NCBI Summary
The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Protein
Protein (NP_775890)
C-type lectin domain family 18 member C
C-type lectin domain family 18 member C (Mannose receptor-like protein 3)
CLEC18C
C-type lectin domain family 18 member C
Undefined
Low evidence
C-type lectin
Undefined
C-type - Others
a/b mixed / C-type lectin-like
Fucoidan and fungal polysaccharides
NP_775890
283971
Q8NCF0
ENSP00000444875.2
A5D8T8
Undefined
10.1074/jbc.M115.649814
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (446 amino acids) Download
MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGIPTPSLASGLWRTLQVGWNMQLLPAGLASFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWNNQRCKTRNRYICQFAQEHISRWGPGS
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q8NCF0-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.58, 2.05] ÅDownload
The location of the lectin domain structural model is: 306-441
We infer [1.58, 2.05] Å as the interval of error of this structural model.
Template 1: 7L67 chain: A, P22897, NP_002429.1, sequence identity: 26.5%, coverage: 85.3%, location in sequence: 659-779, (641-761 in PDB).
Template 2: 3L9J chain: C, P05452, NP_003269.2, sequence identity: 25.0%, coverage: 89.7%, location in sequence: 67-201, (46-180 in PDB).
Template 3: 2OX9 chain: A, Q8K4Q8, NP_569716.2, sequence identity: 23.5%, coverage: 87.5%, location in sequence: 606-735, (606-735 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC18C Gene
References
NCBI References (2 PubMed Identifiers)
  • Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. [26170455]
  • The C-type lectin-like domain superfamily. [16336259]
UniProt Main References (2 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
XP_011521338.1, NP_775890.2, XP_024306007.1
RNA
RNA (Transcript ID: NM_173619.4)
NM_173619.4
C-type lectin domain family 18 member C
All isoforms of CLEC18C containing a lectin domain
ENST00000541793.7
272..1612 (or 70174279.. 70186520)
70173787.. 70186895
NCBI Matured mRNA sequence 1987 NTPDownload 
m7G-5')ppp(5'-GCCCAGUUUCUGCUCACCAGAAGGACCAUAGCCGAGGUCCUCCUCCCAGGGCCCGGGGCUGGGGAGCGGAAGCCAUCAGUGGGCUCGGAGGACACUGUCCCAGCCAGGACACGGCCAUCGGUCACUAAUCUGCAGCACUGGAAUGUCCGCAGGCCAAUCAGCGGGCCCAGCCUGACUCCUGGAGAUUGUGAAUAGCUCCAUCCAGCCUGAGAAACAAGCCGGGUGGCUGAGCCAGGCUGUGCACGGAGUGCCUGACGGGCCCAACAGACCCAUGCUGCAUCCAGAGACCUCCCCUGGCCGGGGGCAUCUCCUGGCUGUGCUCCUGGCCCUCCUUGGCACCGCCUGGGCAGAGGUGUGGCCACCCCAGCUGCAGGAGCAGGCUCCGAUGGCCGGAGCCCUGAACAGGAAGGAGAGUUUCUUGCUCCUCUCCCUGCACAACCGCCUGCGCAGCUGGGUCCAGCCCCCUGCGGCUGACAUGCGGAGGCUGGACUGGAGUGACAGCCUGGCCCAACUGGCUCAAGCCAGGGCAGCCCUCUGUGGAAUCCCAACCCCGAGCCUGGCGUCCGGCCUGUGGCGCACCCUGCAAGUGGGCUGGAACAUGCAGCUGCUGCCCGCGGGCUUGGCGUCCUUUGUUGAAGUGGUCAGCCUAUGGUUUGCAGAGGGGCAGCGGUACAGCCACGCGGCAGGAGAGUGUGCUCGCAACGCCACCUGCACCCACUACACGCAGCUCGUGUGGGCCACCUCAAGCCAGCUGGGCUGUGGGCGGCACCUGUGCUCUGCAGGCCAGGCAGCGAUAGAAGCCUUUGUCUGUGCCUACUCCCCCAGAGGCAACUGGGAGGUCAACGGGAAGACAAUCGUCCCCUAUAAGAAGGGUGCCUGGUGUUCGCUCUGCACAGCCAGUGUCUCAGGCUGCUUCAAAGCCUGGGACCAUGCAGGGGGGCUCUGUGAGGUCCCCAGGAAUCCUUGUCGCAUGAGCUGCCAGAACCAUGGACGUCUCAACAUCAGCACCUGCCACUGCCACUGUCCCCCUGGCUACACGGGCAGAUACUGCCAAGUGAGGUGCAGCCUGCAGUGUGUGCACGGCCGGUUCCGGGAGGAGGAGUGCUCGUGCGUCUGUGACAUCGGCUACGGGGGAGCCCAGUGUGCCACCAAGGUGCAUUUUCCCUUCCACACCUGUGACCUGAGGAUCGACGGAGACUGCUUCAUGGUGUCUUCAGAGGCAGACACCUAUUACAGAGCCAGGAUGAAAUGUCAGAGGAAAGGCGGGGUGCUGGCCCAGAUCAAGAGCCAGAAAGUGCAGGACAUCCUCGCCUUCUAUCUGGGCCGCCUGGAGACCACCAACGAGGUGAUUGACAGUGACUUCGAGACCAGGAACUUCUGGAUCGGGCUCACCUACAAGACCGCCAAGGACUCCUUCCGCUGGGCCACAGGGGAGCACCAGGCCUUCACCAGUUUUGCCUUUGGGCAGCCUGACAACCACGGGUUUGGCAACUGCGUGGAGCUGCAGGCUUCAGCUGCCUUCAACUGGAACAACCAGCGCUGCAAAACCCGAAACCGUUACAUCUGCCAGUUUGCCCAGGAGCACAUCUCCCGGUGGGGCCCAGGGUCCUGAGGCCUGACCACAUGGCUCCCUCGCCUGCCCUGGGAGCACCGGCUCUGCUUACCUGUCCGCCCACCUGUCUGGAACAAGGGCCAGGUUAAGACCACAUGCCUCAUGUCCAAAGAGGUCUCAGACCUUGCACAAUGCCAGAAGUUGGGCAGAGAGAGGCAGGGAGGCCAGUGAGGGCCAGGGAGUGAGUGUUAGAAGAAGCUGGGGCCCUUCGCCUGCUUUUGAUUGGGAAGAUGGGCUUCAAUUAGAUGGCAAAGGAGAGGACACCGCCAGUGGUCCAAAAAGGCUGCUCUCUUCCACCUGGCCCAGACCCUGUGGGGCAGCGGAGCUUCCCUGUGGCAUGAACCCCACAGGGUAUUAAAUUAUGAAUCAGCUGAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 283971)
CLEC18C
C-type lectin domain family 18 member C
NC_000016.10
16  70174279.. 70186520
70174279.. 70186520
strand +
CCDS32473.1
MGI:2672935
ClinVar, dbVar
ENSG00000157335
MGC34761
uc059wnv.1
INSDC: AL833339
28538
616573
OTTHUMG00000176982
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1341 bp)
5'-ATGCTGCATCCAGAGACCTCCCCTGGCCGGGGGCATCTCCTGGCTGTGCTCCTGGCCCTCCTTGGCACCGCCTGGGCAGAGGTGTGGCCACCCCAGCTGCAGGAGCAGGCTCCGATGGCCGGAGCCCTGAACAGGAAGGAGAGTTTCTTGCTCCTCTCCCTGCACAACCGCCTGCGCAGCTGGGTCCAGCCCCCTGCGGCTGACATGCGGAGGCTGGACTGGAGTGACAGCCTGGCCCAACTGGCTCAAGCCAGGGCAGCCCTCTGTGGAATCCCAACCCCGAGCCTGGCGTCCGGCCTGTGGCGCACCCTGCAAGTGGGCTGGAACATGCAGCTGCTGCCCGCGGGCTTGGCGTCCTTTGTTGAAGTGGTCAGCCTATGGTTTGCAGAGGGGCAGCGGTACAGCCACGCGGCAGGAGAGTGTGCTCGCAACGCCACCTGCACCCACTACACGCAGCTCGTGTGGGCCACCTCAAGCCAGCTGGGCTGTGGGCGGCACCTGTGCTCTGCAGGCCAGGCAGCGATAGAAGCCTTTGTCTGTGCCTACTCCCCCAGAGGCAACTGGGAGGTCAACGGGAAGACAATCGTCCCCTATAAGAAGGGTGCCTGGTGTTCGCTCTGCACAGCCAGTGTCTCAGGCTGCTTCAAAGCCTGGGACCATGCAGGGGGGCTCTGTGAGGTCCCCAGGAATCCTTGTCGCATGAGCTGCCAGAACCATGGACGTCTCAACATCAGCACCTGCCACTGCCACTGTCCCCCTGGCTACACGGGCAGATACTGCCAAGTGAGGTGCAGCCTGCAGTGTGTGCACGGCCGGTTCCGGGAGGAGGAGTGCTCGTGCGTCTGTGACATCGGCTACGGGGGAGCCCAGTGTGCCACCAAGGTGCATTTTCCCTTCCACACCTGTGACCTGAGGATCGACGGAGACTGCTTCATGGTGTCTTCAGAGGCAGACACCTATTACAGAGCCAGGATGAAATGTCAGAGGAAAGGCGGGGTGCTGGCCCAGATCAAGAGCCAGAAAGTGCAGGACATCCTCGCCTTCTATCTGGGCCGCCTGGAGACCACCAACGAGGTGATTGACAGTGACTTCGAGACCAGGAACTTCTGGATCGGGCTCACCTACAAGACCGCCAAGGACTCCTTCCGCTGGGCCACAGGGGAGCACCAGGCCTTCACCAGTTTTGCCTTTGGGCAGCCTGACAACCACGGGTTTGGCAACTGCGTGGAGCTGCAGGCTTCAGCTGCCTTCAACTGGAACAACCAGCGCTGCAAAACCCGAAACCGTTACATCTGCCAGTTTGCCCAGGAGCACATCTCCCGGTGGGGCCCAGGGTCCTGA-3'
NCBI CDS gene sequence with introns (location: 70174279.. 70186520) (12242 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 70173787.. 70186895) (13109 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [70173787 - 1000].. 70186895) (14109 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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