NCBI Summary
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_006803)
MRH - mannose-6-phosphate receptor homology domain
Protein OS-9 (Amplified in osteosarcoma 9)
OS9
OS9 endoplasmic reticulum lectin
Undefined
Curated
P-type lectin-like
P-typeLectins
b-barrel
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF
Mol* PDB structure viewerUniLectin3D
Structural models
Ligand
Glycan ligands from structural data
Man(a1-6)Man.png)
References
NCBI References (10 PubMed Identifiers)
- Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis. [32437666]
- Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation. [29706535]
- The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. [28419469]
- Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). [28827405]
- Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. [26972000]
- Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. [9562620]
- Genomic organization of the OS-9 gene amplified in human sarcomas. [9498564]
- Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. [9192850]
- Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas. [8634085]
- Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection. [8090779]
UniProt Main References (14 PubMed Identifiers)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
- The finished DNA sequence of human chromosome 12. [16541075]
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
- Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. [10403379]
- OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. [17932042]
- A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal. [18417469]
- Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. [18502753]
- OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. [18264092]
- Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans. [19346256]
- Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins. [19084021] Show more
All isoforms of this gene containing a lectin domain
RNA
RNA (Transcript ID: NM_006812.4)
OS9 endoplasmic reticulum lectin, transcript variant 1
m7G-5')ppp(5'-AGAUUCUCUGCAUAAGAAGGGGAACGAAAGAUGGCGGCGGAAACGCUGCUGUCCAGUUUGUUAGGACUGCUGCUUCUGGGACUCCUGUUACCCGCAAGUCUGACCGGCGGUGUCGGGAGCCUGAACCUGGAGGAGCUGAGUGAGAUGCGUUAUGGGAUCGAGAUCCUGCCGUUGCCUGUCAUGGGAGGGCAGAGCCAAUCUUCGGACGUGGUGAUUGUCUCCUCUAAGUACAAACAGCGCUAUGAGUGUCGCCUGCCAGCUGGAGCUAUUCACUUCCAGCGUGAAAGGGAGGAGGAAACACCUGCUUACCAAGGGCCUGGGAUCCCUGAGUUGUUGAGCCCAAUGAGAGAUGCUCCCUGCUUGCUGAAGACAAAGGACUGGUGGACAUAUGAAUUCUGUUAUGGACGCCACAUCCAGCAAUACCACAUGGAAGAUUCAGAGAUCAAAGGUGAAGUCCUCUAUCUCGGCUACUACCAAUCAGCCUUCGACUGGGAUGAUGAAACAGCCAAGGCCUCCAAGCAGCAUCGUCUUAAACGCUACCACAGCCAGACCUAUGGCAAUGGGUCCAAGUGCGACCUUAAUGGGAGGCCCCGGGAGGCCGAGGUUCGGUUCCUCUGUGACGAGGGUGCAGGUAUCUCUGGGGACUACAUCGAUCGCGUGGACGAGCCCUUGUCCUGCUCUUAUGUGCUGACCAUUCGCACUCCUCGGCUCUGCCCCCACCCUCUCCUCCGGCCCCCACCCAGUGCUGCACCGCAGGCCAUCCUCUGUCACCCUUCCCUACAGCCUGAGGAGUACAUGGCCUACGUUCAGAGGCAAGCCGACUCAAAGCAGUAUGGAGAUAAAAUCAUAGAGGAGCUGCAAGAUCUAGGCCCCCAAGUGUGGAGUGAGACCAAGUCUGGGGUGGCACCCCAAAAGAUGGCAGGUGCGAGCCCGACCAAGGAUGACAGUAAGGACUCAGAUUUCUGGAAGAUGCUUAAUGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGUGCCGGCUGAGGAGCAGGACCCAAGCCCUGAGGCAGCAGAUUCAGCUUCUGGUGCUCCCAAUGAUUUUCAGAACAACGUGCAGGUCAAAGUCAUUCGAAGCCCUGCGGAUUUGAUUCGAUUCAUAGAGGAGCUGAAAGGUGGAACAAAAAAGGGGAAGCCAAAUAUAGGCCAAGAGCAGCCUGUGGAUGAUGCUGCAGAAGUCCCUCAGAGGGAACCAGAGAAGGAAAGGGGUGAUCCAGAACGGCAGAGAGAGAUGGAAGAAGAGGAGGAUGAGGAUGAGGAUGAGGAUGAAGAUGAGGAUGAACGGCAGUUACUGGGAGAAUUUGAGAAGGAACUGGAAGGGAUCCUGCUUCCGUCAGACCGAGACCGGCUCCGUUCGGAGGUGAAGGCUGGCAUGGAGCGGGAACUGGAAAACAUCAUCCAGGAGACAGAGAAAGAGCUGGACCCAGAUGGGCUGAAGAAGGAGUCAGAGCGGGAUCGGGCAAUGCUGGCUCUCACAUCCACUCUCAACAAACUCAUCAAAAGACUGGAGGAAAAACAGAGUCCAGAGCUGGUGAAGAAGCACAAGAAAAAGAGGGUUGUCCCCAAAAAGCCUCCCCCAUCACCCCAACCUACAGAGGAGGAUCCUGAGCACAGAGUCCGGGUCCGGGUCACCAAGCUCCGUCUCGGAGGCCCUAAUCAGGAUCUGACUGUCCUCGAGAUGAAACGGGAAAACCCACAGCUGAAACAAAUCGAGGGGCUGGUGAAGGAGCUGCUGGAGAGGGAGGGACUCACAGCUGCAGGGAAAAUUGAGAUCAAAAUUGUCCGCCCAUGGGCUGAAGGGACUGAAGAGGGUGCACGUUGGCUGACUGAUGAGGACACGAGAAACCUCAAGGAGAUCUUCUUCAAUAUCUUGGUGCCGGGAGCUGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCUGGAGAGCAAUUACCGCCGGGUGUGGGGCUCUCCAGGUGGGGAGGGCACAGGGGACCUGGACGAAUUUGACUUCUGAGACCAACACUACACUUGACCCUUCACGGAAUCCAGACUCUUCCUGGACUGGCUUGCCUCCUCCCCACCUCCCCACCCUGGAACCCCUGAGGGCCAAACAGCAGAGUGGAGCUGAGCUGUGGACCUCUCGGGCAACUCUGUGGGUGUGGGGGCCCUGGGUGAAUGCUGCUGCCCCUGCUGGCAGCCACCUUGAGACCUCACCGGGCCUGUGAUAUUUGCUCUCCUGAACUCUCACUCAAUCCUCUUCCUCUCCUCUGUGGCUUUUCCUGUUAUUGUCCCCUAAUGAUAGGAUAUUCCCUGCUGCCUACCUGGAGAUUCAGUAGGAUCUUUUGAGUGGAGGUGGGUAGAGAGAGCAAGGAGGGCAGGACACUUAGCAGGCACUGAGCAAGCAGGCCCCCACCUGCCCUUAGUGAUGUUUGGAGUCGUUUUACCCUCUUCUAUUGAAUUGCCUUGGGAUUUCCUUCUCCCUUUCCCUGCCCACCCUGUCCCCUACAAUUUGUGCUUCUGAGUUGAGGAGCCUUCACCUCUGUUGCUGAGGAAAUGGUAGAAUGCUGCCUAUCACCUCCAGCACAAUCCCAGUGAAAAAGGUGUGAAGCACCCACCAUGUUCUUGAACAAUCAGGUUUCUAAAUAAACAACUGGACCAUCAA-3'- Poly-A tail
