NCBI Summary
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011].
Protein
Protein (NP_056516)
Endoplasmic reticulum lectin 1
Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) (XTP3-transactivated gene B protein)
ERLEC1
endoplasmic reticulum lectin 1
Undefined
Curated
P-type lectin-like
P-typeLectins
b-barrel
Man(a1-3)[Man(a1-6)][Man(a1-6)][Man(a1-3)]Man
NP_056516
27248
Q96DZ1
ENSP00000185150.4
Q96DZ1
0.486
10.1093/glycob/cwp182
PFAM, InterPro
Protein sequence and protein families (fasta) (483 amino acids) Download
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEEEEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKNIEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFKPLTLRQLEQQEEILRVPFRRNKEEDLQSTKEERFPAIHKSIAIGSQPVLTVGTTHISKLTDDQLIKEFLSGSYCFRGGVGWWKYEFCYGKHVHQYHEDKDSGKTSVVVGTWNQEEHIEWAKKNTARAYHLQDDGTQTVRMVSHFYGNGDICDITDKPRQVTVKLKCKESDSPHAVTVYMLEPHSCQYILGVESPVICKILDTADENGLLSLPN
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q96DZ1-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions
May form a complex with OS9, HSPA5, SYVN1, and SEL1L with which it interacts directly. Interacts (via PRKCSH 2 domain) with KREMEN2 (when glycosylated). Interacts with HSPA5
Annotation
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
Functionality temporarily unavailable.
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Identification of pathogenic variants of ERLEC1 in individuals with Class III malocclusion by exome sequencing. [32442352]
  • Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation. [29706535]
  • Identification of ERAD components essential for dislocation of the null Hong Kong variant of alpha-1-antitrypsin (NHK). [25660456]
  • Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded alpha1-antitrypsin variant. [23356641]
  • Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways. [21118962]
  • Human XTP3-B binds to alpha1-antitrypsin variant null(Hong Kong) via the C-terminal MRH domain in a glycan-dependent manner. [19917667]
  • Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. [18502753]
  • Sweet bays of ERAD. [18538572]
  • OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. [18264092]
  • The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. [16531414]
UniProt Main References (5 PubMed Identifiers)
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [15815621]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • N-terminome analysis of the human mitochondrial proteome. [25944712]
All isoforms of this gene containing a lectin domain
NP_001120870.1, NP_056516.2, XP_024308561.1, XP_011531068.1, XP_024308560.1, NP_001120869.1
RNA
RNA (Transcript ID: NM_015701.5)
NM_015701.5
endoplasmic reticulum lectin 1, transcript variant 1
All isoforms of ERLEC1 containing a lectin domain
ENST00000185150.9
168..1619 (or 53787211.. 53817969)
53787044.. 53818796
NCBI Matured mRNA sequence 2446 NTPDownload 
m7G-5')ppp(5'-GGAGGCGGCGUUGCCGGGCUCUCCGGAAGGAGACGUGGCGGCGGUUGGGCCGGUGAUACCCGGGCGCUUUAUAGUCCCGCCGCCUCCUCCUCCACCUCCUCCUCCUCCUCCUCUCCUCCUGGAGCAGAGGAGGUUGUGGCGGUGGCUGGAGAAAGCGGCGGCGGAGGAUGGAGGAAGGAGGCGGCGGCGUACGGAGUCUGGUCCCGGGCGGGCCGGUGUUACUGGUCCUCUGCGGCCUCCUGGAGGCGUCCGGCGGCGGCCGAGCCCUUCCUCAACUCAGCGAUGACAUCCCUUUCCGAGUCAACUGGCCCGGCACCGAGUUCUCUCUGCCCACAACUGGAGUUUUAUAUAAAGAAGAUAAUUAUGUCAUCAUGACAACUGCACAUAAAGAAAAAUAUAAAUGCAUACUUCCCCUUGUGACAAGUGGGGAUGAGGAAGAAGAAAAGGAUUAUAAAGGCCCUAAUCCAAGAGAGCUUUUGGAGCCACUAUUUAAACAAAGCAGUUGUUCCUACAGAAUUGAGUCUUAUUGGACUUACGAAGUAUGUCAUGGAAAACACAUUCGGCAGUACCAUGAAGAGAAAGAAACUGGUCAGAAAAUAAAUAUUCACGAGUACUACCUUGGGAAUAUGUUGGCCAAGAACCUUCUAUUUGAAAAAGAACGAGAAGCAGAAGAAAAGGAAAAAUCAAAUGAGAUUCCCACUAAAAAUAUCGAAGGUCAGAUGACACCAUACUAUCCUGUGGGAAUGGGAAAUGGUACACCUUGUAGUUUGAAACAGAACCGGCCCAGAUCAAGUACUGUGAUGUACAUAUGUCAUCCUGAAUCUAAGCAUGAAAUUCUUUCAGUAGCUGAAGUUACAACUUGUGAAUAUGAAGUUGUCAUUUUGACACCACUCUUGUGCAGUCAUCCUAAAUAUAGGUUCAGAGCAUCUCCUGUGAAUGACAUAUUUUGUCAAUCACUGCCAGGAUCUCCAUUUAAGCCCCUCACCCUGAGGCAGCUGGAGCAGCAGGAAGAAAUACUAAGGGUGCCUUUUAGGAGAAAUAAAGAGGAAGAUUUGCAAUCAACUAAAGAAGAGAGAUUUCCAGCGAUCCACAAGUCGAUUGCUAUUGGCUCUCAGCCAGUGCUCACUGUUGGGACAACCCACAUAUCCAAAUUGACAGAUGACCAACUCAUAAAAGAGUUUCUUAGUGGUUCUUACUGCUUUCGUGGGGGUGUCGGUUGGUGGAAAUAUGAAUUCUGCUAUGGCAAACAUGUACAUCAAUACCAUGAGGACAAGGAUAGUGGGAAAACCUCUGUGGUUGUCGGGACAUGGAACCAAGAAGAGCAUAUUGAAUGGGCUAAGAAGAAUACUGCUAGAGCUUAUCAUCUUCAAGACGAUGGUACCCAGACAGUCAGGAUGGUGUCACAUUUUUAUGGAAAUGGAGAUAUUUGUGAUAUAACUGACAAACCAAGACAGGUGACUGUAAAACUAAAGUGCAAAGAAUCAGAUUCACCUCAUGCUGUUACUGUAUAUAUGCUAGAGCCUCACUCCUGUCAAUAUAUUCUUGGGGUUGAAUCUCCAGUGAUCUGUAAAAUCUUAGAUACAGCAGAUGAAAAUGGACUUCUUUCUCUCCCCAACUAAAGGAUAUUAAAGUUAGGGGAAAGAAAAGAUCAUUGAAAGUCAUGAUAAUUUCUGUCCCACUGUGUCUCAUUAUAGAGUUCUCAGCCAUUGGACCUCUUCUAAAGGAUGGUAUAAAAUGACUCUCAACCACUUUGUGAAUACAUAUGUGUAUAUAAGAGGUUAUUGAUAAACUUCUGAGGCAGACAUUUGUCUCGCUUUUUUUCAUUUUUGUUGUGUCUUAUAAACUGACUGUUUUUCUUUGCUUGGAUACUGUGAUUCCAAAAUAAAUCUCAUCCAAGCAAGUUAGAGUCCAGCCUAAUCAAAUGUCAUAAUUGUUGUACCUAUUGAAAGUUUUUAAAUAAUAGAUUUAUUAUGUAAAUUAUAGUAUAUGUAAGUAGCUAAUGAAGUAAAGAUCAUGAAGAAAGAAAUUGAUAGGUGUAAAUGAGAGACCAUGUAAAAUAUGUAAAUUCUAGUACCUGAAAUCCUUUCAACAGAUUUUUAUAUAGCAACUGCUCUCUGCAAGUAGUUAAACUAGAAACUGGGCACAUGGUAGAGGCUCACAUGGGAGUUGUCCUCACCCUUGUUAAUCUCAAGAAACUCUUAUUUAUAAUAGGUUGCUUCUCUCUCAGAACUUUUAUCUAUUACUUUUUUCUUCUUAUGAGUAUGUUUACUCUCAGAGUAUCUAUCUGAUGUAGACAGUUGGUGAUGCUUCUGAGACUCAGAAUGGUUUACUCUAACAAAACACUGUGCUGUCUAUCCCUUGUACUUGCCUACUGUAAUAUGGAUUUCACUUCUGAACAGUUUACAGCACAAUAUUUAUUUUAAAGUGAAUAAAAUGUCCACAAGCA-3'- Poly-A tail
