NCBI Summary
This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Protein
Protein (NP_689551)
Zymogen granule protein 16
Zymogen granule membrane protein 16 (Zymogen granule protein 16) (hZG16) (Secretory lectin ZG16)
ZG16
zymogen granule protein 16
Undefined
Curated
Jacalin-like
Undefined
b-prism I
Man / Man(a1-3)Man / Man-Ser
NP_689551
653808
O60844
ENSP00000383563.4
O60844
0.543
10.1074/jbc.M113.539114
neXtProt, PFAM, InterPro, CFG data
Protein sequence and protein families (fasta) (167 amino acids) Download
MLTVALLALLCASASGNAIQARSSSYSGEYGGGGGKRFSHSGNQLDGPITALRVRVNTYYIVGLQVRYGKVWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLVFVTDKGRYLSFGKDSGTSFNAVPLHPNTVLRFISGRSGSLIDAIGLHWDVYPSSCSRC
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-O60844-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
bGlc13Glc
Glc(b1-3)Glc
3VY6
3VY6
GlyConnect Structures
aMan13Man
Man(a1-3)Man
3VZE
3VZE
GlyConnect Structures
aMan-O-Thr, aMeMan, aMan-O-Ser
Man
3VY7, 3VZG, 3VZF
3VY7, 3VZG, 3VZF
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for ZG16 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • A reference map of the human binary protein interactome. [32296183]
  • Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer. [29661177]
  • Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer. [27880730]
  • Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides. [25919894]
  • Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system. [21893569]
  • Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold. [21110947]
  • hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma. [17307141]
  • Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system. [16237761]
  • Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
  • cDNA cloning and characterization of a novel 16 kDa protein located in zymogen granules of rat pancreas and goblet cells of the gut. [7720729]
UniProt Main References (4 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The sequence and analysis of duplication-rich human chromosome 16. [15616553]
  • Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. [10493829]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_689551.3, XP_011544223.1
RNA
RNA (Transcript ID: NM_152338.4)
NM_152338.4
zymogen granule protein 16
All isoforms of ZG16 containing a lectin domain
ENST00000400752.6
59..562 (or 29779267.. 29780419)
29778256.. 29782973
NCBI Matured mRNA sequence 3116 NTPDownload 
m7G-5')ppp(5'-AUAAAACAUCUGGAAGUUUCCAGGGGGCUGCUUUGCAUCUGAAACUGUCAGCCCCAGAAUGUUGACAGUCGCUCUCCUAGCCCUUCUCUGUGCCUCAGCCUCUGGCAAUGCCAUUCAGGCCAGGUCUUCCUCCUAUAGUGGAGAGUAUGGAGGUGGUGGUGGAAAGCGAUUCUCUCAUUCUGGCAACCAGUUGGACGGCCCCAUCACCGCCCUCCGGGUCCGAGUCAACACAUACUACAUCGUAGGUCUUCAGGUGCGCUAUGGCAAGGUGUGGAGCGACUAUGUGGGUGGUCGCAACGGAGACCUGGAGGAGAUCUUUCUGCACCCUGGGGAAUCAGUGAUCCAGGUUUCUGGGAAGUACAAGUGGUACCUGAAGAAGCUGGUAUUUGUGACAGACAAGGGCCGCUAUCUGUCUUUUGGGAAAGACAGUGGCACAAGUUUCAAUGCCGUCCCCUUGCACCCCAACACCGUGCUCCGCUUCAUCAGUGGCCGGUCUGGUUCUCUCAUCGAUGCCAUUGGCCUGCACUGGGAUGUUUACCCCAGUAGCUGCAGCAGAUGCUGAGCCUCCUCUCCUUGGCAGGGGCACUGUGAUGAGGAGUAAGAACUCCCUUAUCACUAACCCCCAUCCAAAUGGCUCAAUAAAAAAAAUAUGGUUAAGGCUAGUCUGUGUGGGGGCAUCUGUGGCUGGGAUAUCUGCCUCCUGACUUAGCCGGGGACGUGCAAAUCUCACUUCUGGCUGGCUUUGGACAUCUGUCUGGAAGAUGGGAAGAUGAGGGAGAGGUAUGUAAGAAUCCUGGGCUUUGUGCUAUAAUUUAUCAAGAGGAGAUGAGAUUCUGGCUUGCAUCAACGCUCUUCAAGGACAGCUCCUUGGAACAUUGAUCCAAACUGGAGUCAUGGGUCUGAGGGCAAGGCCUAGUUGUGGCUUACACCAAAACCCCAGAUGUCCCACUCUCCAGCUCUCCUCACCCCUGGUCCUCCCCUUGAGAAAGUGGUGAACUCACUUGCUGUGUGUGGGUGGCCAGGACCAUUAGCCUUUGUUCUUUCCCAGAACCCACCUGACUCCUGAAACUUAGCUGAAGUCUGUGCCCGAGGACCCUGCCCUGUUACCAGGCCCAGUUCCUCCUCACCUCUACCCAUGAGCCCCGGUGUCCUGCUAAGCCCUCUCAGAUCUGGGAUUCCUCCUUCCUCAGGAAGCCACCACCUUCUCAGCAGUGGAAACCCUGCCCACACUAUGCUCUUAGGCUUUAGCCAUCAGAAGGUUACAGUGGACUGCGGGAGGCUGACACUAGGCUGAACUCAUUAAGGAAUGAAUGGGAGGUGAGAAGACACAGGCAGCAAGAAUCGAGUGUUUCAAGAAGUUUGGCUGUGGUUUGCCAGAAAUAGGCAAGUCAGUUUUCGGGGGUGUAAGGAAAAAGGGUUUUGUGUCUUUUUAAAAUCCUAGACAGGAGAGUCACAAGCAUGUUCACAUGAUAAAGAGGAAGAAAGAGAAAGAGGCUGGAGAUUCUGAAAAGAGAUCACUGGUGAGGUCUCAAAAGAGAUAGAAGAGGAUGGUUAUGUAGUUGGGGAAAGAAAUUUUAAGAAGGGAAGAAAAUUAAAAUGAGUGAAGGUAUACGUUAGUUUUGUAAAAGUUAUCAAUAUCUGGCUGGGCACAGUGCUCACACCUGUAAUCCCAGCACUUUGGGAGGCCAAGGCAGGCAGAUCAUUUGAGGUCAGGAGUUGGAGACAAGCCUCCAACAUGGUAAAACCCUGUCUCUACUAAAAAUACAAAAAUUAGCCAGGUGUGGUGGCAGUCACCUGUAAUCCCAGCUACUUGGGAGGCUGAGGCAUGAGAAUCACUUGAAUGCUGGAGGCAGAGGUUACAAUGAGUUGAGACAGCACAACUGCACCCCAGCCUGGAUGACAGAGUGAGACUCCAUCUAAAAAAAAAAGGAAUGUUAUCAGUAUCAAAAUGGAGUAACAUAUGUCACAUCCUAACAAAAUGGAACCAACCUGACACCUAAAUUAAGCAUUGCACCUGAUAACACCAUGGAGGACUGGGUGGAGAAUCAGCAGACAAUGGCAGGGAGAGGCAGUCUGUGGACCAAGUUCAGGUGAAAGGAUCACCCAUCAUGUUGGGCAUCAGAUCAGGCAGGUUCACACACUACCUGAGGAAGCUGGUCUUUGUGACAGACAAGAGCUGCUCUGCCUCUUGGGAAACACAGGCACCAGUUUUAGUGCCAUCUUCUUGCACCCAAAUGCUGUCCUUUAACUCAUCAGUUACAGUGCUGGAUCCCUCAUCACUGCCAAUACGGGGCUAGCAAUAUGUCUGCCCCAGUGAAUGCAGCCGCCACGGAGCCCCAGCCUCCUCUAUGGCAGGGGCCCUGUGGUGGGGAAUGAGGACUUCUCUAUCAUUAACCUCCAUGCAGUUGGCUCAAGAAAAGGAUAUGGUAGUUGGGCAAGGGGGCUCACACCUGUAAUCCCAGCACACUUGUAAUCCCAGGAGGGUCGCUUGAGCCCAGGAGUUUAAGGCCAGCCCGGGCAACAUAGCAACCUGUUUGUAGGCAAAAUGAGGAGUUGAAGUUCCCCGUAGGAUCUUCUAGGGCUCAACCAGCCUUCAUGUGCAGUGGGACUGGCAAGAAAUCUGUCAUCCCUGUUACCACUUUGAAGGUCUCAGUGUGUAUGCAGGUCCUGAAAAGUUCAAGUCCCACCUGAAACGCAACACAGCAUCAUGCUCUGAUUCAUCAGUGAUUCCCUAAUCAAUGCCAUUGGCUUGCAUUGGGACUAUCUAUCCCAGCCUAUCCAGUGACUUCAGCAGCUGCAGAGCCCCAGCCUCUUCUUUGGCAGGGGCACUGUGGUGAGGAGGAAGGAUUCCCUUAUCACAAAUCUCCAUCCAAUUGGUUCUAUAAACAGAUAUGGUGGCCCAACUGUUGCGGGAAGUCAGGGACCCCGAACGGAGGGACUGGCUGGAGCCACAGCUGAGGAACAUAAAUUGUGAAGAUUUCAUGGACAUUUACCAGUUCCCAAAAUUAAUACUUUUAUACUUUCUUAUGCCUGUCUUUACUGCAAUCACUAAACAUAAAUUGUGAAGAUUUCAUGAACAUUUAUCAGUUCCCAAAUAAUACUCUUAUAAUUUCUUA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 653808)
ZG16
zymogen granule protein 16
NC_000016.10
16  29779267.. 29780419
29779267.. 29780419
strand +
CCDS54000.1
MGI:1916286
ClinVar, dbVar
ENSG00000174992
hZG16, JCLN1, ZG16A
uc002dtr.5
INSDC: AK125559
30961
617311
OTTHUMG00000177139
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (504 bp)
5'-ATGTTGACAGTCGCTCTCCTAGCCCTTCTCTGTGCCTCAGCCTCTGGCAATGCCATTCAGGCCAGGTCTTCCTCCTATAGTGGAGAGTATGGAGGTGGTGGTGGAAAGCGATTCTCTCATTCTGGCAACCAGTTGGACGGCCCCATCACCGCCCTCCGGGTCCGAGTCAACACATACTACATCGTAGGTCTTCAGGTGCGCTATGGCAAGGTGTGGAGCGACTATGTGGGTGGTCGCAACGGAGACCTGGAGGAGATCTTTCTGCACCCTGGGGAATCAGTGATCCAGGTTTCTGGGAAGTACAAGTGGTACCTGAAGAAGCTGGTATTTGTGACAGACAAGGGCCGCTATCTGTCTTTTGGGAAAGACAGTGGCACAAGTTTCAATGCCGTCCCCTTGCACCCCAACACCGTGCTCCGCTTCATCAGTGGCCGGTCTGGTTCTCTCATCGATGCCATTGGCCTGCACTGGGATGTTTACCCCAGTAGCTGCAGCAGATGCTGA-3'
NCBI CDS gene sequence with introns (location: 29779267.. 29780419) (1153 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 29778256.. 29782973) (4718 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [29778256 - 1000].. 29782973) (5718 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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