NCBI Summary
This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. This gene appears to be a polymorphic pseudogene in humans, and the reference genome encodes a non-functional allele. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2019].
Protein
Protein (NP_001070248)
Polycystin-1L2
Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2)
PKD1L2
polycystin 1 like 2 (gene/pseudogene)
Undefined
Very low evidence
C-type lectin
Undefined
C-type - Polycysti
a/b mixed / C-type lectin-like
Uncharacterised
NP_001070248
114780
Q7Z442
Undefined
Q7Z442-3
0.336
10.1007/s00894-007-0201-z
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (991 amino acids) Download
MSAVGLVLLVLALRLRATTVKPEEGSFCSNSQVAFRDACYEFVPLGRTFRDAQSWCEGQGGHLVFIQDEGTQWFLQKHISQDREWWIGLTWNLARNGTTEGPGTWLDTSNVTYSNWHGGQAAAAPDTCGHIGRGPSSEWVTSDCAQTFAFMCEFRVGQSLACEGLNATVHCGLGQVIQVQDAVYGRQNPHFCTQDAGRPSDLEQGCSWANVKEEVAGQCQELQSCQVAADETYFGNLCPTQGSYLWVQYQCREALQLMVSSESFIFDNVTISLTWLLSPYIGNLSCIISTGDSHTFDPYNPPSVSSNVTHQFTSPGEFTVFAECTTSEWHVTAQRQVTVRDKMETLSVTACSGLSQSGAGPLCQAVFGDPLWIQVELDGGTGVTYTVLLGDITLAESTTQKGSLPYNLILDRETQKLMGPGRHRLEIQATGNTTTSTISRNITVHLVELLSGLQASWASDHLELGQDLLITISLAQGTPEELTFEVAGLNATFSHEQVSFGEPFGICRLAVPVEGTFLVTMLVRNAFSNLSLEIGNITITAPSGLQEPSGMNAEGKSKDKGDMEVYIQPGPYVDPFTTVTLGWPDNDKELRFQWSCGSCWALWSSCVERQLLRTDQRELVVPASCLPPPDSAVTLRLAVLRGQELENRAEQCLYVSAPWELRPRVSCERNCRPVNASKDILLRVTMGEDSPVAMFSWYLDNTPTEQAEPLLDACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREVPACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGEENNDFVLTVVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSLSAVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQGSCMGDSWEGAPPAAHVSHAR
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q7Z442-F1DownloadSee the associated sequence to the AlphaFold v2 model, which is different to this entry(NCBI sequence).
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.52, 1.94] ÅDownload
The location of the lectin domain structural model is: 23-159
We infer [1.52, 1.94] Å as the interval of error of this structural model.
Template 1: 2OX9 chain: A, Q8K4Q8, NP_569716.2, sequence identity: 30.7%, coverage: 92.0%, location in sequence: 606-735, (606-735 in PDB).
Template 2: 2OX8 chain: A, Q5KU26, NP_569057.2, sequence identity: 28.5%, coverage: 91.2%, location in sequence: 606-734, (606-734 in PDB).