  • Coding region
mRNA-related data
DNA
DNA (Gene ID: 27248)
ERLEC1
endoplasmic reticulum lectin 1
NC_000002.12
2  53787211.. 53817969
53787211.. 53817969
strand +
CCDS1848.1
MGI:1914003
ClinVar, dbVar
ENSG00000068912
CL25084, XTP3TPB, XTP3-B, ERLECTIN
uc002rxl.4
INSDC: AF131849
25222
611229
OTTHUMG00000129281
ENA, DDBJ, Monarch
Gene-related data
NCBI CDS gene sequence (1452 bp)
5'-ATGGAGGAAGGAGGCGGCGGCGTACGGAGTCTGGTCCCGGGCGGGCCGGTGTTACTGGTCCTCTGCGGCCTCCTGGAGGCGTCCGGCGGCGGCCGAGCCCTTCCTCAACTCAGCGATGACATCCCTTTCCGAGTCAACTGGCCCGGCACCGAGTTCTCTCTGCCCACAACTGGAGTTTTATATAAAGAAGATAATTATGTCATCATGACAACTGCACATAAAGAAAAATATAAATGCATACTTCCCCTTGTGACAAGTGGGGATGAGGAAGAAGAAAAGGATTATAAAGGCCCTAATCCAAGAGAGCTTTTGGAGCCACTATTTAAACAAAGCAGTTGTTCCTACAGAATTGAGTCTTATTGGACTTACGAAGTATGTCATGGAAAACACATTCGGCAGTACCATGAAGAGAAAGAAACTGGTCAGAAAATAAATATTCACGAGTACTACCTTGGGAATATGTTGGCCAAGAACCTTCTATTTGAAAAAGAACGAGAAGCAGAAGAAAAGGAAAAATCAAATGAGATTCCCACTAAAAATATCGAAGGTCAGATGACACCATACTATCCTGTGGGAATGGGAAATGGTACACCTTGTAGTTTGAAACAGAACCGGCCCAGATCAAGTACTGTGATGTACATATGTCATCCTGAATCTAAGCATGAAATTCTTTCAGTAGCTGAAGTTACAACTTGTGAATATGAAGTTGTCATTTTGACACCACTCTTGTGCAGTCATCCTAAATATAGGTTCAGAGCATCTCCTGTGAATGACATATTTTGTCAATCACTGCCAGGATCTCCATTTAAGCCCCTCACCCTGAGGCAGCTGGAGCAGCAGGAAGAAATACTAAGGGTGCCTTTTAGGAGAAATAAAGAGGAAGATTTGCAATCAACTAAAGAAGAGAGATTTCCAGCGATCCACAAGTCGATTGCTATTGGCTCTCAGCCAGTGCTCACTGTTGGGACAACCCACATATCCAAATTGACAGATGACCAACTCATAAAAGAGTTTCTTAGTGGTTCTTACTGCTTTCGTGGGGGTGTCGGTTGGTGGAAATATGAATTCTGCTATGGCAAACATGTACATCAATACCATGAGGACAAGGATAGTGGGAAAACCTCTGTGGTTGTCGGGACATGGAACCAAGAAGAGCATATTGAATGGGCTAAGAAGAATACTGCTAGAGCTTATCATCTTCAAGACGATGGTACCCAGACAGTCAGGATGGTGTCACATTTTTATGGAAATGGAGATATTTGTGATATAACTGACAAACCAAGACAGGTGACTGTAAAACTAAAGTGCAAAGAATCAGATTCACCTCATGCTGTTACTGTATATATGCTAGAGCCTCACTCCTGTCAATATATTCTTGGGGTTGAATCTCCAGTGATCTGTAAAATCTTAGATACAGCAGATGAAAATGGACTTCTTTCTCTCCCCAACTAA-3'
NCBI CDS gene sequence with introns (location: 53787211.. 53817969) (30759 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 53787044.. 53818796) (31753 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [53787044 - 1000].. 53818796) (32753 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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