NCBI Summary
This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_002548)
Oviductin
Oviduct-specific glycoprotein (Estrogen-dependent oviduct protein) (Mucin-9) (Oviductal glycoprotein) (Oviductin)
OVGP1
oviductal glycoprotein 1
Undefined
Low evidence
chi-lectin TIM
Chilectins
a/b barrel / TIM
GlcNAc(b1-4)GlcNAc / Chitooligosaccharides
Undefined
Protein sequence and protein families (fasta) (678 amino acids) Download
MWKLLLWVGLVLVLKHHDGAAHKLVCYFTNWAHSRPGPASILPHDLDPFLCTHLIFAFASMNNNQIVAKDLQDEKILYPEFNKLKERNRELKTLLSIGGWNFGTSRFTTMLSTFANREKFIASVISLLRTHDFDGLDLFFLYPGLRGSPMHDRWTFLFLIEELLFAFRKEALLTMRPRLLLSAAVSGVPHIVQTSYDVRFLGRLLDFINVLSYDLHGSWERFTGHNSPLFSLPEDPKSSAYAMNYWRKLGAPSEKLIMGIPTYGRTFRLLKASKNGLQARAIGPASPGKYTKQEGFLAYFEICSFVWGAKKHWIDYQYVPYANKGKEWVGYDNAISFSYKAWFIRREHFGGAMVWTLDMDDVRGTFCGTGPFPLVYVLNDILVRAEFSSTSLPQFWLSSAVNSSSTDPERLAVTTAWTTDSKILPPGGEAGVTEIHGKCENMTITPRGTTVTPTKETVSLGKHTVALGEKTEITGAMTMTSVGHQSMTPGEKALTPVGHQSVTTGQKTLTSVGYQSVTPGEKTLTPVGHQSVTPVSHQSVSPGGTTMTPVHFQTETLRQNTVAPRRKAVAREKVTVPSRNISVTPEGQTMPLRGENLTSEVGTHPRMGNLGLQMEAENRMMLSSSPVIQLPEQTPLAFDNRFVPIYGNHSSVNSVTPQTSPLSLKKEIPENSAVDEEA
No structure currently available in the PDB RCSB Databank.
Structural models
Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.


SWISS-MODEL structural models
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
References
NCBI References (10 PubMed Identifiers)
  • Human OVGP1 enhances tyrosine phosphorylation of proteins in the fibrous sheath involving AKAP3 and increases sperm-zona binding. [31254143]
  • Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion. [29968069]
  • Reduced expression of mucin 9 (MUC9) in patients with ulcerative colitis. [22028245]
  • Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. [20800603]
  • Oviductal glycoprotein (OVGP1, MUC9): a differentiation-based mucin present in serum of women with ovarian cancer. [20130498]
  • Variable expression of oviductin mRNA at different stages of human reproductive cycle. [12503889]
  • Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter. [11818519]
  • Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). [9341614]
  • Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. [7819450]
  • The in vitro synthesis and release of proteins by the human oviduct. [3278893]
UniProt Main References (3 PubMed Identifiers)
  • The DNA sequence and biological annotation of human chromosome 1. [16710414]
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
  • The consensus coding sequences of human breast and colorectal cancers. [16959974]
RNA
RNA (Transcript ID: NM_002557.4)
oviductal glycoprotein 1
m7G-5')ppp(5'-AUCAGACCAUUGAGAUGUGGAAGCUGUUGCUGUGGGUUGGGCUGGUUCUUGUGCUGAAACACCACGAUGGUGCUGCCCAUAAACUCGUGUGUUAUUUCACCAACUGGGCACACAGUCGGCCAGGCCCUGCCUCGAUCUUGCCCCAUGACCUGGACCCCUUUCUCUGCACCCACCUGAUAUUUGCCUUUGCCUCAAUGAACAACAAUCAGAUUGUUGCUAAGGAUCUCCAGGAUGAGAAAAUUCUCUACCCAGAGUUCAACAAACUAAAGGAGAGGAACAGAGAGCUGAAAACACUACUGUCCAUCGGCGGGUGGAACUUUGGCACCUCAAGAUUCACCACUAUGUUGUCCACAUUUGCCAACCGUGAAAAGUUUAUUGCUUCAGUUAUAUCCCUUCUGAGGACACAUGACUUUGAUGGUCUUGACCUUUUCUUCUUAUAUCCUGGACUAAGAGGCAGCCCCAUGCAUGACCGGUGGACUUUUCUCUUCUUAAUUGAAGAGCUCCUGUUUGCCUUCCGGAAGGAGGCACUGCUCACCAUGCGCCCGAGGCUGCUGCUGUCUGCUGCUGUUUCUGGGGUCCCACACAUCGUCCAAACAUCCUAUGAUGUGCGCUUUCUAGGAAGACUCCUGGAUUUCAUCAAUGUCUUGUCUUAUGACUUACAUGGAAGUUGGGAAAGGUUCACAGGACAUAAUAGCCCCCUCUUCUCUCUGCCUGAAGACCCCAAAUCUUCGGCAUAUGCUAUGAAUUAUUGGAGAAAGCUUGGGGCACCCUCAGAGAAGCUCAUCAUGGGGAUCCCCACCUAUGGACGUACCUUUCGCCUCCUCAAAGCCUCUAAGAAUGGGUUGCAGGCCAGAGCGAUCGGACCAGCAUCUCCAGGGAAGUACACCAAGCAAGAAGGCUUCUUGGCUUAUUUUGAGAUUUGUUCCUUUGUCUGGGGAGCGAAGAAGCACUGGAUUGAUUACCAGUAUGUCCCGUAUGCCAACAAGGGGAAAGAGUGGGUUGGCUAUGACAAUGCCAUCAGCUUCAGUUACAAGGCAUGGUUUAUAAGGCGAGAGCAUUUUGGGGGGGCCAUGGUGUGGACAUUGGACAUGGAUGACGUCAGGGGCACGUUCUGUGGCACUGGCCCUUUCCCCCUUGUCUACGUAUUGAAUGAUAUCCUGGUGCGGGCUGAGUUCAGUUCAACUUCUUUACCACAAUUUUGGCUGUCAUCUGCUGUGAAUUCUUCAAGCACUGACCCUGAAAGGCUGGCUGUGACCACGGCAUGGACCACUGAUAGUAAGAUUUUGCCCCCAGGAGGAGAGGCUGGGGUCACUGAGAUCCACGGAAAGUGUGAAAAUAUGACUAUAACCCCUAGAGGUACAACUGUGACCCCUACAAAGGAAACUGUAUCCCUUGGAAAGCACACUGUAGCUCUAGGAGAGAAGACUGAGAUCACUGGGGCAAUGACCAUGACUUCUGUGGGUCAUCAGUCCAUGACCCCUGGAGAGAAGGCCCUGACCCCUGUGGGUCAUCAAUCUGUGACCACUGGACAGAAGACCCUGACCUCUGUGGGUUAUCAGUCUGUGACCCCUGGGGAAAAGACCCUGACCCCUGUGGGUCAUCAGUCUGUGACCCCUGUGAGUCAUCAGUCUGUGAGCCCUGGAGGAACGACUAUGACCCCUGUCCAUUUUCAGACUGAGACCCUUAGACAGAAUACAGUGGCCCCUAGAAGGAAGGCUGUGGCCCGUGAAAAGGUGACUGUCCCCUCCAGAAACAUAUCAGUCACCCCUGAAGGGCAGACUAUGCCUUUAAGAGGGGAGAAUUUGACUUCUGAGGUGGGCACUCACCCCAGGAUGGGUAACUUGGGUCUUCAGAUGGAAGCUGAAAACAGGAUGAUGCUGUCCUCCAGCCCCGUCAUCCAGCUCCCGGAACAAACUCCUCUAGCUUUUGACAACCGCUUUGUUCCCAUCUAUGGAAACCAUUCCUCUGUCAACUCAGUAACCCCUCAAACAAGUCCUCUUUCUCUAAAAAAAGAAAUCCCAGAAAACUCUGCUGUGGAUGAAGAAGCCUAAGCCCCUCUGGUGUCAGAAACCAGGGAAAACCCUUGUCUUUUCUUCUAAGUGACAUGUUGGAAGCCUUCUCAUCCCGGGGCAAAGCAGGCAUCAAAACCAGAAUAGGCCAAUCUCUUUUCCAUUAAAUAAACUGUAAACACAAGAA-3'- Poly-A tail
  • Coding region
;
DNA
DNA (Gene ID: 5016)
oviductal glycoprotein 1
strand -
CHIT5
NCBI CDS gene sequence (2037 bp)
5'-ATGTGGAAGCTGTTGCTGTGGGTTGGGCTGGTTCTTGTGCTGAAACACCACGATGGTGCTGCCCATAAACTCGTGTGTTATTTCACCAACTGGGCACACAGTCGGCCAGGCCCTGCCTCGATCTTGCCCCATGACCTGGACCCCTTTCTCTGCACCCACCTGATATTTGCCTTTGCCTCAATGAACAACAATCAGATTGTTGCTAAGGATCTCCAGGATGAGAAAATTCTCTACCCAGAGTTCAACAAACTAAAGGAGAGGAACAGAGAGCTGAAAACACTACTGTCCATCGGCGGGTGGAACTTTGGCACCTCAAGATTCACCACTATGTTGTCCACATTTGCCAACCGTGAAAAGTTTATTGCTTCAGTTATATCCCTTCTGAGGACACATGACTTTGATGGTCTTGACCTTTTCTTCTTATATCCTGGACTAAGAGGCAGCCCCATGCATGACCGGTGGACTTTTCTCTTCTTAATTGAAGAGCTCCTGTTTGCCTTCCGGAAGGAGGCACTGCTCACCATGCGCCCGAGGCTGCTGCTGTCTGCTGCTGTTTCTGGGGTCCCACACATCGTCCAAACATCCTATGATGTGCGCTTTCTAGGAAGACTCCTGGATTTCATCAATGTCTTGTCTTATGACTTACATGGAAGTTGGGAAAGGTTCACAGGACATAATAGCCCCCTCTTCTCTCTGCCTGAAGACCCCAAATCTTCGGCATATGCTATGAATTATTGGAGAAAGCTTGGGGCACCCTCAGAGAAGCTCATCATGGGGATCCCCACCTATGGACGTACCTTTCGCCTCCTCAAAGCCTCTAAGAATGGGTTGCAGGCCAGAGCGATCGGACCAGCATCTCCAGGGAAGTACACCAAGCAAGAAGGCTTCTTGGCTTATTTTGAGATTTGTTCCTTTGTCTGGGGAGCGAAGAAGCACTGGATTGATTACCAGTATGTCCCGTATGCCAACAAGGGGAAAGAGTGGGTTGGCTATGACAATGCCATCAGCTTCAGTTACAAGGCATGGTTTATAAGGCGAGAGCATTTTGGGGGGGCCATGGTGTGGACATTGGACATGGATGACGTCAGGGGCACGTTCTGTGGCACTGGCCCTTTCCCCCTTGTCTACGTATTGAATGATATCCTGGTGCGGGCTGAGTTCAGTTCAACTTCTTTACCACAATTTTGGCTGTCATCTGCTGTGAATTCTTCAAGCACTGACCCTGAAAGGCTGGCTGTGACCACGGCATGGACCACTGATAGTAAGATTTTGCCCCCAGGAGGAGAGGCTGGGGTCACTGAGATCCACGGAAAGTGTGAAAATATGACTATAACCCCTAGAGGTACAACTGTGACCCCTACAAAGGAAACTGTATCCCTTGGAAAGCACACTGTAGCTCTAGGAGAGAAGACTGAGATCACTGGGGCAATGACCATGACTTCTGTGGGTCATCAGTCCATGACCCCTGGAGAGAAGGCCCTGACCCCTGTGGGTCATCAATCTGTGACCACTGGACAGAAGACCCTGACCTCTGTGGGTTATCAGTCTGTGACCCCTGGGGAAAAGACCCTGACCCCTGTGGGTCATCAGTCTGTGACCCCTGTGAGTCATCAGTCTGTGAGCCCTGGAGGAACGACTATGACCCCTGTCCATTTTCAGACTGAGACCCTTAGACAGAATACAGTGGCCCCTAGAAGGAAGGCTGTGGCCCGTGAAAAGGTGACTGTCCCCTCCAGAAACATATCAGTCACCCCTGAAGGGCAGACTATGCCTTTAAGAGGGGAGAATTTGACTTCTGAGGTGGGCACTCACCCCAGGATGGGTAACTTGGGTCTTCAGATGGAAGCTGAAAACAGGATGATGCTGTCCTCCAGCCCCGTCATCCAGCTCCCGGAACAAACTCCTCTAGCTTTTGACAACCGCTTTGTTCCCATCTATGGAAACCATTCCTCTGTCAACTCAGTAACCCCTCAAACAAGTCCTCTTTCTCTAAAAAAAGAAATCCCAGAAAACTCTGCTGTGGATGAAGAAGCCTAA-3'
NCBI CDS gene sequence with introns (location: 111414464.. 111427721) (13258 bp)Download
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 111414319.. 111427735) (13417 bp)Download
NCBI gene sequence (location: [111414319.. 111427735 + 1000]) (14417 bp)Download
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