HumanLectome - Human Lectin Entry

NCBI Summary

This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Protein name

Regenerating family member 4

Synonym(s)

Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV)

HGNC gene name

REG4

HGNC name

regenerating family member 4

Protein_CD_name

Undefined

Lectin confidence

Curated

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - Free C-type Lectin Domains CTLDs

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Man / Mannan

RefSeq accession

NP_001152824

Gene ID

83998

UniProt accession

Q9BYZ8

Ensembl protein ID

Undefined

UniRef cluster ID

Q9BYZ8

LectomeXplore score

0.31

Reference

10.1016/j.jmb.2010.07.061

Other links

neXtProt, PFAM, InterPro

Protein sequence and protein families (fasta) (158 amino acids) Download

MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-Q9BYZ8-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Expression

Human Protein Atlas

GeneCards

mRNA expression in normal human tissues for REG4 Gene

ProteomicsDB

References

NCBI References (10 PubMed Identifiers)

Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer. [34577861]

CDX2 and Reg IV expression and correlation in gastric cancer. [33639844]

A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/beta-catenin signaling. [31605540]

Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma. [31659102]

REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. [31428934]

Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]

Overexpression of Reg IV in colorectal adenoma. [14550954]

RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. [12819006]

Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. [12455032]

Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. [11311942]

UniProt Main References (3 PubMed Identifiers)

The DNA sequence and biological annotation of human chromosome 1. [16710414]

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]

Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. [20692269]

All isoforms of this gene containing a lectin domain

NP_001152824.1, NP_114433.1

RNA

RNA (Transcript ID: NM_001159352.2)

RNA RefSeq ID

NM_001159352.2

RNA name

regenerating family member 4, transcript variant 1

Isoforms

All isoforms of REG4 containing a lectin domain

RNA Ensembl ID

Coding region

321..797 (or 119794618.. 119808769)

mRNA location

119794017.. 119811460

NCBI Matured mRNA sequence 1398 NTP Download

m⁷G-5')ppp(5'-ACUGGAGACACUGAAGAAGGCAGGGGCCCUUAGAGUCUUGGUUGCCAAACAGAAUGCCCAUAUCCGUCUUACCUGUGAGGAAGCUUGCCUUGGGCGCCCUCUGCUGGCCCUCCUGAAGCUAACAGGGGCGAGUGCUCGGUGGUUUACAAAUUGCCUCCAUGCAGACUAUGAAACUGUUCAGCCUGCUAUAGUUAGAUCUCUGGCACUGGCCCAGGAGGUCUUGCAGAUUUGCAGAUCAAGGAGAACCCAGGAGUUUCAAAGAAGCGCUAGUAAGGUCUCUGAGAUCCUUGCACUAGCUACAUCCUCAGGGUAGGAGGAAGAUGGCUUCCAGAAGCAUGCGGCUGCUCCUAUUGCUGAGCUGCCUGGCCAAAACAGGAGUCCUGGGUGAUAUCAUCAUGAGACCCAGCUGUGCUCCUGGAUGGUUUUACCACAAGUCCAAUUGCUAUGGUUACUUCAGGAAGCUGAGGAACUGGUCUGAUGCCGAGCUCGAGUGUCAGUCUUACGGAAACGGAGCCCACCUGGCAUCUAUCCUGAGUUUAAAGGAAGCCAGCACCAUAGCAGAGUACAUAAGUGGCUAUCAGAGAAGCCAGCCGAUAUGGAUUGGCCUGCACGACCCACAGAAGAGGCAGCAGUGGCAGUGGAUUGAUGGGGCCAUGUAUCUGUACAGAUCCUGGUCUGGCAAGUCCAUGGGUGGGAACAAGCACUGUGCUGAGAUGAGCUCCAAUAACAACUUUUUAACUUGGAGCAGCAACGAAUGCAACAAGCGCCAACACUUCCUGUGCAAGUACCGACCAUAGAGCAAGAAUCAAGAUUCUGCUAACUCCUGCACAGCCCCGUCCUCUUCCUUUCUGCUAGCCUGGCUAAAUCUGCUCAUUAUUUCAGAGGGGAAACCUAGCAAACUAAGAGUGAUAAGGGCCCUACUACACUGGCUUUUUUAGGCUUAGAGACAGAAACUUUAGCAUUGGCCCAGUAGUGGCUUCUAGCUCUAAAUGUUUGCCCCGCCAUCCCUUUCCACAGUAUCCUUCUUCCCUCCUCCCCUGUCUCUGGCUGUCUCGAGCAGUCUAGAAGAGUGCAUCUCCAGCCUAUGAAACAGCUGGGUCUUUGGCCAUAAGAAGUAAAGAUUUGAAGACAGAAGGAAGAAACUCAGGAGUAAGCUUCUAGACCCCUUCAGCUUCUACACCCUUCUGCCCUCUCUCCAUUGCCUGCACCCCACCCCAGCCACUCAACUCCUGCUUGUUUUUCCUUUGGCCAUGGGAAGGUUUACCAGUAGAAUCCUUGCUAGGUUGAUGUGGGCCAUACAUUCCUUUAAUAAACCAUUGUGUACAUAAGAGGUUGCUGUGUUCCAGUUCAGUAAUGGUGAAUGUGGAAAAGUGAAAUAAGACCAAGAAAUACACCCAA-3'- Poly-A tail

Coding region

NCBI Matured mRNA sequence viewer

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More about the NCBI sViewer.

DNA

DNA (Gene ID: 83998)

HGNC Gene symbol

REG4

HGNC Gene name

regenerating family member 4

Chr. RefSeq ID

NC_000001.11

Chromosome N°

1 119794618.. 119808769

CDS location

119794618.. 119808769

DNA strand

strand -

CCDS ID

CCDS906.1

Mouse ortholog gene

MGI:1914959

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000134193

HGNC other symbol

REG-IV, RELP, GISP

UCSC ID

uc001eif.4

GeneBank

INSDC: AY007243

GeneCards

22977

MIM

609846

VEGA ID

OTTHUMG00000012175

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