NCBI Summary
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_002513)
Neuronal pentraxin 1
Neuronal pentraxin-1 (NP1) (Neuronal pentraxin I) (NP-I)
NPTX1
neuronal pentraxin 1
Undefined
Very low evidence
Pentraxin
L-Type Lectins
b-sandwich / ConA-like
MPAGRAARTCALLALCLLGAGAQDFGPTRFICTSVPVDADMCAASVAAGGAEELRSSVLQLRETVLQQKETILSQKETIRELTAKLGRCESQSTLDPGAGEARAGGGRKQPGSGKNTMGDLSRTPAAETLSQLGQTLQSLKTRLENLEQYSRLNSSSQTNSLKDLLQSKIDELERQVLSRVNTLEEGKGGPRNDTEERVKIETALTSLHQRISELEKGQKDNRPGDKFQLTFPLRTNYMYAKVKKSLPEMYAFTVCMWLKSSATPGVGTPFSYAVPGQANELVLIEWGNNPMEILINDKVAKLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQGGSGENLAPYHPIKPQGVLVLGQEQDTLGGGFDATQAFVGELAHFNIWDRKLTPGEVYNLATCSTKALSGNVIAWAESHIEIYGGATKWTFEACRQIN
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Downregulation of NPTX1 induces cell cycle progression through Wnt/beta-catenin signaling in breast cancer. [34212686]
- Long non coding RNA SLC26A4-AS1 exerts antiangiogenic effects in human glioma by upregulating NPTX1 via NFKB1 transcriptional factor. [32255252]
- MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1. [31118494]
- As a downstream target of the AKT pathway, NPTX1 inhibits proliferation and promotes apoptosis in hepatocellular carcinoma. [31113871]
- Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease. [29501530]
- NPTX1 regulates neural lineage specification from human pluripotent stem cells. [24529709]
- Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain. [17151277]
- Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. [16115696]
- Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. [10748068]
- Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. [8884281]
UniProt Main References (2 PubMed Identifiers)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_002522.4)
m7G-5')ppp(5'-GGCAGUGGGGGCCUGAUAGCGCGGCGGUGUGGACCGCGCGGCCGAAGAGCGCGGCGCCCAGAGCGCGGGCCGCUCGCGGAGCCACAGCCCGAGCCGGGUCCCAGCCGGAGCCGAGCCCCAGCCGAGCCGAGCCGGGCCCGGAGCGCCCGGUGCCCGCAGCCAUGCCGGCCGGCCGCGCCGCGCGCACCUGUGCGCUGCUCGCCCUCUGCCUCCUGGGCGCCGGGGCCCAGGAUUUCGGGCCGACGCGCUUCAUCUGCACCUCGGUGCCCGUGGACGCCGACAUGUGCGCCGCGUCCGUGGCCGCCGGCGGCGCCGAGGAGCUCCGGAGCAGCGUGCUGCAGCUCCGCGAGACGGUGCUGCAGCAGAAGGAGACCAUCCUGAGCCAGAAGGAGACCAUCCGCGAGCUGACCGCCAAGCUGGGCCGCUGCGAGAGCCAGAGCACGCUGGACCCCGGAGCCGGCGAGGCCCGGGCGGGCGGCGGCCGCAAGCAGCCCGGCUCGGGCAAGAACACCAUGGGCGACCUGUCCCGGACACCGGCCGCCGAGACGCUCAGCCAACUCGGGCAAACUUUGCAAUCGCUCAAAACCCGCCUGGAGAACCUCGAGCAGUACAGCCGCCUCAAUUCCUCCAGCCAGACCAACAGCCUCAAGGAUCUGCUGCAGAGCAAGAUCGAUGAGCUGGAGAGGCAGGUGCUGUCCCGGGUGAACACCCUGGAGGAGGGCAAGGGGGGCCCCAGGAACGACACCGAGGAGAGGGUCAAGAUCGAGACCGCCCUGACCUCCCUGCACCAGCGGAUCAGCGAGCUCGAGAAAGGUCAGAAAGACAACCGCCCUGGAGACAAGUUCCAGCUCACAUUCCCACUGCGGACCAACUAUAUGUAUGCCAAGGUGAAGAAGAGCCUGCCAGAGAUGUACGCCUUCACUGUCUGCAUGUGGCUCAAGUCCAGCGCCACGCCAGGUGUGGGCACGCCCUUCUCCUACGCUGUGCCCGGCCAGGCCAACGAGCUGGUCCUCAUUGAGUGGGGCAACAACCCCAUGGAGAUCCUCAUCAAUGACAAGGUGGCCAAGUUGCCUUUUGUCAUCAAUGAUGGCAAGUGGCACCACAUCUGUGUCACCUGGACCACCCGGGACGGGGUCUGGGAGGCCUACCAGGAUGGCACGCAGGGUGGCAGUGGCGAGAACUUGGCGCCCUAUCACCCCAUCAAGCCCCAGGGCGUGCUGGUGCUGGGCCAGGAGCAGGACACUCUGGGUGGUGGGUUUGAUGCCACCCAGGCAUUUGUGGGUGAGCUGGCCCACUUCAACAUCUGGGACCGCAAGCUGACCCCCGGGGAGGUGUACAACCUGGCCACCUGCAGCACCAAGGCUCUGUCCGGCAAUGUCAUCGCCUGGGCUGAAUCCCACAUCGAGAUCUACGGAGGGGCCACCAAGUGGACCUUCGAGGCCUGUCGCCAGAUCAACUGAGCACGGCAGGCCAGGCUGAGCCCGCCCGCCCUCGCCCCCUGCUUGUGCGGCGAUGAUCUGUUUUGUGCGUCUCUUCUCUCCCUUUUCCCCAGGAAUGAACCGAGGCCGUCGCCCCUGCACACGCACACGCACACAGCCUGGUUUUGUCCUCAUGCACACGAAGCAGCCCCUGCUCCCAUCUGUCCCUGAGGAAGCCCCACUUCUCUGUAGGAGCCCGGACUCUCUCAGGCAUGCCCCAUUCACAGCUGAAGUGGGUGCUGCAACGUCUUGAACAAGGCAGAAGUUGGUGAGAGGAUCUGUGUGUGCGUGUCUACAUGUGUGUGUCUACGUGUGUGCGUGCGUGGCUGGGGGAGGCCUUUUCUUUGAGGACGUACCUCAUUUCCUUCUUUCUUCUGGCUUUGGAAAAAUCUCAUGAUGAAAAUUCAUAUUUGCCAACUUUGUUAGCUGCGUGCGUGCUUUGGGGUUGGUGCAACCUCAGUACACGCAUUUGUCUUUGUUUGCAAACCUUUCUCAGAGCGACAUAUCUUUAUAUUGAUGUAAUAAAUGUCUUUUAGUGGUUUGUCAAAGGCCGGGGGCGGGGGCUCUCUACAGAGAAUUUUUAUUUUGUAAUAGAAGUGAACUGUCUCUGAAGGGUGAAGGCAGGCCGUCCUGGGAUGGUACCCUGUGCUCUCCCGUGGAGGAGAGGGGAUGGCUGAGGACACUGGCCCUUACCCCAGGGCCAGACAGCAUCCAUCCCUGCUGUUUGCAUCUGAGAGCAGCAUGGGGCCUGGGAGGUCGGCCUGUGUGCCCAGCUCAGCUAGCUCUGCCCCAGGACGGCCCUGCCCUCGACCUUCCCACCUCCUCAGAUCCUGCAAGGCUGGGGUCUGCCCCUCCCUUCUCACCUCUGGAGCUGUGCUGCACUGCUUCAGCCCAGAGGGCCCUGAGAGAGGAGCGUGCCACCCACAGCCCGGGAAGCCGGGCCCCAGCACCCCUCUCCUUUGGCCUCCGGCAGUGCAGACCAGAGGGGACCUUUUAAGGAAAGAAGCCGUGUUUCGAUGAAGACCUGGCCACAUGGGGCCACUGGGACUUCAACCCAGCCCAUCGGUGGGAAGGUCCUUUUUGGGGGACUUUGACAGCCAUAUCCCUCCCAGCACACCAGGCGCCAGGUGAGCUGGUUCAGACCCCUCCAGGGGUACUCCAGAGACCUCACGUGUGGAGCCAGGCCUGGCCAGGGCAGGGGCCUGAAACCCACUCCUCCAUCUCAUGGGGCUCACGGCCUACAGCAGCCCACAAGCUGCCACUGGCCGGCGACACUGACACCUGAGCAGUGUCCAGAACCUUUUUGCCUUUUUUUGUUCCCCGUGAAAAGCAACAUGGACAUUUCCUUCUAGUCCUUCCAAGGAGGGGAGAGAAGUGUAUGUGCAUUUGUGUGUGUGUGUGUGUGUUGUGUGUGUGUGUGCGCUAAGUGAGAAAGAGAGCAGGCUCGGGAGGCCCUGCCCAGGGUAGGAGGAGCUUCCUGCUUUGCACCAUCUGGUGGUCGCACGCCCUGAGGGCACCCCGACUCUGUCUCCAGGAGUCUCAUCAGCAAACCGCUGACAAGUCUUUCUAGAAAUUCUACUGCACUGCCUGGCUCAGCUGCAGCUGCAGACAUUUCUGCAGGAGGAGCAGGUGUUUCUGUCUUCUGUUCCUUCUAGGGCCACCUGUCCCCUUAAACACAGGUCCACGUUGUGUCAAGAACCUAGUGCAUCUGUGUGUGUCUGUCAGUGUCUCUGUGUCAGUGUUCUCGUGGGUGUCUGCACGGUACCCGGCCGCCGUUCUGCAAUGCAUCACUCCCGCAGAGGGGGGUGCAGAUCAGGCGCCGUGCUGCGCGUUGUUGUUCAACAGUGGCUUUUUCUUAGAUAAUCGUGCUUCCUCAGCGCCCGUCGGGUUGUGGCAUCCUUGGAUCUGCAGGGAUCUUCUCCGUUUGCAUGUUCCUCGGGGUGGCGUGUUCCUUGCUCCCUGGGUCCGACAUGUGUUCCCGCACCUGCAUGGACUGCCCCGGUUCUGUGUUGUGUGCCGAGUGCCGCCCAGUGUUCUGUGACCACCCGUGUAGCUACUGAAAAUGGCUGGGUAAGCAAGUCAAGGGUGUUGGAGGAGGUCAAGAGAGAGCUCAGUUUCCCUCUCCCCCUCCCCAAACACACCAAGAAGCAUUUUUAACGUGUAGGUUGAGAACAAGCCUAAAGGAUUCCCACAGCUGGGAGCCAGCAAGAGAGCUUGGAGUCGCCUCUCUAGACCAGAUCUAGCCCCACCCUCACUCCAGCCAUCUCGGAGCCCUUGUGUAGGCAACGCCCGGUGCGGGCUGUGUGGGGUGCUCCCCUGCCAGCACCUCCGGCCAGCCCCGCCCCUGCCGAUCUACUGGACCGCAGACCACCUUCUGCCCCCGUGGGCCAGGUGGGAGCUGUCCGUUCAGGACCAUGAGCCAUCCUCUGCCCUGACUAGCGAGGGGCAGAGCACACCCCAGUGCUUACGCCUCCACCCCUGCAGCCUCCUGGCCCGCUCACCUUCCUCACCCCUCCUCUGACCCACCCAUGGUGCCAGGGCCGAAGCUGACCUUUAGCUCCCUCCUGCCCCUUGCUAGGGUCUGAGCCAAGCCCCUCGACUCCCUCACUGUGUUGACACUUGGCACUUUGCUGGCCCCGAGAAAGGUCGAUGACACAGCCGCAAAUCUAAUCCACGUAGUUCCCAUUUACUCCUUAAUCUGAUUGAUGUUCCCUCUUGCACUGAAUAAUACAUGCCUCUCUCAGGUAAGCCAUUUUAUAAAACAAGAAGAUAAAAAGCACUGUUGAGGCAGUGUUUGCUUUUGCCGAGCUGGUGUCCGACAGCUCCCUGGGUGUCCGGGGUGGGAGAGCUGUUGACAGAAGCUCUCCGGGCCCUCAGGGGCUUAGAUCCCACUUGAGUCGUAAGCCUUCUUGCUUUUGAUAACACAGUAUUAUUUCUCUUACUGUAGAAGAAAAAGUUUAUUACCAAACAAGAGUAUUUUUAUGAAAGAAAAGGACAAACCUAUAAAUUAACUCAACCUAUAUCUCCCUUGAAAAUACUUUCAGGCUCCACCAAAACGUAGAACUGAAAGCAUGUAUUUUGGAAGAAAGAGAUACAUUUUGUAUGCUUUCUUUUCCUUUUGUAGAUUCCCAGUUUAUUUUCUAAGACUGCAAAGAUCACUUUGUCACCAGCCCUGGGACCUGAGACCAAGGGGGUGUCUUGUGGGCAGUGAGGGGGUGAGGAGAGGCUGGCAUGAGGUUCAGUCAUUCCAGUGAGCUCCAAAGAGGGGCCACCUGUUCUCAAAAGCAUGUUGGGGACCAGGAGGUAAAACUGGCCAUUUAUGGUGAACCUGUGUCUUGGAGCUGACUUACUAAGUGGAAUGAGCCGAGGAUUUGAAUAUCAGUUCUAACCUUGAUAGAAGAACCUUGGGUUACAUGUGGUUCACAUUAAGAGGAUAGAAUCCUUUGGAAUCUUAUGGCAACCAAAUGUGGCUUGACGAAGUCGUGGUUUCAUCUCUUAAACACAGUGUGUAAAUUUAUUCAACUAACGAUGGGAAAUGUAUUACUUCUGUACACAGUGGACUGAAGUGCAAUUUGUUGAAAGGGAACAAGUCAUUGAAGAGAAAAAAAAAGCCCAAUACUUAGAGUCCCAAUUUUGUCUCAUUUGCCAAAAAAAAAAAAAAAAAAAAAGCAAACCCCCUAUGGUUGAUAUUGUUAUAAUGUAUAUACUGUAUAAUAUGAAAGAGAAUCGAUGUAUCUCACUUUUUCAUUAUUUGCUAACCAAAGCUGUACAUUUUUCAUAUGAUCUGCAGCCUUUUGGGUAUCAAAUGGGUCAAAACCAUGGGACCUGCCACCUCCCAUCAGCAAUUCUGGAAAUGCACUAUUUCUACUGGUAUUCUUGCUUUUUUUUUUUUUUUCAUUUUCUUGCUGAAAUGACAUGAAUUGUUGAGUUUAUUUUUACACAGUAAAGAGUGGAGAAAGAC-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 4884)
neuronal pentraxin 1
strand -
NCBI CDS gene sequence (1299 bp)
5'-ATGCCGGCCGGCCGCGCCGCGCGCACCTGTGCGCTGCTCGCCCTCTGCCTCCTGGGCGCCGGGGCCCAGGATTTCGGGCCGACGCGCTTCATCTGCACCTCGGTGCCCGTGGACGCCGACATGTGCGCCGCGTCCGTGGCCGCCGGCGGCGCCGAGGAGCTCCGGAGCAGCGTGCTGCAGCTCCGCGAGACGGTGCTGCAGCAGAAGGAGACCATCCTGAGCCAGAAGGAGACCATCCGCGAGCTGACCGCCAAGCTGGGCCGCTGCGAGAGCCAGAGCACGCTGGACCCCGGAGCCGGCGAGGCCCGGGCGGGCGGCGGCCGCAAGCAGCCCGGCTCGGGCAAGAACACCATGGGCGACCTGTCCCGGACACCGGCCGCCGAGACGCTCAGCCAACTCGGGCAAACTTTGCAATCGCTCAAAACCCGCCTGGAGAACCTCGAGCAGTACAGCCGCCTCAATTCCTCCAGCCAGACCAACAGCCTCAAGGATCTGCTGCAGAGCAAGATCGATGAGCTGGAGAGGCAGGTGCTGTCCCGGGTGAACACCCTGGAGGAGGGCAAGGGGGGCCCCAGGAACGACACCGAGGAGAGGGTCAAGATCGAGACCGCCCTGACCTCCCTGCACCAGCGGATCAGCGAGCTCGAGAAAGGTCAGAAAGACAACCGCCCTGGAGACAAGTTCCAGCTCACATTCCCACTGCGGACCAACTATATGTATGCCAAGGTGAAGAAGAGCCTGCCAGAGATGTACGCCTTCACTGTCTGCATGTGGCTCAAGTCCAGCGCCACGCCAGGTGTGGGCACGCCCTTCTCCTACGCTGTGCCCGGCCAGGCCAACGAGCTGGTCCTCATTGAGTGGGGCAACAACCCCATGGAGATCCTCATCAATGACAAGGTGGCCAAGTTGCCTTTTGTCATCAATGATGGCAAGTGGCACCACATCTGTGTCACCTGGACCACCCGGGACGGGGTCTGGGAGGCCTACCAGGATGGCACGCAGGGTGGCAGTGGCGAGAACTTGGCGCCCTATCACCCCATCAAGCCCCAGGGCGTGCTGGTGCTGGGCCAGGAGCAGGACACTCTGGGTGGTGGGTTTGATGCCACCCAGGCATTTGTGGGTGAGCTGGCCCACTTCAACATCTGGGACCGCAAGCTGACCCCCGGGGAGGTGTACAACCTGGCCACCTGCAGCACCAAGGCTCTGTCCGGCAATGTCATCGCCTGGGCTGAATCCCACATCGAGATCTACGGAGGGGCCACCAAGTGGACCTTCGAGGCCTGTCGCCAGATCAACTGA-3'
By using this site you agree to our privacy policy.
Please confirm you agree with the privacy policy before using the site.