NCBI Summary
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016].
Protein
Protein (NP_002843)
Pentraxin 3
Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14)
PTX3
pentraxin 3
Undefined
Very low evidence
Pentraxin
L-Type Lectins
b-sandwich / ConA-like
Heparin
NP_002843
5806
P26022
ENSP00000295927.3
P26022
0.381
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (381 amino acids) Download
MHLLAILFCALWSAVLAENSDDYDLMYVNLDNEIDNGLHPTEDPTPCACGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-P26022-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for PTX3 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Pentraxin 3 secreted by human adipose-derived stem cells promotes dopaminergic neuron repair in Parkinson's disease via the inhibition of apoptosis. [34152016]
  • The Assessment of Pentraxin 3: A Novel Biomarker in Early Detection of Infection in Newborns. [34307663]
  • Correlation between single nucleotide polymorphisms in the 3 primer untranslated region of PTX3 and the risk of essential hypertension: A case-control study. [34128842]
  • PTX3 Effects on Osteogenic Differentiation in Osteoporosis: An In Vitro Study. [34073015]
  • Pentraxin 3: a powerful orchestrator in urinary tract infection. [34055573]
  • Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes. [7949102]
  • Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. [7523502]
  • TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins. [7679696]
  • Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. [1429570]
  • A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. [1730767]
UniProt Main References (6 PubMed Identifiers)
  • IL-1 inducible genes in human umbilical vein endothelial cells. [8131794]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The DNA sequence, annotation and analysis of human chromosome 3. [16641997]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity. [12763682]
  • Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization. [18223257]
RNA
RNA (Transcript ID: NM_002852.4)
NM_002852.4
pentraxin 3
All isoforms of PTX3 containing a lectin domain
ENST00000295927.4
85..1230 (or 157436934.. 157442979)
157436850.. 157443633
NCBI Matured mRNA sequence 1884 NTPDownload 
m7G-5')ppp(5'-ACUCUCACUCUCCUCCGCUCAAACUCAGCUCACUUGAGAGUCUCCUCCCGCCAGCUGUGGAAAGAACUUUGCGUCUCUCCAGCAAUGCAUCUCCUUGCGAUUCUGUUUUGUGCUCUCUGGUCUGCAGUGUUGGCCGAGAACUCGGAUGAUUAUGAUCUCAUGUAUGUGAAUUUGGACAACGAAAUAGACAAUGGACUCCAUCCCACUGAGGACCCCACGCCGUGCGCCUGCGGUCAGGAGCACUCGGAAUGGGACAAGCUCUUCAUCAUGCUGGAGAACUCGCAGAUGAGAGAGCGCAUGCUGCUGCAAGCCACGGACGACGUCCUGCGGGGCGAGCUGCAGAGGCUGCGGGAGGAGCUGGGCCGGCUCGCGGAAAGCCUGGCGAGGCCGUGCGCGCCGGGGGCUCCCGCAGAGGCCAGGCUGACCAGUGCUCUGGACGAGCUGCUGCAGGCGACCCGCGACGCGGGCCGCAGGCUGGCGCGUAUGGAGGGCGCGGAGGCGCAGCGCCCAGAGGAGGCGGGGCGCGCCCUGGCCGCGGUGCUAGAGGAGCUGCGGCAGACGCGAGCCGACCUGCACGCGGUGCAGGGCUGGGCUGCCCGGAGCUGGCUGCCGGCAGGUUGUGAAACAGCUAUUUUAUUCCCAAUGCGUUCCAAGAAGAUUUUUGGAAGCGUGCAUCCAGUGAGACCAAUGAGGCUUGAGUCUUUUAGUGCCUGCAUUUGGGUCAAAGCCACAGAUGUAUUAAACAAAACCAUCCUGUUUUCCUAUGGCACAAAGAGGAAUCCAUAUGAAAUCCAGCUGUAUCUCAGCUACCAAUCCAUAGUGUUUGUGGUGGGUGGAGAGGAGAACAAACUGGUUGCUGAAGCCAUGGUUUCCCUGGGAAGGUGGACCCACCUGUGCGGCACCUGGAAUUCAGAGGAAGGGCUCACAUCCUUGUGGGUAAAUGGUGAACUGGCGGCUACCACUGUUGAGAUGGCCACAGGUCACAUUGUUCCUGAGGGAGGAAUCCUGCAGAUUGGCCAAGAAAAGAAUGGCUGCUGUGUGGGUGGUGGCUUUGAUGAAACAUUAGCCUUCUCUGGGAGACUCACAGGCUUCAAUAUCUGGGAUAGUGUUCUUAGCAAUGAAGAGAUAAGAGAGACCGGAGGAGCAGAGUCUUGUCACAUCCGGGGGAAUAUUGUUGGGUGGGGAGUCACAGAGAUCCAGCCACAUGGAGGAGCUCAGUAUGUUUCAUAAAUGUUGUGAAACUCCACUUGAAGCCAAAGAAAGAAACUCACACUUAAAACACAUGCCAGUUGGGAAGGUCUGAAAACUCAGUGCAUAAUAGGAACACUUGAGACUAAUGAAAGAGAGAGUUGAGACCAAUCUUUAUUUGUACUGGCCAAAUACUGAAUAAACAGUUGAAGGAAAGACAUUGGAAAAAGCUUUUGAGGAUAAUGUUACUAGACUUUAUGCCAUGGUGCUUUCAGUUUAAUGCUGUGUCUCUGUCAGAUAAACUCUCAAAUAAUUAAAAAGGACUGUAUUGUUGAACAGAGGGACAAUUGUUUUACUUUUCUUUGGUUAAUUUUGUUUUGGCCAGAGAUGAAUUUUACAUUGGAAGAAUAACAAAAUAAGAUUUGUUGUCCAUUGUUCAUUGUUAUUGGUAUGUACCUUAUUACAAAAAAAAGAUGAAAACAUAUUUAUACUACAAGGUGACUUAACAACUAUAAAUGUAGUUUAUGUGUUAUAAUCGAAUGUCACGUUUUUGAGAAGAUAGUCAUAUAAGUUAUAUUGCAAAAGGGAUUUGUAUUAAUUUAAGACUAUUUUUGUAAAGCUCUACUGUAAAUAAAAUAUUUUAUAAAACUAGCUCACGUCAUUUAAUUAUAAAUUUAAGAGAUGUUUUGGAGCAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 5806)
PTX3
pentraxin 3
NC_000003.12
3  157436934.. 157442979
157436934.. 157442979
strand +
CCDS3180.1
MGI:104641
ClinVar, dbVar
ENSG00000163661
TSG-14
uc003fbl.5
INSDC: X63613
9692
602492
OTTHUMG00000158750
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1146 bp)
5'-ATGCATCTCCTTGCGATTCTGTTTTGTGCTCTCTGGTCTGCAGTGTTGGCCGAGAACTCGGATGATTATGATCTCATGTATGTGAATTTGGACAACGAAATAGACAATGGACTCCATCCCACTGAGGACCCCACGCCGTGCGCCTGCGGTCAGGAGCACTCGGAATGGGACAAGCTCTTCATCATGCTGGAGAACTCGCAGATGAGAGAGCGCATGCTGCTGCAAGCCACGGACGACGTCCTGCGGGGCGAGCTGCAGAGGCTGCGGGAGGAGCTGGGCCGGCTCGCGGAAAGCCTGGCGAGGCCGTGCGCGCCGGGGGCTCCCGCAGAGGCCAGGCTGACCAGTGCTCTGGACGAGCTGCTGCAGGCGACCCGCGACGCGGGCCGCAGGCTGGCGCGTATGGAGGGCGCGGAGGCGCAGCGCCCAGAGGAGGCGGGGCGCGCCCTGGCCGCGGTGCTAGAGGAGCTGCGGCAGACGCGAGCCGACCTGCACGCGGTGCAGGGCTGGGCTGCCCGGAGCTGGCTGCCGGCAGGTTGTGAAACAGCTATTTTATTCCCAATGCGTTCCAAGAAGATTTTTGGAAGCGTGCATCCAGTGAGACCAATGAGGCTTGAGTCTTTTAGTGCCTGCATTTGGGTCAAAGCCACAGATGTATTAAACAAAACCATCCTGTTTTCCTATGGCACAAAGAGGAATCCATATGAAATCCAGCTGTATCTCAGCTACCAATCCATAGTGTTTGTGGTGGGTGGAGAGGAGAACAAACTGGTTGCTGAAGCCATGGTTTCCCTGGGAAGGTGGACCCACCTGTGCGGCACCTGGAATTCAGAGGAAGGGCTCACATCCTTGTGGGTAAATGGTGAACTGGCGGCTACCACTGTTGAGATGGCCACAGGTCACATTGTTCCTGAGGGAGGAATCCTGCAGATTGGCCAAGAAAAGAATGGCTGCTGTGTGGGTGGTGGCTTTGATGAAACATTAGCCTTCTCTGGGAGACTCACAGGCTTCAATATCTGGGATAGTGTTCTTAGCAATGAAGAGATAAGAGAGACCGGAGGAGCAGAGTCTTGTCACATCCGGGGGAATATTGTTGGGTGGGGAGTCACAGAGATCCAGCCACATGGAGGAGCTCAGTATGTTTCATAA-3'
NCBI CDS gene sequence with introns (location: 157436934.. 157442979) (6046 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 157436850.. 157443633) (6784 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [157436850 - 1000].. 157443633) (7784 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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