NCBI Summary
This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_055108)
Neuronal pentraxin receptor
Neuronal pentraxin receptor
NPTXR
neuronal pentraxin receptor
Undefined
Very low evidence
Pentraxin
L-Type Lectins
b-sandwich / ConA-like
Uncharacterised
NP_055108
23467
O95502
ENSP00000327545.3
O95502
0.358
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (500 amino acids) Download
MKFLAVLLAAGMLAFLGAVICIIASVPLAASPARALPGGADNASVASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-O95502-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.58, 2.04] ÅDownload
The location of the lectin domain structural model is: 292-494
We infer [1.58, 2.04] Å as the interval of error of this structural model.
Template 1: 3PVN chain: A, P02741, NP_000558.2, sequence identity: 26.6%, coverage: 97.5%, location in sequence: 19-224, (1-206 in PDB).
Template 2: 1HAS chain: A, P07629, NP_0NO0REFSEQ0.0, sequence identity: 26.1%, coverage: 97.5%, location in sequence: 23-234, (1-212 in PDB).
Template 3: 1GYK chain: A, P02743, NP_001630.1, sequence identity: 24.6%, coverage: 92.1%, location in sequence: 20-223, (1-204 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for NPTXR Gene
ProteomicsDB
References
NCBI References (9 PubMed Identifiers)
  • Decreased cerebrospinal fluid neuronal pentraxin receptor is associated with PET-Abeta load and cerebrospinal fluid Abeta in a pilot study of Alzheimer's disease. [32450185]
  • Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses. [27986928]
  • Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. [25231870]
  • Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases. [19368810]
  • Regulation of neuronal type genes in congestive heart failure rats. [16497176]
  • Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. [16115696]
  • Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. [10748068]
  • The DNA sequence of human chromosome 22. [10591208]
  • Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. [9261167]
UniProt Main References (1 PubMed Identifiers)
RNA
RNA (Transcript ID: NM_014293.4)
