Protein
Protein (NP_001177370)
Galectin 16
Galectin-16
LGALS16
galectin 16
Undefined
Low evidence
Galectin
S-Type Lectins - Prototypical
b-sandwich / ConA-like
Only for mutated forms
NP_001177370
148003
A8MUM7
ENSP00000375904.2
A8MUM7
0.389
10.1016/j.bbagen.2020.129755
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (142 amino acids) Download
MSFLTVPYKLPVSLSVGSCVIIKGTLIDSSINEPQLQVDFYTEMNEDSEIAFHLRVHLGRRVVMNSREFGIWMLEENLHYVPFEDGKPFDLRIYVCHNEYEVKVNGEYIYAFVHRIPPSYVKMIQVWRDVSLDSVLVNNGRR
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-A8MUM7-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

Ligand
Glycan ligands from structural data
bGal14Glc
Gal(b1-4)Glc
6LJQ, 6LJR
6LJQ, 6LJR
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS16 Gene
References
NCBI References (2 PubMed Identifiers)
  • Human galectin-16 has a pseudo ligand binding site and plays a role in regulating c-Rel-mediated lymphocyte activity. [33011338]
  • A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. [19497882]
UniProt Main References (1 PubMed Identifiers)
  • The DNA sequence and biology of human chromosome 19. [15057824]
RNA
RNA (Transcript ID: NM_001190441.3)
NM_001190441.3
galectin 16
All isoforms of LGALS16 containing a lectin domain
ENST00000392051.4
50..478 (or 39655962.. 39660520)
39655913.. 39660647
NCBI Matured mRNA sequence 605 NTPDownload 
m7G-5')ppp(5'-ACUCAGAAGACUGGACACAAUUCCGAAGGUCGCCCAGAAGGAGAGGACAAUGUCAUUUCUAACUGUGCCAUACAAACUGCCUGUGUCUUUGUCUGUUGGUUCCUGCGUGAUAAUCAAAGGGACACUGAUCGACUCUUCUAUCAACGAACCACAGCUGCAGGUGGAUUUCUACACUGAGAUGAAUGAGGACUCAGAAAUUGCCUUCCAUUUGCGAGUGCACUUAGGCCGUCGUGUGGUCAUGAACAGUCGUGAGUUUGGGAUAUGGAUGUUGGAGGAGAAUUUACACUAUGUGCCCUUUGAGGAUGGCAAACCAUUUGACUUGCGCAUCUACGUGUGUCACAAUGAGUAUGAGGUAAAGGUAAAUGGUGAAUACAUUUAUGCCUUUGUCCAUCGAAUCCCGCCAUCAUAUGUGAAGAUGAUUCAAGUGUGGAGAGAUGUCUCCCUGGACUCAGUGCUUGUCAACAAUGGACGGAGAUGAUCACACUCCUCAUUGUUGAGGAAACCCUCUUUCUACCUGACCAUGGGAUUCCUAGAGCCUGCUAACAGAAUAAUCCCUCCUCAACCCCUUCCCCUACACUUGGUCAUUAAAACAGCACCAAACCGUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 148003)
LGALS16
galectin 16
NC_000019.10
19  39655962.. 39660520
39655962.. 39660520
strand +
CCDS54267.1
ClinVar, dbVar
ENSG00000249861
uc021uun.2
INSDC:
40039
OTTHUMG00000183083
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (429 bp)
5'-ATGTCATTTCTAACTGTGCCATACAAACTGCCTGTGTCTTTGTCTGTTGGTTCCTGCGTGATAATCAAAGGGACACTGATCGACTCTTCTATCAACGAACCACAGCTGCAGGTGGATTTCTACACTGAGATGAATGAGGACTCAGAAATTGCCTTCCATTTGCGAGTGCACTTAGGCCGTCGTGTGGTCATGAACAGTCGTGAGTTTGGGATATGGATGTTGGAGGAGAATTTACACTATGTGCCCTTTGAGGATGGCAAACCATTTGACTTGCGCATCTACGTGTGTCACAATGAGTATGAGGTAAAGGTAAATGGTGAATACATTTATGCCTTTGTCCATCGAATCCCGCCATCATATGTGAAGATGATTCAAGTGTGGAGAGATGTCTCCCTGGACTCAGTGCTTGTCAACAATGGACGGAGATGA-3'
NCBI CDS gene sequence with introns (location: 39655962.. 39660520) (4559 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 39655913.. 39660647) (4735 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [39655913 - 1000].. 39660647) (5735 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905