HumanLectome - Human Lectin Entry

Protein name

SIGLEC-15

Synonym(s)

Sialic acid-binding Ig-like lectin 15 (Siglec-15) (CD33 antigen-like 3)

HGNC gene name

SIGLEC15

HGNC name

sialic acid binding Ig like lectin 15

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

I-type lectin

Known lectin group

I-Type Lectins - Siglecs common to mammals

Lectin fold

b-sandwich / Ig-like

Glycan specificity

NeuAc / Neu5Ac(a2-6)GalNAc

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.182

Reference

10.1146/annurev-immunol-102419-035900

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (328 amino acids) Download

MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRWSMQVPPEVSAEAGDAAVLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNPRRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNISVLPSPAHAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAANSLGRSEASVYLFRFHGASGASTVALLLGALGFKALLLLGVLAARAARRRPEHLDTPDTPPRSQAQESNYENLSQMNPRSPPATMCSP

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q6ZMC9-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for SIGLEC15 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Siglec-15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44. [34328657]

Sialic acid-binding immunoglobulin-like lectin (Sigelac)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells. [33951750]

Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters. [33666065]

Sialic acid-binding immunoglobulin-like lectin-15 expression on peritumoral macrophages is a favorable prognostic factor for primary central nervous system lymphoma patients. [33441719]

Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer. [33537076]

The diverse functions of Siglec-15 in bone remodeling and antitumor responses. [32112821]

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases. [31900164]

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. [30833750]

The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-beta secretion from monocytes/macrophages through the DAP12-Syk pathway. [23035012]

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. [17483134]

UniProt Main References (3 PubMed Identifiers)

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

DNA sequence and analysis of human chromosome 18. [16177791]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]

RNA

RNA (Transcript ID: NM_213602.3)

RNA RefSeq ID

NM_213602.3

RNA name

sialic acid binding Ig like lectin 15

Isoforms

All isoforms of SIGLEC15 containing a lectin domain

RNA Ensembl ID

ENST00000389474.8

Coding region

55..1041 (or 45825729.. 45842187)

