NCBI Summary
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_006803)
MRH - mannose-6-phosphate receptor homology domain
Protein OS-9 (Amplified in osteosarcoma 9)
OS9
OS9 endoplasmic reticulum lectin
Undefined
Curated
P-type lectin-like
P-typeLectins
b-barrel
Man(a1-3)[Man(a1-6)][Man(a1-6)][Man(a1-3)]Man
NP_006803
10956
Q13438
ENSP00000318165.7
Q13438
1.0
10.1016/j.molcel.2010.11.017
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (667 amino acids) Download
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF
Mol* PDB structure viewerUniLectin3D
Structural models
AlphaFold v2: AF-Q13438-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Ligand
Glycan ligands from structural data
aMan16aMan16Man
Man(a1-6)Man(a1-6)Man
3AIH
3AIH
GlyConnect Structures
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for OS9 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis. [32437666]
  • Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation. [29706535]
  • The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. [28419469]
  • Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). [28827405]
  • Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. [26972000]
  • Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. [9562620]
  • Genomic organization of the OS-9 gene amplified in human sarcomas. [9498564]
  • Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. [9192850]
  • Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas. [8634085]
  • Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection. [8090779]
UniProt Main References (14 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The finished DNA sequence of human chromosome 12. [16541075]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. [10403379]
  • OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. [17932042]
  • A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. [18417469]
  • Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. [18502753]
  • OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. [18264092]
  • Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans. [19346256]
  • Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins. [19084021]
    • Show more
All isoforms of this gene containing a lectin domain
NP_001017957.1, XP_006719264.1, NP_001017956.1, NP_001248349.1, NP_001017958.1, XP_006719263.1, NP_006803.1, XP_005268638.1, NP_001248352.1, NP_001248350.1, NP_001248351.1
RNA
RNA (Transcript ID: NM_006812.4)
NM_006812.4
OS9 endoplasmic reticulum lectin, transcript variant 1
All isoforms of OS9 containing a lectin domain
ENST00000315970.12
31..2034 (or 57694162.. 57720909)
57694132.. 57721557
NCBI Matured mRNA sequence 2682 NTPDownload 
m7G-5')ppp(5'-AGAUUCUCUGCAUAAGAAGGGGAACGAAAGAUGGCGGCGGAAACGCUGCUGUCCAGUUUGUUAGGACUGCUGCUUCUGGGACUCCUGUUACCCGCAAGUCUGACCGGCGGUGUCGGGAGCCUGAACCUGGAGGAGCUGAGUGAGAUGCGUUAUGGGAUCGAGAUCCUGCCGUUGCCUGUCAUGGGAGGGCAGAGCCAAUCUUCGGACGUGGUGAUUGUCUCCUCUAAGUACAAACAGCGCUAUGAGUGUCGCCUGCCAGCUGGAGCUAUUCACUUCCAGCGUGAAAGGGAGGAGGAAACACCUGCUUACCAAGGGCCUGGGAUCCCUGAGUUGUUGAGCCCAAUGAGAGAUGCUCCCUGCUUGCUGAAGACAAAGGACUGGUGGACAUAUGAAUUCUGUUAUGGACGCCACAUCCAGCAAUACCACAUGGAAGAUUCAGAGAUCAAAGGUGAAGUCCUCUAUCUCGGCUACUACCAAUCAGCCUUCGACUGGGAUGAUGAAACAGCCAAGGCCUCCAAGCAGCAUCGUCUUAAACGCUACCACAGCCAGACCUAUGGCAAUGGGUCCAAGUGCGACCUUAAUGGGAGGCCCCGGGAGGCCGAGGUUCGGUUCCUCUGUGACGAGGGUGCAGGUAUCUCUGGGGACUACAUCGAUCGCGUGGACGAGCCCUUGUCCUGCUCUUAUGUGCUGACCAUUCGCACUCCUCGGCUCUGCCCCCACCCUCUCCUCCGGCCCCCACCCAGUGCUGCACCGCAGGCCAUCCUCUGUCACCCUUCCCUACAGCCUGAGGAGUACAUGGCCUACGUUCAGAGGCAAGCCGACUCAAAGCAGUAUGGAGAUAAAAUCAUAGAGGAGCUGCAAGAUCUAGGCCCCCAAGUGUGGAGUGAGACCAAGUCUGGGGUGGCACCCCAAAAGAUGGCAGGUGCGAGCCCGACCAAGGAUGACAGUAAGGACUCAGAUUUCUGGAAGAUGCUUAAUGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGUGCCGGCUGAGGAGCAGGACCCAAGCCCUGAGGCAGCAGAUUCAGCUUCUGGUGCUCCCAAUGAUUUUCAGAACAACGUGCAGGUCAAAGUCAUUCGAAGCCCUGCGGAUUUGAUUCGAUUCAUAGAGGAGCUGAAAGGUGGAACAAAAAAGGGGAAGCCAAAUAUAGGCCAAGAGCAGCCUGUGGAUGAUGCUGCAGAAGUCCCUCAGAGGGAACCAGAGAAGGAAAGGGGUGAUCCAGAACGGCAGAGAGAGAUGGAAGAAGAGGAGGAUGAGGAUGAGGAUGAGGAUGAAGAUGAGGAUGAACGGCAGUUACUGGGAGAAUUUGAGAAGGAACUGGAAGGGAUCCUGCUUCCGUCAGACCGAGACCGGCUCCGUUCGGAGGUGAAGGCUGGCAUGGAGCGGGAACUGGAAAACAUCAUCCAGGAGACAGAGAAAGAGCUGGACCCAGAUGGGCUGAAGAAGGAGUCAGAGCGGGAUCGGGCAAUGCUGGCUCUCACAUCCACUCUCAACAAACUCAUCAAAAGACUGGAGGAAAAACAGAGUCCAGAGCUGGUGAAGAAGCACAAGAAAAAGAGGGUUGUCCCCAAAAAGCCUCCCCCAUCACCCCAACCUACAGAGGAGGAUCCUGAGCACAGAGUCCGGGUCCGGGUCACCAAGCUCCGUCUCGGAGGCCCUAAUCAGGAUCUGACUGUCCUCGAGAUGAAACGGGAAAACCCACAGCUGAAACAAAUCGAGGGGCUGGUGAAGGAGCUGCUGGAGAGGGAGGGACUCACAGCUGCAGGGAAAAUUGAGAUCAAAAUUGUCCGCCCAUGGGCUGAAGGGACUGAAGAGGGUGCACGUUGGCUGACUGAUGAGGACACGAGAAACCUCAAGGAGAUCUUCUUCAAUAUCUUGGUGCCGGGAGCUGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCUGGAGAGCAAUUACCGCCGGGUGUGGGGCUCUCCAGGUGGGGAGGGCACAGGGGACCUGGACGAAUUUGACUUCUGAGACCAACACUACACUUGACCCUUCACGGAAUCCAGACUCUUCCUGGACUGGCUUGCCUCCUCCCCACCUCCCCACCCUGGAACCCCUGAGGGCCAAACAGCAGAGUGGAGCUGAGCUGUGGACCUCUCGGGCAACUCUGUGGGUGUGGGGGCCCUGGGUGAAUGCUGCUGCCCCUGCUGGCAGCCACCUUGAGACCUCACCGGGCCUGUGAUAUUUGCUCUCCUGAACUCUCACUCAAUCCUCUUCCUCUCCUCUGUGGCUUUUCCUGUUAUUGUCCCCUAAUGAUAGGAUAUUCCCUGCUGCCUACCUGGAGAUUCAGUAGGAUCUUUUGAGUGGAGGUGGGUAGAGAGAGCAAGGAGGGCAGGACACUUAGCAGGCACUGAGCAAGCAGGCCCCCACCUGCCCUUAGUGAUGUUUGGAGUCGUUUUACCCUCUUCUAUUGAAUUGCCUUGGGAUUUCCUUCUCCCUUUCCCUGCCCACCCUGUCCCCUACAAUUUGUGCUUCUGAGUUGAGGAGCCUUCACCUCUGUUGCUGAGGAAAUGGUAGAAUGCUGCCUAUCACCUCCAGCACAAUCCCAGUGAAAAAGGUGUGAAGCACCCACCAUGUUCUUGAACAAUCAGGUUUCUAAAUAAACAACUGGACCAUCAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 10956)
OS9
OS9 endoplasmic reticulum lectin
NC_000012.12
12  57694162.. 57720909
57694162.. 57720909
strand +
CCDS31843.1
MGI:1924301
ClinVar, dbVar
ENSG00000135506
OS-9, ERLEC2
uc001spj.4
INSDC: AB002806
16994
609677
OTTHUMG00000170284
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (2004 bp)
5'-ATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGGACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTCTGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCTACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCATAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAGATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAGATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCGGATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGGGAAGCCAAATATAGGCCAAGAGCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAACGGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAGTTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTCGGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAAAACATCATCCAGGAGACAGAGAAAGAGCTGGACCCAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAACTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGTCCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTGAGCACAGAGTCCGGGTCCGGGTCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTCGAGATGAAACGGGAAAACCCACAGCTGAAACAAATCGAGGGGCTGGTGAAGGAGCTGCTGGAGAGGGAGGGACTCACAGCTGCAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTCTTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCTGA-3'
NCBI CDS gene sequence with introns (location: 57694162.. 57720909) (26748 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 57694132.. 57721557) (27426 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [57694132 - 1000].. 57721557) (28426 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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