NCBI Summary
This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010].
Protein
Protein (NP_001136007)
Galectin 12
Galectin-12 (Gal-12) (Galectin-related inhibitor of proliferation)
LGALS12
galectin 12
Undefined
Low evidence
galectin-like
S-Type Lectins - Tandem repeat
b-sandwich / ConA-like
Gal
NP_001136007
85329
Q96DT0
Undefined
G3QDF8
0.412
Undefined
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (315 amino acids) Download
MSPGEKLDPIPDSFILQPPVFHPVVPYVTTIFGGLHAGKMVMLQGVVPLDAHSRFQVDFQCGCSLCPRPDIAFHFNPRFHTTKPHVICNTLHGGRWQREARWPHLALRRGSSFLILFLFGNEEVKVSVNGQHFLHFRYRLPLSHVDTLGIFGDILVEAVGFLNINPFVEGSREYPAGHPFLLMSPRLEVPCSHALPQGLSPGQVIIVRGLVLQEPKHFTVSLRDQAAHAPVTLRASFADRTLAWISRWGQKKLISAPFLFYPQRFFEVLLLFQEGGLKLALNGQGLGATSMNQQALEQLRELRISGSVQLYCVHS
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q96DT0-F1DownloadSee the associated sequence to the AlphaFold v2 model, which is different to this entry(NCBI sequence).
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.46, 1.84] ÅDownload
The location of the lectin domain structural model is: 16-183
We infer [1.46, 1.84] Å as the interval of error of this structural model.
Template 1: 4BMB chain: A, O00214_Nter, NP_963837.1, sequence identity: 35.1%, coverage: 86.3%, location in sequence: 9-153, (9-153 in PDB).
Template 2: 2ZHN chain: A, O00182_Nter, NP_033665.1, sequence identity: 32.7%, coverage: 83.3%, location in sequence: 8-147, (8-147 in PDB).
Template 3: 5DUV chain: C, P56470_Nter, NP_006140.1, sequence identity: 32.7%, coverage: 81.5%, location in sequence: 15-151, (15-151 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for LGALS12 Gene
ProteomicsDB
References
NCBI References (8 PubMed Identifiers)
  • Ablation of Galectin-12 Inhibits Atherosclerosis through Enhancement of M2 Macrophage Polarization. [32752134]
  • Deciphering the galectin-12 protein interactome reveals a major impact of galectin-12 on glutamine anaplerosis in colon cancer cells. [30935948]
  • Analyzing epigenetic control of galectin expression indicates silencing of galectin-12 by promoter methylation in colorectal cancer. [29098769]
  • Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while promoting lipogenesis. [27256573]
  • Expression profiling of cancer-related galectins in acute myeloid leukemia. [25953264]
  • Galectin-12 is required for adipogenic signaling and adipocyte differentiation. [15131127]
  • Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity. [11435439]
  • Cell cycle regulation by galectin-12, a new member of the galectin superfamily. [11283015]
UniProt Main References (3 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • Human chromosome 11 DNA sequence and analysis including novel gene identification. [16554811]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
All isoforms of this gene containing a lectin domain
NP_149092.3, NP_001136008.2, NP_001136007.2, NP_001136009.1, NP_001136010.1, XP_016873947.1
RNA
RNA (Transcript ID: NM_001142535.2)
NM_001142535.2
galectin 12, transcript variant 1
All isoforms of LGALS12 containing a lectin domain
376..1323 (or 63506459.. 63516393)
63506084.. 63516772
NCBI Matured mRNA sequence 1702 NTPDownload 
