NCBI Summary
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008].
Protein
Protein (NP_059113)
CBM13-ppGalNAc-T8
Probable polypeptide N-acetylgalactosaminyltransferase 8 (EC 2.4.1.41) (Polypeptide GalNAc transferase 8) (GalNAc-T8) (pp-GaNTase 8) (Protein-UDP acetylgalactosaminyltransferase 8) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 8)
GALNT8
polypeptide N-acetylgalactosaminyltransferase 8
Undefined
Curated
Ricin-like
R-Type Lectins
b-trefoil
GalNAc / Mucin-type glycopeptide
NP_059113
26290
Q9NY28
ENSP00000252318.2
Q9NY28
Undefined
10.1074/jbc.M111.273722
neXtProt, PFAM, InterPro
Protein sequence and protein families (fasta) (637 amino acids) Download
MMFWRKLPKALFIGLTLAIAVNLLLVFSSKGTLQNLFTGGLHRELPLHLNKRYGAVIKRLSHLEVELQDLKESMKLALRQQENVNSTLKRAKDEVRPLLKAMETKVNETKKHKTQMKLFPHSQLFRQWGEDLSEAQQKAAQDLFRKFGYNAYLSNQLPLNRTIPDTRDYRCLRKTYPSQLPSLSVILIFVNEALSIIQRAITSIINRTPSRLLKEIILVDDFSSNGELKVHLDEKIKLYNQKYPGLLKIIRHPERKGLAQARNTGWEAATADVVAILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFKLDKYELAVDGFNWELWCRYDALPQAWIDLHDVTAPVKSPSIMGILAANRHFLGEIGSLDGGMLIYGGENVELSLRVWQCGGKVEILPCSRIAHLERHHKPYALDLTAALKRNALRVAEIWMDEHKHMVYLAWNIPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNVYPLLKPLHTIVGYGRMKNLLDENVCLDQGPVPGNTPIMYYCHEFSSQNVYYHLTGELYVGQLIAEASASDRCLTDPGKAEKPTLEPCSKAAKNRLHIYWDFKPGGAVINRDTKRCLEMKKDLLGSHVLVLQTCSTQVWEIQHTVRDWGQTNSQ
No structure currently available in the PDB RCSB Databank.
Structural models
AlphaFold v2: AF-Q9NY28-F1Download
  Model Confidence:
  •    Very high (pLDDT > 90)
  •    Confident (90 > pLDDT > 70)
  •    Low (70 > pLDDT > 50)
  •    Very low (pLDDT < 50)

  AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

AlphaFold_v2 structural model assessment through SWISS-MODEL tools.

SWISS-MODEL structural models
SWISS-MODEL structural model
Modeller structural model (Homology modelling pipeline), Error: [ err > 2 Å]Download
The location of the lectin domain structural model is: 496-634
We infer [ err > 2 Å] as the interval of error of this structural model.
Template: 1XHB chain: A, O08912, NP_001153876.1, sequence identity: 18.0%, coverage: 85.6%, location in sequence: 95-553, (95-553 in PDB).
Show the alignment used for the construction of the structural model, Download.
Show the plot of DOPE energy score, Download.
Ligand
Glycan ligands from structural data
No crystal structures of complexes with glycan ligand.
Expression
Human Protein Atlas
GeneCards
mRNA expression in normal human tissues for GALNT8 Gene
ProteomicsDB
References
NCBI References (6 PubMed Identifiers)
  • Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis. [29741668]
  • Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings. [24038392]
  • Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C. [23034592]
  • Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. [20800603]
  • Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2. [12438318]
  • Molecular cloning of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T8, and analysis as a candidate autosomal dominant hypophosphatemic rickets (ADHR) gene. [10767557]
UniProt Main References (1 PubMed Identifiers)
