NCBI Summary
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_006803)
MRH - mannose-6-phosphate receptor homology domain
Protein OS-9 (Amplified in osteosarcoma 9)
OS9
OS9 endoplasmic reticulum lectin
Undefined
Curated
P-type lectin-like
P-typeLectins
b-barrel
1.0
Protein sequence and protein families (fasta) (667 amino acids) Download
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF
Mol* PDB structure viewerUniLectin3D
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.


Ligand
Glycan ligands from structural data
aMan16aMan16Man
Man(a1-6)Man(a1-6)Man
References
NCBI References (10 PubMed Identifiers)
  • Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis. [32437666]
  • Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation. [29706535]
  • The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. [28419469]
  • Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). [28827405]
  • Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. [26972000]
  • Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. [9562620]
  • Genomic organization of the OS-9 gene amplified in human sarcomas. [9498564]
  • Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. [9192850]
  • Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas. [8634085]
  • Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection. [8090779]
UniProt Main References (14 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The finished DNA sequence of human chromosome 12. [16541075]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. [10403379]
  • OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. [17932042]
  • A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. [18417469]
  • Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. [18502753]
  • OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. [18264092]
  • Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans. [19346256]
  • Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins. [19084021]
  • Show more
All isoforms of this gene containing a lectin domain
NP_001017957.1, XP_006719264.1, NP_001017956.1, NP_001248349.1, NP_001017958.1, XP_006719263.1, NP_006803.1, XP_005268638.1, NP_001248352.1, NP_001248350.1, NP_001248351.1
RNA
RNA (Transcript ID: NM_006812.4)
OS9 endoplasmic reticulum lectin, transcript variant 1
m7G-5')ppp(5'-AGAUUCUCUGCAUAAGAAGGGGAACGAAAGAUGGCGGCGGAAACGCUGCUGUCCAGUUUGUUAGGACUGCUGCUUCUGGGACUCCUGUUACCCGCAAGUCUGACCGGCGGUGUCGGGAGCCUGAACCUGGAGGAGCUGAGUGAGAUGCGUUAUGGGAUCGAGAUCCUGCCGUUGCCUGUCAUGGGAGGGCAGAGCCAAUCUUCGGACGUGGUGAUUGUCUCCUCUAAGUACAAACAGCGCUAUGAGUGUCGCCUGCCAGCUGGAGCUAUUCACUUCCAGCGUGAAAGGGAGGAGGAAACACCUGCUUACCAAGGGCCUGGGAUCCCUGAGUUGUUGAGCCCAAUGAGAGAUGCUCCCUGCUUGCUGAAGACAAAGGACUGGUGGACAUAUGAAUUCUGUUAUGGACGCCACAUCCAGCAAUACCACAUGGAAGAUUCAGAGAUCAAAGGUGAAGUCCUCUAUCUCGGCUACUACCAAUCAGCCUUCGACUGGGAUGAUGAAACAGCCAAGGCCUCCAAGCAGCAUCGUCUUAAACGCUACCACAGCCAGACCUAUGGCAAUGGGUCCAAGUGCGACCUUAAUGGGAGGCCCCGGGAGGCCGAGGUUCGGUUCCUCUGUGACGAGGGUGCAGGUAUCUCUGGGGACUACAUCGAUCGCGUGGACGAGCCCUUGUCCUGCUCUUAUGUGCUGACCAUUCGCACUCCUCGGCUCUGCCCCCACCCUCUCCUCCGGCCCCCACCCAGUGCUGCACCGCAGGCCAUCCUCUGUCACCCUUCCCUACAGCCUGAGGAGUACAUGGCCUACGUUCAGAGGCAAGCCGACUCAAAGCAGUAUGGAGAUAAAAUCAUAGAGGAGCUGCAAGAUCUAGGCCCCCAAGUGUGGAGUGAGACCAAGUCUGGGGUGGCACCCCAAAAGAUGGCAGGUGCGAGCCCGACCAAGGAUGACAGUAAGGACUCAGAUUUCUGGAAGAUGCUUAAUGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGUGCCGGCUGAGGAGCAGGACCCAAGCCCUGAGGCAGCAGAUUCAGCUUCUGGUGCUCCCAAUGAUUUUCAGAACAACGUGCAGGUCAAAGUCAUUCGAAGCCCUGCGGAUUUGAUUCGAUUCAUAGAGGAGCUGAAAGGUGGAACAAAAAAGGGGAAGCCAAAUAUAGGCCAAGAGCAGCCUGUGGAUGAUGCUGCAGAAGUCCCUCAGAGGGAACCAGAGAAGGAAAGGGGUGAUCCAGAACGGCAGAGAGAGAUGGAAGAAGAGGAGGAUGAGGAUGAGGAUGAGGAUGAAGAUGAGGAUGAACGGCAGUUACUGGGAGAAUUUGAGAAGGAACUGGAAGGGAUCCUGCUUCCGUCAGACCGAGACCGGCUCCGUUCGGAGGUGAAGGCUGGCAUGGAGCGGGAACUGGAAAACAUCAUCCAGGAGACAGAGAAAGAGCUGGACCCAGAUGGGCUGAAGAAGGAGUCAGAGCGGGAUCGGGCAAUGCUGGCUCUCACAUCCACUCUCAACAAACUCAUCAAAAGACUGGAGGAAAAACAGAGUCCAGAGCUGGUGAAGAAGCACAAGAAAAAGAGGGUUGUCCCCAAAAAGCCUCCCCCAUCACCCCAACCUACAGAGGAGGAUCCUGAGCACAGAGUCCGGGUCCGGGUCACCAAGCUCCGUCUCGGAGGCCCUAAUCAGGAUCUGACUGUCCUCGAGAUGAAACGGGAAAACCCACAGCUGAAACAAAUCGAGGGGCUGGUGAAGGAGCUGCUGGAGAGGGAGGGACUCACAGCUGCAGGGAAAAUUGAGAUCAAAAUUGUCCGCCCAUGGGCUGAAGGGACUGAAGAGGGUGCACGUUGGCUGACUGAUGAGGACACGAGAAACCUCAAGGAGAUCUUCUUCAAUAUCUUGGUGCCGGGAGCUGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCUGGAGAGCAAUUACCGCCGGGUGUGGGGCUCUCCAGGUGGGGAGGGCACAGGGGACCUGGACGAAUUUGACUUCUGAGACCAACACUACACUUGACCCUUCACGGAAUCCAGACUCUUCCUGGACUGGCUUGCCUCCUCCCCACCUCCCCACCCUGGAACCCCUGAGGGCCAAACAGCAGAGUGGAGCUGAGCUGUGGACCUCUCGGGCAACUCUGUGGGUGUGGGGGCCCUGGGUGAAUGCUGCUGCCCCUGCUGGCAGCCACCUUGAGACCUCACCGGGCCUGUGAUAUUUGCUCUCCUGAACUCUCACUCAAUCCUCUUCCUCUCCUCUGUGGCUUUUCCUGUUAUUGUCCCCUAAUGAUAGGAUAUUCCCUGCUGCCUACCUGGAGAUUCAGUAGGAUCUUUUGAGUGGAGGUGGGUAGAGAGAGCAAGGAGGGCAGGACACUUAGCAGGCACUGAGCAAGCAGGCCCCCACCUGCCCUUAGUGAUGUUUGGAGUCGUUUUACCCUCUUCUAUUGAAUUGCCUUGGGAUUUCCUUCUCCCUUUCCCUGCCCACCCUGUCCCCUACAAUUUGUGCUUCUGAGUUGAGGAGCCUUCACCUCUGUUGCUGAGGAAAUGGUAGAAUGCUGCCUAUCACCUCCAGCACAAUCCCAGUGAAAAAGGUGUGAAGCACCCACCAUGUUCUUGAACAAUCAGGUUUCUAAAUAAACAACUGGACCAUCAA-3'- Poly-A tail
  • Coding region
;
DNA
DNA (Gene ID: 10956)
OS9
OS9 endoplasmic reticulum lectin
strand +
OS-9, ERLEC2
NCBI CDS gene sequence (2004 bp)
5'-ATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGGACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTCTGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCTACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCATAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAGATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAGATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCGGATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGGGAAGCCAAATATAGGCCAAGAGCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAACGGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAGTTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTCGGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAAAACATCATCCAGGAGACAGAGAAAGAGCTGGACCCAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAACTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGTCCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTGAGCACAGAGTCCGGGTCCGGGTCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTCGAGATGAAACGGGAAAACCCACAGCTGAAACAAATCGAGGGGCTGGTGAAGGAGCTGCTGGAGAGGGAGGGACTCACAGCTGCAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTCTTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCTGA-3'
NCBI CDS gene sequence with introns (location: 57694162.. 57720909) (26748 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 57694132.. 57721557) (27426 bp)Download
NCBI gene sequence (location: [57694132 - 1000].. 57721557) (28426 bp)Download
How to cite: Schnider B., M'Rad Y., el Ahmadie J., de Brevern AG., Imberty A., Lisacek F., HumanLectome, an update of UniLectin for the annotation and prediction of human lectins, Nucleic Acids Reasearch doi.org/10.1093/nar/gkad905