m7G-5')ppp(5'-ACAAACCCUCGUUGGCCCCACAGGAGCCAGCCUCUGGCUUCUCUCUGCAAUGGCCAUGUGCUGCAGACCCGGAGUGGGUAGUUAGUUGGUUAAUGCCAGUCUUCCUCCCCUGGACACUGAGUUCUGCUGACAGCCCCCGCCCAGCCAGAGCUCUGCUGUAUACCACCGGGAGUGGGGCUGGUGUGGAGCCUGGAGGUCGCCCGCUGCCCUCCUAGGGCUGCUCCAGACAGCAUUAAAACGCUGCAGGUCGCAGGUGAGACUAACAGCUGGGAGAGCUGCUCCAGGCAUUUAGGACCCUGACUGGGGCAGAUGAGUCAGCCCAGUGGGGGCAGGGCUCCUGGAACGAGGAUCUACAGUUGGAGUUGCCCCACUGUCAUGUCACCUGGAGAAAAACUGGACCCAAUUCCUGACAGCUUCAUUCUGCAACCACCAGUCUUCCACCCGGUGGUUCCUUAUGUCACGACGAUUUUUGGAGGCCUGCAUGCAGGCAAGAUGGUCAUGCUGCAAGGAGUGGUCCCUCUAGAUGCACACAGUAGGUUUCAGGUGGACUUCCAGUGUGGCUGCAGCCUGUGUCCCCGGCCAGAUAUCGCCUUCCACUUCAACCCUCGCUUCCAUACCACCAAGCCCCAUGUCAUCUGCAACACCCUGCAUGGUGGACGCUGGCAAAGGGAGGCCCGGUGGCCCCACCUGGCCCUGCGAAGAGGCUCCAGCUUCCUCAUCCUCUUUCUCUUCGGGAAUGAGGAAGUGAAGGUGAGUGUGAAUGGACAGCACUUUCUCCACUUCCGCUACCGGCUCCCACUGUCUCAUGUGGACACGCUGGGUAUAUUUGGUGACAUCCUGGUAGAGGCUGUUGGAUUCCUGAACAUCAAUCCAUUUGUGGAGGGCAGCAGAGAGUACCCAGCUGGACAUCCUUUCCUGCUGAUGAGCCCCAGGCUGGAGGUGCCCUGCUCACAUGCUCUUCCCCAGGGUCUCUCGCCUGGGCAGGUCAUCAUAGUACGGGGACUGGUCUUGCAAGAGCCGAAGCAUUUUACUGUGAGCCUGAGGGACCAGGCUGCCCAUGCUCCUGUGACACUCAGGGCCUCCUUCGCAGACAGAACUCUGGCCUGGAUCUCCCGCUGGGGGCAGAAGAAACUGAUCUCAGCCCCCUUCCUCUUUUACCCCCAGAGAUUCUUUGAGGUGCUGCUCCUGUUCCAGGAGGGAGGGCUGAAGCUGGCGCUCAAUGGGCAGGGGCUGGGGGCCACCAGCAUGAACCAGCAGGCCCUGGAGCAGCUGCGGGAGCUCCGGAUCAGUGGAAGUGUCCAGCUCUACUGUGUCCACUCCUGAGGAUGGUUCCAGGGAAAUACCGCCAGAAAACAAGAAGGUCAGCCCACUCCCAGGGCCCCACUCUCCUCCCCUCAUUAAACCAUCCACCUGACACCAGCACAUCAGGCCUGGUUCACCUCUGGGGUCACGAGACUGAGUCUACAGGAGCUUUGGGCCUGAGGGAAGGCACAAGAGUGCAAAGGUUCCUCGAACUCUGCACCUUCCUCCACCAGGAGCCUGGGAUAUGGCUCCAUCUGCCUUCAGGGCCUGGACUGCACUCACAGAGGCAAGUGUUGUAGACUAACAAAGAUACUCCAAAAUACAAUGGCUUAAAGAAUGUGGUCAUUUAUUCUUUAUUAUUUAUUUAUUUGUGGUCAAAUAAAUAAAUAAGGUUAUUUAU-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 85329)
LGALS12
galectin 12
NC_000011.10
11  63506459.. 63516393
63506459.. 63516393
strand +
CCDS44633.1
MGI:1929094
ClinVar, dbVar
ENSG00000133317
GRIP1
uc001nxa.3
INSDC: AF222695
15788
606096
OTTHUMG00000167807
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (948 bp)
5'-ATGTCACCTGGAGAAAAACTGGACCCAATTCCTGACAGCTTCATTCTGCAACCACCAGTCTTCCACCCGGTGGTTCCTTATGTCACGACGATTTTTGGAGGCCTGCATGCAGGCAAGATGGTCATGCTGCAAGGAGTGGTCCCTCTAGATGCACACAGTAGGTTTCAGGTGGACTTCCAGTGTGGCTGCAGCCTGTGTCCCCGGCCAGATATCGCCTTCCACTTCAACCCTCGCTTCCATACCACCAAGCCCCATGTCATCTGCAACACCCTGCATGGTGGACGCTGGCAAAGGGAGGCCCGGTGGCCCCACCTGGCCCTGCGAAGAGGCTCCAGCTTCCTCATCCTCTTTCTCTTCGGGAATGAGGAAGTGAAGGTGAGTGTGAATGGACAGCACTTTCTCCACTTCCGCTACCGGCTCCCACTGTCTCATGTGGACACGCTGGGTATATTTGGTGACATCCTGGTAGAGGCTGTTGGATTCCTGAACATCAATCCATTTGTGGAGGGCAGCAGAGAGTACCCAGCTGGACATCCTTTCCTGCTGATGAGCCCCAGGCTGGAGGTGCCCTGCTCACATGCTCTTCCCCAGGGTCTCTCGCCTGGGCAGGTCATCATAGTACGGGGACTGGTCTTGCAAGAGCCGAAGCATTTTACTGTGAGCCTGAGGGACCAGGCTGCCCATGCTCCTGTGACACTCAGGGCCTCCTTCGCAGACAGAACTCTGGCCTGGATCTCCCGCTGGGGGCAGAAGAAACTGATCTCAGCCCCCTTCCTCTTTTACCCCCAGAGATTCTTTGAGGTGCTGCTCCTGTTCCAGGAGGGAGGGCTGAAGCTGGCGCTCAATGGGCAGGGGCTGGGGGCCACCAGCATGAACCAGCAGGCCCTGGAGCAGCTGCGGGAGCTCCGGATCAGTGGAAGTGTCCAGCTCTACTGTGTCCACTCCTGA-3'
NCBI CDS gene sequence with introns (location: 63506459.. 63516393) (9935 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 63506084.. 63516772) (10689 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [63506084 - 1000].. 63516772) (11689 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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