  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [15489334]
RNA
RNA (Transcript ID: NM_017417.2)
NM_017417.2
polypeptide N-acetylgalactosaminyltransferase 8
All isoforms of GALNT8 containing a lectin domain
ENST00000252318.7
279..2192 (or 4720678.. 4772597)
4720400.. 4772726
NCBI Matured mRNA sequence 2321 NTPDownload 
m7G-5')ppp(5'-GUUAUCUCCCUGAGCAACCUGUGGAAAGCCGCUGAGCAACCUGUGGAAAGCCGCUGAGCGGUUAUCCUCUCGGGGCAUAAAGACAAAGAAGGCAAUAAGGAGACUUUGCUCCUCAGAGGCCACCCGUGGCUUCCCAUGGGUGUCUCACACAGGGGAGACCAACUCAACUGGCACCUAGAACUCUCUUUCCCACAAAAGCUAGGCUGGUUCUGAUUCUUAACCUGCUCCAGCAGUGACACACUCAGUCCCACAGGGAGUGGACGACCCCCAGGAAGAAGAUGAUGUUUUGGAGGAAACUCCCCAAAGCCCUCUUCAUUGGGCUGACUCUGGCCAUUGCUGUCAAUCUCCUUCUGGUAUUUUCUAGCAAGGGGACUUUACAAAACCUGUUUACGGGUGGUCUCCACAGGGAGCUUCCUUUACAUCUGAAUAAACGCUACGGGGCAGUGAUAAAGAGACUCUCCCACUUGGAGGUGGAAUUGCAGGAUCUGAAAGAAAGUAUGAAAUUAGCUCUGAGGCAACAAGAAAAUGUGAACAGCACACUGAAGAGGGCGAAAGAUGAAGUACGCCCUCUUCUAAAGGCAAUGGAAACCAAGGUGAAUGAGACAAAGAAGCACAAAACCCAAAUGAAACUCUUCCCACACUCACAGCUUUUCAGGCAAUGGGGCGAGGAUCUUUCUGAGGCCCAGCAGAAGGCGGCCCAGGACCUCUUCCGGAAGUUUGGUUACAACGCGUACCUCAGCAACCAGCUGCCUCUCAAUCGCACCAUCCCCGACACGCGAGACUACAGAUGUCUUCGGAAGACAUAUCCUUCCCAACUCCCAUCCCUCAGUGUCAUUCUCAUAUUCGUGAAUGAAGCUCUGUCCAUUAUACAACGGGCCAUCACCAGUAUCAUCAACCGGACGCCCUCUCGAUUGUUGAAGGAAAUCAUCUUGGUGGAUGAUUUCAGCUCAAAUGGAGAACUAAAGGUACACUUGGAUGAGAAGAUUAAGCUUUACAACCAGAAGUAUCCAGGACUACUGAAAAUAAUACGGCAUCCUGAAAGGAAAGGUCUUGCUCAAGCCCGCAACACUGGCUGGGAAGCUGCCACAGCAGACGUGGUCGCCAUCUUGGAUGCUCACAUUGAAGUCAAUGUUGGGUGGGCAGAGCCAAUCUUGGCUCGGAUUCAGGAGGACCGCACUGUGAUUGUGUCUCCUGUGUUUGACAACAUUCGUUUUGACACCUUCAAACUGGAUAAGUAUGAACUGGCAGUUGAUGGGUUUAACUGGGAACUCUGGUGCCGCUACGAUGCACUGCCACAAGCCUGGAUUGAUCUGCAUGAUGUCACUGCCCCAGUGAAGAGUCCUUCAAUCAUGGGCAUCCUGGCUGCUAACAGGCACUUCCUGGGAGAGAUCGGGUCUCUGGAUGGUGGAAUGCUCAUCUAUGGAGGAGAGAACGUGGAGCUUAGCCUGAGGGUGUGGCAGUGUGGAGGGAAGGUCGAGAUUUUGCCCUGUUCCCGGAUUGCCCACCUAGAGAGACACCACAAGCCCUACGCCUUGGAUCUCACCGCUGCCUUGAAGCGCAAUGCUCUGCGAGUGGCCGAAAUCUGGAUGGAUGAGCACAAACACAUGGUCUACUUGGCCUGGAACAUACCUCUCCAGAACUCUGGAAUAGAUUUUGGAGACGUUUCUUCCAGAAUGGCACUCCGGGAAAAACUGAAAUGUAAAACUUUUGACUGGUACCUGAAAAAUGUUUAUCCACUCUUGAAGCCACUCCACACCAUCGUGGGCUAUGGAAGAAUGAAAAACCUAUUGGAUGAAAAUGUCUGCUUGGAUCAGGGACCCGUUCCAGGCAACACCCCCAUCAUGUAUUACUGCCAUGAAUUCAGCUCACAGAAUGUCUACUAUCACCUAACUGGGGAGCUCUAUGUGGGACAACUGAUUGCAGAGGCCAGUGCUAGUGAUCGCUGCCUGACAGACCCUGGCAAGGCGGAGAAGCCCACCUUAGAACCAUGCUCCAAGGCAGCUAAGAAUAGACUGCAUAUAUAUUGGGAUUUUAAACCGGGAGGAGCUGUCAUAAACAGAGAUACCAAGCGGUGUCUGGAGAUGAAGAAGGAUCUUUUGGGUAGCCACGUGCUUGUGCUCCAGACCUGUAGCACGCAAGUGUGGGAAAUCCAGCACACUGUCAGAGACUGGGGUCAGACCAACAGCCAGUGAUCCUCAGAUGGUGCUGGAUCUGGGUCAUCAAUUCUUGCAAGUGGAAUGGCUUCUACUCCUAACACUCCCAGCUUCUUUCUCAAUGAGAAAGAAAGCAUGUGUAUGUCUGUUUAUGGCGACUUCAGGUGG-3'- Poly-A tail
  • Coding region
NCBI Matured mRNA sequence viewer
;
More about the NCBI sViewer.
DNA
DNA (Gene ID: 26290)
GALNT8
polypeptide N-acetylgalactosaminyltransferase 8
NC_000012.12
12  4720678.. 4772597
4720678.. 4772597
strand +
CCDS8533.1
ClinVar, dbVar
ENSG00000130035
GALNAC-T8
uc001qne.2
INSDC: AJ271385
4130
606250
OTTHUMG00000166188
ENA, DDBJ, Monarch
NCBI CDS Gene viewer
More about the NCBI sViewer.
NCBI CDS gene sequence (1914 bp)
5'-ATGATGTTTTGGAGGAAACTCCCCAAAGCCCTCTTCATTGGGCTGACTCTGGCCATTGCTGTCAATCTCCTTCTGGTATTTTCTAGCAAGGGGACTTTACAAAACCTGTTTACGGGTGGTCTCCACAGGGAGCTTCCTTTACATCTGAATAAACGCTACGGGGCAGTGATAAAGAGACTCTCCCACTTGGAGGTGGAATTGCAGGATCTGAAAGAAAGTATGAAATTAGCTCTGAGGCAACAAGAAAATGTGAACAGCACACTGAAGAGGGCGAAAGATGAAGTACGCCCTCTTCTAAAGGCAATGGAAACCAAGGTGAATGAGACAAAGAAGCACAAAACCCAAATGAAACTCTTCCCACACTCACAGCTTTTCAGGCAATGGGGCGAGGATCTTTCTGAGGCCCAGCAGAAGGCGGCCCAGGACCTCTTCCGGAAGTTTGGTTACAACGCGTACCTCAGCAACCAGCTGCCTCTCAATCGCACCATCCCCGACACGCGAGACTACAGATGTCTTCGGAAGACATATCCTTCCCAACTCCCATCCCTCAGTGTCATTCTCATATTCGTGAATGAAGCTCTGTCCATTATACAACGGGCCATCACCAGTATCATCAACCGGACGCCCTCTCGATTGTTGAAGGAAATCATCTTGGTGGATGATTTCAGCTCAAATGGAGAACTAAAGGTACACTTGGATGAGAAGATTAAGCTTTACAACCAGAAGTATCCAGGACTACTGAAAATAATACGGCATCCTGAAAGGAAAGGTCTTGCTCAAGCCCGCAACACTGGCTGGGAAGCTGCCACAGCAGACGTGGTCGCCATCTTGGATGCTCACATTGAAGTCAATGTTGGGTGGGCAGAGCCAATCTTGGCTCGGATTCAGGAGGACCGCACTGTGATTGTGTCTCCTGTGTTTGACAACATTCGTTTTGACACCTTCAAACTGGATAAGTATGAACTGGCAGTTGATGGGTTTAACTGGGAACTCTGGTGCCGCTACGATGCACTGCCACAAGCCTGGATTGATCTGCATGATGTCACTGCCCCAGTGAAGAGTCCTTCAATCATGGGCATCCTGGCTGCTAACAGGCACTTCCTGGGAGAGATCGGGTCTCTGGATGGTGGAATGCTCATCTATGGAGGAGAGAACGTGGAGCTTAGCCTGAGGGTGTGGCAGTGTGGAGGGAAGGTCGAGATTTTGCCCTGTTCCCGGATTGCCCACCTAGAGAGACACCACAAGCCCTACGCCTTGGATCTCACCGCTGCCTTGAAGCGCAATGCTCTGCGAGTGGCCGAAATCTGGATGGATGAGCACAAACACATGGTCTACTTGGCCTGGAACATACCTCTCCAGAACTCTGGAATAGATTTTGGAGACGTTTCTTCCAGAATGGCACTCCGGGAAAAACTGAAATGTAAAACTTTTGACTGGTACCTGAAAAATGTTTATCCACTCTTGAAGCCACTCCACACCATCGTGGGCTATGGAAGAATGAAAAACCTATTGGATGAAAATGTCTGCTTGGATCAGGGACCCGTTCCAGGCAACACCCCCATCATGTATTACTGCCATGAATTCAGCTCACAGAATGTCTACTATCACCTAACTGGGGAGCTCTATGTGGGACAACTGATTGCAGAGGCCAGTGCTAGTGATCGCTGCCTGACAGACCCTGGCAAGGCGGAGAAGCCCACCTTAGAACCATGCTCCAAGGCAGCTAAGAATAGACTGCATATATATTGGGATTTTAAACCGGGAGGAGCTGTCATAAACAGAGATACCAAGCGGTGTCTGGAGATGAAGAAGGATCTTTTGGGTAGCCACGTGCTTGTGCTCCAGACCTGTAGCACGCAAGTGTGGGAAATCCAGCACACTGTCAGAGACTGGGGTCAGACCAACAGCCAGTGA-3'
NCBI CDS gene sequence with introns (location: 4720678.. 4772597) (51920 bp)Download
NCBI Gene Viewer (CDS + introns)
NCBI CDS gene sequence with introns, 5'UTR and 3'UTR (location: 4720400.. 4772726) (52327 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions)
NCBI gene sequence (location: [4720400 - 1000].. 4772726) (53327 bp)Download
NCBI Gene Viewer (CDS + introns + Untranslated regions + 1000 dNTP to potentially reach the promotor)
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