HumanLectome - Human Lectin Entry

Protein

Protein (NP_001177694)

Protein name

KLRF2 / Killer cell lectin-like receptor F member 2

Synonym(s)

Killer cell lectin-like receptor subfamily F member 2 (Lectin-like receptor F2) (Activating coreceptor NKp65)

HGNC gene name

KLRF2

HGNC name

killer cell lectin like receptor F2

Protein_CD_name

Undefined

Lectin confidence

Very low evidence

UniLectin class

C-type lectin

C-type classification

Undefined

Known lectin group

C-type - Natural Killer NK

Lectin fold

a/b mixed / C-type lectin-like

Glycan specificity

Uncharacterised

RefSeq accession

Gene ID

UniProt accession

Ensembl protein ID

UniRef cluster ID

LectomeXplore score

0.331

Reference

Undefined

Other links

PFAM, InterPro

Protein sequence and protein families (fasta) (207 amino acids) Download

MENEDGYMTLSFKNRCKSKQKSKDFSLYPQYYCLLLIFGCIVILIFIMTGIDLKFWHKKMDFSQNVNVSSLSGHNYLCPNDWLLNEGKCYWFSTSFKTWKESQRDCTQLQAHLLVIQNLDELEFIQNSLKPGHFGWIGLYVTFQGNLWMWIDEHFLVPELFSVIGPTDDRSCAVITGNWVYSEDCSSTFKGICQRDAILTHNGTSGV

Mol* PDB structure viewerUniLectin3D

Select a PDB entry:

Structural models

AlphaFold v2: AF-D3W0D1-F1 Download

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Oligomerization and Known Interactions

Homodimer; non-disulfide-linked (PubMed:28082678). Interacts with CLEC2A (PubMed:20194751, PubMed:25510854)

Annotation

Ligand

Glycan ligands from structural data

No crystal structures of complexes with glycan ligand.

Expression

Human Protein Atlas

GeneCards

Functionality temporarily unavailable.

References

NCBI References (4 PubMed Identifiers)

The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk). [28082678]

Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65. [25510854]

Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex. [23803857]

Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. [20194751]

UniProt Main References (1 PubMed Identifiers)

The finished DNA sequence of human chromosome 12. [16541075]

RNA

RNA (Transcript ID: NM_001190765.1)

RNA RefSeq ID

NM_001190765.1

RNA name

killer cell lectin like receptor F2

Isoforms

All isoforms of KLRF2 containing a lectin domain

RNA Ensembl ID

ENST00000535540.1

Coding region

108..731 (or 9881596.. 9895833)

mRNA location

9881489.. 9895833

NCBI Matured mRNA sequence 731 NTP Download

m⁷G-5')ppp(5'-AGUUUUCUUUUAGUACCUUGUGCCAAAGAGACAUAUCCAAGGUUGAGAUUAGUUUCCAUUUUCUUUGUACUAUUUUCUGGAUAAUAAGACAUUAGACAUUUGAAGAGAUGGAGAAUGAAGAUGGGUAUAUGACGCUGAGUUUCAAGAAUCGUUGUAAAUCGAAGCAGAAAUCUAAAGAUUUCUCCCUAUAUCCACAAUAUUAUUGUCUUCUGCUCAUAUUUGGAUGCAUUGUGAUCCUUAUAUUCAUUAUGACAGGGAUUGACCUGAAGUUCUGGCAUAAAAAAAUGGAUUUCUCCCAGAAUGUAAACGUCAGCAGUCUAUCAGGACACAAUUACUUGUGCCCAAAUGACUGGCUGUUGAACGAAGGGAAAUGUUACUGGUUUUCAACUUCUUUUAAAACGUGGAAAGAGAGUCAACGUGAUUGUACACAGCUACAGGCACAUUUACUGGUGAUUCAAAAUUUGGAUGAGCUGGAGUUCAUACAGAACAGUUUAAAACCUGGACAUUUUGGUUGGAUUGGACUAUAUGUUACAUUCCAAGGGAACCUAUGGAUGUGGAUAGAUGAACACUUUUUAGUUCCAGAAUUGUUUUCAGUGAUUGGACCAACUGAUGACAGGAGCUGUGCCGUUAUCACAGGAAACUGGGUGUAUUCUGAAGACUGUAGCUCCACAUUUAAGGGCAUUUGCCAGAGAGAUGCGAUCUUGACGCACAAUGGAACCAGUGGUGUGUAA-3'- Poly-A tail

Coding region

mRNA-related data

DNA

DNA (Gene ID: 100431172)

HGNC Gene symbol

KLRF2

HGNC Gene name

killer cell lectin like receptor F2

Chr. RefSeq ID

NC_000012.12

Chromosome N°

12 9881596.. 9895833

CDS location

9881596.. 9895833

DNA strand

strand +

CCDS ID

CCDS53743.1

Mouse ortholog gene

Gene Variant

ClinVar, dbVar

DNA Ensembl ID

ENSG00000256797

HGNC other symbol

NKp65

UCSC ID

uc021quy.1

GeneBank

INSDC:

GeneCards

37646

MIM

618814

VEGA ID

OTTHUMG00000187141

Other links

ENA, DDBJ, Monarch

Gene-related data

NCBI CDS gene sequence (624 bp)

5'-ATGGAGAATGAAGATGGGTATATGACGCTGAGTTTCAAGAATCGTTGTAAATCGAAGCAGAAATCTAAAGATTTCTCCCTATATCCACAATATTATTGTCTTCTGCTCATATTTGGATGCATTGTGATCCTTATATTCATTATGACAGGGATTGACCTGAAGTTCTGGCATAAAAAAATGGATTTCTCCCAGAATGTAAACGTCAGCAGTCTATCAGGACACAATTACTTGTGCCCAAATGACTGGCTGTTGAACGAAGGGAAATGTTACTGGTTTTCAACTTCTTTTAAAACGTGGAAAGAGAGTCAACGTGATTGTACACAGCTACAGGCACATTTACTGGTGATTCAAAATTTGGATGAGCTGGAGTTCATACAGAACAGTTTAAAACCTGGACATTTTGGTTGGATTGGACTATATGTTACATTCCAAGGGAACCTATGGATGTGGATAGATGAACACTTTTTAGTTCCAGAATTGTTTTCAGTGATTGGACCAACTGATGACAGGAGCTGTGCCGTTATCACAGGAAACTGGGTGTATTCTGAAGACTGTAGCTCCACATTTAAGGGCATTTGCCAGAGAGATGCGATCTTGACGCACAATGGAACCAGTGGTGTGTAA-3'

NCBI CDS gene sequence with introns (location: 9881596.. 9895833) (14238 bp)Download

NCBI Gene Viewer (CDS + introns)

NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 9881489.. 9895833) (14345 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions)

NCBI gene sequence (location: [9881489 - 1000].. 9895833) (15345 bp)Download

NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)

How to cite

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