- Coding region
DNA
DNA (Gene ID: 10956)
OS9 endoplasmic reticulum lectin
strand +
OS-9, ERLEC2
NCBI CDS gene sequence (2004 bp)
5'-ATGGCGGCGGAAACGCTGCTGTCCAGTTTGTTAGGACTGCTGCTTCTGGGACTCCTGTTACCCGCAAGTCTGACCGGCGGTGTCGGGAGCCTGAACCTGGAGGAGCTGAGTGAGATGCGTTATGGGATCGAGATCCTGCCGTTGCCTGTCATGGGAGGGCAGAGCCAATCTTCGGACGTGGTGATTGTCTCCTCTAAGTACAAACAGCGCTATGAGTGTCGCCTGCCAGCTGGAGCTATTCACTTCCAGCGTGAAAGGGAGGAGGAAACACCTGCTTACCAAGGGCCTGGGATCCCTGAGTTGTTGAGCCCAATGAGAGATGCTCCCTGCTTGCTGAAGACAAAGGACTGGTGGACATATGAATTCTGTTATGGACGCCACATCCAGCAATACCACATGGAAGATTCAGAGATCAAAGGTGAAGTCCTCTATCTCGGCTACTACCAATCAGCCTTCGACTGGGATGATGAAACAGCCAAGGCCTCCAAGCAGCATCGTCTTAAACGCTACCACAGCCAGACCTATGGCAATGGGTCCAAGTGCGACCTTAATGGGAGGCCCCGGGAGGCCGAGGTTCGGTTCCTCTGTGACGAGGGTGCAGGTATCTCTGGGGACTACATCGATCGCGTGGACGAGCCCTTGTCCTGCTCTTATGTGCTGACCATTCGCACTCCTCGGCTCTGCCCCCACCCTCTCCTCCGGCCCCCACCCAGTGCTGCACCGCAGGCCATCCTCTGTCACCCTTCCCTACAGCCTGAGGAGTACATGGCCTACGTTCAGAGGCAAGCCGACTCAAAGCAGTATGGAGATAAAATCATAGAGGAGCTGCAAGATCTAGGCCCCCAAGTGTGGAGTGAGACCAAGTCTGGGGTGGCACCCCAAAAGATGGCAGGTGCGAGCCCGACCAAGGATGACAGTAAGGACTCAGATTTCTGGAAGATGCTTAATGAGCCAGAGGACCAGGCCCCAGGAGGGGAGGAGGTGCCGGCTGAGGAGCAGGACCCAAGCCCTGAGGCAGCAGATTCAGCTTCTGGTGCTCCCAATGATTTTCAGAACAACGTGCAGGTCAAAGTCATTCGAAGCCCTGCGGATTTGATTCGATTCATAGAGGAGCTGAAAGGTGGAACAAAAAAGGGGAAGCCAAATATAGGCCAAGAGCAGCCTGTGGATGATGCTGCAGAAGTCCCTCAGAGGGAACCAGAGAAGGAAAGGGGTGATCCAGAACGGCAGAGAGAGATGGAAGAAGAGGAGGATGAGGATGAGGATGAGGATGAAGATGAGGATGAACGGCAGTTACTGGGAGAATTTGAGAAGGAACTGGAAGGGATCCTGCTTCCGTCAGACCGAGACCGGCTCCGTTCGGAGGTGAAGGCTGGCATGGAGCGGGAACTGGAAAACATCATCCAGGAGACAGAGAAAGAGCTGGACCCAGATGGGCTGAAGAAGGAGTCAGAGCGGGATCGGGCAATGCTGGCTCTCACATCCACTCTCAACAAACTCATCAAAAGACTGGAGGAAAAACAGAGTCCAGAGCTGGTGAAGAAGCACAAGAAAAAGAGGGTTGTCCCCAAAAAGCCTCCCCCATCACCCCAACCTACAGAGGAGGATCCTGAGCACAGAGTCCGGGTCCGGGTCACCAAGCTCCGTCTCGGAGGCCCTAATCAGGATCTGACTGTCCTCGAGATGAAACGGGAAAACCCACAGCTGAAACAAATCGAGGGGCTGGTGAAGGAGCTGCTGGAGAGGGAGGGACTCACAGCTGCAGGGAAAATTGAGATCAAAATTGTCCGCCCATGGGCTGAAGGGACTGAAGAGGGTGCACGTTGGCTGACTGATGAGGACACGAGAAACCTCAAGGAGATCTTCTTCAATATCTTGGTGCCGGGAGCTGAAGAGGCCCAGAAGGAACGCCAGCGGCAGAAAGAGCTGGAGAGCAATTACCGCCGGGTGTGGGGCTCTCCAGGTGGGGAGGGCACAGGGGACCTGGACGAATTTGACTTCTGA-3'
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