Protein
Protein (NP_660295)
Zymogen granule protein 16 homolog B
Zymogen granule protein 16 homolog B
ZG16B
zymogen granule protein 16B
Undefined
Curated
Jacalin-like
Undefined
b-prism I
MLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSVQVKLGDSWDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMYTSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEWNYPLEEPTTEPPVNLTYSANSPVGR
Mol* PDB structure viewerUniLectin3D
Oligomerization and Known Interactions
Interacts with MUC7; this interaction enhances the capture of commensal bacteria and promotes their removal via the mucin-assisted clearance pathway (PubMed:37216558). Found in a complex with the salivary mucin MUC7 and with Streptococcus vestibularis (PubMed:37216558)
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/beta-catenin pathway. [31095674]
- A reference map of the human binary protein interactome. [32296183]
- DCPP1 is the mouse ortholog of human PAUF that possesses functional analogy in pancreatic cancer. [28988106]
- Pancreatic adenocarcinoma up-regulated factor has oncogenic functions in oral squamous cell carcinoma. [27706833]
- Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer. [27322081]
- Identification of a human ortholog of the mouse Dcpp gene locus, encoding a novel member of the CSP-1/Dcpp salivary protein family. [16954406]
- Human colostrum: identification of minor proteins in the aqueous phase by proteomics. [16502470]
- Transcriptome analysis of human gastric cancer. [16341674]
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
- Mass spectrometry allows direct identification of proteins in large genomes. [11678034]
UniProt Main References (4 PubMed Identifiers)
- The sequence and analysis of duplication-rich human chromosome 16. [15616553]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
- Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold. [21110947]
RNA
RNA (Transcript ID: NM_145252.3)
m7G-5')ppp(5'-CAACCAGACGCCCAGUCACAGGCGAGAGCCCUGGGAUGCACCGGCCAGAGGCCAUGCUGCUGCUGCUCACGCUUGCCCUCCUGGGGGGCCCCACCUGGGCAGGGAAGAUGUAUGGCCCUGGAGGAGGCAAGUAUUUCAGCACCACUGAAGACUACGACCAUGAAAUCACAGGGCUGCGGGUGUCUGUAGGUCUUCUCCUGGUGAAAAGUGUCCAGGUGAAACUUGGAGACUCCUGGGACGUGAAACUGGGAGCCUUAGGUGGGAAUACCCAGGAAGUCACCCUGCAGCCAGGCGAAUACAUCACAAAAGUCUUUGUCGCCUUCCAAGCUUUCCUCCGGGGUAUGGUCAUGUACACCAGCAAGGACCGCUAUUUCUAUUUUGGGAAGCUUGAUGGCCAGAUCUCCUCUGCCUACCCCAGCCAAGAGGGGCAGGUGCUGGUGGGCAUCUAUGGCCAGUAUCAACUCCUUGGCAUCAAGAGCAUUGGCUUUGAAUGGAAUUAUCCACUAGAGGAGCCGACCACUGAGCCACCAGUUAAUCUCACAUACUCAGCAAACUCACCCGUGGGUCGCUAGGGUGGGGUAUGGGGCCAUCCGAGCUGAGGCCAUCUGGGUGGUGGUGGCUGAUGGUACUGGAGUAACUGAGUCGGGACGCUGAAUCUGAAUCCACCAAUAAAUAAAGGUUCUGCAGAA-3'- Poly-A tail - Coding region
DNA
DNA (Gene ID: 124220)
zymogen granule protein 16B
strand +
HRPE773, PRO1567, JCLN2
NCBI CDS gene sequence (519 bp)
5'-ATGCTGCTGCTGCTCACGCTTGCCCTCCTGGGGGGCCCCACCTGGGCAGGGAAGATGTATGGCCCTGGAGGAGGCAAGTATTTCAGCACCACTGAAGACTACGACCATGAAATCACAGGGCTGCGGGTGTCTGTAGGTCTTCTCCTGGTGAAAAGTGTCCAGGTGAAACTTGGAGACTCCTGGGACGTGAAACTGGGAGCCTTAGGTGGGAATACCCAGGAAGTCACCCTGCAGCCAGGCGAATACATCACAAAAGTCTTTGTCGCCTTCCAAGCTTTCCTCCGGGGTATGGTCATGTACACCAGCAAGGACCGCTATTTCTATTTTGGGAAGCTTGATGGCCAGATCTCCTCTGCCTACCCCAGCCAAGAGGGGCAGGTGCTGGTGGGCATCTATGGCCAGTATCAACTCCTTGGCATCAAGAGCATTGGCTTTGAATGGAATTATCCACTAGAGGAGCCGACCACTGAGCCACCAGTTAATCTCACATACTCAGCAAACTCACCCGTGGGTCGCTAG-3'
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