NCBI Summary
This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Protein
Protein (NP_001152824)
Regenerating family member 4
Regenerating islet-derived protein 4 (REG-4) (Gastrointestinal secretory protein) (REG-like protein) (Regenerating islet-derived protein IV) (Reg IV)
REG4
regenerating family member 4
Undefined
Curated
C-type lectin
Undefined
C-type - Free C-type Lectin Domains CTLDs
a/b mixed / C-type lectin-like
Man / Mannan
Undefined
0.31
MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP
Mol* PDB structure viewerUniLectin3D
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer. [34577861]
- CDX2 and Reg IV expression and correlation in gastric cancer. [33639844]
- A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/beta-catenin signaling. [31605540]
- Regulation of REG4 Expression and Prediction of 5-Fluorouracil Sensitivity by CDX2 in Ovarian Mucinous Carcinoma. [31659102]
- REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. [31428934]
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. [15340161]
- Overexpression of Reg IV in colorectal adenoma. [14550954]
- RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa. [12819006]
- Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. [12455032]
- Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. [11311942]
UniProt Main References (3 PubMed Identifiers)
- The DNA sequence and biological annotation of human chromosome 1. [16710414]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites. [20692269]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_001159352.2)
regenerating family member 4, transcript variant 1
m7G-5')ppp(5'-ACUGGAGACACUGAAGAAGGCAGGGGCCCUUAGAGUCUUGGUUGCCAAACAGAAUGCCCAUAUCCGUCUUACCUGUGAGGAAGCUUGCCUUGGGCGCCCUCUGCUGGCCCUCCUGAAGCUAACAGGGGCGAGUGCUCGGUGGUUUACAAAUUGCCUCCAUGCAGACUAUGAAACUGUUCAGCCUGCUAUAGUUAGAUCUCUGGCACUGGCCCAGGAGGUCUUGCAGAUUUGCAGAUCAAGGAGAACCCAGGAGUUUCAAAGAAGCGCUAGUAAGGUCUCUGAGAUCCUUGCACUAGCUACAUCCUCAGGGUAGGAGGAAGAUGGCUUCCAGAAGCAUGCGGCUGCUCCUAUUGCUGAGCUGCCUGGCCAAAACAGGAGUCCUGGGUGAUAUCAUCAUGAGACCCAGCUGUGCUCCUGGAUGGUUUUACCACAAGUCCAAUUGCUAUGGUUACUUCAGGAAGCUGAGGAACUGGUCUGAUGCCGAGCUCGAGUGUCAGUCUUACGGAAACGGAGCCCACCUGGCAUCUAUCCUGAGUUUAAAGGAAGCCAGCACCAUAGCAGAGUACAUAAGUGGCUAUCAGAGAAGCCAGCCGAUAUGGAUUGGCCUGCACGACCCACAGAAGAGGCAGCAGUGGCAGUGGAUUGAUGGGGCCAUGUAUCUGUACAGAUCCUGGUCUGGCAAGUCCAUGGGUGGGAACAAGCACUGUGCUGAGAUGAGCUCCAAUAACAACUUUUUAACUUGGAGCAGCAACGAAUGCAACAAGCGCCAACACUUCCUGUGCAAGUACCGACCAUAGAGCAAGAAUCAAGAUUCUGCUAACUCCUGCACAGCCCCGUCCUCUUCCUUUCUGCUAGCCUGGCUAAAUCUGCUCAUUAUUUCAGAGGGGAAACCUAGCAAACUAAGAGUGAUAAGGGCCCUACUACACUGGCUUUUUUAGGCUUAGAGACAGAAACUUUAGCAUUGGCCCAGUAGUGGCUUCUAGCUCUAAAUGUUUGCCCCGCCAUCCCUUUCCACAGUAUCCUUCUUCCCUCCUCCCCUGUCUCUGGCUGUCUCGAGCAGUCUAGAAGAGUGCAUCUCCAGCCUAUGAAACAGCUGGGUCUUUGGCCAUAAGAAGUAAAGAUUUGAAGACAGAAGGAAGAAACUCAGGAGUAAGCUUCUAGACCCCUUCAGCUUCUACACCCUUCUGCCCUCUCUCCAUUGCCUGCACCCCACCCCAGCCACUCAACUCCUGCUUGUUUUUCCUUUGGCCAUGGGAAGGUUUACCAGUAGAAUCCUUGCUAGGUUGAUGUGGGCCAUACAUUCCUUUAAUAAACCAUUGUGUACAUAAGAGGUUGCUGUGUUCCAGUUCAGUAAUGGUGAAUGUGGAAAAGUGAAAUAAGACCAAGAAAUACACCCAA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 83998)
regenerating family member 4
strand -
REG-IV, RELP, GISP
NCBI CDS gene sequence (477 bp)
5'-ATGGCTTCCAGAAGCATGCGGCTGCTCCTATTGCTGAGCTGCCTGGCCAAAACAGGAGTCCTGGGTGATATCATCATGAGACCCAGCTGTGCTCCTGGATGGTTTTACCACAAGTCCAATTGCTATGGTTACTTCAGGAAGCTGAGGAACTGGTCTGATGCCGAGCTCGAGTGTCAGTCTTACGGAAACGGAGCCCACCTGGCATCTATCCTGAGTTTAAAGGAAGCCAGCACCATAGCAGAGTACATAAGTGGCTATCAGAGAAGCCAGCCGATATGGATTGGCCTGCACGACCCACAGAAGAGGCAGCAGTGGCAGTGGATTGATGGGGCCATGTATCTGTACAGATCCTGGTCTGGCAAGTCCATGGGTGGGAACAAGCACTGTGCTGAGATGAGCTCCAATAACAACTTTTTAACTTGGAGCAGCAACGAATGCAACAAGCGCCAACACTTCCTGTGCAAGTACCGACCATAG-3'
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