Template 3: 4KZV chain: A, E1BHM0, XP_010803863.1, sequence identity: 27.0%, coverage: 91.2%, location in sequence: 78-208, (78-208 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for PKD1L2 Gene
ProteomicsDB
References
NCBI References (7 PubMed Identifiers)
  • A copy number variation in PKD1L2 is associated with colorectal cancer predisposition in korean population. [27605020]
  • The TRPP subfamily and polycystin-1 proteins. [24756726]
  • Direct recording and molecular identification of the calcium channel of primary cilia. [24336289]
  • Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. [19844255]
  • Upregulation of PKD1L2 provokes a complex neuromuscular disease in the mouse. [19578180]
  • Polycystin-1L2 is a novel G-protein-binding protein. [15203210]
  • Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. [12782129]
UniProt Main References (4 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. [11572484]
  • The sequence and analysis of duplication-rich human chromosome 16. [15616553]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_001076780.2)
NM_001076780.2
polycystin 1 like 2 (gene/pseudogene), transcript variant 3
All isoforms of PKD1L2 containing a lectin domain
25..3000 (or 81170740.. 81220370)
81170289.. 81220394
NCBI Matured mRNA sequence 3451 NTPDownload 
m7G-5')ppp(5'-AGAGGCCCCAGCAGUGGUUCAAGCAUGAGUGCAGUGGGCUUGGUACUCCUGGUGCUUGCUCUGAGGCUUAGGGCCACCACUGUUAAGCCAGAGGAAGGCAGCUUUUGCUCUAACAGCCAGGUGGCCUUCAGAGAUGCUUGCUAUGAAUUUGUGCCACUCGGACGCACCUUCCGUGAUGCCCAGAGCUGGUGCGAGGGGCAAGGAGGCCAUUUGGUCUUCAUUCAGGACGAAGGCACCCAGUGGUUUCUGCAGAAGCACAUCUCCCAGGACAGGGAAUGGUGGAUUGGACUCACGUGGAACUUGGCACGGAAUGGAACCACGGAGGGGCCGGGGACUUGGUUGGACACCUCCAAUGUGACCUACAGCAACUGGCAUGGAGGGCAGGCCGCCGCUGCCCCUGACACCUGCGGCCACAUCGGGAGAGGCCCUUCCUCUGAGUGGGUGACCUCGGACUGCGCCCAGACCUUCGCCUUCAUGUGCGAGUUCCGGGUUGGCCAGAGCCUGGCCUGCGAGGGACUCAAUGCCACCGUGCACUGUGGCUUGGGGCAGGUCAUCCAGGUCCAGGAUGCCGUCUACGGGCGCCAGAAUCCCCAUUUCUGCACCCAGGAUGCCGGGCGUCCUUCAGAUCUGGAGCAGGGAUGCAGCUGGGCCAACGUCAAGGAGGAGGUGGCAGGCCAGUGCCAGGAGCUACAGUCAUGCCAGGUGGCAGCAGAUGAGACCUACUUUGGAAACCUGUGUCCGACUCAGGGCAGUUACCUGUGGGUGCAGUACCAGUGCCGGGAAGCCCUGCAGCUGAUGGUGUCCAGUGAGAGUUUCAUCUUUGACAAUGUCACCAUCUCCCUGACGUGGCUCCUCUCACCCUACAUAGGAAACCUGUCCUGUAUAAUUAGUACAGGAGACAGCCACACUUUUGAUCCCUACAACCCGCCGAGUGUGUCCAGCAAUGUGACCCACCAGUUCACAUCUCCUGGGGAAUUCACCGUGUUUGCUGAAUGCACAACCAGUGAGUGGCAUGUGACAGCUCAGAGGCAGGUGACCGUGCGAGACAAGAUGGAGACGCUCAGUGUGACUGCAUGCUCCGGCCUGUCCCAGUCAGGAGCCGGCCCUCUCUGCCAGGCUGUCUUUGGGGAUCCUCUGUGGAUUCAGGUGGAGCUUGAUGGAGGAACAGGAGUGACUUACACUGUGCUUUUGGGUGACAUAACCCUGGCCGAGUCCACCACCCAAAAGGGCUCGCUACCGUACAAUCUGAUCCUGGACAGAGAAACCCAGAAACUGAUGGGCCCUGGGAGGCACCGCCUGGAGAUCCAAGCCACCGGCAACACCACCACCUCUACAAUCUCCAGAAACAUUACAGUCCACUUGGUGGAGCUGCUGUCAGGGCUGCAGGCCUCCUGGGCUUCUGACCAUUUGGAGCUUGGACAGGACCUAUUGAUCACCAUCUCAUUGGCUCAGGGCACCCCGGAAGAGCUGACCUUUGAGGUGGCUGGACUCAAUGCAACCUUCUCCCACGAGCAAGUGAGCUUUGGAGAGCCAUUUGGGAUUUGCCGCCUGGCUGUUCCGGUUGAAGGCACCUUUCUGGUCACCAUGCUGGUGAGGAAUGCCUUCUCCAACCUGAGUUUGGAAAUCGGGAACAUCACUAUCACAGCCCCUUCCGGUCUCCAAGAACCAUCUGGGAUGAAUGCUGAAGGAAAGAGUAAAGAUAAAGGCGAUAUGGAGGUGUACAUCCAACCUGGUCCAUAUGUGGAUCCUUUCACGACAGUGACCCUGGGCUGGCCAGACAAUGACAAGGAGUUACGCUUCCAAUGGUCAUGUGGGUCUUGCUGGGCUCUGUGGAGCAGCUGUGUUGAGAGGCAGCUGCUUCGCACAGACCAGAGGGAGCUGGUGGUUCCAGCAUCCUGCCUGCCGCCGCCUGACUCUGCUGUCACCCUGCGCCUGGCUGUUCUGAGAGGCCAAGAGCUGGAGAACAGGGCAGAGCAGUGCCUCUACGUGUCUGCGCCCUGGGAACUCAGGCCUCGAGUCAGCUGUGAGAGGAACUGCAGGCCAGUUAAUGCCAGCAAAGACAUUCUGCUCAGGGUCACCAUGGGGGAGGACUCUCCAGUGGCUAUGUUCAGCUGGUAUUUGGACAACACCCCAACAGAGCAGGCUGAGCCCCUCCUGGAUGCCUGCAGACUCAGAGGAUUUUGGCCAAGGUCCUUAACCCUCCUCCAGAGCAACACCUCCACGUUGCUGUUGAACAGCUCGUUUCUGCAGUCCCGGGGAGAGGUCAUCCGAAUCAGAGCCACAGCACUGACCAGGCAUGCCUAUGGGGAGGACACCUAUGUGAUCAGCACUGUGCCUCCCCGUGAGGUGCCUGCCUGCACUAUUGCCCCAGAGGAGGGCACCGUUCUGACGAGCUUUGCCAUCUUCUGCAACGCCUCCACAGCCCUGGGACCCCUGGAGUUCUGCUUCUGUCUGGAAUCAGGUUCCUGCCUACACUGUGGCCCUGAACCUGCCCUCCCAUCAGUGUAUCUGCCACUUGGAGAGGAGAACAAUGACUUUGUGCUGACAGUAGUUAUUUCUGCCACCAAUCGUGCAGGGGACACGCAGCAGACCCAGGCCAUGGCUAAGGUGGCACUCGGAGACACAUGUGUUGAGGAUGUAGCAUUCCAGGCUGCCGUGUCAGAGAAAAUCCCCACAGCUCUGCAAGGCGAGGGUGGCCCCGAGCAGCUCCUCCAGCUGGCCAAGGCUGUGUCCUCCAUGCUGAACCAAGAGCAUGAAAGCCAGGGCUCAGGACAGUCACUGAGCAUAGACGUCAGACAGAAGGUCAGAGAGCAUGUGCUGGGAUCACUGUCUGCAGUCACCACCGGCUUGGAGGACGUGCAGAGGGUGCAGGAGCUGGCCGAGGUGCUGAGAGAGGUGACCUGCCGGAGUAAGGAACUCACACCCUCGGCCCAGGGGUCCUGCAUGGGCGAUUCAUGGGAAGGUGCCCCUCCUGCUGCCCAUGUAUCUCACGCUAGGUGAGAGGGCCUGUUUGCCCAGACUCUCACUCCUGCAUCUGCUGGUGAGCAAGUUGAGGGAGUAACUGAAUCUCAUUAAUAUUUGGGUGGCCAAAUGUGAGUCCAGACACUGCUACUGACUGCCCAUGUUCUCAACUUCAGUACAUGCCAGCCUGACAUCUGGCUGCCAGCUCCUGUGCUUCCUUAUCCUUCUGGGGGUCUUCUCUGACCCUCAGAGCCUACUGUACCUGCCCAUAUGGCUGUGAAUUCAUGCAGUGUUCAGUGACUAAUGAAGCUGGCUUAUAAACACCCCAGCUACCUCACCCCUCUUGAUGGAUAAUCCCAAGCAGGAGUGAAUCCCAGGUAAUGGGCUUGAUCACACUCCUGUACUGGCUUCCACCCUUCCCUGUCUCACACCCCCUACUCCCCACAAGUGUUUCUUGGGAUCAUGUCCAAAUAAAUGACUUGCUCUCAAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 114780)
PKD1L2
polycystin 1 like 2 (gene/pseudogene)
NC_000016.10
16  81170740.. 81220370
81170740.. 81220370
strand -
MGI:2664668
ClinVar, dbVar
ENSG00000166473
KIAA1879
uc032egc.1
INSDC: AY164483
21715
607894
OTTHUMG00000166126
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (2976 bp)
5'-ATGAGTGCAGTGGGCTTGGTACTCCTGGTGCTTGCTCTGAGGCTTAGGGCCACCACTGTTAAGCCAGAGGAAGGCAGCTTTTGCTCTAACAGCCAGGTGGCCTTCAGAGATGCTTGCTATGAATTTGTGCCACTCGGACGCACCTTCCGTGATGCCCAGAGCTGGTGCGAGGGGCAAGGAGGCCATTTGGTCTTCATTCAGGACGAAGGCACCCAGTGGTTTCTGCAGAAGCACATCTCCCAGGACAGGGAATGGTGGATTGGACTCACGTGGAACTTGGCACGGAATGGAACCACGGAGGGGCCGGGGACTTGGTTGGACACCTCCAATGTGACCTACAGCAACTGGCATGGAGGGCAGGCCGCCGCTGCCCCTGACACCTGCGGCCACATCGGGAGAGGCCCTTCCTCTGAGTGGGTGACCTCGGACTGCGCCCAGACCTTCGCCTTCATGTGCGAGTTCCGGGTTGGCCAGAGCCTGGCCTGCGAGGGACTCAATGCCACCGTGCACTGTGGCTTGGGGCAGGTCATCCAGGTCCAGGATGCCGTCTACGGGCGCCAGAATCCCCATTTCTGCACCCAGGATGCCGGGCGTCCTTCAGATCTGGAGCAGGGATGCAGCTGGGCCAACGTCAAGGAGGAGGTGGCAGGCCAGTGCCAGGAGCTACAGTCATGCCAGGTGGCAGCAGATGAGACCTACTTTGGAAACCTGTGTCCGACTCAGGGCAGTTACCTGTGGGTGCAGTACCAGTGCCGGGAAGCCCTGCAGCTGATGGTGTCCAGTGAGAGTTTCATCTTTGACAATGTCACCATCTCCCTGACGTGGCTCCTCTCACCCTACATAGGAAACCTGTCCTGTATAATTAGTACAGGAGACAGCCACACTTTTGATCCCTACAACCCGCCGAGTGTGTCCAGCAATGTGACCCACCAGTTCACATCTCCTGGGGAATTCACCGTGTTTGCTGAATGCACAACCAGTGAGTGGCATGTGACAGCTCAGAGGCAGGTGACCGTGCGAGACAAGATGGAGACGCTCAGTGTGACTGCATGCTCCGGCCTGTCCCAGTCAGGAGCCGGCCCTCTCTGCCAGGCTGTCTTTGGGGATCCTCTGTGGATTCAGGTGGAGCTTGATGGAGGAACAGGAGTGACTTACACTGTGCTTTTGGGTGACATAACCCTGGCCGAGTCCACCACCCAAAAGGGCTCGCTACCGTACAATCTGATCCTGGACAGAGAAACCCAGAAACTGATGGGCCCTGGGAGGCACCGCCTGGAGATCCAAGCCACCGGCAACACCACCACCTCTACAATCTCCAGAAACATTACAGTCCACTTGGTGGAGCTGCTGTCAGGGCTGCAGGCCTCCTGGGCTTCTGACCATTTGGAGCTTGGACAGGACCTATTGATCACCATCTCATTGGCTCAGGGCACCCCGGAAGAGCTGACCTTTGAGGTGGCTGGACTCAATGCAACCTTCTCCCACGAGCAAGTGAGCTTTGGAGAGCCATTTGGGATTTGCCGCCTGGCTGTTCCGGTTGAAGGCACCTTTCTGGTCACCATGCTGGTGAGGAATGCCTTCTCCAACCTGAGTTTGGAAATCGGGAACATCACTATCACAGCCCCTTCCGGTCTCCAAGAACCATCTGGGATGAATGCTGAAGGAAAGAGTAAAGATAAAGGCGATATGGAGGTGTACATCCAACCTGGTCCATATGTGGATCCTTTCACGACAGTGACCCTGGGCTGGCCAGACAATGACAAGGAGTTACGCTTCCAATGGTCATGTGGGTCTTGCTGGGCTCTGTGGAGCAGCTGTGTTGAGAGGCAGCTGCTTCGCACAGACCAGAGGGAGCTGGTGGTTCCAGCATCCTGCCTGCCGCCGCCTGACTCTGCTGTCACCCTGCGCCTGGCTGTTCTGAGAGGCCAAGAGCTGGAGAACAGGGCAGAGCAGTGCCTCTACGTGTCTGCGCCCTGGGAACTCAGGCCTCGAGTCAGCTGTGAGAGGAACTGCAGGCCAGTTAATGCCAGCAAAGACATTCTGCTCAGGGTCACCATGGGGGAGGACTCTCCAGTGGCTATGTTCAGCTGGTATTTGGACAACACCCCAACAGAGCAGGCTGAGCCCCTCCTGGATGCCTGCAGACTCAGAGGATTTTGGCCAAGGTCCTTAACCCTCCTCCAGAGCAACACCTCCACGTTGCTGTTGAACAGCTCGTTTCTGCAGTCCCGGGGAGAGGTCATCCGAATCAGAGCCACAGCACTGACCAGGCATGCCTATGGGGAGGACACCTATGTGATCAGCACTGTGCCTCCCCGTGAGGTGCCTGCCTGCACTATTGCCCCAGAGGAGGGCACCGTTCTGACGAGCTTTGCCATCTTCTGCAACGCCTCCACAGCCCTGGGACCCCTGGAGTTCTGCTTCTGTCTGGAATCAGGTTCCTGCCTACACTGTGGCCCTGAACCTGCCCTCCCATCAGTGTATCTGCCACTTGGAGAGGAGAACAATGACTTTGTGCTGACAGTAGTTATTTCTGCCACCAATCGTGCAGGGGACACGCAGCAGACCCAGGCCATGGCTAAGGTGGCACTCGGAGACACATGTGTTGAGGATGTAGCATTCCAGGCTGCCGTGTCAGAGAAAATCCCCACAGCTCTGCAAGGCGAGGGTGGCCCCGAGCAGCTCCTCCAGCTGGCCAAGGCTGTGTCCTCCATGCTGAACCAAGAGCATGAAAGCCAGGGCTCAGGACAGTCACTGAGCATAGACGTCAGACAGAAGGTCAGAGAGCATGTGCTGGGATCACTGTCTGCAGTCACCACCGGCTTGGAGGACGTGCAGAGGGTGCAGGAGCTGGCCGAGGTGCTGAGAGAGGTGACCTGCCGGAGTAAGGAACTCACACCCTCGGCCCAGGGGTCCTGCATGGGCGATTCATGGGAAGGTGCCCCTCCTGCTGCCCATGTATCTCACGCTAGGTGA-3'
NCBI CDS gene sequence with introns (location: 81170740.. 81220370) (49631 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 81170289.. 81220394) (50106 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [81170289.. 81220394 + 1000]) (51106 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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