Protein
Protein (NP_001011880)
C-type lectin domain family 18 member B
C-type lectin domain family 18 member B (Mannose receptor-like protein 1)
CLEC18B
C-type lectin domain family 18 member B
Undefined
Very low evidence
C-type lectin
Undefined
C-type - Others
a/b mixed / C-type lectin-like
Uncharacterised
NP_001011880
497190
Q6UXF7
Undefined
A5D8T8
0.315
10.1074/jbc.M115.649814
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (455 amino acids) Download
MLHPETSPGRGHLLAVLLALLGTTWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGIPTPSLASGLWRTLQVGWNMQLLPAGLASFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQTAIEAFVCAYSPGGNWEVNGKTIIPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGLVWLSAAMGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q6UXF7-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [1.62, 2.12] ÅDownload
The location of the lectin domain structural model is: 301-450
We infer [1.62, 2.12] Å as the interval of error of this structural model.
Template 1: 2OX9 chain: A, Q8K4Q8, NP_569716.2, sequence identity: 23.3%, coverage: 84.7%, location in sequence: 606-735, (606-735 in PDB).
Template 2: 2OX8 chain: A, Q5KU26, NP_569057.2, sequence identity: 22.0%, coverage: 84.0%, location in sequence: 606-734, (606-734 in PDB).
Template 3: 6PY1 chain: A, Q8IUN9, NP_878910.1, sequence identity: 22.0%, coverage: 82.0%, location in sequence: 179-308, (179-308 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for CLEC18B Gene
References
NCBI References (4 PubMed Identifiers)
  • Overexpression of CLEC18B Associates With the Proliferation, Migration, and Prognosis of Glioblastoma. [29914265]
  • Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity. [26170455]
  • The C-type lectin-like domain superfamily. [16336259]
  • The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. [12975309]
UniProt Main References (2 PubMed Identifiers)
  • Complete sequencing and characterization of 21,243 full-length human cDNAs. [14702039]
  • The sequence and analysis of duplication-rich human chromosome 16. [15616553]
All isoforms of this gene containing a lectin domain
NP_001372123.1, NP_001372124.1, NP_001372121.1, NP_001372122.1, NP_001011880.2
RNA
RNA (Transcript ID: NM_001011880.3)
NM_001011880.3
C-type lectin domain family 18 member B, transcript variant 3
All isoforms of CLEC18B containing a lectin domain
209..1576 (or 74409006.. 74421270)
74408631.. 74421478
NCBI Matured mRNA sequence 1951 NTPDownload 
m7G-5')ppp(5'-CUCUUUUCAUGCCAGCGCCAACAGGAGGCUGUCUGGACACACUGAUUACUCACUCACCAGCCUCCUUCUUUUGUUCACCAGCCCCCCUCUUUUGUCCACCAGCCCAGCCUGACUCCUGGAGAUUGUGAAUAGCUCCAUCCAGCCUGAGAAACAAGCCGGGUGGCUGAGCCAGGCUGUGCACGGAGCGCCUGACGGGCCCAACAGACCCAUGCUGCAUCCAGAGACCUCCCCUGGCCGGGGGCAUCUCCUGGCUGUGCUCCUGGCCCUCCUUGGCACCACCUGGGCAGAGGUGUGGCCACCCCAGCUGCAGGAGCAGGCUCCGAUGGCCGGAGCCCUGAACAGGAAGGAGAGUUUCUUGCUCCUCUCCCUGCACAACCGCCUGCGCAGCUGGGUCCAGCCCCCUGCGGCUGACAUGCGGAGGCUGGACUGGAGUGACAGCCUGGCCCAACUGGCUCAAGCCAGGGCAGCCCUCUGUGGAAUCCCAACCCCGAGCCUGGCGUCCGGCCUGUGGCGCACCCUGCAAGUGGGCUGGAACAUGCAGCUGCUGCCCGCGGGCUUGGCGUCCUUUGUUGAAGUGGUCAGCCUGUGGUUUGCAGAGGGGCAGCGGUACAGCCACGCGGCAGGAGAGUGUGCUCGCAACGCCACCUGCACCCACUACACGCAGCUCGUGUGGGCCACCUCAAGCCAGCUGGGCUGUGGGCGGCACCUGUGCUCUGCAGGCCAGACAGCGAUAGAAGCCUUUGUCUGUGCCUACUCCCCCGGAGGCAACUGGGAGGUCAACGGGAAGACAAUCAUCCCCUAUAAGAAGGGUGCCUGGUGUUCGCUCUGCACAGCCAGUGUCUCAGGCUGCUUCAAAGCCUGGGACCAUGCAGGGGGGCUCUGUGAGGUCCCCAGGAAUCCUUGUCGCAUGAGCUGCCAGAACCAUGGACGUCUCAACAUCAGCACCUGCCACUGCCACUGUCCCCCUGGCUACACGGGCAGAUACUGCCAAGUGAGGUGCAGCCUGCAGUGUGUGCACGGCCGGUUCCGGGAGGAGGAGUGCUCGUGCGUCUGUGACAUCGGCUACGGGGGAGCCCAGUGUGCCACCAAGGUGCAUUUUCCCUUCCACACCUGUGACCUGAGGAUCGACGGAGACUGCUUCAUGGUGUCUUCAGAGGCAGACACCUAUUACAGAGCCAGGAUGAAAUGUCAGAGGAAAGGCGGGGUGCUGGCCCAGAUCAAGAGCCAGAAAGUGCAGGACAUCCUCGCCUUCUAUCUGGGCCGCCUGGAGACCACCAACGAGGUGAUUGACAGUGACUUCGAGACCAGGAACUUCUGGAUCGGGCUCACCUACAAGACCGCCAAGGACUCCUUCCGCUGGGCCACAGGGGAGCACCAGGCCUUCACCAGUUUUGCCUUUGGGCAGCCUGACAACCACGGGCUGGUGUGGCUGAGUGCUGCCAUGGGGUUUGGCAACUGCGUGGAGCUGCAGGCUUCAGCUGCCUUCAACUGGAACGACCAGCGCUGCAAAACCCGAAACCGUUACAUCUGCCAGUUUGCCCAGGAGCACAUCUCCCGGUGGGGCCCAGGGUCCUGAGGCCUGACCACAUGGCUCCCUCGCCUGCCCUGGGAGCACCGGCUCUGCUUACCUGUCUGCCCACCUGUCUGGAACAAGGGCCAGGUUAAGACCACAUGCCUCAUGUCCAAAGAGGUCUCAGACCUUGCACAAUGCCAGAAGUUGGGCAGAGAGAGGCAGGGAGGCCAGUGAGGGCCAGGGAGUGAGUGUUAGAAGAAGCUGGGGCCCUUCGCCUGCUUUUGAUUGGGAAGAUGGGCUUCAAUUAGAUGGCGAAGGAGAGGACACCGCCAGUGGUCCAAAAAGGCUGCUCUCUUCCACCUGGCCCAGACCCUGUGGGGCAGCGGAGCUUCCCUGUGGCAUGAACCCCACGGGGUAUUAAAUUAUGAAUCAGCUGAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 497190)
CLEC18B
C-type lectin domain family 18 member B
NC_000016.10
16  74409006.. 74421270
74409006.. 74421270
strand -
CCDS32484.1
MGI:2672935
ClinVar, dbVar
ENSG00000140839
uc002fct.4
INSDC: AY358373
33849
616572
OTTHUMG00000176998
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1368 bp)
5'-ATGCTGCATCCAGAGACCTCCCCTGGCCGGGGGCATCTCCTGGCTGTGCTCCTGGCCCTCCTTGGCACCACCTGGGCAGAGGTGTGGCCACCCCAGCTGCAGGAGCAGGCTCCGATGGCCGGAGCCCTGAACAGGAAGGAGAGTTTCTTGCTCCTCTCCCTGCACAACCGCCTGCGCAGCTGGGTCCAGCCCCCTGCGGCTGACATGCGGAGGCTGGACTGGAGTGACAGCCTGGCCCAACTGGCTCAAGCCAGGGCAGCCCTCTGTGGAATCCCAACCCCGAGCCTGGCGTCCGGCCTGTGGCGCACCCTGCAAGTGGGCTGGAACATGCAGCTGCTGCCCGCGGGCTTGGCGTCCTTTGTTGAAGTGGTCAGCCTGTGGTTTGCAGAGGGGCAGCGGTACAGCCACGCGGCAGGAGAGTGTGCTCGCAACGCCACCTGCACCCACTACACGCAGCTCGTGTGGGCCACCTCAAGCCAGCTGGGCTGTGGGCGGCACCTGTGCTCTGCAGGCCAGACAGCGATAGAAGCCTTTGTCTGTGCCTACTCCCCCGGAGGCAACTGGGAGGTCAACGGGAAGACAATCATCCCCTATAAGAAGGGTGCCTGGTGTTCGCTCTGCACAGCCAGTGTCTCAGGCTGCTTCAAAGCCTGGGACCATGCAGGGGGGCTCTGTGAGGTCCCCAGGAATCCTTGTCGCATGAGCTGCCAGAACCATGGACGTCTCAACATCAGCACCTGCCACTGCCACTGTCCCCCTGGCTACACGGGCAGATACTGCCAAGTGAGGTGCAGCCTGCAGTGTGTGCACGGCCGGTTCCGGGAGGAGGAGTGCTCGTGCGTCTGTGACATCGGCTACGGGGGAGCCCAGTGTGCCACCAAGGTGCATTTTCCCTTCCACACCTGTGACCTGAGGATCGACGGAGACTGCTTCATGGTGTCTTCAGAGGCAGACACCTATTACAGAGCCAGGATGAAATGTCAGAGGAAAGGCGGGGTGCTGGCCCAGATCAAGAGCCAGAAAGTGCAGGACATCCTCGCCTTCTATCTGGGCCGCCTGGAGACCACCAACGAGGTGATTGACAGTGACTTCGAGACCAGGAACTTCTGGATCGGGCTCACCTACAAGACCGCCAAGGACTCCTTCCGCTGGGCCACAGGGGAGCACCAGGCCTTCACCAGTTTTGCCTTTGGGCAGCCTGACAACCACGGGCTGGTGTGGCTGAGTGCTGCCATGGGGTTTGGCAACTGCGTGGAGCTGCAGGCTTCAGCTGCCTTCAACTGGAACGACCAGCGCTGCAAAACCCGAAACCGTTACATCTGCCAGTTTGCCCAGGAGCACATCTCCCGGTGGGGCCCAGGGTCCTGA-3'
NCBI CDS gene sequence with introns (location: 74409006.. 74421270) (12265 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 74408631.. 74421478) (12848 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [74408631.. 74421478 + 1000]) (13848 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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