NCBI Summary
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011].
Protein
Protein (NP_056516)
Endoplasmic reticulum lectin 1
Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) (XTP3-transactivated gene B protein)
ERLEC1
endoplasmic reticulum lectin 1
Undefined
Curated
P-type lectin-like
P-typeLectins
b-barrel
Man(a1-3)[Man(a1-6)][Man(a1-6)][Man(a1-3)]Man
0.486
MEEGGGGVRSLVPGGPVLLVLCGLLEASGGGRALPQLSDDIPFRVNWPGTEFSLPTTGVLYKEDNYVIMTTAHKEKYKCILPLVTSGDEEEEKDYKGPNPRELLEPLFKQSSCSYRIESYWTYEVCHGKHIRQYHEEKETGQKINIHEYYLGNMLAKNLLFEKEREAEEKEKSNEIPTKNIEGQMTPYYPVGMGNGTPCSLKQNRPRSSTVMYICHPESKHEILSVAEVTTCEYEVVILTPLLCSHPKYRFRASPVNDIFCQSLPGSPFKPLTLRQLEQQEEILRVPFRRNKEEDLQSTKEERFPAIHKSIAIGSQPVLTVGTTHISKLTDDQLIKEFLSGSYCFRGGVGWWKYEFCYGKHVHQYHEDKDSGKTSVVVGTWNQEEHIEWAKKNTARAYHLQDDGTQTVRMVSHFYGNGDICDITDKPRQVTVKLKCKESDSPHAVTVYMLEPHSCQYILGVESPVICKILDTADENGLLSLPN
No structure currently available in the PDB RCSB Databank.
Structural models
SWISS-MODEL structural models
The location of the lectin domain structural model is: 342-469
We infer [1.54, 1.97] Å as the interval of error of this structural model.
Template: 3AIH chain: B, Q13438, NP_006803.1, sequence identity: 29.7%, coverage: 93.0%, location in sequence: 109-228, (109-228 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
We infer [1.54, 1.97] Å as the interval of error of this structural model.
Template: 3AIH chain: B, Q13438, NP_006803.1, sequence identity: 29.7%, coverage: 93.0%, location in sequence: 109-228, (109-228 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
- Identification of pathogenic variants of ERLEC1 in individuals with Class III malocclusion by exome sequencing. [32442352]
- Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation. [29706535]
- Identification of ERAD components essential for dislocation of the null Hong Kong variant of alpha-1-antitrypsin (NHK). [25660456]
- Endoplasmic reticulum lectin XTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded alpha1-antitrypsin variant. [23356641]
- Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress-response pathways. [21118962]
- Human XTP3-B binds to alpha1-antitrypsin variant null(Hong Kong) via the C-terminal MRH domain in a glycan-dependent manner. [19917667]
- Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. [18502753]
- Sweet bays of ERAD. [18538572]
- OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. [18264092]
- The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. [16531414]
UniProt Main References (5 PubMed Identifiers)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
- Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [15815621]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- N-terminome analysis of the human mitochondrial proteome. [25944712]
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_015701.5)
endoplasmic reticulum lectin 1, transcript variant 1
m7G-5')ppp(5'-GGAGGCGGCGUUGCCGGGCUCUCCGGAAGGAGACGUGGCGGCGGUUGGGCCGGUGAUACCCGGGCGCUUUAUAGUCCCGCCGCCUCCUCCUCCACCUCCUCCUCCUCCUCCUCUCCUCCUGGAGCAGAGGAGGUUGUGGCGGUGGCUGGAGAAAGCGGCGGCGGAGGAUGGAGGAAGGAGGCGGCGGCGUACGGAGUCUGGUCCCGGGCGGGCCGGUGUUACUGGUCCUCUGCGGCCUCCUGGAGGCGUCCGGCGGCGGCCGAGCCCUUCCUCAACUCAGCGAUGACAUCCCUUUCCGAGUCAACUGGCCCGGCACCGAGUUCUCUCUGCCCACAACUGGAGUUUUAUAUAAAGAAGAUAAUUAUGUCAUCAUGACAACUGCACAUAAAGAAAAAUAUAAAUGCAUACUUCCCCUUGUGACAAGUGGGGAUGAGGAAGAAGAAAAGGAUUAUAAAGGCCCUAAUCCAAGAGAGCUUUUGGAGCCACUAUUUAAACAAAGCAGUUGUUCCUACAGAAUUGAGUCUUAUUGGACUUACGAAGUAUGUCAUGGAAAACACAUUCGGCAGUACCAUGAAGAGAAAGAAACUGGUCAGAAAAUAAAUAUUCACGAGUACUACCUUGGGAAUAUGUUGGCCAAGAACCUUCUAUUUGAAAAAGAACGAGAAGCAGAAGAAAAGGAAAAAUCAAAUGAGAUUCCCACUAAAAAUAUCGAAGGUCAGAUGACACCAUACUAUCCUGUGGGAAUGGGAAAUGGUACACCUUGUAGUUUGAAACAGAACCGGCCCAGAUCAAGUACUGUGAUGUACAUAUGUCAUCCUGAAUCUAAGCAUGAAAUUCUUUCAGUAGCUGAAGUUACAACUUGUGAAUAUGAAGUUGUCAUUUUGACACCACUCUUGUGCAGUCAUCCUAAAUAUAGGUUCAGAGCAUCUCCUGUGAAUGACAUAUUUUGUCAAUCACUGCCAGGAUCUCCAUUUAAGCCCCUCACCCUGAGGCAGCUGGAGCAGCAGGAAGAAAUACUAAGGGUGCCUUUUAGGAGAAAUAAAGAGGAAGAUUUGCAAUCAACUAAAGAAGAGAGAUUUCCAGCGAUCCACAAGUCGAUUGCUAUUGGCUCUCAGCCAGUGCUCACUGUUGGGACAACCCACAUAUCCAAAUUGACAGAUGACCAACUCAUAAAAGAGUUUCUUAGUGGUUCUUACUGCUUUCGUGGGGGUGUCGGUUGGUGGAAAUAUGAAUUCUGCUAUGGCAAACAUGUACAUCAAUACCAUGAGGACAAGGAUAGUGGGAAAACCUCUGUGGUUGUCGGGACAUGGAACCAAGAAGAGCAUAUUGAAUGGGCUAAGAAGAAUACUGCUAGAGCUUAUCAUCUUCAAGACGAUGGUACCCAGACAGUCAGGAUGGUGUCACAUUUUUAUGGAAAUGGAGAUAUUUGUGAUAUAACUGACAAACCAAGACAGGUGACUGUAAAACUAAAGUGCAAAGAAUCAGAUUCACCUCAUGCUGUUACUGUAUAUAUGCUAGAGCCUCACUCCUGUCAAUAUAUUCUUGGGGUUGAAUCUCCAGUGAUCUGUAAAAUCUUAGAUACAGCAGAUGAAAAUGGACUUCUUUCUCUCCCCAACUAAAGGAUAUUAAAGUUAGGGGAAAGAAAAGAUCAUUGAAAGUCAUGAUAAUUUCUGUCCCACUGUGUCUCAUUAUAGAGUUCUCAGCCAUUGGACCUCUUCUAAAGGAUGGUAUAAAAUGACUCUCAACCACUUUGUGAAUACAUAUGUGUAUAUAAGAGGUUAUUGAUAAACUUCUGAGGCAGACAUUUGUCUCGCUUUUUUUCAUUUUUGUUGUGUCUUAUAAACUGACUGUUUUUCUUUGCUUGGAUACUGUGAUUCCAAAAUAAAUCUCAUCCAAGCAAGUUAGAGUCCAGCCUAAUCAAAUGUCAUAAUUGUUGUACCUAUUGAAAGUUUUUAAAUAAUAGAUUUAUUAUGUAAAUUAUAGUAUAUGUAAGUAGCUAAUGAAGUAAAGAUCAUGAAGAAAGAAAUUGAUAGGUGUAAAUGAGAGACCAUGUAAAAUAUGUAAAUUCUAGUACCUGAAAUCCUUUCAACAGAUUUUUAUAUAGCAACUGCUCUCUGCAAGUAGUUAAACUAGAAACUGGGCACAUGGUAGAGGCUCACAUGGGAGUUGUCCUCACCCUUGUUAAUCUCAAGAAACUCUUAUUUAUAAUAGGUUGCUUCUCUCUCAGAACUUUUAUCUAUUACUUUUUUCUUCUUAUGAGUAUGUUUACUCUCAGAGUAUCUAUCUGAUGUAGACAGUUGGUGAUGCUUCUGAGACUCAGAAUGGUUUACUCUAACAAAACACUGUGCUGUCUAUCCCUUGUACUUGCCUACUGUAAUAUGGAUUUCACUUCUGAACAGUUUACAGCACAAUAUUUAUUUUAAAGUGAAUAAAAUGUCCACAAGCA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 27248)
endoplasmic reticulum lectin 1
strand +
CL25084, XTP3TPB, XTP3-B, ERLECTIN
NCBI CDS gene sequence (1452 bp)
5'-ATGGAGGAAGGAGGCGGCGGCGTACGGAGTCTGGTCCCGGGCGGGCCGGTGTTACTGGTCCTCTGCGGCCTCCTGGAGGCGTCCGGCGGCGGCCGAGCCCTTCCTCAACTCAGCGATGACATCCCTTTCCGAGTCAACTGGCCCGGCACCGAGTTCTCTCTGCCCACAACTGGAGTTTTATATAAAGAAGATAATTATGTCATCATGACAACTGCACATAAAGAAAAATATAAATGCATACTTCCCCTTGTGACAAGTGGGGATGAGGAAGAAGAAAAGGATTATAAAGGCCCTAATCCAAGAGAGCTTTTGGAGCCACTATTTAAACAAAGCAGTTGTTCCTACAGAATTGAGTCTTATTGGACTTACGAAGTATGTCATGGAAAACACATTCGGCAGTACCATGAAGAGAAAGAAACTGGTCAGAAAATAAATATTCACGAGTACTACCTTGGGAATATGTTGGCCAAGAACCTTCTATTTGAAAAAGAACGAGAAGCAGAAGAAAAGGAAAAATCAAATGAGATTCCCACTAAAAATATCGAAGGTCAGATGACACCATACTATCCTGTGGGAATGGGAAATGGTACACCTTGTAGTTTGAAACAGAACCGGCCCAGATCAAGTACTGTGATGTACATATGTCATCCTGAATCTAAGCATGAAATTCTTTCAGTAGCTGAAGTTACAACTTGTGAATATGAAGTTGTCATTTTGACACCACTCTTGTGCAGTCATCCTAAATATAGGTTCAGAGCATCTCCTGTGAATGACATATTTTGTCAATCACTGCCAGGATCTCCATTTAAGCCCCTCACCCTGAGGCAGCTGGAGCAGCAGGAAGAAATACTAAGGGTGCCTTTTAGGAGAAATAAAGAGGAAGATTTGCAATCAACTAAAGAAGAGAGATTTCCAGCGATCCACAAGTCGATTGCTATTGGCTCTCAGCCAGTGCTCACTGTTGGGACAACCCACATATCCAAATTGACAGATGACCAACTCATAAAAGAGTTTCTTAGTGGTTCTTACTGCTTTCGTGGGGGTGTCGGTTGGTGGAAATATGAATTCTGCTATGGCAAACATGTACATCAATACCATGAGGACAAGGATAGTGGGAAAACCTCTGTGGTTGTCGGGACATGGAACCAAGAAGAGCATATTGAATGGGCTAAGAAGAATACTGCTAGAGCTTATCATCTTCAAGACGATGGTACCCAGACAGTCAGGATGGTGTCACATTTTTATGGAAATGGAGATATTTGTGATATAACTGACAAACCAAGACAGGTGACTGTAAAACTAAAGTGCAAAGAATCAGATTCACCTCATGCTGTTACTGTATATATGCTAGAGCCTCACTCCTGTCAATATATTCTTGGGGTTGAATCTCCAGTGATCTGTAAAATCTTAGATACAGCAGATGAAAATGGACTTCTTTCTCTCCCCAACTAA-3'
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