mRNA location

45825675.. 45844094

NCBI Matured mRNA sequence 2948 NTP Download

m⁷G-5')ppp(5'-ACUGGGGAGGUGGCCGAGAGCGGGUCUGGCCUGGGGUGUUCAGAUGCUCACAGCAUGGAAAAGUCCAUCUGGCUGCUGGCCUGCUUGGCGUGGGUUCUCCCGACAGGCUCAUUUGUGAGAACUAAAAUAGAUACUACGGAGAACUUGCUCAACACAGAGGUGCACAGCUCGCCAGCGCAGCGCUGGUCCAUGCAGGUGCCACCCGAGGUGAGCGCGGAGGCAGGCGACGCGGCAGUGCUGCCCUGCACCUUCACGCACCCGCACCGCCACUACGACGGGCCGCUGACGGCCAUCUGGCGCGCGGGCGAGCCCUAUGCGGGCCCGCAGGUGUUCCGCUGCGCUGCGGCGCGGGGCAGCGAGCUCUGCCAGACGGCGCUGAGCCUGCACGGCCGCUUCCGGCUGCUGGGCAACCCGCGCCGCAACGACCUCUCGCUGCGCGUCGAGCGCCUCGCCCUGGCUGACGACCGCCGCUACUUCUGCCGCGUCGAGUUCGCCGGCGACGUCCAUGACCGCUACGAGAGCCGCCACGGCGUCCGGCUGCACGUGACAGCCGCGCCGCGGAUCGUCAACAUCUCGGUGCUGCCCAGUCCGGCUCACGCCUUCCGCGCGCUCUGCACUGCCGAAGGGGAGCCGCCGCCCGCCCUCGCCUGGUCCGGCCCGGCCCUGGGCAACAGCUUGGCAGCCGUGCGGAGCCCGCGUGAGGGUCACGGCCACCUAGUGACCGCCGAACUGCCCGCACUGACCCAUGACGGCCGCUACACGUGUACGGCCGCCAACAGCCUGGGCCGCUCCGAGGCCAGCGUCUACCUGUUCCGCUUCCAUGGCGCCAGCGGGGCCUCGACGGUCGCCCUCCUGCUCGGCGCUCUCGGCUUCAAGGCGCUGCUGCUGCUCGGGGUCCUGGCCGCCCGCGCUGCCCGCCGCCGCCCAGAGCAUCUGGACACCCCGGACACCCCACCACGGUCCCAGGCCCAGGAGUCCAAUUAUGAAAAUUUGAGCCAGAUGAACCCCCGGAGCCCACCAGCCACCAUGUGCUCACCGUGAGGAGUCCCUCAGCCACCAACAUCCAUUUCAGCACUGUAAAGAACAAAGGCCAGUGCGAGGCUUGGCUGGCACAGCCAGUCCUGGUUCUCGGGCACCUUGGCAGCCCCCAGCUGGGUGGCUCCUCCCCUGCUCAAGGUCAAGACCCUGCUCAAGGAGGCUCAUCUGGCCUCCUAUGUGGACAACCAUUUCGGAGCUCCCUGAUAUUUUUGCCAGCAUUUCGUAAAUGUGCAUACGUCUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAGUACACGCAUUAGCUUGAGCGUGAAACUUCCAGAAAUGUUCCCUUGCCCUUUCUUACCUAGAACACCUGCUAUAGUAAAGCAGACAGGAAACUGUUUACAGGGCCUGGAGGCCCAGUCUUGUCCUCCUCUGUCACCGACUUGCUGUGUGGACCUGGGACACUCUCUUCACUUCUCUGGGUCUCAAUUCAUUUACUGUUGAACACGGACAAUCAUAUUCUUCCCUCCUGGCUGGGAGGACUACAAAGAUCUGAGGAAAUAAUGGAUAUGAAGGGGCUUUGGAAAGUACAAAGCCAUCUUCUCAUGAGGGGCAUGACAGAACCCUCUUUGCAGAGUGACCUUUGGACGUGCAGUCAGUUCUUGGAGAAGUGUGGCCCCUGCAGCAGUGUCACGGAGAACACAGAGUUCCAGAGAGCAAGCCUGGGGCAGGGGCUGUGCAAACGUGUGGUCAGAGGAACAUCAAAUCCUGGAAACUUGGUGGCAGGGAGAGGCCUGGGGCCUUUACCCCAUGCCCCCUGGGAUCUCCACUGUGACUGUCCCACACCCUCUGCCCAACUCUUGCCCCAUCAGCUGCCCUGCAUUGCCUUGAGCUGGGACCCCUAGGAAAUGGAAACCAGGCUCCCCUCUCUCAAGGUAUCUGGGAACCACUGUCUCAGGAGCUGAAGCCGGGAGACCUGAGGGGAGGUCUGGCCGGAGAGUCCGUGCGUAAAGCAGCUACAGCUCUGACCUCUCUGACCUGCAGCCUCUCAGGGCGUGCGAAGUCCAAACGCACUGGCAACUUCACCCCCUUUGCCCUAACGCGGGCAGGCUGACUUGGAGGGGUGCUUCCCUAUUUACACCUCAGGGUGAAUUUGUUGAUCACCUUAGCUCCUGUGGUCCUUGGGGCUUAGGGAGAGGAGGGAGGCAUGCCUGGGUCCCAGGUAAGCUGGCAAGAGGAAAGGGCCACAGGCUAGGGGAAUAACGAGGCCAUGAACAAGACAUCUCACCCCAGUUACAAUGGCUUUUAUCCAAAAGACAGGCAAUGACAAAUGCUGAUGAGAAAGUGGAGAAAGAGGAAUCCCCAUAUACUAUUGGUGGGAAUGUAAAUUAGUAUAGCCACUAUGGAGAACAGUACAGUUUCCUCAAAAAACUAAAAAUAGGCUGGGCGUGGUGGCUCAUGCCUGUAAUCCCAGCACCCUGGGAGGCCGAGGCAGGUGGAUCACUUGAGGUCAGGAGUUCGAGACCAGCCUAGCUAACAUGGUAAAACUCUGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCGUGCUGGCACGUGCCUAUAGUCCCAGCAACUUGGGAGGCUGAGGCAGAAGUAUUGCUUGAACCCAGGAGGCAGAGGUUGCAGUGAGCUGAGAUCACCCCACUGUCCUCCAGCCUGGGCAACAGAGAGACUGUCUCCAAAGAAAAAAAAAGAAAUAGAACUACCAUAUGAUCCAGUAAUCCCACUGCUGGGUAUCUGUCAGCAAGGAAAUCAGUAUAUUGAAAAGAUACCAGUACUCCCAUGUUUACUGCAGCACUAUUUGCAAUAGCCAAGAUAUGGAAUCAGCCUAAGUGUCCAUCCACGAAUGAAUGAAGAAAAUGAACACACAAUGAAAUAUUCAGCCAUAAAAAAAAAAAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

;

More about the NCBI sViewer.

DNA

DNA (Gene ID: 284266)

HGNC Gene symbol

SIGLEC15

HGNC Gene name

sialic acid binding Ig like lectin 15

Chr. RefSeq ID

NC_000018.10

Chromosome N°

18 45825729.. 45842187

CDS location

45825729.. 45842187

DNA strand

strand +

CCDS ID

CCDS32819.1

Mouse ortholog gene

MGI:3646642

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000197046

HGNC other symbol

HsT1361

UCSC ID

uc002lbl.2

GeneBank

INSDC: AK095432

GeneCards

27596

MIM

618105

VEGA ID

OTTHUMG00000170870

How to cite: