NCBI Summary
This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_002548)
Oviductin
Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Mucin-9) (Oviductal glycoprotein) (Oviductin)
OVGP1
oviductal glycoprotein 1
Undefined
Low evidence
chi-lectin (TIM)
Chilectins
a/b barrel / TIM
GlcNAc(b1-4)GlcNAc / Chitooligosaccharides
NP_002548
5016
Q12889
ENSP00000358747.3
Q12889
Undefined
10.1002/mrd.1080410315
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (678 amino acids) Download
MWKLLLWVGLVLVLKHHDGAAHKLVCYFTNWAHSRPGPASILPHDLDPFLCTHLIFAFASMNNNQIVAKDLQDEKILYPEFNKLKERNRELKTLLSIGGWNFGTSRFTTMLSTFANREKFIASVISLLRTHDFDGLDLFFLYPGLRGSPMHDRWTFLFLIEELLFAFRKEALLTMRPRLLLSAAVSGVPHIVQTSYDVRFLGRLLDFINVLSYDLHGSWERFTGHNSPLFSLPEDPKSSAYAMNYWRKLGAPSEKLIMGIPTYGRTFRLLKASKNGLQARAIGPASPGKYTKQEGFLAYFEICSFVWGAKKHWIDYQYVPYANKGKEWVGYDNAISFSYKAWFIRREHFGGAMVWTLDMDDVRGTFCGTGPFPLVYVLNDILVRAEFSSTSLPQFWLSSAVNSSSTDPERLAVTTAWTTDSKILPPGGEAGVTEIHGKCENMTITPRGTTVTPTKETVSLGKHTVALGEKTEITGAMTMTSVGHQSMTPGEKALTPVGHQSVTTGQKTLTSVGYQSVTPGEKTLTPVGHQSVTPVSHQSVSPGGTTMTPVHFQTETLRQNTVAPRRKAVAREKVTVPSRNISVTPEGQTMPLRGENLTSEVGTHPRMGNLGLQMEAENRMMLSSSPVIQLPEQTPLAFDNRFVPIYGNHSSVNSVTPQTSPLSLKKEIPENSAVDEEA
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q12889-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

SWISS-MODEL structural models
SWISS-MODEL structural model
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for OVGP1 Gene
ProteomicsDB
References
NCBI References (10 PubMed Identifiers)
  • Human OVGP1 enhances tyrosine phosphorylation of proteins in the fibrous sheath involving AKAP3 and increases sperm-zona binding. [31254143]
  • Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion. [29968069]
  • Reduced expression of mucin 9 (MUC9) in patients with ulcerative colitis. [22028245]
  • Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. [20800603]
  • Oviductal glycoprotein (OVGP1, MUC9): a differentiation-based mucin present in serum of women with ovarian cancer. [20130498]
  • Variable expression of oviductin mRNA at different stages of human reproductive cycle. [12503889]
  • Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter. [11818519]
  • Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). [9341614]
  • Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. [7819450]
  • The in vitro synthesis and release of proteins by the human oviduct. [3278893]
UniProt Main References (3 PubMed Identifiers)
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • The consensus coding sequences of human breast and colorectal cancers. [16959974]
RNA
RNA (Transcript ID: NM_002557.4)
