HumanLectome - Human Lectin Entry

NCBI Summary

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].

Protein

Protein (NP_000192)

Protein name

Intercellular adhesion molecule 1

Synonym(s)

Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)

HGNC gene name

ICAM1

HGNC name

intercellular adhesion molecule 1

Protein_CD_name

CD54

Lectin confidence

Low evidence

UniLectin class

I-type lectin

Known lectin group

I-Type Lectins

Lectin fold

b-sandwich / Ig-like

Glycan specificity

Hyaluronan

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

Undefined

Reference

10.1016/S0021-9258(18)43775-1

Other links

PFAM, InterPro

Protein sequence and protein families (fasta) (532 amino acids) Download

MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-P05362-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions

Homodimer (PubMed:12526797, PubMed:15099525). Interacts with MUC1 and promotes cell aggregation in epithelial cells (PubMed:11173916). Interacts with ARHGEF26/SGEF (PubMed:17875742). Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells (PubMed:23858057)

(Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243)

(Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703)

Annotation

Ligand

Glycan ligands from structural data

No crystal structures of complexes with glycan ligand.

Expression

Human Protein Atlas

GeneCards

Functionality temporarily unavailable.

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo. [34484188]

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer. [34381029]

Role of ICAM-1 in impaired retinal circulation in rhegmatogenous retinal detachment. [34321574]

Small Molecule Compounds Identified from Mixture-Based Library Inhibit Binding between Plasmodium falciparum Infected Erythrocytes and Endothelial Receptor ICAM-1. [34073419]

Vertebral-specific activation of the CX3CL1/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions. [33754027]

Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. [1448173]

Epidermotropism of T cells correlates with intercellular adhesion molecule (ICAM1) expression in human papillomavirus (HPV)-induced lesions. [1361527]

Expression of leucocyte adhesion molecules at the human blood-brain barrier (BBB). [1374132]

VLA molecule expression may be involved in the release of acute myeloid leukaemic cells from the bone marrow. [1625472]

Cloning and characterization of the 5'-transcriptional regulatory region of the human intercellular adhesion molecule 1 gene. [1677359]

UniProt Main References (36 PubMed Identifiers)

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. [3340213]

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. [3349522]

cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1. [2544880]

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5'-regulatory region. Induction by cytokines and phorbol ester. [1680919]

Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Structural characteristics of the 5' region of the human ICAM-1 gene. [1983003]

The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs). [15572059]

The major human rhinovirus receptor is ICAM-1. [2538243]

A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection. [1968231]

Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1. [11160747]

A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. [11413168]

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. [16335952]

MARCH-IX mediates ubiquitination and downregulation of ICAM-1. [17174307]

RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. [17875742]

A quantitative atlas of mitotic phosphorylation. [18669648]

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. [19159218]

A strategy for precise and large scale identification of core fucosylated glycoproteins. [19139490]

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. [19349973]

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. [20068231]

Initial characterization of the human central proteome. [21269460]

Toward a comprehensive characterization of a human cancer cell phosphoproteome. [23186163]

CD81 controls sustained T cell activation signaling and defines the maturation stages of cognate immunological synapses. [23858057]

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. [24275569]

N-terminome analysis of the human mitochondrial proteome. [25944712]

A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. [9539702]

The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand. [9539703]

Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor. [10562537]

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. [12526797]

Structural basis for dimerization of ICAM-1 on the cell surface. [15099525]

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. [16004874]

Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster. [7525451]

DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis. [8557254]

A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya. [9259284]

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. [10391210]

RNA

RNA (Transcript ID: NM_000201.3)

RNA RefSeq ID

NM_000201.3

RNA name

intercellular adhesion molecule 1

Isoforms

All isoforms of ICAM1 containing a lectin domain

RNA Ensembl ID

ENST00000264832.8

Coding region

41..1639 (or 10271160.. 10285287)

mRNA location

10271120.. 10286615

NCBI Matured mRNA sequence 2967 NTP Download

m⁷G-5')ppp(5'-GAGCUCCUCUGCUACUCAGAGUUGCAACCUCAGCCUCGCUAUGGCUCCCAGCAGCCCCCGGCCCGCGCUGCCCGCACUCCUGGUCCUGCUCGGGGCUCUGUUCCCAGGACCUGGCAAUGCCCAGACAUCUGUGUCCCCCUCAAAAGUCAUCCUGCCCCGGGGAGGCUCCGUGCUGGUGACAUGCAGCACCUCCUGUGACCAGCCCAAGUUGUUGGGCAUAGAGACCCCGUUGCCUAAAAAGGAGUUGCUCCUGCCUGGGAACAACCGGAAGGUGUAUGAACUGAGCAAUGUGCAAGAAGAUAGCCAACCAAUGUGCUAUUCAAACUGCCCUGAUGGGCAGUCAACAGCUAAAACCUUCCUCACCGUGUACUGGACUCCAGAACGGGUGGAACUGGCACCCCUCCCCUCUUGGCAGCCAGUGGGCAAGAACCUUACCCUACGCUGCCAGGUGGAGGGUGGGGCACCCCGGGCCAACCUCACCGUGGUGCUGCUCCGUGGGGAGAAGGAGCUGAAACGGGAGCCAGCUGUGGGGGAGCCCGCUGAGGUCACGACCACGGUGCUGGUGAGGAGAGAUCACCAUGGAGCCAAUUUCUCGUGCCGCACUGAACUGGACCUGCGGCCCCAAGGGCUGGAGCUGUUUGAGAACACCUCGGCCCCCUACCAGCUCCAGACCUUUGUCCUGCCAGCGACUCCCCCACAACUUGUCAGCCCCCGGGUCCUAGAGGUGGACACGCAGGGGACCGUGGUCUGUUCCCUGGACGGGCUGUUCCCAGUCUCGGAGGCCCAGGUCCACCUGGCACUGGGGGACCAGAGGUUGAACCCCACAGUCACCUAUGGCAACGACUCCUUCUCGGCCAAGGCCUCAGUCAGUGUGACCGCAGAGGACGAGGGCACCCAGCGGCUGACGUGUGCAGUAAUACUGGGGAACCAGAGCCAGGAGACACUGCAGACAGUGACCAUCUACAGCUUUCCGGCGCCCAACGUGAUUCUGACGAAGCCAGAGGUCUCAGAAGGGACCGAGGUGACAGUGAAGUGUGAGGCCCACCCUAGAGCCAAGGUGACGCUGAAUGGGGUUCCAGCCCAGCCACUGGGCCCGAGGGCCCAGCUCCUGCUGAAGGCCACCCCAGAGGACAACGGGCGCAGCUUCUCCUGCUCUGCAACCCUGGAGGUGGCCGGCCAGCUUAUACACAAGAACCAGACCCGGGAGCUUCGUGUCCUGUAUGGCCCCCGACUGGACGAGAGGGAUUGUCCGGGAAACUGGACGUGGCCAGAAAAUUCCCAGCAGACUCCAAUGUGCCAGGCUUGGGGGAACCCAUUGCCCGAGCUCAAGUGUCUAAAGGAUGGCACUUUCCCACUGCCCAUCGGGGAAUCAGUGACUGUCACUCGAGAUCUUGAGGGCACCUACCUCUGUCGGGCCAGGAGCACUCAAGGGGAGGUCACCCGCAAGGUGACCGUGAAUGUGCUCUCCCCCCGGUAUGAGAUUGUCAUCAUCACUGUGGUAGCAGCCGCAGUCAUAAUGGGCACUGCAGGCCUCAGCACGUACCUCUAUAACCGCCAGCGGAAGAUCAAGAAAUACAGACUACAACAGGCCCAAAAAGGGACCCCCAUGAAACCGAACACACAAGCCACGCCUCCCUGAACCUAUCCCGGGACAGGGCCUCUUCCUCGGCCUUCCCAUAUUGGUGGCAGUGGUGCCACACUGAACAGAGUGGAAGACAUAUGCCAUGCAGCUACACCUACCGGCCCUGGGACGCCGGAGGACAGGGCAUUGUCCUCAGUCAGAUACAACAGCAUUUGGGGCCAUGGUACCUGCACACCUAAAACACUAGGCCACGCAUCUGAUCUGUAGUCACAUGACUAAGCCAAGAGGAAGGAGCAAGACUCAAGACAUGAUUGAUGGAUGUUAAAGUCUAGCCUGAUGAGAGGGGAAGUGGUGGGGGAGACAUAGCCCCACCAUGAGGACAUACAACUGGGAAAUACUGAAACUUGCUGCCUAUUGGGUAUGCUGAGGCCCCACAGACUUACAGAAGAAGUGGCCCUCCAUAGACAUGUGUAGCAUCAAAACACAAAGGCCCACACUUCCUGACGGAUGCCAGCUUGGGCACUGCUGUCUACUGACCCCAACCCUUGAUGAUAUGUAUUUAUUCAUUUGUUAUUUUACCAGCUAUUUAUUGAGUGUCUUUUAUGUAGGCUAAAUGAACAUAGGUCUCUGGCCUCACGGAGCUCCCAGUCCUAAUCACAUUCAAGGUCACCAGGUACAGUUGUACAGGUUGUACACUGCAGGAGAGUGCCUGGCAAAAAGAUCAAAUGGGGCUGGGACUUCUCAUUGGCCAACCUGCCUUUCCCCAGAAGGAGUGAUUUUUCUAUCGGCACAAAAGCACUAUAUGGACUGGUAAUGGUUACAGGUUCAGAGAUUACCCAGUGAGGCCUUAUUCCUCCCUUCCCCCCAAAACUGACACCUUUGUUAGCCACCUCCCCACCCACAUACAUUUCUGCCAGUGUUCACAAUGACACUCAGCGGUCAUGUCUGGACAUGAGUGCCCAGGGAAUAUGCCCAAGCUAUGCCUUGUCCUCUUGUCCUGUUUGCAUUUCACUGGGAGCUUGCACUAUGCAGCUCCAGUUUCCUGCAGUGAUCAGGGUCCUGCAAGCAGUGGGGAAGGGGGCCAAGGUAUUGGAGGACUCCCUCCCAGCUUUGGAAGCCUCAUCCGCGUGUGUGUGUGUGUGUAUGUGUAGACAAGCUCUCGCUCUGUCACCCAGGCUGGAGUGCAGUGGUGCAAUCAUGGUUCACUGCAGUCUUGACCUUUUGGGCUCAAGUGAUCCUCCCACCUCAGCCUCCUGAGUAGCUGGGACCAUAGGCUCACAACACCACACCUGGCAAAUUUGAUUUUUUUUUUUUUUCCAGAGACGGGGUCUCGCAACAUUGCCCAGACUUCCUUUGUGUUAGUUAAUAAAGCUUUCUCAACUGCC-3'- Poly-A tail

Coding region

mRNA-related data

DNA

DNA (Gene ID: 3383)

HGNC Gene symbol

ICAM1

HGNC Gene name

intercellular adhesion molecule 1

Chr. RefSeq ID

NC_000019.10

Chromosome N°

19 10271160.. 10285287

CDS location

10271160.. 10285287

DNA strand

strand +

CCDS ID

CCDS12231.1

Mouse ortholog gene

MGI:96392

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000090339

HGNC other symbol

BB2, CD54

UCSC ID

uc002mnq.3

GeneBank

INSDC:

GeneCards

5344

MIM

147840

VEGA ID

OTTHUMG00000180403

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