NM_014293.4
neuronal pentraxin receptor
All isoforms of NPTXR containing a lectin domain
ENST00000333039.4
171..1673 (or 38822609.. 38843858)
38818452.. 38844028
NCBI Matured mRNA sequence 5830 NTPDownload 
m7G-5')ppp(5'-AGAGCGGCGGCAGCAGCGGCCGCGGCGACAGCUCCAGCUCCGGCUCCGGCUCCGGCUCCGGCUCCGGCUCCCGCGCCUGCCCCGCUCGGCCCAGCGCGCCCGGGCUCCGCGCCCCGACCCCGCCGCCGCGCCUGCCGGGGGCCUCGGGCGCCCCCGCCGCCCGCCUCACGCUGAAGUUCCUGGCCGUGCUGCUGGCCGCGGGCAUGCUGGCGUUCCUCGGUGCCGUCAUCUGCAUCAUCGCCAGCGUGCCCCUGGCGGCCAGCCCGGCGCGGGCGCUGCCCGGCGGCGCCGACAAUGCUUCGGUCGCCUCGGGCGCCGCCGCGUCCCCGGGCCCGCAGCGGAGCCUGAGCGCGCUGCACGGCGCGGGCGGUUCAGCCGGGCCCCCCGCGCUGCCCGGGGCACCCGCGGCCAGCGCGCACCCGCUGCCGCCCGGGCCCCUGUUCAGCCGCUUCCUGUGCACGCCGCUGGCUGCUGCCUGCCCGUCGGGGGCCCAGCAGGGGGACGCGGCGGGCGCUGCGCCGGGCGAGCGCGAAGAGCUGCUGCUGCUGCAGAGCACGGCCGAGCAGCUGCGCCAGACGGCGCUGCAGCAGGAGGCGCGCAUCCGCGCCGACCAGGACACCAUCCGUGAGCUCACCGGCAAGCUGGGCCGCUGCGAGAGCGGCCUGCCGCGCGGCCUCCAGGGCGCCGGGCCCCGCCGCGACACCAUGGCCGACGGGCCCUGGGACUCGCCUGCGCUCAUUCUGGAGCUGGAGGACGCCGUGCGCGCCCUGCGGGACCGCAUCGACCGCCUGGAGCAGGAGCUUCCAGCCCGUGUGAACCUCUCAGCUGCCCCAGCCCCAGUCUCUGCUGUGCCCACCGGCCUACACUCCAAGAUGGACCAGCUGGAGGGGCAGCUGCUGGCCCAGGUGCUGGCACUGGAGAAGGAGCGUGUGGCCCUCAGCCACAGCAGCCGCCGGCAGAGGCAGGAAGUGGAAAAGGAGUUGGACGUCCUGCAGGGUCGUGUGGCUGAGCUGGAGCACGGGUCCUCAGCCUACAGUCCUCCAGAUGCCUUCAAGAUCAGCAUCCCCAUCCGUAACAACUACAUGUACGCCCGCGUGCGGAAGGCUCUGCCCGAGCUCUACGCAUUCACCGCCUGCAUGUGGCUGCGGUCCAGGUCCAGCGGCACCGGCCAGGGCACCCCCUUCUCCUACUCAGUGCCCGGGCAGGCCAACGAGAUUGUACUGCUAGAGGCGGGCCAUGAGCCCAUGGAGCUGCUGAUCAACGACAAGGUGGCCCAGCUGCCCCUGAGCCUGAAGGACAAUGGCUGGCACCACAUCUGCAUCGCCUGGACCACAAGGGAUGGCCUAUGGUCUGCCUACCAGGACGGGGAGCUGCAGGGCUCCGGUGAGAACCUGGCUGCCUGGCACCCCAUCAAGCCUCAUGGGAUCCUUAUCUUGGGCCAGGAGCAGGAUACCCUGGGUGGCCGGUUUGAUGCCACCCAGGCCUUUGUCGGUGACAUUGCCCAGUUUAACCUGUGGGACCACGCCCUGACACCAGCCCAGGUCCUGGGCAUUGCCAACUGCACUGCGCCACUGCUGGGCAACGUCCUUCCCUGGGAAGACAAGUUGGUGGAGGCCUUUGGGGGUGCAACAAAGGCUGCCUUCGAUGUCUGCAAGGGGAGGGCCAAGGCAUGAGGGGCCACCUCAUCCAGGGCCCCUCCCUUGCCUGCCACUUUGGGGACUUGAGGGGGGUCAUAUUCCCUCCUCAGCCUGCCCACGCACUGGCCUUCCCUCCUGCCCCACUCCUGGCUGUGCCUCCCAUUUCCCCUCACCUGUACCCACACCUCCAGAAUGCCCUGCCCUGCGAGUGUGUCCCCUGUCCCCACCUGAGUGGGGAGGAGCGUCUCAAGUGAACAGUGGGAGCCUGCCCACCUGGCACUGCACUGGAGUUGUCUCUUACCCCACCCUCCCUGCCCAUCAACUGUAUCUGAUUUCACUAAUUUUGACAGCACCCCCAGUAGGGUAGGAUUGUGUAUGAGGGGGACCCCACUAUCUCAGUGGUGGGGGUGGCCGCCCGCCCCCUUGUCCCCCAUGCAACAGGCCCAGUGGCUUCCCCUUCAGGGCCACAACAGGCUGUAGAAGGGGAUGACGAGGACAUCAGAGGUUAGACUUACCCUCCUCCCUCUUUCCACCAGCUGCCAGUCAAGGGCAGUGGGAUCUCGAUGGAGCCUCCCCCCCCCCCCACCCAUGCCUCCCUCUUCCUCCUCUUUCCUCCUCUCUUUGUGUGUAGCGGUUUGAAUGUUGGUUCCAUGCCUGGCCCAGCCCCACCUCAGUCUCCAGGACAUUCCUUUCCCAGCUCCAGCCUGGAGGGAAGGGGACAAAGACCCCAGGAGGCCAAAGGGCUGCAGUCACCCCUUGUGCUCACCCAUAGUGAUGGCCACUGGUAUAGUCAUCGCUCUCCCUCCAUGCCAAGGACAGGACUUGGACCGCUUCAGCCUGGGCUGGGAGCAGCCCUAAGGUAGAGGCCUCAUGGCCCAGGAGACCCCACCUCUGGCAGAGCCACAUUACCUACCCUGUGCAUGGUCCUGGGGCAGCAAGGAAGAAGCUCAGAGGGUGGGGAGAAGCAUGAAGCAGUGAGCAGAGCACUGGGUGAGAGGGAGAAGACCUUGGUUCCUAGCCAGCCCUGCUAAUGUGCUGUGUGGCCUUCUGUAAGUCCCUGCCCUCUCUGGGCCUGGCCUUCCUCAUUCGUGAGCUGAGGCCCUCGCUUUGGUCAUUUGCUCUCCAGAUUGGGUGUGAGCUUCUCUGUGAUUCCAGGUGGAUAUGUGGGGAAAGCUCUGGUGACCCUGGGCUUCGCAGGGGUAGAUCCCAGGACUCGGCAGUGGAUGGGAUGCAGCCAGUCAUGGGUUAGGGUCAGCAGAGACUCAGAGUCCAGGGCAAGGUUCAAGGCAGACUAACCUCAUGCAUGGAUUGUAAAAAACCAGCUCCCUUUGGAUCAACCCAGCCUGGCACCCUUGCCUGUCUGAGAGUGUCUCAAAGGGCUGAUGGCUUCCUGGUCCCCUUGAGUCAUCACCAGCUUCCCCAAGAGAGUGUCAGAAUCUUAAGAGCUGAGAGGCCGGGCACGGUGGCUCACGCCUGUAAUCCCAGCACUUUGGGAGGCUGAGACAGGCAGAUCACUUGAGGUCAGGAGUUCGAAGUCAGCCUGGCCAACGUGGUGAAACCCCAUCUUCACUAAAAAUACAAAACUUAGCUGGUUAGGUGGUGCAUGCCUGUAGUCCCAGCUACUCGGGAGGCCGAGGCAGAAGAAUCUCUUGAACUGAGGAGGUGGAGGUUGCAGUGAGCCGAGAUCACGCCAUUGCACUCCAGCCUGGGCAACAGAGCAAGACUCCAUCUCAAAAAAAUAAUAAUAAUCUUAAAGAUGAGAAAAGCCACCCCAUCUGGCACCACAGCUGCAUCUUGCUUGUGAGAAAUGGGGAAGAGUUCAGGGAGGACACGUGACCUGCACAGGAUCACAGAGCAUGGGGCAGAGCCAGGACUAGAGCUCAGGGCAUCUGACUCCCUCUUCAGUGUUCUUCCCCCUCCAUGUUGCCUGCCCCUGAAGACCUUUGAGUUCAGUCUACACCUAAGCAGGUAGACAUCCGCGAGGUCAGAUGCUUUCCAACAUGACACCUGAACAUCUUCCUUUAUGCAACACCCAAACAUCUUGGCAUCCCCACCCCAGGAAGUGCGGGGAGGAGGUUAUGAUCCCUGGGCGCUUCGGCAGAAUGGAGAGCUGAGGUGUCCCUCCCCUGCUAGUCACCUACCAGGUGUCUGAGCAGCUGCAUGCUCCCUGGCUCAAGUGGGCACUGUACCUUUUGCCUGCCUUUUUGUUCCCUAUCUCCACUCCCUGAGGCCACUUAGCCUGAGACAUGAUGCAAGAGCUGCAGGCCGGGGGGCUCAGUGCCAUGGAAGCUACUCCAAGUUGCAUUGCCUCCCGCGCCCAGAUCCUGCUUUCCAUUUCGAGAACAUAAAUAGAUUGCCCAGCCCCUCCAGUACAAUCCCACUGGAAGAAAAGGCAAUGGCGGGCUUCAGCCAGACCUGCUGAGACCUAGGUUGCCACGGUAACAGCCAAAGACAUCAACCCAAGUGCUGGGUCAAGUGUCUCAUCAUACUGGCACUGUUGCUGGGGUGACGGCAGAAUUCAGAACUUCAAUUUCAGUGACGCCAAGCUUGAUGUGUUUCUGUUAUUGUUUUGAAGAAGGUAGCUCUUGUGGAGGACUUGGGAGAAGGAUGGGGUCUUAGGAAGGAGGUGACAGCACUUGCAUGGUCACUUGAGCCCACACACACGCUCAACCCCAAGUCCUUUAUGCUUUGUCACAGUGAAGAUGAGACCUCUGACGUCCAAGCCUUGUUCCUGUGCUGCAUCACCCACUCAGCCUUCCAAAGGGAACAGGAACAAAUUUCCCCAGCACCACUGUUUGGGUCCCGCUUUUCCUAUCUUCUGCUGCCCCUGAGCACAUCCAAGCAGACAGGGAAAGAGGAGUCAGACAUGGCCCAGUCACAUCCUGAGCUGCUCCUGGCUGAUAACCACGAUGGAGCCCGUGUUUGUCCUGCCAUCUGGCACUGCACUGAGUGUGGCACAGGCACCGUCCUGUUGAUCUCACAACACAGUUCUAAGUUAGGACGUUCUUGGCUCCGUUAGACAGGUGAGGAAACUGGGGCACAGAGAGGUGAUGUCAUCUGCCUGGUGUCAAUCAGCUAGCAAGUGAUGGAGCCCAGAUUUCAAACCAAAGGGGGUUACGUCCAGGGGCUGAGUUCCCACUCACCUGUGUAGAGUGCCAUCUGGGCACCAUUGCUCCAGACGUGUUCCGACCCCUUUCCCAGCCCACAGGGCUUGAAGUGAAGGAACAGAGGCAGGGGGUGGGCCAGCCCCAGGGCCAGGGUCCCCUUGGUGAAGCCGUGCCAGGGGGCUCAGCUGCUUCAGGGAAUGUGUCCCUCCCACCAUGGGCCAGAGCUUCAGCCCUUCUUUAGCUCAGCUAGAGUUCACAGGAGAGCCAAAAAAGAAAAGGAAGCUGAGCAUCUCCCGAGUCCUGGGCAGGGAAGGGGAGGGAAAUUGCUGCUUCUCCAACUCUUGCUUGGGGCCAAGCCCUGCACCAGUUGCUUCCCAGCUGUUAUCUGCCAGAUCUUCCCAUCUUGUGGCAUGUGGUGCCCCCACCAACAUCCCAAGGGGACCAAUCCCCUUGCCACCACUUUGCAUCACCUGGGACCACAGAUUUGGACAGGAAGGGCUCUGAGAAGAGGCCAAAGCCCUCAUUUUACAGAUGAGGAAGCUGAAGCCCGGGGAGGGGAGCGACCCUCAAGGCCACCCAGCUGGACACGGGAGACUUGAGCCCAGCCUUCUGACUGCAUUCAGCCCUCUCUAGGACGCAGCAGCCUCUCCCCAGCACUGAGUCCCCCCUCCUUUGUGUGUCCCAGCACCCUUGGCCUGAGUAAACUUGGAAAGGGGCUCCCUCCCAGAGAAGGGACUACUCUCUUCACCCCUUUAUUCCAGCUGCCUGCCACCCCAGACCCCCACCUCCCACCCUGACCCCCGACCCCUGGGUGGGGAAGGGGCUCACAUGGGCCCAGGCUGAGUGUGAGUGAGCAUGUCAAGUUGUCUGACACUGUGACAUUAGUGCACCCUACUGACAACCCCUCCCCAGCCUUGCCCCUUUCUCCUCUCCCUGUUUUGUACAUAAAUUGACAUGAGCUGCAACAUGUGUGCGUGUGUGUGCGUGUGUGUGUGUGUGUAUGUGUGUGUGAUCUGUGUCAUGGUUUUGUUACCUUUUUGUUUUUGUAAACUUGAAUGUUCAAAAUAAACAUGCUGUUUACUCUGA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 23467)
NPTXR
neuronal pentraxin receptor
NC_000022.11
22  38822609.. 38843858
38822609.. 38843858
strand -
CCDS33647.1
MGI:1920590
ClinVar, dbVar
ENSG00000221890
uc062eix.1
INSDC: AF052163
7954
609474
OTTHUMG00000150458
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1503 bp)
5'-CTGAAGTTCCTGGCCGTGCTGCTGGCCGCGGGCATGCTGGCGTTCCTCGGTGCCGTCATCTGCATCATCGCCAGCGTGCCCCTGGCGGCCAGCCCGGCGCGGGCGCTGCCCGGCGGCGCCGACAATGCTTCGGTCGCCTCGGGCGCCGCCGCGTCCCCGGGCCCGCAGCGGAGCCTGAGCGCGCTGCACGGCGCGGGCGGTTCAGCCGGGCCCCCCGCGCTGCCCGGGGCACCCGCGGCCAGCGCGCACCCGCTGCCGCCCGGGCCCCTGTTCAGCCGCTTCCTGTGCACGCCGCTGGCTGCTGCCTGCCCGTCGGGGGCCCAGCAGGGGGACGCGGCGGGCGCTGCGCCGGGCGAGCGCGAAGAGCTGCTGCTGCTGCAGAGCACGGCCGAGCAGCTGCGCCAGACGGCGCTGCAGCAGGAGGCGCGCATCCGCGCCGACCAGGACACCATCCGTGAGCTCACCGGCAAGCTGGGCCGCTGCGAGAGCGGCCTGCCGCGCGGCCTCCAGGGCGCCGGGCCCCGCCGCGACACCATGGCCGACGGGCCCTGGGACTCGCCTGCGCTCATTCTGGAGCTGGAGGACGCCGTGCGCGCCCTGCGGGACCGCATCGACCGCCTGGAGCAGGAGCTTCCAGCCCGTGTGAACCTCTCAGCTGCCCCAGCCCCAGTCTCTGCTGTGCCCACCGGCCTACACTCCAAGATGGACCAGCTGGAGGGGCAGCTGCTGGCCCAGGTGCTGGCACTGGAGAAGGAGCGTGTGGCCCTCAGCCACAGCAGCCGCCGGCAGAGGCAGGAAGTGGAAAAGGAGTTGGACGTCCTGCAGGGTCGTGTGGCTGAGCTGGAGCACGGGTCCTCAGCCTACAGTCCTCCAGATGCCTTCAAGATCAGCATCCCCATCCGTAACAACTACATGTACGCCCGCGTGCGGAAGGCTCTGCCCGAGCTCTACGCATTCACCGCCTGCATGTGGCTGCGGTCCAGGTCCAGCGGCACCGGCCAGGGCACCCCCTTCTCCTACTCAGTGCCCGGGCAGGCCAACGAGATTGTACTGCTAGAGGCGGGCCATGAGCCCATGGAGCTGCTGATCAACGACAAGGTGGCCCAGCTGCCCCTGAGCCTGAAGGACAATGGCTGGCACCACATCTGCATCGCCTGGACCACAAGGGATGGCCTATGGTCTGCCTACCAGGACGGGGAGCTGCAGGGCTCCGGTGAGAACCTGGCTGCCTGGCACCCCATCAAGCCTCATGGGATCCTTATCTTGGGCCAGGAGCAGGATACCCTGGGTGGCCGGTTTGATGCCACCCAGGCCTTTGTCGGTGACATTGCCCAGTTTAACCTGTGGGACCACGCCCTGACACCAGCCCAGGTCCTGGGCATTGCCAACTGCACTGCGCCACTGCTGGGCAACGTCCTTCCCTGGGAAGACAAGTTGGTGGAGGCCTTTGGGGGTGCAACAAAGGCTGCCTTCGATGTCTGCAAGGGGAGGGCCAAGGCATGA-3'
NCBI CDS gene sequence with introns (location: 38822609.. 38843858) (21250 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 38818452.. 38844028) (25577 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [38818452.. 38844028 + 1000]) (26577 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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