NM_002557.4
oviductal glycoprotein 1
All isoforms of OVGP1 containing a lectin domain
ENST00000369732.4
15..2051 (or 111414464.. 111427721)
111414319.. 111427735
NCBI Matured mRNA sequence 2196 NTPDownload 
m7G-5')ppp(5'-AUCAGACCAUUGAGAUGUGGAAGCUGUUGCUGUGGGUUGGGCUGGUUCUUGUGCUGAAACACCACGAUGGUGCUGCCCAUAAACUCGUGUGUUAUUUCACCAACUGGGCACACAGUCGGCCAGGCCCUGCCUCGAUCUUGCCCCAUGACCUGGACCCCUUUCUCUGCACCCACCUGAUAUUUGCCUUUGCCUCAAUGAACAACAAUCAGAUUGUUGCUAAGGAUCUCCAGGAUGAGAAAAUUCUCUACCCAGAGUUCAACAAACUAAAGGAGAGGAACAGAGAGCUGAAAACACUACUGUCCAUCGGCGGGUGGAACUUUGGCACCUCAAGAUUCACCACUAUGUUGUCCACAUUUGCCAACCGUGAAAAGUUUAUUGCUUCAGUUAUAUCCCUUCUGAGGACACAUGACUUUGAUGGUCUUGACCUUUUCUUCUUAUAUCCUGGACUAAGAGGCAGCCCCAUGCAUGACCGGUGGACUUUUCUCUUCUUAAUUGAAGAGCUCCUGUUUGCCUUCCGGAAGGAGGCACUGCUCACCAUGCGCCCGAGGCUGCUGCUGUCUGCUGCUGUUUCUGGGGUCCCACACAUCGUCCAAACAUCCUAUGAUGUGCGCUUUCUAGGAAGACUCCUGGAUUUCAUCAAUGUCUUGUCUUAUGACUUACAUGGAAGUUGGGAAAGGUUCACAGGACAUAAUAGCCCCCUCUUCUCUCUGCCUGAAGACCCCAAAUCUUCGGCAUAUGCUAUGAAUUAUUGGAGAAAGCUUGGGGCACCCUCAGAGAAGCUCAUCAUGGGGAUCCCCACCUAUGGACGUACCUUUCGCCUCCUCAAAGCCUCUAAGAAUGGGUUGCAGGCCAGAGCGAUCGGACCAGCAUCUCCAGGGAAGUACACCAAGCAAGAAGGCUUCUUGGCUUAUUUUGAGAUUUGUUCCUUUGUCUGGGGAGCGAAGAAGCACUGGAUUGAUUACCAGUAUGUCCCGUAUGCCAACAAGGGGAAAGAGUGGGUUGGCUAUGACAAUGCCAUCAGCUUCAGUUACAAGGCAUGGUUUAUAAGGCGAGAGCAUUUUGGGGGGGCCAUGGUGUGGACAUUGGACAUGGAUGACGUCAGGGGCACGUUCUGUGGCACUGGCCCUUUCCCCCUUGUCUACGUAUUGAAUGAUAUCCUGGUGCGGGCUGAGUUCAGUUCAACUUCUUUACCACAAUUUUGGCUGUCAUCUGCUGUGAAUUCUUCAAGCACUGACCCUGAAAGGCUGGCUGUGACCACGGCAUGGACCACUGAUAGUAAGAUUUUGCCCCCAGGAGGAGAGGCUGGGGUCACUGAGAUCCACGGAAAGUGUGAAAAUAUGACUAUAACCCCUAGAGGUACAACUGUGACCCCUACAAAGGAAACUGUAUCCCUUGGAAAGCACACUGUAGCUCUAGGAGAGAAGACUGAGAUCACUGGGGCAAUGACCAUGACUUCUGUGGGUCAUCAGUCCAUGACCCCUGGAGAGAAGGCCCUGACCCCUGUGGGUCAUCAAUCUGUGACCACUGGACAGAAGACCCUGACCUCUGUGGGUUAUCAGUCUGUGACCCCUGGGGAAAAGACCCUGACCCCUGUGGGUCAUCAGUCUGUGACCCCUGUGAGUCAUCAGUCUGUGAGCCCUGGAGGAACGACUAUGACCCCUGUCCAUUUUCAGACUGAGACCCUUAGACAGAAUACAGUGGCCCCUAGAAGGAAGGCUGUGGCCCGUGAAAAGGUGACUGUCCCCUCCAGAAACAUAUCAGUCACCCCUGAAGGGCAGACUAUGCCUUUAAGAGGGGAGAAUUUGACUUCUGAGGUGGGCACUCACCCCAGGAUGGGUAACUUGGGUCUUCAGAUGGAAGCUGAAAACAGGAUGAUGCUGUCCUCCAGCCCCGUCAUCCAGCUCCCGGAACAAACUCCUCUAGCUUUUGACAACCGCUUUGUUCCCAUCUAUGGAAACCAUUCCUCUGUCAACUCAGUAACCCCUCAAACAAGUCCUCUUUCUCUAAAAAAAGAAAUCCCAGAAAACUCUGCUGUGGAUGAAGAAGCCUAAGCCCCUCUGGUGUCAGAAACCAGGGAAAACCCUUGUCUUUUCUUCUAAGUGACAUGUUGGAAGCCUUCUCAUCCCGGGGCAAAGCAGGCAUCAAAACCAGAAUAGGCCAAUCUCUUUUCCAUUAAAUAAACUGUAAACACAAGAA-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 5016)
OVGP1
oviductal glycoprotein 1
NC_000001.11
1  111414464.. 111427721
111414464.. 111427721
strand -
CCDS834.1
MGI:106661
ClinVar, dbVar
ENSG00000085465
CHIT5
uc001eba.4
INSDC: U09550
8524
603578
OTTHUMG00000011746
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (2037 bp)
5'-ATGTGGAAGCTGTTGCTGTGGGTTGGGCTGGTTCTTGTGCTGAAACACCACGATGGTGCTGCCCATAAACTCGTGTGTTATTTCACCAACTGGGCACACAGTCGGCCAGGCCCTGCCTCGATCTTGCCCCATGACCTGGACCCCTTTCTCTGCACCCACCTGATATTTGCCTTTGCCTCAATGAACAACAATCAGATTGTTGCTAAGGATCTCCAGGATGAGAAAATTCTCTACCCAGAGTTCAACAAACTAAAGGAGAGGAACAGAGAGCTGAAAACACTACTGTCCATCGGCGGGTGGAACTTTGGCACCTCAAGATTCACCACTATGTTGTCCACATTTGCCAACCGTGAAAAGTTTATTGCTTCAGTTATATCCCTTCTGAGGACACATGACTTTGATGGTCTTGACCTTTTCTTCTTATATCCTGGACTAAGAGGCAGCCCCATGCATGACCGGTGGACTTTTCTCTTCTTAATTGAAGAGCTCCTGTTTGCCTTCCGGAAGGAGGCACTGCTCACCATGCGCCCGAGGCTGCTGCTGTCTGCTGCTGTTTCTGGGGTCCCACACATCGTCCAAACATCCTATGATGTGCGCTTTCTAGGAAGACTCCTGGATTTCATCAATGTCTTGTCTTATGACTTACATGGAAGTTGGGAAAGGTTCACAGGACATAATAGCCCCCTCTTCTCTCTGCCTGAAGACCCCAAATCTTCGGCATATGCTATGAATTATTGGAGAAAGCTTGGGGCACCCTCAGAGAAGCTCATCATGGGGATCCCCACCTATGGACGTACCTTTCGCCTCCTCAAAGCCTCTAAGAATGGGTTGCAGGCCAGAGCGATCGGACCAGCATCTCCAGGGAAGTACACCAAGCAAGAAGGCTTCTTGGCTTATTTTGAGATTTGTTCCTTTGTCTGGGGAGCGAAGAAGCACTGGATTGATTACCAGTATGTCCCGTATGCCAACAAGGGGAAAGAGTGGGTTGGCTATGACAATGCCATCAGCTTCAGTTACAAGGCATGGTTTATAAGGCGAGAGCATTTTGGGGGGGCCATGGTGTGGACATTGGACATGGATGACGTCAGGGGCACGTTCTGTGGCACTGGCCCTTTCCCCCTTGTCTACGTATTGAATGATATCCTGGTGCGGGCTGAGTTCAGTTCAACTTCTTTACCACAATTTTGGCTGTCATCTGCTGTGAATTCTTCAAGCACTGACCCTGAAAGGCTGGCTGTGACCACGGCATGGACCACTGATAGTAAGATTTTGCCCCCAGGAGGAGAGGCTGGGGTCACTGAGATCCACGGAAAGTGTGAAAATATGACTATAACCCCTAGAGGTACAACTGTGACCCCTACAAAGGAAACTGTATCCCTTGGAAAGCACACTGTAGCTCTAGGAGAGAAGACTGAGATCACTGGGGCAATGACCATGACTTCTGTGGGTCATCAGTCCATGACCCCTGGAGAGAAGGCCCTGACCCCTGTGGGTCATCAATCTGTGACCACTGGACAGAAGACCCTGACCTCTGTGGGTTATCAGTCTGTGACCCCTGGGGAAAAGACCCTGACCCCTGTGGGTCATCAGTCTGTGACCCCTGTGAGTCATCAGTCTGTGAGCCCTGGAGGAACGACTATGACCCCTGTCCATTTTCAGACTGAGACCCTTAGACAGAATACAGTGGCCCCTAGAAGGAAGGCTGTGGCCCGTGAAAAGGTGACTGTCCCCTCCAGAAACATATCAGTCACCCCTGAAGGGCAGACTATGCCTTTAAGAGGGGAGAATTTGACTTCTGAGGTGGGCACTCACCCCAGGATGGGTAACTTGGGTCTTCAGATGGAAGCTGAAAACAGGATGATGCTGTCCTCCAGCCCCGTCATCCAGCTCCCGGAACAAACTCCTCTAGCTTTTGACAACCGCTTTGTTCCCATCTATGGAAACCATTCCTCTGTCAACTCAGTAACCCCTCAAACAAGTCCTCTTTCTCTAAAAAAAGAAATCCCAGAAAACTCTGCTGTGGATGAAGAAGCCTAA-3'
NCBI CDS gene sequence with introns (location: 111414464.. 111427721) (13258 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 111414319.. 111427735) (13417 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [111414319.. 111427735 + 1000]) (14417 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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