGCAUGCCUGGGUCCCAGGUAAGCUGGCAAGAGGAAAGGGCCACAGGCUAGGGGAAUAACGAGGCCAUGAACAAGACAUCUCACCCCAGUUACAAUGGCUUUUAUCCAAAAGACAGGCAAUGACAAAUGCUGAUGAGAAAGUGGAGAAAGAGGAAUCCCCAUAUACUAUUGGUGGGAAUGUAAAUUAGUAUAGCCACUAUGGAGAACAGUACAGUUUCCUCAAAAAACUAAAAAUAGGCUGGGCGUGGUGGCUCAUGCCUGUAAUCCCAGCACCCUGGGAGGCCGAGGCAGGUGGAUCACUUGAGGUCAGGAGUUCGAGACCAGCCUAGCUAACAUGGUAAAACUCUGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCGUGCUGGCACGUGCCUAUAGUCCCAGCAACUUGGGAGGCUGAGGCAGAAGUAUUGCUUGAACCCAGGAGGCAGAGGUUGCAGUGAGCUGAGAUCACCCCACUGUCCUCCAGCCUGGGCAACAGAGAGACUGUCUCCAAAGAAAAAAAAAGAAAUAGAACUACCAUAUGAUCCAGUAAUCCCACUGCUGGGUAUCUGUCAGCAAGGAAAUCAGUAUAUUGAAAAGAUACCAGUACUCCCAUGUUUACUGCAGCACUAUUUGCAAUAGCCAAGAUAUGGAAUCAGCCUAAGUGUCCAUCCACGAAUGAAUGAAGAAAAUGAACACACAAUGAAAUAUUCAGCCAUAAAAAAAAAAAA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 284266)
SIGLEC15
sialic acid binding Ig like lectin 15
NC_000018.10
18  45825729.. 45842187
45825729.. 45842187
strand +
CCDS32819.1
MGI:3646642
ClinVar, dbVar
ENSG00000197046
HsT1361
uc002lbl.2
INSDC: AK095432
27596
618105
OTTHUMG00000170870
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (987 bp)
5'-ATGGAAAAGTCCATCTGGCTGCTGGCCTGCTTGGCGTGGGTTCTCCCGACAGGCTCATTTGTGAGAACTAAAATAGATACTACGGAGAACTTGCTCAACACAGAGGTGCACAGCTCGCCAGCGCAGCGCTGGTCCATGCAGGTGCCACCCGAGGTGAGCGCGGAGGCAGGCGACGCGGCAGTGCTGCCCTGCACCTTCACGCACCCGCACCGCCACTACGACGGGCCGCTGACGGCCATCTGGCGCGCGGGCGAGCCCTATGCGGGCCCGCAGGTGTTCCGCTGCGCTGCGGCGCGGGGCAGCGAGCTCTGCCAGACGGCGCTGAGCCTGCACGGCCGCTTCCGGCTGCTGGGCAACCCGCGCCGCAACGACCTCTCGCTGCGCGTCGAGCGCCTCGCCCTGGCTGACGACCGCCGCTACTTCTGCCGCGTCGAGTTCGCCGGCGACGTCCATGACCGCTACGAGAGCCGCCACGGCGTCCGGCTGCACGTGACAGCCGCGCCGCGGATCGTCAACATCTCGGTGCTGCCCAGTCCGGCTCACGCCTTCCGCGCGCTCTGCACTGCCGAAGGGGAGCCGCCGCCCGCCCTCGCCTGGTCCGGCCCGGCCCTGGGCAACAGCTTGGCAGCCGTGCGGAGCCCGCGTGAGGGTCACGGCCACCTAGTGACCGCCGAACTGCCCGCACTGACCCATGACGGCCGCTACACGTGTACGGCCGCCAACAGCCTGGGCCGCTCCGAGGCCAGCGTCTACCTGTTCCGCTTCCATGGCGCCAGCGGGGCCTCGACGGTCGCCCTCCTGCTCGGCGCTCTCGGCTTCAAGGCGCTGCTGCTGCTCGGGGTCCTGGCCGCCCGCGCTGCCCGCCGCCGCCCAGAGCATCTGGACACCCCGGACACCCCACCACGGTCCCAGGCCCAGGAGTCCAATTATGAAAATTTGAGCCAGATGAACCCCCGGAGCCCACCAGCCACCATGTGCTCACCGTGA-3'
NCBI CDS gene sequence with introns (location: 45825729.. 45842187) (16459 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 45825675.. 45844094) (18420 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [45825675 - 1000].. 45844094) (19420 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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